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1.

001-es BibID:BIBFORM040367
Első szerző:Cayli, Sevil
Cím:Biochemical markers of sperm function : male fertility and sperm selection for ICSI / Cayli, S., Jakab, A., Ovari, L., Delpiano, E., Celik-Ozenci, C., Sakkas, D., Ward, D., Huszar, G.
Dátum:2003
ISSN:1472-6483
Megjegyzések:The expression of a 70 kDa chaperone protein, HspA2 (formerly called CK-M), has been identified in mature human spermatozoa. The central role of HspA2 has been established, as the expression level of this protein is related to sperm cellular maturity, DNA integrity, chromatin maturity, chromosomal aneuploidy frequency and sperm function, including fertilizing potential. The spermiogenetic events of cytoplasmic extrusion and remodelling of the plasma membrane, which facilitate the formation of zona pellucida binding site(s) in human spermatozoa, are related. Finally, the presence of the hyaluronic acid (HA) receptor on the plasma membrane of mature sperm coupled with the HA-coated slide sperm-binding assay, facilitates the testing of infertile men and the selection of single mature spermatozoa for ICSI. Because mature spermatozoa have no residual cytoplasm, the HA-bound sperm fraction is also enriched in spermatozoa that are normal by the Kruger strict morphology method.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Reproductive Biomedicine Online. - 7 : 4 (2003), p. 462-468. -
További szerzők:Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus) Óvári László (szülész-nőgyógyász, sebész) Delpiano, Elena Celik-Ozenci, Ciler Sakkas, Denny Ward, D. Huszár Gábor
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2.

001-es BibID:BIBFORM040368
Első szerző:Delpiano, Elena
Cím:Frequency of chromosomal aneuploidis and diploidies in oligozoospermic and normozoospermic men / Delpiano, E., Jakab, A., Kovács, T., Ward, D. C., Revelli, A., Huszar, G.
Dátum:2003
ISSN:1472-6483
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:Reproductive Biomedicine Online. - 7 : Suppl. 1. (2003), p. 12-13. -
További szerzők:Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus) Kovács Tamás (1959-) (szülész-nőgyógyász, humángenetikus) Ward, David Revelli, Alberto Huszár Gábor
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM085289
Első szerző:Di Guardo, Federica
Cím:Evaluation and treatment of the infertile women with Asherman syndrome: an updated review focusing on the role of hysteroscopy / Di Guardo Federica, Della Corte Luigi, Vilos George Angelos, Carugno Jose, Török Péter, Giampaolino Pierluigi, Manchanda Rahul, Vitale Salvatore Giovanni
Dátum:2020
ISSN:1472-6483
Megjegyzések:Asherman syndrome is a rare acquired clinical condition resulting in the obliteration of the uterine cavity due to the presence of partial or complete fibrous intrauterine adhesions involving at least two-thirds of the uterine cavity potentially obstructing the internal cervical os. Common reported symptoms of the disease are alterations of the menstrual pattern with decreased menstrual bleeding leading up to amenorrhea and infertility. Hysteroscopy is currently considered the gold standard diagnostic and therapeutic approach of patients with intrauterine adhesions. However, an integrated approach including preoperative, intraoperative and postoperative therapeutic measures are warranted due to the complexity of the syndrome. This review aims to summarize the most recent evidence on the recommended preoperative, intraoperative and postoperative procedures to restore the uterine cavity and a functional endometrium, as well as on the concomitant use of adjuvant therapies to achieve optimal fertility outcomes.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Asherman's syndrome
Hysteroscopy
Infertility
Intrauterine adhesions
Synechiae
Megjelenés:Reproductive Biomedicine Online. - 41 : 1 (2020), p. 55-61. -
További szerzők:Della Corte, Luigi Vilos, George Carugno, Jose Török Péter (1975-) (szülész-nőgyógyász) Giampaolino, Pierluigi Manchanda, Rahul Vitale, Salvatore Giovanni
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4.

001-es BibID:BIBFORM002256
Első szerző:Huszár Gábor
Cím:Fertility testing and ICSI sperm selection by hyaluronic acid binding : clinical and genetic aspects / Gabor Huszar, Attila Jakab, Denny Sakkas, Ciler-Celik Ozenci, Sevil Cayli, Elena Delpiano, Sinan Ozkavukcu
Dátum:2007
Megjegyzések:The testis-expressed chaperone protein, HspA2 (previously creatine kinase M isoform) was established as a measure of human sperm cellular maturity, function and fertility. The presence of HspA2 in the synaptonemal complex is likely to link low HspA2 expression and increased frequency of chromosomal aneuploidies in arrested-maturity spermatozoa. A relationship also exists between HspA2 expression in elongating spermatids and the associated spermatogenetic events, including plasma membrane remodelling and the formation of zona pellucida and hyaluronic acid (HA) binding sites. The HA receptor of mature spermatozoa, when coupled with HA-coated slides and/or Petri dishes, allows visual observation of sperm-HA binding, providing a basis for sperm maturity testing, a major improvement in semen evaluation, and selection of mature spermatozoa for intracytoplasmic sperm injection (ICSI). Thus, in HA-selected spermatozoa the frequency of chromosomal disomy and diploidy is reduced 4- to 6-fold compared with semen sperm fractions. This reduction is similar to the increase in numerical chromosomal aberrations in ICSI children. Combined studies of sperm shape and chromosome probes demonstrated that sperm morphology does not aid selection of haploid spermatozoa. The HA-mediated sperm selection is a novel and efficient technique that may alleviate potential problems related to ICSI fertilization with visually selected spermatozoa.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Reproductive Biomedicine Online 14 : 5 (2007), p. 650-663. -
További szerzők:Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus) Sakkas, Denny Ozenci, Ciler-Celik Cayli, Sevil Delpiano, Elena Ozkavukcu, Sinan
Internet cím:elektronikus változat
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5.

