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001-es BibID:BIBFORM083135
035-os BibID:(cikkazonosító)68 (scopus)85078993240 (wos)000519243400011
Első szerző:Bencze János (orvos)
Cím:Lemur tyrosine kinase 2 (LMTK2) level inversely correlates with phospho-tau in neuropathological stages of Alzheimer's disease / János Bencze, Máté Szarka, Viktor Bencs, Renáta Nóra Szabó, László V. Módis, Dag Aarsland, Tibor Hortobágyi
Dátum:2020
Megjegyzések:Alzheimer's disease (AD) is the most common neurodegenerative dementia. Mapping the pathomechanism and providing novel therapeutic options have paramount significance. Recent studies have proposed the role of LMTK2 in AD. However, its expression pattern and association with the pathognomonic neurofibrillary tangles (NFTs) in different brain regions and neuropathological stages of AD is not clear. We performed chromogenic (CHR) LMTK2 and fluorescent phospho-tau/LMTK2 double-labelling (FDL) immunohistochemistry (IHC) on 10-10 post-mortem middle frontal gyrus (MFG) and anterior hippocampus (aHPC) samples with early and late neuropathological Braak tau stages of AD. MFG in early stage was our ♭endogenous control' region as it is not affected by NFTs. Semi-quantitative CHR-IHC intensity scoring revealed significantly higher (p<0.001) LMTK2 values in this group compared to NFT-affected regions. FDL-IHC demonstrated LMTK2 predominance in the endogenous control region, while phospho-tau overburden and decreased LMTK2 immunolabelling were detected in NFT-affected groups (aHPC in early and both regions in late stage). Spearman's correlation coefficient showed strong negative correlation between phospho-tau/LMTK2 signals within each group. According to our results LMTK2 expression is inversely proportionate to the extent of NFT pathology, as well as decreased LMTK2 level is not a general feature in AD brain, rather it is characteristic to the NFT-affected regions.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Alzheimer's disease
LMTK2
neurodegeneration
tau
digital image analysis
Megjelenés:Brain Sciences. - 10 : 2 (2020), p. 1-14. -
További szerzők:Szarka Máté (1990-) Bencs Viktor (1995-) (orvos) Szabó Renáta Nóra Módis László V. (neurológus) Aarsland, Dag Hortobágyi Tibor (1965-) (patológus)
Pályázati támogatás:EFOP-3.6.3-VEKOP-16-2017-00009
EFOP
ÚNKP-19-3
Egyéb
NAP (2017-1.2.1-NKP-2017-00002)
Egyéb
GINOP-2.3.2-15-2016-00043
GINOP
ÚNKP-19-2
Egyéb
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM087222
Első szerző:Gál Judit (aneszteziológiai és ITO szakorvos)
Cím:Assessment of two prophylactic fluid strategies in aneurysmal subarachnoid hemorrhage : a randomized trial / Judit Gál, Bela Fülesdi, Dávid Varga, Babett Fodor, Eszter Varga, Péter Siró, Dániel Bereczki, Sándor Szabó, Csilla Molnár
Dátum:2020
ISSN:0300-0605
Megjegyzések:Objective: To compare the effect of two prophylactic euvolemic fluid strategy regimens on the incidence of cerebral vasospasm and clinical outcomes in patients with aneurysmal subarachnoid hemorrhage (SAH). Methods: Ninety-six patients with a basal intravenous intake of 15 mL/kg/day of Ringer's lactate solution were included, and an additional 15 to 50 mL/kg/day Ringer's lactate (RL-group) or hydroxyethyl starch 130/0.4 solution (HES-group) was administered to maintain the targeted mean arterial pressure. The primary end point was the occurrence of cerebral vasospasm during the first 14 days. The secondary end points were case fatality, Barthel's index, and Glasgow Outcome Scores (GOS) at 30 days after SAH. Results: Cerebral vasospasm developed in 42 patients (43.7%), and nine of these events were severe. The vasospasm rate among the RL- and HES-based groups was 25/48 and 17/48, respectively. For the secondary endpoint, four patients (4%) died by the end of follow-up (two in each group). Unfavorable outcome cases were not different in the RL and HES groups (9 vs. 14, respectively). There was no difference between the Barthel's scores at 30 days between the two groups.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Aneurysmal subarachnoid hemorrhage, cerebral vasospasm, prophylactic fluid strategy, hydroxyethyl starch, euvolemic, Barthel's index, Glasgow outcome score
Megjelenés:Journal Of International Medical Research. - 48 : 7 (2020), p. 1-10. -
További szerzők:Fülesdi Béla (1961-) (aneszteziológus) Varga Dávid (1983-) (aneszteziológus, intenzív terápiás szakorvos) Fodor Babett (1984-) (aneszteziológus, intenzív terápiás szakorvos) Varga Eszter Siró Péter (1973-) (neurológus, aneszteziológus, intenzív terápiás szakorvos) Bereczki Dániel (1960-) (neurológus) Szabó Sándor (1957-) (idegsebész) Molnár Csilla (1962-) (aneszteziológus)
Pályázati támogatás:2017-1.2.1-NKP-2017-00002
Egyéb
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3.

