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1.

001-es BibID:BIBFORM038652
Első szerző:Alberth Márta (fogszakorvos)
Cím:Significance of oral Candida infections in children with cancer / Alberth M., Majoros L., Kovalecz G., Borbás E., Szegedi I., Márton I. J., Kiss C.
Dátum:2006
ISSN:1219-4956
Megjegyzések:Candidiasis is common in children with cancer, particularly during periods of severe immunosuppression and neutropenia. Our aim was to study the microbiological changes in the oral cavity of children with newly diagnosed cancer. The study group consisted of 30 consecutive children and adolescents, 16 with acute lymphoblastic leukemia and 14 with solid tumors. Oral cultures to detect fungi and bacteria were conducted for all patients before treatment, during and after neutropenic episodes. In 23 patients developing fever simultaneous throat, urine and blood sampling was carried out. No pathogens were found in the cultures taken before the outset (30 cultures) or after recovery from (30 cultures) the neutropenic episodes. In the 45 oral cultures taken during the neutropenic episodes 38 (84.4%) proved positive. Fungi were the most frequently isolated oral pathogens: 33/38 yeast and 6/38 bacterial infections were identified. There was no association between the underlying malignancy and the occurrence of the positive cultures. Of the 30 patients, all 23 (76.7%) who have developed moderate-to-severe neutropenia, developed oral fungal colonization or clinically obvious fungal infection at least on one occasion during the study. In addition to oral samples, fungi were identified in 9/23 pharyngeal swabs, 6/23 urine and 1/23 blood cultures. The initial fungal pathogen was exclusively (33/33) Candida albicans. In extended severe neutropenic states, C. albicans was replaced by non-albicans species (C. kefyr, C. lusitaniae, C. sake, C. tropicalis) in 5 patients between 4 to 6 days of the neutropenic episodes. Four of the nonalbicans Candida strains were resistant to azole-type antifungal agents. Neutropenic episodes of children with cancer are associated with an increased risk of developing oral and even systemic infections with C. albicans that can be replaced by azole-resistant nonalbicans strains in prolonged neutropenia contributing to morbidity of these patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Pathology and Oncology Research. - 12 : 4 (2006), p. 237-241. -
További szerzők:Majoros László (1966-) (szakorvos, klinikai mikrobiológus) Kovalecz Gabriella (1973-) (fogszakorvos) Borbás Emese Szegedi István (1969-) (hematológus, onkológus, nefrológus) Márton Ildikó (1954-) (fogszakorvos) Kiss Csongor (1956-) (hematológus, onkológus)
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2.

001-es BibID:BIBFORM081820
035-os BibID:(WOS)000492009300002 (Scopus)85074658973
Első szerző:András Csilla (onkológus szakorvos)
Cím:Retrospective Analysis of Cancer-Associated Myositis Patients over the Past 3 Decades in a Hungarian Myositis Cohort / András Csilla, Bodoki Levente, Nagy-Vincze Melinda, Griger Zoltán, Csiki Emese, Dankó Katalin
Dátum:2020
ISSN:1219-4956 1532-2807
Megjegyzések:Association between cancer and myositis has been extensively reported and malignancy is a potentially life-threating complication in myositis. In this retrospective study authors give an overview of Hungarian cancer-associated myositis (CAM) patients treated at a single centre managing 450 myositis patients. All patients were diagnosed according to Bohan and Peter. Statistical analysis of disease onset, age, sex,muscle, skin and extramuscular symptoms,muscle enzymes, presence of antibodies, treatment and prognosis was performed. 43 patients could be considered as having CAM. 83.72% had cancer within one year of diagnosis of myositis. Most common localizations were ductal carcinoma of breast and adenocarcinoma of lung. Significant differences were observed between CAM and the non-CAM control patients: DM:PM ratio was 2.31:1 vs. 0.87:1, respectively (p = 0.029), age at diagnosis was 56.60 ? 12.79 vs. 38.88 ? 10.88 years, respectively (p < 0.001). Tumour-treatment was the following: surgical removal in 55.81%, chemotherapy in 51.1%, radiotherapy in 39.53%, hormone treatment in 18.6%, combination therapy in 51.16% of patients. Muscle enzyme levels of patients undergoing surgery were significantly reduced after intervention. 36 patients died (83.72%); 25 DM(83.33%) and 11 PM patients (84.62%); 5 years survival was 15.4% for PM and 27.5% for DM. This study demonstrates that DM, distal muscle weakness, asymmetric Raynaud's phenomenon, older age, ANA-negativity are risk factors for developing malignancy and polymyositis patients have less chance of long-lasting survival. It is very important to think about cancer and follow every single myositis patient in the clinical routine because survival rate of CAM is very poor.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Cancer-associatedmyositis (CAM)
Dermatomyositis (DM)
Polymyositis (PM)
Cancer
Muscle weakness
Megjelenés:Pathology & Oncology Research. - 26 : 3 (2020), p. 1749-1755. -
További szerzők:Bodoki Levente (1986-) (PhD hallgató) Nagy-Vincze Melinda (1985-) (orvos) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Csiki Emese (1986-) (onkoradiológus) Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus)
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3.

