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1.

001-es BibID:BIBFORM082799
035-os BibID:(PMID)31907366
Első szerző:Altieri, Barbara
Cím:Vitamin D testing : advantages and limits of the current assays / Barbara Altieri, Etienne Cavalier, Harjit Pal Bhattoa, Faustino R. Pérez-López, María T. López-Baena, Gonzalo R. Pérez-Roncero, Peter Chedraui, Cedric Annweiler, Silvia Della Casa, Sieglinde Zelzer, Markus Herrmann, Antongiulio Faggiano, Annamaria Colao, Michael F. Holick
Dátum:2020
ISSN:0954-3007
Megjegyzések:Vitamin D deficiency and insufficiency has become a pandemic health problem with a consequent increase of requests for determining circulating levels of 25-hydroxyvitamin D [25(OH)D]. However, the analytical performance of these immunoassays, including radioimmunoassay and ELISA, is highly variable, and even mass spectrometric methods, which nowadays serves as the gold standard for the quantitatively determination of 25(OH)D, do not necessarily produce comparable results, creating limitations for the definition of normal vitamin D status ranges. To solve this problem, great efforts have been made to promote standardization of laboratory assays, which is important to achieve comparable results across different methods and manufacturers. In this review, we performed a systematic analysis evaluating critically the advantages and limits of the current assays available for the measure of vitamin D status, i.e., circulating 25(OH)D and its metabolites, making suggestions that could be used in the clinical practice. Moreover, we also suggest the use of alternatives to blood test, including standardized surveys that may be of value in alerting health-care professionals about the vitamin D status of their patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:European Journal Of Clinical Nutrition. - 74 : 2 (2020), p. 231-247. -
További szerzők:Cavalier, Etienne Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Pérez-López, Faustino R. López-Baena, María T. Pérez-Roncero, Gonzalo R. Chedraui, Peter Annweiler, Cedric Della Casa, Silvia Zelzer, Sieglinde Herrmann, Markus Faggiano, Antongiulio Colao, Annamaria Holick, Michael F.
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2.

001-es BibID:BIBFORM002149
Első szerző:Audikovszky Mária (belgyógyász, lipidológus)
Cím:Orlistat increases serum paraoxonase activity in obese patients / Audikovszky Mária, Pados Gyula, Seres Ildikó, Harangi Mariann, Fülöp Péter, Katona Evelin, Illyés László, Winkler Gábor, Katona Éva, Paragh György
Dátum:2007
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Nutrition, Metabolism and Cardiovascular Diseases. - 17 : 4 (2007), p. 268-273. -
További szerzők:Pados Gyula Seres Ildikó (1954-) (biokémikus) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Fülöp Péter (1974-) (belgyógyász, endokrinológus, lipidológus) Katona Evelin (1974-) (belgyógyász) Illyés László Winkler Gábor Katona Éva (1967-) (belgyógyász, diabetológus) Paragh György (1953-) (belgyógyász)
Internet cím:elektronikus változat
DOI
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3.

001-es BibID:BIBFORM057430
Első szerző:Auricchio, Renata
Cím:The frequency of coeliac disease (CD) in high-risk young children from families with CD : the Preventcd cohort / R. Auricchio, C. Hogen Esch, G. Castillejo, E. Mummert, E. Bravi, I. Korponay-Szabo, S. Koletzko, L. Greco, R. Troncone, M. L. Mearin, The PreventCD Study Group
Dátum:2011
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:Journal of Pediatric Gastroenterology and Nutrition 52 : Suppl. 2 (2011), p. E7. -
További szerzők:Hogen Esch, Caroline Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Mummert, Eckart Bravi, Enzo (biológus) Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Koletzko, Sibylle Greco, Luigi Troncone, Riccardo Mearin, Maria Luisa the PREVENTCD Study Group
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM065683
Első szerző:Aydemir, Gamze (biotechnológus)
Cím:Lycopene supplementation restores vitamin A deficiency in mice and possesses thereby partial pro-vitamin A activity transmitted via RAR-signaling / Gamze Aydemir, Yasamin Kasiri, Emöke-Márta Bartók, Eszter Birta, Kati Fröhlich, Volker Böhm, Johanna Mihaly, Ralph Rühl
Dátum:2016
ISSN:1613-4125
Megjegyzések:SCOPE:The aim of this study was to compare if lycopene also possesses pro-vitamin A (VA) activity comparable to known VA derivatives.MATERIALS AND METHODS:We used a transgenic retinoic acid response element reporter mouse model (n = 8, per group) for this study, and after the initial wash out of VA using a vitamin A deficient diet (VAD) for 18 weeks, the animals were supplemented further with (a) VAD-fed mice, (b) VAD-fed mice plus retinol (20 mg/kg bw), (c) VAD-fed mice plus ?-carotene (40 mg/kg bw), and (d) VAD-fed mice plus lycopene (40 mg/kg bw). Using ex vivo scanning and gene expression analysis of retinoid target and VA marker gene analysis in various organs of these supplemented mice (b, c, d), we found increased luciferase activity and normalized marker and target gene analysis compared to group a.CONCLUSIONS:Lycopene can restore VA deficiency and compensate VA for retinoic acid receptor (RAR)-mediated signaling as the major function of VA in the mammalian organism. Lycopene administration can initiate upregulation of RAR-mediated signaling in various organs in VAD-fed animals via potential novel bioactive lycopene metabolites. This indicates that lycopene possesses partial pro-VA activity in mice transmitted via RAR-mediated signaling.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Carotenoid
Retinoic acid receptor
Retinol
Tomato
Megjelenés:Molecular Nutrition & Food Research 60 : 11 (2016), p. 2413-2420. -
További szerzők:Kasiri, Yasamin Bartók Emőke Márta Birta Eszter Fröhlich Kati Böhm, Volker Mihály Johanna (1982-) (biológus, vegyész) Rühl, Ralph (1969-) (vegyész)
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5.

