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1.

001-es BibID:BIBFORM087107
Első szerző:Árkosy Péter (általános sebész, mellkassebész)
Cím:Results of Treatment of Pancreatic Cancer / Árkosy Péter, Sasi Szabó László, Szentkereszty Zsolt, Szántó János, András Csilla, Sápy Péter
Dátum:2003
ISSN:1424-3903
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:Pancreatology. - 3 : 3 (2003), p. 212. -
További szerzők:Sasi Szabó László András (1974-) (sebész) Szentkereszty Zsolt (1961-) (sebész) Szántó János (1949-) (onkológus szakorvos) András Csilla (1961-) (onkológus szakorvos) Sápy Péter (1942-) (sebész)
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2.

001-es BibID:BIBFORM105511
Első szerző:Bokor Barbara Anna
Cím:Clinical significance of pathogenic CTRC mutations in childhood-onset pancreatitis (data analysis from APPLE study) / Bokor Barbara Anna, Sándor Máté, Németh Balázs Csaba, Párniczky Andrea, Tóth Anna Zsófia, Mosztbacher Dóra, Lásztity Natália, Demcsák Alexandra, Szentesi Andrea, Pienar Corina, Tokodi István, Vass Ibolya, Kadenczki Orsolya, Czelecz Judit, Andorka Csilla, Kaán Kinga, Horváth Enikő, Juhász Félix, Veres Gábor, Guthy Ildikó, Tomsits Erika, Gárdos László, Ila Veronika, Vörös Krisztina, Horváth Emese, Hegyi Péter
Dátum:2017
ISSN:1424-3903
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:Pancreatology. - 17 : 3 (2017), p. S99-S100. -
További szerzők:Sándor Máté Németh Balázs Csaba Párniczky Andrea (gyermekgyógyász) Tóth Anna Zsófia Mosztbacher Dóra Lásztity Natália (gyermekgyógyász, gasztroenterológus) Demcsák Alexandra Szentesi Andrea Pienar, Corina Tokodi István Vass Ibolya Kadenczki Orsolya (1974-) (csecsemő- és gyermekgyógyász) Czelecz Judit Andorka Csilla Kaán Kinga Horváth Enikő Juhász Márk Félix Veres Gábor (1969-2020) (csecsemő- és gyermekgyógyász, gasztroenterológus) Guthy Ildikó Tomsits Erika Gárdos László Ila Veronika Vörös Krisztina Horváth Emese Hegyi Péter Jenő (belgyógyász)
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3.

001-es BibID:BIBFORM057270
Első szerző:Csiszkó Adrienn
Cím:Primary angiosarcoma of the pancreas mimicking severe acute pancreatitis : case report / Csiszkó A., László I., Palatka K., Szabó K. G., Kanyári Zs., Bidiga L., Csonka T., Damjanovich L., Szentkereszty Zs.
Dátum:2014
ISSN:1424-3903
Megjegyzések:Primary angiosarcoma of the pancreas is an extremely rare neoplasm that often mimicks severe acute pancreatitis. A 58-year-old man was admitted with clinical and laboratory signs of severe acute pancreatitis. Contrast enhanced CT scan demonstrated haemorrhagic necrotizing inflammation of the pancreas involving the pancreatic tail, splenic hilum and small bowels with multiple peripancreatic and free abdominal fluid collection. Percutaneous drainage was performed. After 13 days, laparotomy was indicated because of persistent intra-abdominal bleeding, fever and a palpable, rapidly growing mass in the left upper quadrant of the abdomen. During the operation a necrotic, haemorrhagic mass was found in the pancreatic tail; a frozen section showed malignancy, although the tumour was unresectable. Despite all conservative and surgical therapeutic attempts, the patient died within four weeks after diagnosis. Final histology justified primary angiosarcoma of the pancreas. If a patient with signs of severe acute pancreatitis has fever without elevated PCT, the presence of a malignant tumour of the pancreas should be considered.