001-es BibID:BIBFORM033721
Első szerző:András Csilla (onkológus szakorvos)
Cím:Docetaxel (Taxotere) az emlőrák neoadjuváns kezelésében / András Csilla, Szántó János
Dátum:2002
Tárgyszavak:Orvostudományok Klinikai orvostudományok magyar nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Pathology and oncology research. - 8 : Suppl. 2 (2002), p. 11-14. -
További szerzők:Szántó János (1949-) (onkológus szakorvos)
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4.

001-es BibID:BIBFORM024679
Első szerző:András Csilla (onkológus szakorvos)
Cím:Retrospective Evaluation of 5-fluorouracil-interferon-alfa Treatment of Advanced Colorectal Cancer Patients / Csilla András, Zoltán Csiki, István Gál, István Takács, Lajos Antal, Gyula Szegedi
Dátum:2000
ISSN:1532-2807
Megjegyzések:The authors describe the retrospective analysis of treatment by 5-fluorouracil and interferon-a aof 34 patients with advanced colorectal cancer. An average of 4.6 treatment cycles (3 12) was applied. Complete remission was not observed; partial remission was observed in 8 patients; in 13 patients no change occurred and progression was detected in 14 cases. Remission rate was 22.8%, mean response time was 5.2 (3 12) months, mean progress-free survival 5.6 (0 22) months. Mean survival from the start of treatment was 11.9 (1 42) months and from the establishment of the diagnosis 26.1 (3 60) months. Severe life-threatening side-effects did not occur; other side-effects such as fever, nausea, diarrhea, leucopenia, and anemia responded to drugs. Treatment by 5-FU and interferon, in accordance with other authors findings, improved survival and well-being of patients but no breakthrough has been achieved.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Pathology and Oncology Research. - 6 : 3 (2000), p. 175-178. -
További szerzők:Csiki Zoltán (1962-) (belgyógyász, allergológus, klinikai immunológus, reumatológus) Gál István (sebész) Takács István (1963-) (sebész) Antal Lajos Szegedi Gyula (1936-2013) (belgyógyász, immunológus)
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5.

