CCL

Összesen 2 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM009104
Első szerző:Marincsák Rita (fogszakorvos)
Cím:Increased expression of TRPV1 in squamous cell carcinoma of the human tongue / Marincsak, R., Toth, B. I., Czifra, G., Marton, I., Redl, P., Tar, I., Toth, L., Kovacs, L., Biro, T.
Dátum:2009
ISSN:1354-523X
Megjegyzések:Recent reports have unambiguously identified the presence and the growth-modulatory role of transient receptor potential vanilloid-1 (TRPV1), a central integrator of pain sensation, on numerous non-neuronal cell types and, of great importance, in certain malignancies. In this study, we have investigated the molecular expression of TRPV1 in the human tongue and its high-incidence malignant (squamous cell carcinoma, SCC) and premalignant (leukoplakia) conditions. Methods: Immunohistochemistry, Western blotting and quantitative 'real-time' Q-PCR were performed to define the expression of TRPV1. Results: A weak and sparse TRPV1-specific immunoreactivity was identified in the basal layers of the healthy human tongue epithelium. By contrast, we observed a dramatically elevated TRPV1-immunoreactivity in all layers of the epithelium both in precancerous and malignant samples. Furthermore, statistical analysis revealed that the marked overexpression of TRPV1 found in all grades of SCC showed no correlation with the degree of malignancy of the tumours. Finally, the molecular expression of TRPV1 was also identified in an SCC-derived cell line and was shown to be increased in parallel with the accelerated growth of the cells. Conclusion: Collectively, our findings identify TRPV1 as a novel, promising target molecule in the supportive treatment and diagnosis of human tongue SCC.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Oral Diseases. - 15 : 5 (2009), p. 328-335. -
További szerzők:Tóth István Balázs (1978-) (élettanász) Czifra Gabriella (1975-) (élettanász) Márton Ildikó (1954-) (fogszakorvos) Redl Pál (1953-) (szájsebész) Tar Ildikó (1967-) (fogszakorvos) Tóth László (1971-) (patológus) Kovács László (1939-) (élettanász) Bíró Tamás (1968-) (élettanász)
Internet cím:DOI
elektronikus változat
elektronikus változat
Borító:

2.

001-es BibID:BIBFORM040240
Első szerző:Márton K.
Cím:Evaluation of palatal saliva flow rate and oral manifestations in patients with Sjogren's syndrome / Márton K., Boros I., Varga G., Zelles T., Fejérdy P., Zeher M., Nagy G.
Dátum:2006
ISSN:1354-523X
Megjegyzések:OBJECTIVE: The purpose of this study was to describe the oral properties of Sjögren's syndrome (SS), including the determination of palatal saliva (PS) flow rate. SUBJECTS AND METHODS: Forty-nine SS patients and 43 healthy controls participated. Subjective symptoms were recorded and clinical assessments of the oral mucosal, dental and periodontal status were made. Unstimulated whole saliva (WS) and PS flow rates, the number of decayed, missing and filled teeth (DMF-T number), the gingival bleeding index (GBI) and the periodontal probing depth (PPD) were determined. RESULTS: Despite the decrease in the flow rate of WS in SS patients, PS was not different from those of the controls (1.57 +/- 1.02 and 1.35 +/- 2.5 microl cm(-2) min(-1), respectively). GBI (20.0% vs. 10.5%, respectively), DMF-T (27.1 +/- 6.12 vs. 23.0 +/- 6.99, respectively) and PPD (2.28 +/- 1.09 mm vs. 1.82 +/- 0.73 mm, respectively) were higher in SS compared with the controls (P < 0.05). DMF-T and PPD showed a positive correlation with anti-SSA and/or anti-SSB antibody positivity in the serum (P < 0.05). CONCLUSIONS: Data of the present study suggest that the subjective feeling of xerostomia in SS patients is the result of a decrease in the volume of the whole saliva, and not of the viscous PS. Correlation of DMF-T and PPD with autoantibody positivity reveals that the oral health status of SS patients may be associated with the general autoimmune process.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Oral Diseases. - 12 : 5 (2006), p. 480-486. -
További szerzők:Boros István Varga G. Zelles Tivadar Fejérdy P. (Budapest) Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Nagy G. (Budapest)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1