Tárgyszavak:Orvostudományok Klinikai orvostudományok esettanulmány
Megjelenés:Pancreatology. - 15 : 1 (2014), p. 84-87. -
További szerzők:László István (1978-) (aneszteziológus) Palatka Károly (1961-) (belgyógyász, gasztroenterológus) Szabó Károly (1982-) (sebész) Kanyári Zsolt (1964-) (orvos) Bidiga László (1977-) (patológus) Csonka Tamás (1984-) (pathológus) Damjanovich László (1960-) (általános sebész) Szentkereszty Zsolt (1961-) (sebész)
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4.

001-es BibID:BIBFORM088207
Első szerző:Demcsák Alexandra
Cím:Acid suppression therapy, gastrointestinal bleeding and infection in acute pancreatitis - An international cohort study / Alexandra Demcsak, Alexandra Soos, Lilla Kincses, Ines Capunge, Georgi Minkov, Mila Kovacheva-Slavova, Radislav Nakov, Dong Wu, Wei Huang, Qing Xia, Lihui Deng, Marcus Hollenbach, Alexander Schneider, Michael Hirth, Orestis Ioannidis, Aron Vincze, Judit Bajor, Patrícia Sarlos, Laszló Czakó, Dora Illés, Ferenc Izbeki, Laszló Gajdán, Maria Papp, Jozsef Hamvas, Marta Varga, Peter Kanizsai, Ernő Bóna, Alexandra Miko, Szilard Váncsa, Márk Félix Juhász, Klementina Ocskay, Erika Darvasi, Emőke Miklós, Balint Erőss, Andrea Szentesi, Andrea Parniczky, Riccardo Casadei, Claudio Ricci, Carlo Ingaldi, Laura Mastrangelo, Elio Jovine, Vincenzo Cennamo, Marco V. Marino, Giedrius Barauskas, Povilas Ignatavicius, Mario Pelaez-Luna, Andrea Soriano Rios, Svetlana Turcan, Eugen Tcaciuc, Ewa Małecka-Panas, Hubert Zatorski, Vitor Nunes, Antonio Gomes, Tiago Cúrdia Gonçalves, Marta Freitas, Júlio Constantino, Milene Sa, Jorge Pereira, Bogdan Mateescu, Gabriel Constantinescu, Vasile Sandru, Ionut Negoi, Cezar Ciubotaru, Valentina Negoita, Stefania Bunduc, Cristian Gheorghe, Sorin Barbu, Alina Tantau, Marcel Tantau, Eugen Dumitru, Andra Iulia Suceveanu, Cristina Tocia, Adriana Gherbon, Andrey Litvin, Natalia Shirinskaya, Yliya Rabotyagova, Mihailo Bezmarevic, Péter Jenő Hegyi, Jimin Han, Juan Armando Rodriguez-Oballe, Isabel Miguel Salas, Eva Pijoan Comas, Daniel de la Iglesia Garcia, Andrea Jardi Cuadrado, Adriano Quiroga Castineira, Yu-Ting Chang, Ming-Chu Chang, Ali Kchaou, Ahmed Tlili, Sabite Kacar, Volkan Gokbulut, Deniz Duman, Haluk Tarik Kani, Engin Altintas, Serge Chooklin, Serhii Chuklin, Amir Gougol, George Papachristou, Peter Hegyi Jr.