001-es BibID:BIBFORM049348
035-os BibID:(PMID)23955198 (Scopus)84896034980 (WOS)000329356600017
Első szerző:Bárdi Edit (csecsemő- és gyermekgyógyász)
Cím:Value of FDG-PET/CT Examinations in Different Cancers of Children, Focusing on Lymphomas / Edit Bárdi, Mónika Csóka, Ildikó Garai, István Szegedi, Judit Müller, Tamás Györke, Kornélia Kajáry, Karolina Nemes, Csongor Kiss, Gábor Kovács
Dátum:2014
ISSN:1219-4956 1532-2807
Megjegyzések:The aim of the study was to assess sensitivity and specificity of FDG-PET/CT in different forms of childhood cancer. We retrospectively evaluated the results dedicated of 162 FDG-PET/CT examinations of 86 children treated with: Hodgkin lymphoma (HL; n=31), non-Hodgkin lymphoma (NHL; n=30) and other high grade solid tumors (n=25). Patients were admitted and treated in two departments of pediatric hematology and oncology in Hungary. FDG-PET/CT was performed for staging (n=25) and for posttreatment evaluation (n=137). Imaging was performed in three FDG-PET/CT Laboratories, using dedicated PET/CT scanners. False positive results were defined as resolution or absence of disease progression over at least 1 year on FDG-PET/CT scans without any intervention. In some cases histopathological evaluation of suspicious lesions was performed. Fals negative results were defined as negative FDG-PET/CT results in case of active malignancy. Positive predictive values (PPV) and negative predictive values (NPV) were calculated. NPV was 100 %. The highest PPV was observed in high grade solid tumors (81 %), followed by HL (65 %) and NHL (61 %). There was a major difference of PPV in different histological types of HL (50 % in HL of mixed-cellularity subtype, 90 % in nodular sclerosing, and 100 % in lymphocyte-rich and lymphocyte depleted HL). We treated one patient with nodular lymphocyte predominant HL, who had 5 false positive FDG-PET/CT results. PPV of T- and B-lineage NHL were similar (60 % and 62 %, respectively). We observed an interesting difference of PPV in different stages of HL and NHL. In HL PPV was higher in early than in advanced disease forms: 66 % in stage II HL and 60 % in stage III HL, whereas there was an inverse relationship between PPV and disease stages in NHL 0 % in stage I and II patients, 67 % in stage III and 100 % in stage IV patients. PPV was lower in males (54 %) than in females (65 %). PPV were 64 % vs. 58 % in patients under vs. over 10 years of age. Negative FDG-PET/CT results during follow-up reliably predict the absence of malignancy. Positive FDG-PET/CT scan results in general have a low PPV. The relatively high PPV in patients with histologically proven high grade solid tumors, advanced stages of NHL and with nodular sclerosing, lymphocyte-rich and lymphocyte depleted subtypes of HL warrant a confirmation by biopsy, whereas the watch-and-wait approach can be used in other forms of childhood cancer patients with a positive FDG-PET/CT result in course of follow-up examinations.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
FDG-PET/CT
Megjelenés:Pathology Oncology Research. - 20 : 1 (2014), p. 139-143. -
További szerzők:Csóka Mónika Garai Ildikó (1966-) (radiológus) Szegedi István (1969-) (hematológus, onkológus, nefrológus) Müller Judit Györke Tamás Kajáry Kornélia Nemes Karolina Kiss Csongor (1956-) (hematológus, onkológus) Kovács Gábor (gyermekhaematológus Budapest)
Pályázati támogatás:TÁMOP-4.2.2.A-11/1/KONV-2012-0025
TÁMOP
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6.

001-es BibID:BIBFORM011927
Első szerző:Bárdi Edit (csecsemő- és gyermekgyógyász)
Cím:Differential Effect of Corticosteroids on Serum Cystatin C in Thrombocytopenic Purpura and Leukemia / Bárdi E., Dobos E., Kappelmayer J., Kiss C.
Dátum:2010
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Pathology and Oncology Research. - 16 : 3 (2010), p. 453-456. -
További szerzők:Dobos Éva Kappelmayer János (1960-) (laboratóriumi szakorvos) Kiss Csongor (1956-) (hematológus, onkológus)
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7.

