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001-es BibID:BIBFORM079907
035-os BibID:(WOS)000493389200001 (Scopus)85083896408
Első szerző:Almássy János (élettanász, biológus, angol-magyar szakfordító)
Cím:Safety concerns of diamide insecticides / János Almássy, László Csernoch, Péter P. Nánási
Dátum:2019
ISSN:1096-6080
Tárgyszavak:Orvostudományok Elméleti orvostudományok levél
folyóiratcikk
ryanodine receptor
diamide
insecticide
chlorantraniliprole
Megjelenés:Toxicological Sciences. - 171 : 2 (2019), p. 281. -
További szerzők:Csernoch László (1961-) (élettanász) Nánási Péter Pál (1956-) (élettanász)
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Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM019097
Első szerző:Petrikovics Ilona
Cím:Comparing therapeutic and prophylactic protection against the lethal effect of paraoxon / I. Petrikovics, D. Papahadjopoulos, K. Hong, T. C. Cheng, S. I. Baskin, J. Jiang, J. C. Jaszberenyi, B. A. Logue, M. Szilasi, W. D. McGuinn, J. L. Way
Dátum:2004
ISSN:1096-6080
Megjegyzések:Prophylactic and therapeutic efficacy against organophosphorus (OP) intoxication by pralidoxime (2-PAM) and atropine were studied and compared with sterically stabilized long-circulating liposomes encapsulating recombinant organophosphorus hydrolase (OPH), either alone or in various specific combinations, in paraoxon poisoning. Prophylactic and therapeutic properties of atropine and 2-PAM are diminished when they are used alone. However, their prophylactic effects are enhanced when they are used in combination. Present studies indicate that sterically stabilized liposomes (SL) encapsulating recombinant OPH (SL-OPH) alone can provide much better therapeutic and prophylactic protection than the classic 2-PAM + atropine combination. This protection was even more dramatic when SL-OPH was employed in combination with 2-PAM and/or atropine: the magnitude of prophylactic antidotal protection was an astounding 1022 LD50 [920 mg/kg (LD50 of paraoxon with antagonists)/ 0.95 mg/kg (LD50 of control paraoxon)], and the therapeutic antidotal protection was 156 LD50 [140 mg/kg (LD50 of paraoxon with antagonists)/0.9 mg/kg (LD50 of control paraoxon)]. The current study firmly establishes the value of using liposome encapsulating OPH.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Toxicological Sciences 77 : 2 (2004), p. 258-262. -
További szerzők:Papahadjopoulos, D. Hong, K. Cheng, T. C. Baskin, Steven I. Jiang, J. Jászberényi J. Csaba (1948-) Logue, B. A. Szilasi Mária (1953-) (tüdőgyógyász, klinikai immunológus, allergológus, belgyógyász) McGuinn, W. D. Way, J. L.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM036660
Első szerző:Rühl, Ralph (vegyész)
Cím:Embryonic subcellular distribution of 13-cis- and all-trans-retinoic acid indicates differential cytosolic/nuclear localization / Ralph Rühl, Claudia Plum, Mohamed M. A. Elmazar, Heinz Nau
Dátum:2001
Megjegyzések:Isotretinoin (13-cis-retinoic acid [13CRA], Accutane) is used for the treatment of dermatological diseases. Isotretinoin is, however, teratogenic in animals and humans. The mechanism of action of its teratogenicity is still not clearly identified. It has little or no binding properties to cytosolic retinoid-binding proteins or nuclear retinoid receptors (RAR, RXR). One hypothesis is that the teratogenicity of 2 approximately equipotent teratogenic doses of 13CRA and all-trans-retinoic acids (ATRA) could mainly be correlated to ATRA in the nuclei, where the retinoic acid receptors (RARs) are located. To test this hypothesis, female mice at gestational day 11 were treated with approximately equipotent teratogenic doses of 13-cis-retinoic acid (100 mg/kg orally) or all-trans-retinoic acid (10 mg/kg orally) and sacrificed 1 h and 4 h after administration. Embryos were homogenized and centrifuged into 4 fractions, and the purity of the fractions was tested by quantification of marker constituents for various cell compartments. We analyzed, by RP-HPLC, nuclear, mitochondrial, microsomal, and cytosolic fractions, as well as embryo homogenate and maternal plasma. After treatment with 13-cis-retinoic acid, this substance was mainly located in the nuclear fraction of the embryo (approximately 82%), whereas all-trans-retinoic acid, after ATRA treatment, was mainly located in the cytosolic supernatant (approximately 64%). The binding to cellular retinoid-binding protein (CRABP) may limit the access of ATRA to the nucleus, in contrast to 13CRA, which does not bind to CRABP. The concentration of ATRA in the nuclear fraction was similar after administration of either 13CRA or ATRA. The teratogenic activity of 13-cis-retinoic acid could therefore be explained by its access to the nucleus and its possible conversion to all-trans-retinoic acids, which will interact with the nuclear retinoid receptors.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Toxicological Sciences. - 63 : 1 (2001), p. 82-89. -
További szerzők:Plum, Claudia Elmazar, Mohamed M. A. Nau, Heinz
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Intézményi repozitóriumban (DEA) tárolt változat
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