Dátum:2020
ISSN:1424-3903
Megjegyzések:Background:Acid suppressing drugs (ASD) are generally used in acute pancreatitis (AP); however, largecohorts are not available to understand their efficiency and safety. Therefore, our aims were to evaluatethe association between the administration of ASDs, the outcome of AP, the frequency of gastrointestinal(GI) bleeding and GI infection in patients with AP.Methods:We initiated an international survey and performed retrospective data analysis on AP patientshospitalized between January 2013 and December 2018.Results:Data of 17,422 adult patients with AP were collected from 59 centers of 23 countries. We foundthat 23.3% of patients received ASDs before and 86.6% during the course of AP. ASDs were prescribed to57.6% of patients at discharge. ASD administration was associated with more severe AP and highermortality. GI bleeding was reported in 4.7% of patients, and it was associated with pancreatitis severity,mortality and ASD therapy. Stool culture test was performed in 6.3% of the patients with 28.4% positiveresults.Clostridium difficilewas the cause of GI infection in 60.5% of cases. Among the patients with GIinfections, 28.9% received ASDs, whereas 24.1% were without any acid suppression treatment. GI infec-tion was associated with more severe pancreatitis and higher mortality.Conclusions:Although ASD therapy is widely used, it is unlikely to have beneficial effects either on theoutcome of AP or on the prevention of GI bleeding during AP. Therefore, ASD therapy should be sub-stantially decreased in the therapeutic management of AP.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Acid suppressing drug
Gastrointestinal bleeding
Gastrointestinal infection
Acute pancreatitis
Proton pump inhibitor
Megjelenés:Pancreatology. - 20 : 7 (2020), p. 1323-1331. -
További szerzők:Soós Alexandra Kincses Lilla Capunge, Ines Minkov, Georgi Kovacheva-Slavova, Mila Nakov, Radislav Wu, Dong Huang, Wei Xia, Qing Deng, Lihui Hollenbach, Marcus Schneider, Alexander Hirth, Michael Ioannidis, Orestis Vincze Áron Bajor Judit Sarlós Patrícia Czakó László Illés Dóra Izbéki Ferenc Gajdán László Papp Mária (1975-) (belgyógyász, gasztroenterológus) Hamvas József Varga Márta Kanizsai Péter Bóna Ernő Mikó Alexandra Váncsa Szilárd Juhász Márk Félix Ocskay Klementina Darvasi Erika Miklós Emőke Erőss Bálint Szentesi Andrea Párniczky Andrea (gyermekgyógyász) Casadei, Riccardo Ricci, Claudio Ingaldi, Carlo Mastrangelo, Laura Jovine, Elio Cennamo, Vincenzo Marino, Marco Vito Barauskas, Giedrius Ignatavicius, Povilas Pelaez-Luna, Mario Rios, Andrea Soriano Turcan, Svetlana Tcaciuc, Eugen Małecka-Panas, Ewa Zatorski, Hubert Nunes, Vitor Gomes, António Pedro Gonçalves, Tiago Cúrdia Freitas, Marta Constantino, Júlio Sá, Milene Pereira, Jorge Mateescu, Bogdan Constantinescu, Gabriel Sandru, Vasile Negoi, Ionut Ciubotaru, Cezar Negoita, Valentina Bunduc, Stefania Gheorghe, Cristian Barbu, Sorin Tantau, Alina Tantau, Marcel Dumitru, Eugen Suceveanu, Andra Iulia Tocia, Cristina Gherbon, Adriana Litvin, A. Andrey Shirinskaya, Natalia V. Rabotyagova, Yliya Bezmarevic, Mihailo Hegyi Péter Jenő (belgyógyász) Han, Jimin Rodriguez-Oballe, Juan Armando Salas, Isabel Miguel Comas, Eva Pijoan Garcia, Daniel de la Iglesia Cuadrado, Andrea Jardi Castiñeira, Adriano Quiroga Chang, Yu-Ting Chang, Ming-Chu Kchaou, Ali Tlili, Ahmed Kacar, Sabite Gökbulut, Volkan Duman, Deniz Kani, Haluk Tarik Altintas, Engin Chooklin, Serge Chuklin, Serhii Gougol, Amir Papachristou, Georgios I. Hegyi Péter Jr. (belgyógyász)
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5.

