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001-es BibID:	BIBFORM001037
Első szerző:	Bai Péter (biokémikus)
Cím:	Protein tyrosine nitration and poly(ADP-ribose) polymerase activation in N-methyl-N-nitrosoguanidine-treated thymocytes : implication for cytotoxicity / Bai P., Hegedűs C., Erdélyi K., Szabó E., Bakondi E., Gergely S., Szabó C., Virág L.
Dátum:	2007
Megjegyzések:	1-Methyl-3-nitro-1-nitrosoguanidine (MNNG) is a DNA alkylating agent. DNA alkylation by MNNG is known to trigger accelerated poly(ADP-ribose) metabolism. Various nitroso compounds release nitric oxide (NO). Therefore, we set out to investigate whether MNNG functions as NO donor and whether MNNG-derived NO or secondary NO metabolites such as peroxynitrite contribute to MNNG-induced cytotoxicity. MNNG in aqueous solutions resulted in time- and concentration-dependent NO release and nitrite/nitrate formation. Moreover, various proteins in MNNG-treated thymocytes were found to be nitrated, indicating that MNNG-derived NO may combine with cellular superoxide to form peroxynitrite, a nitrating agent. MNNG also caused DNA breakage and increased poly(ADP-ribose) polymerase activity and cytotoxicity in thymocytes. MNNG-induced DNA damage (measured by the comet assay) and thymocyte death (measured by propidium iodide uptake) was prevented by the PARP inhibitor PJ-34 and by glutathione (GSH) or N-acetylcysteine (NAC). The cytoprotection provided by PJ-34 against necrotic parameters was paralleled by increased outputs in apoptotic parameters (caspase activity, DNA laddering) indicating that PARP activation diverts apoptotic death toward necrosis. As MNNG-induced cytotoxicity showed many similarities to peroxynitrite-induced cell death, we tested whether peroxynitrite was responsible for at least part of the cytotoxicity induced by MNNG. Cell-permeable enzymic antioxidants (superoxide dismutase and catalase), the NO scavenger cPTIO or the peroxynitrite decomposition catalyst FP15 failed to inhibit MNNG-induced DNA breakage and cytotoxicity. In conclusion, MNNG induces tyrosine nitration in thymocytes. Furthermore, MNNG damages DNA by a radical mechanism that does not involve NO or peroxynitrite.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban 1-methyl-3-nitro-1-nitrosoguanidine peroxynitrite egyetemen (Magyarországon) készült közlemény poly(ADP-ribose) polymerase necrosis apoptosis nitric oxide
Megjelenés:	Toxicology Letters 170 : 3 (2007), p. 203-213. -
További szerzők:	Hegedűs Csaba (1980-) (biokémikus, molekuláris biológus) Erdélyi Katalin (1978-) (molekuláris biológus, biokémikus) Szabó Éva (1965-) (bőrgyógyász, kozmetológus) Bakondi Edina (1975-) (biokémikus, vegyész) Gergely Szabolcs (1977-) (kardiológus) Szabó Csaba Virág László (1965-) (biokémikus, sejtbiológus, farmakológus)
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001-es BibID:	BIBFORM099685
035-os BibID:	(Scopus)85122640116 (WOS)000788155600005
Első szerző:	Muhollari, Teuta
Cím:	Methanol in unrecorded fruit spirits. Does it pose a health risk to consumers in the European Union? A probabilistic toxicological approach / Muhollari Teuta, Szűcs Sándor, Ádány Róza, Sándor János, McKee Martin, Pál László
Dátum:	2022
ISSN:	0378-4274
Megjegyzések:	Methanol is present at high concentrations in unrecorded fruit spirits, placing consumers of these beverages at risk of exposure at high levels. When assessing any health risk it is necessary to consider blood methanol levels (BMLs), reference dose (RfD), and maximum tolerable blood methanol level (MTBML). The aim of our study was to estimate daily methanol intake and related BMLs attributable to drinking unrecorded fruit spirits in the European population using a probabilistic Monte Carlo simulation. Data on the concentration of methanol in unrecorded fruit spirits in European Union member states were collected and the health risk posed by consumption of unrecorded fruit spirits was estimated. We found that drinking unrecorded fruit spirits containing methanol at a concentration higher than 8598.1 mg/litre of pure alcohol (p.a.) or 6382.1 mg/litre of p.a. and also at least 10 g ethanol can result in a methanol intake above the RfD by men and women, respectively. We confirmed that consumption of unrecorded fruit spirits containing methanol does not result in BMLs higher than the MTBML. Further studies are required to assess whether there is any health risk from chronic exposure to methanol above the RfD from unrecorded fruit spirits.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Unrecorded fruit spirit Methanol Exposure Blood methanol level Reference dose Maximum tolerable blood methanol level Population-based estimation
Megjelenés:	Toxicology Letters. - 357 (2022), p. 43-56. -
További szerzők:	Szűcs Sándor (1958-) (biokémikus, vegyész) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Sándor János (1966-) (orvos-epidemiológus) McKee, Martin Pál László (1987-) (népegészségügyi szakember, egészségfejlesztő)
Pályázati támogatás:	EFOP-3.6.3-VEKOP-16-2017-00009 Egyéb Hungarian Academy of Sciences (grant numberTK2016-78), Egyéb Ministry of National Resources (Contract No.1Q4DBNX1STIP 320) Egyéb National Research, Developmentand Innovation Fund of Hungary (project number 135784) Egyéb
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