001-es BibID:BIBFORM039857
Első szerző:Mokánszki Attila (molekuláris biológus Ph.D hallgató)
Cím:Correlation study between sperm concentration, hyaluronic acid-binding capacity and sperm aneuploidy in Hungarian patients / Attila Mokánszki, Zsuzsanna Molnár, Anikó Ujfalusi, Erzsébet Balogh, Zsuzsa Kassai Bazsáné, Attila Varga, Attila Jakab, Éva Oláh
Dátum:2012
ISSN:1472-6483
Megjegyzések:Infertile men with low sperm concentration and/or less motile spermatozoa have an increased risk of producing aneuploid spermatozoa. Selecting spermatozoa by hyaluronic acid (HA) binding may reduce genetic risks such as chromosomal rearrangements and numerical aberrations. Fluorescence in-situ hybridization (FISH) has been used to evaluate the presence of aneuploidies. This study examined spermatozoa of 10 oligozoospermic, 9 asthenozoospermic, 9 oligoasthenozoospermic and 17 normozoospermic men by HA binding and FISH. Mean percentage of HA-bound spermatozoa in the normozoospermic group was 81%, which was significantly higher than in the oligozoospermic (P<0.001), asthenozoospermic (P<0.001) and oligoasthenozoospermic (P<0.001) groups. Disomy of sex chromosomes (P=0.014) and chromosome 17 (P=0.0019), diploidy (P=0.03) and estimated numerical chromosome aberrations (P=0.004) were significantly higher in the oligoasthenozoospermic group compared with the other groups. There were statistically significant relationships (P<0.001) between sperm concentration and HA binding (r=0.658), between sperm concentration and estimated numerical chromosome aberrations (r=-0.668) and between HA binding and estimated numerical chromosome aberrations (r=-0.682). HA binding and aneuploidy studies of spermatozoa in individual cases allow prediction of reproductive prognosis and provision of appropriate genetic counselling. Infertile men with normal karyotypes and low sperm concentrations and/or less motile spermatozoa have significantly increased risks of producing aneuploid (diminished mature) spermatozoa. Selecting spermatozoa by hyaluronic acid (HA) binding, based on a binding between sperm receptors for zona pellucida and HA, may reduce the potential genetic risks such as chromosomal rearrangements and numerical aberrations. In the present study we examined sperm samples of 45 men with different sperm parameters by HA-binding assay and fluorescence in-situ hybridization (FISH). Mean percentage of HA-bound spermatozoa in the normozoospermic group was significantly higher than the oligozoospermic, the asthenozoospermic and the oligoasthenozoospermic groups. Using FISH, disomy of sex chromosomes and chromosome 17, diploidy and estimated numerical chromosome aberration frequencies were significantly higher in the oligoasthenozoospermic group compared with the three other groups. A significant positive correlation was found between the sperm concentration and the HA-binding capacity, and significant negative correlations between the sperm concentration and the estimated numerical chromosomes aberrations as well as between the HA-binding ability and the estimated numerical chromosome aberrations were identified. We conclude that HA-binding assay and sperm aneuploidy study using FISH may help to predict the reproductive ability of selected infertile male patients and to provide appropriate genetic counselling.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
lissencephaly
subcortical band heterotopia
LIS1 (PAFAH1B1)
DCX
TUBA1A
pachygyria
agyria
egyetemen (Magyarországon) készült közlemény
Megjelenés:Reproductive Biomedicine Online. - 25 : 6 (2012), p. 620-626. -
További szerzők:Molnár Zsuzsanna (1980-) (szülész-nőgyógyász, labor szakorvosjelölt, urológus) Ujfalusi Anikó (1968-) (gyermekorvos, laboratóriumi szakorvos) Balogh Erzsébet (1949-) (biológus, citogenetikus) Bazsáné Kassai Zsuzsa (1946-) (embriológus) Varga Attila (1949-) (urológus, andrológus) Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus) Oláh Éva (1943-2019) (gyermekgyógyász, klinikai genetikus)
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