001-es BibID:BIBFORM052719
Első szerző:Aydemir, Gamze (biotechnológus)
Cím:Lycopene-derived bioactive retinoic acid receptors/retinoid-X receptors-activating metabolites may be relevant for lycopene's anti-cancer potential / Gamze Aydemir, Yasamin Kasiri, Eszter Birta, Gabriella Béke, Ada L. Garcia, Emőke-Márta Bartók, Ralph Rühl
Dátum:2013
ISSN:1613-4125
Megjegyzések:Dietary consumption of tomato products and especially the red tomato pigment lycopene has been associated with lower risk of cancer. New evidence is emerging toward metabolic pathways mediating the anti-cancer activities of lycopene. In this review, we explore associations between tomatoes and lycopene intake and cancer and relate this to the metabolic activation pathways of lycopene via carotene oxygenases and further carotenoid/retinoid-metabolizing enzymes to apo-lycopenoids. Several of these apo-lycopenoids have already been identified but up to date no direct connection between lycopene metabolism and apo-lycopenoids mediated receptor activation pathways has been established. Retinoic acid receptors/retinoid-X receptors activation pathways in particular, may be mediated via lycopene metabolites that are related to retinoic acids. Various studies have shown an association between lower concentration of insulin-like growth factor-1 upon lycopene treatment, cancer incidences, and retinoid-mediated signaling. In this review, we interrelate tomato/lycopene ingestion and cancer incidence, with metabolic activation of lycopene and retinoid-mediated signaling. The aim is to discuss a potential mechanism to explain lycopene related anti-cancer activities by modulation of insulin-like growth factor-1 concentrations via lycopene metabolite activation of retinoid-mediated signaling.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Molekuláris Medicina
Megjelenés:Molecular Nutrition & Food Research. - 57 : 5 (2013), p. 739-747. -
További szerzők:Kasiri, Yasamin Birta Eszter Béke Gabriella (1987-) (molekuláris biológus) Garcia, Ada L. Bartók Emőke Márta Rühl, Ralph (1969-) (vegyész)
Pályázati támogatás:TÁMOP-4.2.2.A-11/1/KONV-2012-0023
TÁMOP
TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
Az apoptózis molekuláris mechanizmusa
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6.