001-es BibID:BIBFORM105425
035-os BibID:(scopus)85139358640
Első szerző:Dohos Dóra
Cím:Inflammatory bowel disease does not alter the clinical features and the management of acute pancreatitis : A prospective, multicentre, exact-matched cohort analysis / Dora Dohos, Nelli Farkas, Alex Varadi, Balint Erőss, Andrea Parniczky, Andrea Szentesi, Peter Hegyi, Patrícia Sarlos, Hungarian Pancreatic Study Group
Dátum:2022
ISSN:1424-3903
Megjegyzések:Objective and aims: Acute pancreatitis in inflammatory bowel disease occurs mainly as an extraintestinal manifestation or a side effect of medications. We aimed to investigate the prognostic factors and severity indicators of acute pancreatitis and the treatment of patients with both diseases. Design: We performed a matched case-control registry analysis of a multicentre, prospective, interna tional acute pancreatitis registry. Patients with both diseases were matched to patients with acute pancreatitis only in a 1:3 ratio by age and gender. Subgroup analyses were also carried out based on disease type, activity, and treatment of inflammatory bowel disease. Results: No difference in prognostic factors (laboratory parameters, bedside index of severity in acute pancreatitis, imaging results) and outcomes of acute pancreatitis (length of hospitalization, severity, and local or systemic complications) were detected between groups. Significantly lower analgesic use was observed in the inflammatory bowel disease population. Antibiotic use during acute pancreatitis was significantly more common in the immunosuppressed group than in the non-immunosuppressed group (p ? 0.017). However, none of the prognostic parameters or the severity indicators showed a significant difference between any subgroup of patients with inflammatory bowel disease. Conclusion: No significant differences in the prognosis and severity of acute pancreatitis could be detected between patients with both diseases and with pancreatitis only. The need for different acute pancreatitis management is not justified in the coexistence of inflammatory bowel disease, and antibiotic overuse should be avoided. ? 2022 The Authors. Published by Elsevier B.V. on behalf of IAP and EPC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Pancreatology. - 22 : 8 (2022), p. 1071-1078. -
További szerzők:Farkas Nelli Váradi Alex (1991-) (biológus) Erőss Bálint Párniczky Andrea (gyermekgyógyász) Szentesi Andrea Hegyi Péter Jr. (belgyógyász) Sarlós Patrícia Papp Mária (1975-) (belgyógyász, gasztroenterológus) Hungarian Pancreatic Study Group
Pályázati támogatás:ÚNKP-21-5-PTE-1341
Egyéb
FK 132834
Egyéb
FK 138929
Egyéb
ÚNKP-21-5
Egyéb
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6.

001-es BibID:BIBFORM090166
Első szerző:Hágendorn Roland
Cím:Disturbance of consciousness deteriorates the severity of acute pancreatitis. An international multicentre cohort analyses of 1220 prospectively collected patients / R. Hagendorn, Á. Vincze, F. Izbeki, L. Gajdan, S. Godi, A. Illes, P. Sarlos, N. Farkas, B. Erős, V. Lillik, D. Illes, P. Varjú, K. Marta, I. Török, M. Papp, Z. Vitalis, B. Bod, J. Hamvas, Z. Szepes, T. Takacs, L. Czakó, A. Szentesi, A. Parniczky, P. Hegyi, A. Miko
Dátum:2020
ISSN:1424-3903
Megjegyzések:Purpose: Disturbance of consciousness (DOC) may develop in acute pancreatitis (AP). In clinical practice, it is known that DOC may worsen the patient's condition, but we have no exact data on how DOC affects the outcome of AP. Materials and methods: From the Hungarian Pancreatic Study Groups' AP registry, 1220 cases contained the exact data on DOC. Patients were separated to Non-DOC and DOC, whereas DOC was further divided into non-alcohol related DOC (Non-ALC DOC) and ALC-DOC groups. Statistical analysis was performed by SPSS 24 Software Package. Results: From the 1220 patients, 47 (3.85%) developed DOC, 23 (48.9%) cases were ALC DOC vs. 24 (51.1%) Non-ALC DOC. The incidence of severe AP was higher in the DOC compared to the Non-DOC group (19.15% vs. 5.29%, p<0.001). The mortality was higher in the DOC vs. Non-DOC group (14.89% vs. 1.71%, p<0.001). Length of hospitalization (LOH) was longer in the DOC vs. non-DOC group (Me:11; IQR:8-17 days vs. Me:9; IQR:6-13 days, p?0.049). Patients with ALC DOC developed more frequently moderately-severe AP vs. Non-ALC DOC (43.48% vs. 12.5%), while the incidence of severe AP was significantly higher in Non-ALC vs. ALC DOC group (33.33% vs. 4.35%) (p<0.001). LOH showed tendency to be longer in Non-ALC DOC compared to ALC DOC respectively (Me:13; IQR:7-20 days vs. Me:9.5; IQR:8-15.5 days, p?0.119). Conclusions: DOC during AP is associated with a higher rate of moderate and severe AP and increases the risk of mortality; therefore, the DOC should be closely monitored and prevented in AP.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:Pancreatology. - 20 (2020), p. S25. -
További szerzők:Vincze Áron Izbéki Ferenc Gajdán László Gódi Szilárd Illés Árpád (1959-) (belgyógyász, haematológus, onkológus) Sarlós Péter Farkas Nelli Erős Bálint Lillik Veronika Illés Dóra Varjú Péter Márta Katalin Török I. Papp Mária (1975-) (belgyógyász, gasztroenterológus) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Bod Barnabás Hamvas József Szepes Zoltán Takács T. Czakó László Szentesi Andrea Párniczky Andrea (gyermekgyógyász) Hegyi Péter Jenő (belgyógyász) Mikó Alexandra
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7.

