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001-es BibID:BIBFORM119269
Első szerző:Chen-Izu, Ye
Cím:Innovative techniques and new insights : studying cardiac ionic currents and action potentials in physiologically relevant conditions / Ye Chen-Izu, Bence Hegyi, Zhong Jian, Balazs Horvath, John A. Shaw, Tamas Banyasz, Leighton T. Izu
Dátum:2023
Megjegyzések:Cardiac arrhythmias are associated with various forms of heart diseases. Ventricular arrhythmias present a significant risk for sudden cardiac death. Atrial fibrillations predispose to blood clots leading to stroke and heart attack. Scientists have been developing patch-clamp technology to study ion channels and action potentials (APs) underlying cardiac excitation and arrhythmias. Beyond the traditional patch-clamp techniques, innovative new techniques were developed for studying complex arrhythmia mechanisms. Here we review the recent development of methods including AP-Clamp, Dynamic Clamp, AP-Clamp Sequential Dissection, and Patch-Clamp-in-Gel. These methods provide powerful tools for researchers to decipher how the dynamic systems in excitation-Ca2+ signaling-contraction feedforward and feedback to control cardiac function and how their dysregulations lead to heart diseases
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
action potential
arrhythmia
cardiac myocyte
patch-clamp
electrophysiology
Megjelenés:Physiological Mini Reviews. - 16 : 3 (2023), p. 22-34. -
További szerzők:Hegyi Bence (1987-) (élettanász) Jian, Zhong Horváth Balázs (1981-) (élettanász) Shaw, John A. Bányász Tamás (1960-) (élettanász) Izu, Leighton T.
Internet cím:Szerző által megadott URL
Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM013973
Első szerző:Muszbek László (haematológus, kutató orvos)
Cím:Factor XIII : a Coagulation Factor With Multiple Plasmatic and Cellular Functions / Muszbek László, Bereczky Zsuzsanna, Bagoly Zsuzsa, Komáromi István, Katona Éva
Dátum:2011
ISSN:0031-9333
Megjegyzések:Factor XIII (FXIII) is unique among clotting factors for a number of reasons: 1) it is a protransglutaminase, which becomes activated in the last stage of coagulation; 2) it works on an insoluble substrate; 3) its potentially active subunit is also present in the cytoplasm of platelets, monocytes, monocyte-derived macrophages, dendritic cells, chondrocytes, osteoblasts, and osteocytes; and 4) in addition to its contribution to hemostasis, it has multiple extra- and intracellular functions. This review gives a general overview on the structure and activation of FXIII as well as on the biochemical function and downregulation of activated FXIII with emphasis on new developments in the last decade. New aspects of the traditional functions of FXIII, stabilization of fibrin clot, and protection of fibrin against fibrinolysis are summarized. The role of FXIII in maintaining pregnancy, its contribution to the wound healing process, and its proangiogenic function are reviewed in details. Special attention is given to new, less explored, but promising fields of FXIII research that include inhibition of vascular permeability, cardioprotection, and its role in cartilage and bone development. FXIII is also considered as an intracellular enzyme; a separate section is devoted to its intracellular activation, intracellular action, and involvement in platelet, monocyte/macrophage, and dendritic cell functions.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Molekuláris Medicina
Megjelenés:Physiological Reviews. - 91 : 3 (2011), p. 931-972. -
További szerzők:Bereczky Zsuzsanna (1974-) (orvosi laboratóriumi diagnosztika szakorvos) Bagoly Zsuzsa (1978-) (orvos) Komáromi István (1957-) (vegyész, molekuláris biológus, biokémikus) Katona Éva (1961-) (klinikai biokémikus)
Pályázati támogatás:TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
A véralvadás XIII-as faktorának (FXIII) struktúrája, funkciója, előfordulása egyéb testnedvekben és kapcsolata trombotikus megbetegedésekkel
CNK 80776
OTKA
TKI 227
EGYÉB
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
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3.

001-es BibID:BIBFORM030140
Első szerző:Nagy László (molekuláris sejtbiológus, biokémikus)
Cím:Nuclear hormone receptors enable macrophages and dendritic cells to sense their lipid environment and shape their immune response / Lászlo Nagy, Attila Szanto, Istvan Szatmari, Lajos Széles
Dátum:2012
ISSN:0031-9333
Megjegyzések:A key issue in the immune system is to generate specific cell types, often with opposing activities. The mechanisms of differentiation and subtype specification of immune cells such as macrophages and dendritic cells are critical to understand the regulatory principles and logic of the immune system. In addition to cytokines and pathogens, it is increasingly appreciated that lipid signaling also has a key role in differentiation and subtype specification. In this review we explore how intracellular lipid signaling via a set of transcription factors regulates cellular differentiation, subtype specification, and immune as well as metabolic homeostasis. We introduce macrophages and dendritic cells and then we focus on a group of transcription factors, nuclear receptors, which regulate gene expression upon receiving lipid signals. The receptors we cover are the ones with a recognized physiological function in these cell types and ones which heterodimerize with the retinoid X receptor. These are as follows: the receptor for a metabolite of vitamin A, retinoic acid: retinoic acid receptor (RAR), the vitamin D receptor (VDR), the fatty acid receptor: peroxisome proliferator-activated receptor gamma (PPARgamma), the oxysterol receptor liver X receptor (LXR), and their obligate heterodimeric partner, the retinoid X receptor (RXR). We discuss how they can get activated and how ligand is generated and eliminated in these cell types. We also explore how activation of a particular target gene contributes to biological functions and how the regulation of individual target genes adds up to the coordination of gene networks. It appears that RXR heterodimeric nuclear receptors provide these cells with a coordinated and interrelated network of transcriptional regulators for interpreting the lipid milieu and the metabolic changes to bring about gene expression changes leading to subtype and functional specification. We also show that these networks are implicated in various immune diseases and are amenable to therapeutic exploitation.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Molekuláris Medicina
Megjelenés:Physiological Reviews. - 92 : 2 (2012), p. 739-789. -
További szerzők:Szántó Attila (1976-) (orvos, biokémikus) Szatmári István (1971-) (biológus) Széles Lajos (1971-) (molekuláris biológus)
Pályázati támogatás:TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
Dendritikus sejtek transzkripciós átprogramozása
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
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