001-es BibID:bibEBI00026266
Első szerző:Majer Réka
Cím:Neuropsychiatric symptoms, quality of life and caregivers' burden in dementia / Majer Réka, Adeyi Olar, Bagoly Zsuzsa, Simon Viktória, Csiba László, Kardos László, Hortobágyi Tibor, Frecska Ede
Dátum:2020
ISSN:2391-5463 1911-2092
Megjegyzések:The objective of this research is to identify the relationship between the neuropsychiatric symptoms (NPSs) of patients with major neurocognitive disorder (mNCD), their quality of life, illness intrusiveness and the caregiver's burden. We assessed 131 patients with mNCD. Examination methods included WHO well-being index short version, illness intrusiveness rating scale, Alzheimer's Disease Assessment Scale-Cog, Mini Mental State Examination and neuropsychiatric inventory. The results were analysed using standard statistical tests. In our sample, the prevalence of NPSs is 100%. A significant correlation (p < 0.0001) was observed with quality of life and illness intrusiveness. Additionally, a strong relationship was observed between NPSs and the caregiver's burden (r = 0.9). The result is significantly twice as much stronger in comparison to the relationship between NPS and cognitive symptoms (r = 0.4). This is the first study in Hungary to assess the impact of NPS on the burden of relatives and quality of life. NPS had twice stronger impact on caregivers' burden than cognitive decline. However, further studies are needed to assess the sub-syndromes in mNCD in relation to NPS.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Open Medicine. - 15 : 1 (2020), p. 905-914. -
További szerzők:Adeyi, Olar Bagoly Zsuzsa (1978-) (orvos) Simon Viktória Csiba László (1952-) (neurológus, pszichiáter) Kardos László (1970-) (megelőző orvostan és népegészségtan szakorvos) Hortobágyi Tibor (1965-) (patológus) Frecska Ede (1953-) (pszichiáter)
Pályázati támogatás:GINOP-2.3.2-15-2016-00048
GINOP
SZTE ÁOK-KKA No. 5S 567 (A202)
Egyéb
OTKA-NKFIH-SNN 132999
OTKA
K120042 Nemzeti Kutatási, Fejlesztési és Innovációs Alap
Egyéb
Nemzeti Agykutatási Program 2.0 (2017-1.2.1-NKP-2017-00002
Egyéb
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4.

001-es BibID:BIBFORM087868
035-os BibID:(WoS)000529444900043 (Scopus)85082146494
Első szerző:Nemes Réka (aneszteziológus, intenzív terápiás szakorvos)
Cím:Awake Volunteer Pain Scores During Neuromuscular Monitoring / Réka Nemes, György Nagy, Glenn S. Murphy, Ilana I. Logvinov, Béla Fülesdi, J. Ross Renew
Dátum:2020
ISSN:0003-2999
Megjegyzések:BACKGROUND: There is a need for easy to use, reliable neuromuscular monitors (NMMs). This multicenter, prospective, unblinded study compared the discomfort associated with neurostimulation in unmedicated healthy volunteers when using the new electromyography (EMG)-based TetraGraph and acceleromyography (AMG)-based TOF-Watch NMMs. The secondary aim was to compare the repeatability of the train-of-four (TOF) ratios (TOFRs) obtained with the 2 devices. METHODS: The TOF measurements of 135 volunteers from 3 university hospitals were analyzed (age: 38.3 ? 12 years [mean ? standard deviation [SD]]; male/female ratio = 63:72). The left or right ulnar nerve was stimulated at the wrist in TOF mode with 20, 30, 40, and 50 mA stimulating current intensities with both devices in random order. The TOF-Watch used standard electrocardiography (ECG) electrodes (Red Dot; 3M Health Care) for nerve stimulation. The stimulating surface area of 1 ECG electrode is 113 mm2. The piezoelectric probe was attached to the thumb, and a hand adapter was used to ensure consistency of AMG measurements. The TetraGraph uses proprietary surface strip electrodes for nerve stimulation and muscle action potential recording, whose stimulating surface area is roughly twice as big as that of standard ECG electrodes (228.5 mm2). The volunteers were asked to rate the discomfort associated with neurostimulation on a 0?10 verbal numerical rating scale (VNRS) score anchored with 0 (no pain) and 10 (worst pain ever experienced). A linear mixed-effects model was used to evaluate the difference in VNRS scores between devices. P <.05 was accepted as the level of significance. RESULTS: In the linear mixed-effects model, there were no differences in VNRS scores between devices at any of the stimulating current intensities, P = .38. The median (range) VNRS scores obtained with TOF-Watch and TetraGraph devices were 2 (0?7) vs 2 (0?8) at 20 mA, 3 (1?9) vs 3 (1?9) at 30 mA, 5 (1?10) vs 5 (1?10) at 40 mA, and 5 (1?10) vs 6 (1?10) at 50 mA stimulating current intensities. The mean of the 1469 TOFRs obtained with TetraGraph was 100.43% ? 7.74% (standard error = 0.2%). Due to technical difficulties, the repeatability of the TOFRs could not be determined. CONCLUSIONS: Despite the different size and design of the stimulating electrodes, the 2 NMMs caused the same level of discomfort in unmedicated healthy volunteers.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Anesthesia and Analgesia. - 130 : 4 (2020), p. 941-948. -
További szerzők:Nagy György (1986-) (aneszteziológus, intenzív terápiás szakorvos) Murphy, Glenn S. Logvinov, Ilana I. Fülesdi Béla (1961-) (aneszteziológus) Renew, J. Ross
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5.

001-es BibID:BIBFORM090057
Első szerző:Vaskó Attila (tüdőgyógyász)
Cím:Assessment of Systemic and Cerebral Oxygen Saturation during Diagnostic Bronchoscopy : a Prospective, Randomized Study / Attila Vaskó, Sándor Kovács, Béla Fülesdi, Csilla Molnár
Dátum:2020
ISSN:2090-2840 2090-2859
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Bronchoszkópia
oxigenizáció
Megjelenés:Emergency Medicine International. - 2020 (2020), p. 1-6. -
További szerzők:Kovács Sándor (1978-) (matematika tanár) Fülesdi Béla (1961-) (aneszteziológus) Molnár Csilla (1962-) (aneszteziológus)
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