001-es BibID:BIBFORM085501
Első szerző:Hágendorn Roland
Cím:Development of disturbance of consciousness is associated with increased severity in acute pancreatitis / Roland Hágendorn, Áron Vincze, Ferenc Izbéki, László Gajdán, Szilárd Gódi, Anita Illés, Patrícia Sarlós, Nelli Farkas, Bálint Erőss, Veronika Lillik, Dóra Illés, Péter Varjú, Katalin Márta, Imola Török, Mária Papp, Zsuzsanna Vitális, Barnabás Bod, József Hamvas, Zoltán Szepes, Tamás Takács, László Czakó, Zsolt Márton, Andrea Szentesi, Andrea Párniczky, Péter Hegyi, Alexandra Mikó
Dátum:2020
ISSN:1424-3903
Megjegyzések:Background Disturbance of consciousness (DOC) may develop in acute pancreatitis (AP). In clinical practice, it is known that DOC may worsen the patient's condition, but we have no exact data on how DOC affects the outcome of AP. Methods From the Hungarian Pancreatic Study Groups' AP registry, 1220 prospectively collected cases were analysed, which contained exact data on DOC, included patients with confusion, delirium, convulsion, and alcohol withdrawal, answering a post hoc defined research question. Patients were separated to Non-DOC and DOC, whereas DOC was further divided into non-alcohol related DOC (Non-ALC DOC) and ALC DOC groups. For statistical analysis, independent sample t-test, Mann-Whitney, Chi-squared, or Fisher exact test were used. Results From the 1220 patients, 47 (3.9%) developed DOC, 23 (48.9%) cases were ALC DOC vs. 24 (51.1%) Non-ALC DOC. Analysis between the DOC and Non-DOC groups showed a higher incidence of severe AP (19.2% vs. 5.3%, p<0.001), higher mortality (14.9% vs. 1.7%, p<0.001), and a longer length of hospitalization (LOH) (Me=11; IQR: 8-17 days vs. Me=9; IQR: 6-13 days, p=0.049) respectively. Patients with ALC DOC developed more frequently moderate AP vs. Non-ALC DOC (43.5% vs. 12.5%), while the incidence of severe AP was higher in Non-ALC vs. ALC DOC group (33.3% vs. 4.4%) (p<0.001). LOH showed a tendency to be longer in Non-ALC DOC compared to ALC DOC, respectively (Me:13; IQR:7-20 days vs. Me:9.5; IQR:8-15.5 days, p=0.119). Conclusion DOC during AP is associated with a higher rate of moderate and severe AP and increases the risk of mortality.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
disturbance of consciousness
acute pancreatitis
alcohol
delirium
mortality
Megjelenés:Pancreatology. - 20 : 5 (2020), p. 806-812. -
További szerzők:Vincze Áron Izbéki Ferenc Gajdán László Gódi Szilárd Illés Anita Sarlós Patrícia Farkas Nelli Erőss Bálint Lillik Veronika Illés Dóra Varjú Péter Márta Katalin Török Imola Papp Mária (1975-) (belgyógyász, gasztroenterológus) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Bod Barnabás Hamvas József Szepes Zoltán Takács Tamás (Szeged) Czakó László Márton Zsolt Szentesi Andrea Párniczky Andrea (gyermekgyógyász) Hegyi Péter Jenő (belgyógyász) Mikó Alexandra
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8.

