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001-es BibID:	BIBFORM015746
Első szerző:	Machackova, Jarmila
Cím:	Myofibrillar remodelling in cardiac hypertrophy, heart failure and cardiomyopathies / Jarmila Machackova, Barta Judit, Naranjan S. Dhalla
Dátum:	2006
Megjegyzések:	A wide variety of pathological conditions havebeen shown to result in cardiac remodelling and myocardial dysfunction. However, the mechanisms of transition from adaptive to maladaptive alterations, as well as those for changes in cardiac performance leading to heart failure, are poorly understood. OBSERVATIONS: Extensive studies have revealed a broad spectrum of progressive changes in subcellular structures and function, as well asin signal transduction and metabolism in the heart, among different cardiovascular disorders. The present review is focused on identifying the alterations in molecular and biochemical structure of myofibrils (myofibrillar remodelling) in hypertrophied and failing myocardiumin different types of heart diseases. Numerous changes at the level of gene expression for both contractile and regulatory proteins have already been reported in failing hearts and heart diseases; these changes are potential precursors for heart failure such as cardiac hypertrophyand cardiomyopathies. Myofibrillar remodelling, as a consequence of proteolysis, oxidation, and phosphorylation of some functional groups in both contractile and regulatory proteins in hearts failing due to different etiologies, has also been described. CONCLUSIONS: Although myofibrillar remodelling appears to be associated with cardiac dysfunction, alterations in both contractileand regulatory proteins are dependent on the type and stage of heart disease.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Cardiac gene expression Cardiomyopathies Congestive heart failure Myocardial infarction Myofibrillar alterations
Megjelenés:	The Canadian Journal of Cardiology. - 22 : 11 (2006), p. 953-968. -
További szerzők:	Barta Judit (1975-) (kardiológus) Dhalla, Naranjan S.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM015681
Első szerző:	Szabó Zoltán (belgyógyász, kardiológus)
Cím:	Effect of hyperlipidemia on QT dispersion in patients without ischemic heart disease / Szabó Z., Harangi M., Lörincz I., Seres I., Katona E., Karányi Z., Paragh G.
Dátum:	2005
ISSN:	0828-282X
Megjegyzések:	Lipoproteins are known to exert direct and indirect effects on cardiovascular function, but their effects on ventricular repolarization have not yet been clearly elucidated. OBJECTIVES: To assess the effect of hyperlipidemia on the longest QT interval (QTmax) of the 12-lead surface electrocardiogram (ECG) and on QT dispersion (QTd) in type IIb hyperlipidemic patients without myocardial ischemia, and to compare these patients with healthy control subjects. METHODS: Ninety-six hyperlipidemic patients (44 men and 52 women; mean age 53+/-13 years) and 101 healthy control subjects (43 men and 58 women; mean age 46+/-16 years) were examined. Total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol (LDL-C), triglyceride, apolipoprotein (apo) A1, apo B, lipoprotein(a), QTmax and QTd were measured. According to heart rate, corrected QTmax and corrected QTd were also determined. RESULTS: A significant difference was observed between the two groups of subjects with respect to serum cholesterol, LDL-C, triglyceride, apo B, QTmax, corrected QTmax, QTd and corrected QTd. A positive significant correlation was found between cholesterol, triglyceride, LDL-C and all of the studied ECG parameters, between high density lipoprotein cholesterol and QTmax, apo B and QTd, and between body mass index and all of the studied ECG markers. CONCLUSIONS: Hyperlipidemia may have a direct effect on the studied ECG markers.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Canadian Journal Of Cardiology. - 21 : 10 (2005), p. 847-850. -
További szerzők:	Harangi Mariann (1974-) (belgyógyász, endokrinológus) Lőrincz István (1950-) (belgyógyász, kardiológus) Seres Ildikó (1954-) (biokémikus) Katona Evelin (1974-) (belgyógyász) Karányi Zsolt (1961-) (biostatisztikus, bioinformatikus) Paragh György (1953-) (belgyógyász)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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