001-es BibID:BIBFORM001928
Első szerző:Bárdi Edit (csecsemő- és gyermekgyógyász)
Cím:Anthracycline antibiotics induce acute renal tubular toxicity in children with cancer / Bárdi E., Bobok I., V. Oláh A., Kappelmayer J., Kiss C.
Dátum:2007
Megjegyzések:Experimental evidence suggests that anthracyclines, widely used in cancer chemotherapy, may impair kidney function. We assessed kidney function by serum creatinine, urinary N-acetyl-?-D-glucosaminidase activity indices (NAGi) and microalbuminuria (MA) in 160 serum and urine samples obtained from 66 children with cancer. The effect of dexrazoxane was analyzed in 6 children on dexrazoxane supportive therapy in conjunction with daunorubicin (DNR) treatment, as compared with 6 children notreceiving this agent. NAGi was significantly (p<0.05) elevated after treatment by DNR, doxorubicin, epirubicin (EPI) and idarubicin (IDA). MA proved to be a less sensitive indicator of kidney damage than NAGi. DNR resulted in a progressive deterioration of proximal tubular function as determined by linear regression analysis. The mean NAGi in the dexrazoxanetreated group was significantly (p<0.005) lower than in children not receiving dexrazoxane prior to DNR treatment. In conclusion, our study demonstrated that DNR, EPI and IDA induced an acute renal tubular damage similar to known tubulotoxic agents as cisplatin, carboplatin, cyclophosphamide and ifosfamide. The damage was clinically mild and only a minor proportion of patients can be expected to develop long-lasting tubulopathy with negative impact on the quality of life.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
nephrotoxicity
anthracycline therapy
dexrazoxane
NAGi
microalbuminuria
egyetemen (Magyarországon) készült közlemény
Megjelenés:Pathology and Oncology Research. - 13 : 3 (2007), p. 249-253. -
További szerzők:Bobok Ildikó Oláh Anna (1956-) (klinikai biokémikus, vegyész) Kappelmayer János (1960-) (laboratóriumi szakorvos) Kiss Csongor (1956-) (hematológus, onkológus)
Internet cím:elektronikus változat
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8.

001-es BibID:bibEBI15698
Első szerző:Berczi Csaba (urológus, sebész, onkológus)
Cím:Flow cytometric DNA analysis of benign hyperfunctioning parathyroid glands : significant difference in the S phase fraction and proliferative index between adenomas and hyperlpasias / Berczi, C., Bocsi, J., Balazs, G., Lukacs, G.
Dátum:2002
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Pathology. - 34 (2002), p. 442-445. -
További szerzők:Bocsi József Balázs György (1933-) (sebész) Lukács Géza (1941-) (sebész)
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9.

001-es BibID:BIBFORM014374
Első szerző:Bodó Enikő
Cím:A Hot New Twist to Hair Biology : involvement of Vanilloid Receptor-1 (VR1/TRPV1) Signaling in Human Hair Growth Control / Enikő Bodó, Tamás Bíró, Andrea Telek, Gabriella Czifra, Zoltán Griger, Balázs I. Tóth, Alessandra Mescalchin, Taisuke Ito, Albrecht Bettermann, László Kovács, Ralf Paus
Dátum:2005
ISSN:0002-9440
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:American Journal of Pathology 166 : 4 (2005), p. 985-998. -
További szerzők:Bíró Tamás (1968-) (élettanász) Telek Andrea (1977-) (élettanász) Czifra Gabriella (1975-) (élettanász) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Tóth István Balázs (1978-) (élettanász) Mescalchin, Alessandra Ito, Taisuke Bettermann, Albrecht Kovács László (1939-) (élettanász) Paus, Ralf
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10.

001-es BibID:BIBFORM001012
Első szerző:Bodó Enikő
Cím:Dissecting the impact of chemotherapy on the human hair follicle : a pragmatic in vitro assay for studying the pathogenesis and potential management of hair follicle dystrophy / Bodó E., Tobin D. J., Kamenisch Y., Bíró T., Berneburg M., Funk W., Paus R.
Dátum:2007
ISSN:0002-9440 (Print)
Megjegyzések:Chemotherapy-induced alopecia represents one of the major unresolved problems of clinical oncology. The underlying molecular pathogenesis in humans is virtually unknown because of the lack of adequate research models. Therefore, we have explored whether microdissected, organ-cultured, human scalp hair follicles (HFs) in anagen VI can be exploited for dissecting and manipulating the impact of chemotherapy on human HFs. Here, we show that these organ-cultured HFs respond to a key cyclophosphamide metabolite, 4-hydroperoxycyclophosphamide (4-HC), in a manner that resembles chemotherapy-induced HF dystrophy as it occurs in vivo: namely, 4-HC induced melanin clumping and melanin incontinence, down-regulated keratinocyte proliferation, massively up-regulated apoptosis of hair matrix keratinocytes, prematurely induced catagen, and up-regulated p53. In addition, 4-HC induced DNA oxidation and the mitochondrial DNA common deletion. The organ culture system facilitated the identification of new molecular targets for chemotherapy-induced HF damage by microarray technology (eg, interleukin-8, fibroblast growth factor-18, and glypican 6). It was also used to explore candidate chemotherapy protectants, for which we used the cytoprotective cytokine keratinocyte growth factor as exemplary pilot agent. Thus, this novel system serves as a powerful yet pragmatic tool for dissecting and manipulating the impact of chemotherapy on the human HF.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The American Journal of Pathology. - 171 : 4 (2007), p. 1153-1167. -
További szerzők:Tobin, Desmund J. Kamenisch, York Berneburg, Mark Funk, Wolfgang Paus, Ralf Bíró Tamás (1968-) (élettanász)
Internet cím:elektronikus változat
elektronikus változat
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11.