001-es BibID:BIBFORM097905
035-os BibID:(WoS)000784212600006 (Scopus)85118725064
Első szerző:Juhász Márk Félix
Cím:The EFFect of dietary fat content on the recurrence of pancreaTitis (EFFORT) : protocol of a multicenter randomized controlled trial / Juhász Márk Félix, Vereczkei Zsófia, Ocskay Klementina, Szakó Lajos, Farkas Nelli, Szakács Zsolt, Zádori Noémi, Wilschanski Michael, Pandol Stephen J., Joly Francisca, Capurso Gabriele, Arcidiacono Paolo Giorgio, Izbéki Ferenc, Czakó László, Papp Mária, Czopf László, Hegyi Péter Jr., Párniczky Andrea, Hungarian Pancreatic Study Group
Dátum:2022
ISSN:1424-3903
Megjegyzések:Background: Around 20% of patients with acute pancreatitis (AP) will develop acute recurrent pancreatitis (ARP) and 10% will progress to chronic pancreatitis. While interventions to avoid recurrences exist for the two most common causes - abstinence for alcoholic and cholecystectomy for biliary pancreatitis - the are no known preventive measures in idiopathic ARP. Though it is not included in any of the guidelines, a low-fat diet is often recommended. Our aim is to test dietary fat reduction's effect on AP recurrence in a randomized controlled setting, in order to provide high-quality evidence for the validity of such an intervention. Methods, design: Participants with at least 2 episodes of AP in the preceding 2 years of which the last episode was idiopathic will be randomized to one of two diets with different fat contents: a 'reduced fat diet' (15% fat, 65% carbohydrate, 20% protein) and a 'standard healthy diet' (30% fat, 50% carbohydrate, 20% protein; based on WHO recommendations). Participants will be followed-up for 2 years (visits will be scheduled for months 3, 6, 12, 18 and 24) during which they will receive a repeated session of nutritional guidance, complete food frequency questionnaires and data on relapse, mortality, BMI, cardiovascular parameters and serum lipid values will be collected. Discussion: This study will determine the effect of modifying the dietary fat content on AP recurrence, mortality, serum lipids and weight loss in idiopathic cases.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Pancreatology. - 22 : 1 (2022), p. 51-57. -
További szerzők:Vereczkei Zsófia Ocskay Klementina Szakó Lajos Farkas Nelli Szakács Zsolt Zádori Noémi Wilschanski, Michael Pandol, Stephen J. Joly, Francisca Capurso, Gabriele Arcidiacono, Paolo Giorgio Izbéki Ferenc Czakó László Papp Mária (1975-) (belgyógyász, gasztroenterológus) Czopf László Hegyi Péter Jr. (belgyógyász) Párniczky Andrea (gyermekgyógyász) Hungarian Pancreatic Study Group
Pályázati támogatás:GINOP-2.3.2-15-2016-00048
GINOP
EFOP-3.6.2-16-2017-00006
EFOP
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9.