001-es BibID:BIBFORM031277
Első szerző:Aydemir, Gamze (biotechnológus)
Cím:Lycopene induces retinoic acid receptor transcriptional activation in mice / Gamze Aydemir, Harald Carlsen, Rune Blomhoff, Ralph Rühl
Dátum:2012
ISSN:1613-4125
Megjegyzések:Lycopene is a lipophilic carotenoid and provides the red color to tomatoes and tomato product. Various studies indicated that lycopene and tomatoes / tomato products are able to positively influence various diseases associated with a chronic inflammation. The mechanism of action of lycopene to elicit these effects is partly unknown. A possible mechanism is that biological metabolites of lycopene may activate nuclear hormone receptors in mammalian cells. The aim of this study was to investigate the potential of orally administered lycopene and all-trans retinoic acid (ATRA) for the induction of the retinoic acid receptor (RAR) in a transgenic retinoic acid response-element (RARE)-reporter mouse system. Methods and Results:Orally administered lycopene (100 mg/kg bw in beadlets, n=6) and all-trans retinoic acid (ATRA) as an endogenous retinoic acid receptor (RAR)-ligand (50 mg/kg bw, n=6) for the induction of the retinoic acid receptor in male mice using a transgenic retinoic acid response-element (RARE)-reporter mouse system. Lycopene-treatments induced RARE-mediated cell signaling indicated by quantified bio-imaging, increased luciferase activity and up-regulated the retinoid target genes in selected organs of the mice. Conclusion:We conclude that lycopene can induce RAR-transcriptional activation in mice and lycopene might be a precursor of still non identified biologically active metabolites.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
lycopene
retinoid signalling
külföldön készült közlemény
Megjelenés:Molecular Nutrition and Food Research. - 56 : 5 (2012), p. 702-712. -
További szerzők:Carlsen, Harald Blomhoff, Rune Rühl, Ralph (1969-) (vegyész)
Pályázati támogatás:TÁMOP 4.2.1./B-09/1/KONV-2010-007
TÁMOP
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7.

001-es BibID:BIBFORM023029
Első szerző:Balla József (belgyógyász, nephrológus)
Cím:Heme, heme oxygenase and ferritin in vascular endothelial cell injury / Balla József, Vercellotti Gregory M., Jeney Viktória, Yachie Akihiro, Varga Zsuzsa, Eaton John W., Balla György
Dátum:2005
ISSN:1613-4125
Megjegyzések:Iron-derived reactive oxygen species are implicated in the pathogenesis of numerous vascular disorders including atherosclerosis, microangiopathic hemolytic anemia, vasculitis, and reperfusion injury. One abundant source of redox active iron is heme, which is inherently dangerous when released from intracellular heme proteins. The present review concerns the involvement of heme in vascular endothelial cell damage and the strategies used by endothelium to minimize such damage. Exposure of endothelium to heme greatly potentiates cell killing mediated by polymorphonuclear leukocytes and other sources of reactive oxygen. Free heme also promotes the conversion of low-density lipoprotein (LDL) into cytotoxic oxidized products. Only because of its abundance, hemoglobin probably represents the most important potential source of heme within the vascular endothelium; hemoglobin in plasma, when oxidized, transfers heme to endothelium and LDL, thereby enhancing cellular susceptibility to oxidant-mediated injury. As a defense against such toxicity, upon exposure to heme or hemoglobin, endothelial cells up-regulate heme oxygenase-1 and ferritin. Heme oxygenase-1 is a heme-degrading enzyme that opens the porphyrin ring, producing biliverdin, carbon monoxide, and the most dangerous product - free redox active iron. The latter can be effectively controlled by ferritin via sequestration and ferroxidase activity. Ferritin serves as a protective gene by virtue of antioxidant, antiapoptotic, and antiproliferative actions. These homeostatic adjustments have been shown effective in the protection of endothelium against the damaging effects of exogenous heme and oxidants. The central importance of this protective system was recently highlighted by a child diagnosed with heme oxygenase-1 deficiency, who exhibited extensive endothelial damage.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Molecular Nutrition and Food Research. - 49 : 11 (2005), p. 1030-1043. -
További szerzők:Vercellotti, Gregory M. Jeney Viktória (1971-) (vegyész, kémia tanár) Yachie, Akihiro Varga Zsuzsa (1951-) (biokémikus, nephrológus) Eaton, John W. Balla György (1953-) (csecsemő és gyermekgyógyász, neonatológus)
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8.