001-es BibID:BIBFORM046704
Első szerző:Boér Katalin
Cím:Adjuvant therapy of breast cancer with docetaxel-containing combination (TAC) / Katalin Boér, István Láng, Éva Juhos, Tamás Pintér, János Szántó
Dátum:2003
Megjegyzések:he adjuvant chemotherapy of breast cancer changed in the past two decades. Docetaxel containing regimens are highly active in metastatic breast cancer. A logical approach was their incorporation into trials of early breast cancer adjuvant therapy. The authors present the Hungarian interim analysis and experience with the BCIRG 001 randomized, multicentric, phase III clinical trial comparing TAC (docetaxel, doxorubicin, cyclophosphamide) and FAC (5-fluorouracil, doxorubicin, cyclophosphamide) in the adjuvant treatment of node positive breast cancer patients. The results are presented compared to the international data. Three Hungarian centers - Szt. Margit Hospital, Budapest, National Institute of Oncology, Budapest, Petz Aladár Hospital, Győr - participated in the international trial. Between June 1997 and June 1999, 61 patients with node positive breast cancer were enrolled in the study after the surgery. Thirty-four patients were randomized to TAC (75/50/500 mg/m2 6xq3wk) and 27 patients were randomized to FAC (500/50/500 mg/m2 6x q3wk) chemotherapy, with prospective stratification by node (1-3, 4+). Patients with hormone receptor positive tumors received tamoxifen for 5 years after the chemotherapy. Radiotherapy was performed after the 6th cycle of chemotherapy. 33 months of follow up was performed. In both arms the hematological toxicity was more frequent. The TAC group showed a higher incidence of neutropenia (76%) compared to the FAC (22%), as well as a higher incidence of febrile neutropenia (26 % versus none), without grade 3-4 infection and there was no cases of septic death. More grade 3-4 nausea and vomiting was observed in the FAC group. At three years follow up, results indicated improvement in disease-free survival (88% vs. 76%) in favour of TAC, and similar tendency was observed in the case of overall survival (97% vs. 88%). Based on the international data analysis TAC was superior to FAC chemotherapy, the results show statistically significant differences between the two arms. This benefit with TAC was seen regardless of hormone receptor status. Additional follow up data will evaluate the role of TAC in the adjuvant setting of early breast cancer treatment.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
early breast cancer
adjuvant chemotherapy
comparative study
docetaxel
Megjelenés:Pathology and Oncology Research. - 9 : 3 (2003), p. 166-169. -
További szerzők:Láng István Juhos Éva (onkológus) Pintér Tamás Szántó János (1949-) (onkológus szakorvos)
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12.

001-es BibID:BIBFORM035879
Első szerző:Bollmann, Reinhard
Cím:DNA aneuploidy/polyploidy is associated with oncogenic HPV infection in ASCUS and SIL / R. Bollmann, G. Méhes, A. Varnai, D. Bollmann, N. Speich, M. Bollmann
Dátum:2004
ISSN:0344-0338
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:Pathology Research And Practice. - 200 : 4 (2004), p. 356. -
További szerzők:Méhes Gábor (1966-) (patológus) Várnai Alinda Bollmann, D. Speich, Norbert Bollmann, Magdolna
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