001-es BibID:BIBFORM076635
Első szerző:Lengyel Gabriella
Cím:Real-World Virologic Response Rates and Prediction of Outcomes with Peginterferon Alfa-2a/Ribavirin in Hungarian HCV Genotype 1 Patients / Gabriella Lengyel, Judit Gervain, Gabriella Pár, Ferenc Szalay, Béla Hunyady, Ferenc Schneider, Elemér Nemesánszky, Anna Tusnádi, Tivadar Bányai, Katalin Gyulay, István Tornai
Dátum:2014
ISSN:2374-815X
Megjegyzések:Aim: Dual peginterferon/ribavirin therapy remains a viable option for patients with chronic hepatitis C, because of the high cost of Direct-acting Antiviral Agents (DAA). We assessed real-life practice and treatment outcomes in Hungarian treatment-naive HCV genotype 1-infected patients who received peginterferon alfa-2a/ ribavirin treatment. Methods: This analysis of patients enrolled in Hungary as part of a large, multinational cohort study (PROPHESYS) included treatment-naive patients with HCV genotype 1 mono-infection who were prescribed peginterferon alfa-2a plus ribavirin. Results: Of 654 patients included in the analysis, 68% completed ? 80% of the planned duration of treatment (93% and 87% received ? 80% of the planned doses of peginterferon alfa-2a and ribavirin, respectively) and 23% stopped treatment prematurely because of the insufficient virologic response. Virologic response rates (HCV RNA < 50 IU/mL) were 20.3%, 55.2%, and 63.3% by Week 4, 12, and at the end of treatment (EOT), respectively, and a sustained virologic response 24 weeks post-treatment (SVR24) was achieved in 45.9% of patients. In patients with a virologic response at EOT, the relapse rate was 27.4%. SVR24 rates were 63% in patients who received ? 80% of the planned treatment and 55% in patients with lower exposure. Treatment was prolonged to ? 72 weeks in 51 patients with HCV RNA ? 50 IU/mL at Week 12, and < 50 IU/mL at Week 24, among whom the SVR24 rate was 35%. Conclusion: This analysis shows that SVR24 rates achieved in randomized trials can be reproduced in real-world settings by maintaining high rates of adherence and compliance with responseguided therapy.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Gastroenterology, Pancreatology & Liver Disorders. - 1 : 4 (2014), p. 1-8. -
További szerzők:Gervain Judit Pár Gabriella Szalay Ferenc (belgyógyász) Hunyady Béla Schneider Ferenc Nemesánszky Elemér Tusnádi Anna Bányai Tivadar Gyulay Katalin Tornai István (1954-) (belgyógyász, gasztroenterológus)
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10.

001-es BibID:BIBFORM090171
Első szerző:Mikó Alexandra
Cím:Early Phase of Chronic Pancreatitis : results of the First 20 Months of the GOULASH-PLUS Clinical Study / A. Mikó, D. Kato, V. Lillik, L. Gajdán, M. Papp, I. Földi, B. Bodis, N. Faluhelyi, P. Sarlos, Á. Vincze, Z. Szepes, G. Elsayed, P. Mosler, B. Erős, L. Czakó, P. Hegyi
Dátum:2020
ISSN:1424-3903
Megjegyzések:Purpose: Acute pancreatitis (AP) is a severe inflammatory disease that can lead to irreversible complications such as recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP). CP is often diagnosed in an advanced form, though it could be effectively managed at an early stage. However, parameters indicative of early CP are still unknown. We aim to find measurable biomarkers and clinical signs of this early phase through the GOULASH-PLUS follow-up study. Materials and methods: GOULASH-PLUS is a longitudinal study of AP with a 6-year follow-up of patients with a well documented episode of AP. Imaging, physical and laboratory testing is performed annually. To detect endocrine function, blood glucose, HbA1C were measured, and oral glucose tolerance test (OGTT) was performed; exocrine parameters were measured by a stool elastase test. Chi-square test and Fisher exact test were used for statistical analysis. Results: Of the first 133 patients, 57 (43%)were women, 76 (57%)were men, and the average age was 55. 27 (20%) patients had moderate AP, 6 (5%) had severe AP, and 15 (14%) had RAP in the first year. 13 (16%) patients were diagnosed with severe exocrine pancreas insufficiency, 17 (15%) were diagnosed with diabetes and 23 (20%) with impaired glucose tolerance (IGT). Exocrine abnormalities were present in 70% of patients with RAP, compared with only 18% in the group without RAP (p <0.001). There was no difference in endocrine function between RAP and non-RAP groups. Based on OGTT, hyperinsulinemia was detected in IGT and diabetic groups, and endocrine disruption (IGT, DM) was not associated with AP severity. Conclusions: One year after AP, exocrine and endocrine insufficiency can be measured in the majority of patients. In RAP, exocrine abnormalities appear earlier, while the endocrine function is not affected. The development of IGT and DM is independent of the severity of AP.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:Pancreatology. - 20 (2020), p. S29. -
További szerzők:Kató D. Lillik V. Gajdán László Papp Mária (1975-) (belgyógyász, gasztroenterológus) Földi Ildikó (1981-) (orvos) Bódis Beáta Faluhelyi Nándor Sarlós Patrícia Vincze Áron Szepes Zoltán Elsayed, G. Mosler, P. Erős Bálint Czakó László Hegyi Péter Jenő (belgyógyász)
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11.