001-es BibID:BIBFORM095627
035-os BibID:(cikkazonosító)e2021235
Első szerző:Bárány Beatrix (PhD hallgató)
Cím:Nutrient Intake and Nutritional Status in Hungarian Gynecological Cancer Patients / Bárány Beatrix, Póka Róbert
Dátum:2021
Megjegyzések:Summary. Aims: The incidence of malignant diseases is on the rise. Although nutrition and nutritional status do not get enough attention in the therapy of gynecological tumors, they may affect mortality and morbidity. More information on nutrient intake and nutritional status of gynecological cancer patients are needed to provide generalizable advice. The primary aim of our study was to analyze the nutrient intake, risk of malnutrition and quality of life among Hungarian gynecological cancer patients. Methods: We used a 3-day food record in order to assess energy and nutrient intake. The Malnutrition Universal Screening Tool was used to establish malnutrition risk, and the quality of life was evaluated using the EORTC-QLQ-C30 questionnaire. We included one hun-dred ninety-five gynecological oncology patients diagnosed with cervical, endometrial or ovarian cancer in our study. Results: Based on our results malnutrition risk affects 39% of gynecological oncology patients at the time of diagnosis, while this rate is considerably higher among patients under treatment. Furthermore, the intake of most micronutrients was less than the recommended dose, regardless of the status of the disease. Also, we found the quality of life to be strongly related to malnutrition risk. Conclusions: The study suggests that early detection of malnutrition risk and nutritional interventions are necessary among Hungarian gynecological cancer patients to helping improve nutrition intake, nutrition status and quality of life.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Cancer
Dietary intake
Malnutrition risk
Nutritional status
Megjelenés:Progress in Nutrition. - 23 : 2 (2021), p. 1-8. -
További szerzők:Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus)
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9.

001-es BibID:BIBFORM113498
035-os BibID:(scopus)85149265853 (wos)000940835400001
Első szerző:Basdeki, Eirini D.
Cím:A lifestyle pattern characterised by high consumption of sweet and salty snacks, sugar sweetened beverages and sedentary time is associated with blood pressure in families at risk for type 2 diabetes mellitus in Europe : The Feel4Diabetes Study / Basdeki Eirini D., Karatzi Kalliopi, Arnaoutis Giannis, Makrilakis Konstantinos, Liatis Stavros, Cardon Greet, De Craemer Marieke, Iotova Violeta, Tsochev Kaloyan, Tankova Tsvetalina, Kivelä Jemina, Wikström Katja, Rurik Imre, Radó Sándorné, Miguel-Berges María L., Gimenez-Legarre Natalia, Moreno-Aznar Luis, Manios Yannis
Dátum:2023
ISSN:0952-3871
Megjegyzések:BackgroundIndividuals from families at high-risk for type 2 diabetes mellitus (T2DM) are also at high risk for hypertension (HTN) and cardiovascular disease. Studies identifying lifestyle patterns (LPs) combining dietary, physical activity or sedentary variables and examining their possible role with respect to developing blood pressure (BP) are limited. The present study aimed to examine the association of different LPs with BP levels in families at high risk for T2DM in Europe. MethodsIn total, 1844 adults (31.6% males) at high-risk for T2DM across six European countries were included in this cross-sectional study using data from the baseline assessment of the Feel4Diabetes Study. BP measurements and dietary and physical activity assessments were conducted, and screen times were surveyed. LPs were revealed with principal component analysis of various data regarding diet, physical activity, screen time and smoking. ResultsThree LPs were identified. LP3 (high consumption of sweet and salty snacks, sugar sweetened soft drinks and juices, and high amount of screen time) was positively associated with diastolic BP (B, 0.52; 95% confidence interval = 0.05-0.99) and the existence of HTN (odds ratio = 1.12; 95% confidence interval = 1.00-1.25). Participants in the highest tertile of LP3 spent mean 3 h of screen time, consumed 1.5 portions of sweet and/or salty snacks and 1 L of soft drinks on a daily basis, were associated with 12% higher risk of HTN. ConclusionsFocusing on the combination of eating and lifestyle behaviours may more accurately identify, and therefore guide preventive measures tailored to the specific needs of high-risk populations.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal Of Human Nutrition And Dietetics. - 36 : 4 (2023), p. 1564-1575. -
További szerzők:Karatzi, Kalliopi Arnaoutis, Giannis Makrilakis, Konstantinos Liatis, Stavros Cardon, Greet De Craemer, Marieke Iotova, Violeta Tsochev, Kaloyan Tankova, Tsvetalina Kivelä, Jemina Wikström, Katja Rurik Imre (1953-) (háziorvos, foglalkozás-egészségügyi szakorvos, urológus) Radó Sándor Istvánné (1976-) (diplomás ápoló) Miguel-Berges, María L. Giménez-Legarre, Natalia Moreno-Aznar, Luis Manios, Yannis
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10.

