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001-es BibID:	BIBFORM075137
Első szerző:	Balogh Nóra (Pszichológus)
Cím:	Investigating the state-like and trait-like characters of social cognition in schizophrenia: A short term follow-up study / Nóra Balogh, Anikó Égerházi, Roland Berecz, Gábor Csukly
Dátum:	2014
ISSN:	0920-9964
Megjegyzések:	Background and objectives: Controversial ?ndings exist in the literature regarding the state- and trait-like charac- ters of social cognition in schizophrenia. In order to explore the relationship of social cognition with symptom severity in the present study, Theory of mind (ToM) and emotion recognition were tested in an acute phase and later in a clinically stable phase in patients.Methods: ToM and emotion recognition abilities were examined by using the Reading the Mind in the Eyes Test (RMET) and the Ekman 60 Faces Test (FEEST) in 43 patients with schizophrenia and 41 healthy controls. Research diagnoses were based on SCID interviews. Symptom severity in patients was assessed by the Positive and Nega- tive Syndrome Scale (PANSS).Results: ToM and emotion recognition de?cits improved in the clinically stable phase compared to relapse, but were still found to be impaired compared to healthy controls. Negative symptom severity showed strong corre- lation with emotion recognition and ToM at both visits.Conclusions: Both ToM and emotion recognition ?uctuated together with symptom severity, which con?rmed the "state-like" component of these abilities. Our results, taken together with the ?ndings of previous investigations show that social cognition de?cits in schizophrenia have both state-like and trait-like components.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban schizophrenia social cognition
Megjelenés:	Schizophrenia Research. - 159 (2014), p. 499-505. -
További szerzők:	Égerházi Anikó (1957-) (neurológus, pszichiáter, pszichoterapeuta) Berecz Roland (1970-) (pszichiáter szakorvos) Csukly Gábor
Pályázati támogatás:	TÁMOP-4.2.1/B-09/1/KONV-2010-0007 TÁMOP
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM117708
035-os BibID:	(Scopus)85179963423
Első szerző:	Boiko, Dmytro I.
Cím:	Schizophrenia and disruption of circadian rhythms : an overview of genetic, metabolic and clinical signs / Dmytro I. Boiko, Hitesh Chopra, Muhammad Bilal, Pavlo V. Kydon, Larysa O. Herasymenko, Vadym O. Rud, Lesia A. Bodnar, Ganna Yu. Vasylyeva, Rustam I. Isakov, Liliia V. Zhyvotovska, Aashna Mehta, Andrii M. Skrypnikov
Dátum:	2024
ISSN:	0920-9964
Megjegyzések:	A molecular clock in the suprachiasmatic nucleus of the anterior hypothalamus, which is entrained by the dark-light cycle and controls the sleep-wake cycle, regulates circadian rhythms. The risk of developing mental disorders, such as schizophrenia, has long been linked to sleep abnormalities. Additionally, a common aspect of mental disorders is sleep disturbance, which has a direct impact on the intensity of the symptoms and the quality of life of the patient. This relationship can be explained by gene alterations such as CLOCK in schizophrenia which are also important components of the physiological circadian rhythm. The function of dopamine and adenosine in circadian rhythm should also be noted, as these hypotheses are considered to be the most popular theories explaining schizophrenia pathogenesis. Therefore, determining the presence of a causal link between the two can be key to identifying new potential targets in schizophrenia therapy, which can open new avenues for clinical research as well as psychiatric care. We review circadian disruption in schizophrenia at the genetic, metabolic, and clinical levels. We summarize data about clock and clock-controlled genes' alterations, neurotransmitter systems' impairments, and association with chronotype in schizophrenia patients. Our findings demonstrate that in schizophrenia either homeostatic or circadian processes of sleep regulation are disturbed. Also, we found an insufficient number of studies aimed at studying the relationship between known biological phenomena of circadian disorders and clinical signs of schizophrenia.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Schizophrenia Circadian rhythm Chronotype Clock genes Sleep disorders
Megjelenés:	Schizophrenia Research. - 264 (2024), p. 58-70. -
További szerzők:	Chopra, Hitesh Bilal, Muhammad Kydon, Pavlo V. Herasymenko, Larysa O. Rud, Vadym O. Bodnar, Lesia A. Vasylyeva, Ganna Yu. Isakov, Rustam I. Zhyvotovska, Liliia V. Mehta, Aashna Skrypnikov, Andrii M.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM119743
035-os BibID:	(Scopus)85185171099
Első szerző:	Tordai Csongor
Cím:	Probing the biological consequences of a previously undescribed de novo mutation of ZMYND11 in a schizophrenia patient by CRISPR genome editing and induced pluripotent stem cell based in vitro disease-modeling / Csongor Tordai, Edit Hathy, Hella Gyergyák, Katalin Vincze, Máté Baradits, Júlia Koller, Ádám Póti, Bálint Jezsó, László Homolya, Mária Judit Molnár, László Nagy, Dávid Szüts, Ágota Apáti, János M. Réthelyi
Dátum:	2024
ISSN:	0920-9964
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Schizophrenia Research. - [Epub ahead of print] (2024). -
További szerzők:	Hathy Edit Gyergyák Hella Vincze Katalin Baradits Máté Koller Júlia Póti Ádám Jezsó Bálint Homolya László Molnár Mária Judit (1962-) (neurológus) Nagy László (1966-) (molekuláris sejtbiológus, biokémikus) Szüts Dávid Apáti Ágota Réthelyi János
Pályázati támogatás:	NAP Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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