001-es BibID:BIBFORM111530
035-os BibID:(scopus)85158029185
Első szerző:Morales Granda, Nataly C.
Cím:Inhibition of mouse trypsin isoforms by SPINK1 and effect of human pancreatitis-associated mutations / Morales Granda Nataly C., Toldi Vanda, Miczi Márió, Lassoued Meriam, Szabó András
Dátum:2023
ISSN:1424-3903
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Pancreatology. - 23 : 4 (2023), p. 358-366. -
További szerzők:Toldi Vanda (1992-) (molekuláris biológus) Miczi Márió Lassoued, Meriam Szabó András (1981-) (biokémikus)
Pályázati támogatás:FK127942
OTKA
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Intézményi repozitóriumban (DEA) tárolt változat
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12.

001-es BibID:BIBFORM099044
035-os BibID:(WoS)000784212600008 (Scopus)85118996099
Első szerző:Moran, Robert A.
Cím:Early infection is an independent risk factor for increased mortality in patients with culture-confirmed infected pancreatic necrosis / Moran Robert A., Halloran Christopher, Guo Qiang, Umapathy Chandra, Jalaly Niloofar Y., Jain Saransh, Cowzer Darren, Cuadrado Robles Enrique Perez, Quesada-Vázquez Noé, Szentesi Andrea, Papp Mária, Chua Tiffany, Márta Katalin, Sampath Kartik, Jin David X., Sahebally Shaheel Mohammad, Kuschnereit Tobias Philipp, Khashab Mouen A., Rock Clare, Darvasi Erika, Saunders Rebecca, García-Rayado Guillermo, Torrijos Yolanda Sánchez, Coady Laoise, Papachristou Georgios I., Mayerle Julia, Geoghegan Justin, Banks Peter A., Gardner Timothy B., Szabó Anikó Nóra, Stevens Tyler, Tornai Tamás, Tóth Emese, McEntee Gerry, Garg Pramod K., Hegyi Péter, Yadav Dhiraj, Hu Weiming, Neoptolemos John, Singh Vikesh K.
Dátum:2022
ISSN:1424-3903
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Infected pancreatic necrosis
Necrosectomy
Mortality
Surgery
Pancreatic necrosis
Necrotizing pancreatitis
Minimally invasive surgery
Megjelenés:Pancreatology. - 22 : 1 (2022), p. 67-73. -
További szerzők:Halloran, Christopher Guo, Qiang Umapathy, Chandra Jalaly, Niloofar Y. Jain, Saransh Cowzer, Darren Cuadrado Robles, Enrique Perez Quesada-Vázquez, Noé Szentesi Andrea Papp Mária (1975-) (belgyógyász, gasztroenterológus) Chua, Tiffany Márta Katalin Sampath, Kartik Jin, David X. Sahebally, Shaheel Mohammad Kuschnereit, Tobias Philipp Khashab, Mouen A. Rock, Clare Darvasi Erika Saunders, Rebecca García-Rayado, Guillermo Sánchez Torrijos, Yolanda Coady, Laoise Papachristou, Georgios I. Mayerle, Julia Geoghegan, Justin Banks, Peter A. Gardner, Timothy B. Szabó Anikó Nóra Stevens, Tyler Tornai Tamás István (1984-) (belgyógyász) Tóth Emese McEntee, Gerry Garg, Pramod K. Hegyi Péter Jenő (belgyógyász) Yadav, Dhiraj Hu, Weiming Neoptoleomos, Johan P. Singh, Vikesh K.
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