001-es BibID:BIBFORM066170
Első szerző:Bodnár Dóra (molekuláris biológus)
Cím:Dietary selenium augments sarcoplasmic calcium release and mechanical performance in mice / Dóra Bodnár, Olga Ruzsnavszky, Tamás Oláh, Beatrix Dienes, Ildikó Balatoni, Éva Ungvári, Ilona Benkő, Beáta Babka, József Prokisch, László Csernoch, Péter Szentesi
Dátum:2016
ISSN:1743-7075
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Nutrition & Metabolism 13 : 76 (2016), p. 1-13. -
További szerzők:Ruzsnavszky Olga (1983-) (élettanász) Oláh Tamás (1983-) (élettanász) Dienes Beatrix (1972-) (élettanász, molekuláris biológus) Balatoni Ildikó (1970-) (orvos) Ungvári Éva (1986-) (molekuláris biológus) Benkő Ilona (1954-) (orvos, farmakológus) Babka Beáta (1984-) (környezetkutató) Prokisch József (1966-) (vegyész) Csernoch László (1961-) (élettanász) Szentesi Péter (1967-) (élettanász)
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11.

001-es BibID:BIBFORM113269
035-os BibID:(WoS)000882514800006 (scopus)85141235387 (cikkazonosító)111805
Első szerző:Botsi, Eirini
Cím:Association of diet quality with glycemia, insulinemia, and insulin resistance in families at high risk for type 2 diabetes mellitus in Europe : Feel4 Diabetes Study / Botsi E., Karatzi K., Mavrogianni C., Kaloyan Tsochev, Esther M. González-Gil, Radó S., Kivelä J., Wikström K., Cardon G., Rurik I., Liatis S., Tsvetalina Tankova, Violeta Iotova, Luis A. Moreno, Makrillakis K., Manios Y., Tsigos C.
Dátum:2023
ISSN:0899-9007
Megjegyzések:Objective The aim of the present study was to investigate the association of diet quality with fasting glycemia, insulinemia, and insulin resistance in a cross-sectional sample of adults from families at high risk for type 2 diabetes mellitus (T2DM) from six European countries, taking into account their socioeconomic status (SES). Methods Baseline data from non-diabetic adults from the Feel4 Diabetes study were used and diet was assessed by the Healthy Diet Score (HDS). Insulin resistance (IR) was determined by homeostasis model assessment of IR (HOMA-IR). Sociodemographic and lifestyle characteristics were assessed through standardized questionnaires. Multiple linear regressions were adjusted for many confounders, in the total sample and by SES category. Results In 1980 adults, the third tertile of diet quality was inversely associated with insulin levels (?1.48; 95% confidence interval [CI], ?2.34 to 0.62), and HOMA-IR (?0.33; 95% CI, ?0.57 to 0.09), yet with no statistically significant results for glucose levels. In the SES subgroup analysis, in the high SES group, both second and third diet score tertiles were inversely associated with insulin levels (?1.81; 95% CI, ?2.66 to 0.95) and HOMA-IR values (?0.45; 95% CI ?0.69 to 0.21), independent of age, sex, smoking and body mass index. No such associations were observed for glucose levels in the high SES group and for all indices in the low SES group. Conclusion In adults from families at high risk for T2DM, higher diet quality was negatively associated with fasting insulin levels and IR, only in the high SES group and not in the low SES group. Future larger studies may be able to explore further this association, as well as the potential factors that mitigate its strength in the low SES groups.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Nutrition. - 105 (2023), p. 1-6. -
További szerzők:Karatzi, Kalliopi Mavrogianni, Christina Tsochev, Kaloyan González-Gil, Esther Radó Sándor Istvánné (1976-) (diplomás ápoló) Kivelä, Jemina Wikström, Katja Cardon, Greet Rurik Imre (1953-) (háziorvos, foglalkozás-egészségügyi szakorvos, urológus) Liatis, Stavros Tankova, Tsvetalina Iotova, Violeta Moreno, Luis A. Makrilakis, Konstantinos Manios, Yannis Tsigos, Constantine
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12.

001-es BibID:BIBFORM077199
Első szerző:Budai Zsófia (biológus, molekuláris biológus)
Cím:Short-term high-fat meal intake alters the expression of circadian clock-, inflammation-, and oxidative stress-related genes in human skeletal muscle / Zsófia Budai, László Balogh, Zsolt Sarang
Dátum:2019
ISSN:0963-7486
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:International Journal Of Food Sciences And Nutrition. - 70 : 6 (2019), p. 749-758. -
További szerzők:Balogh László (1976-) (kardiológus) Sarang Zsolt (1976-) (mikrobiológus)
Pályázati támogatás:EFOP-3.6.1-16-2016-00022
EFOP
EFOP-3.6.3-VEKOP-16-2017-00009
EFOP
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