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1.

001-es BibID:BIBFORM083085
035-os BibID:(WoS)000542144300010 (Scopus)85076708163
Első szerző:Abrahams, Jodie L.
Cím:Recent advances in glycoinformatic platforms for glycomics and glycoproteomics / Jodie L. Abrahams, Ghazaleh Taherzadeh, Gabor Jarvas, Andras Guttman, Yaoqi Zhou, Matthew P. Campbell
Dátum:2020
ISSN:0959-440X
Megjegyzések:Protein glycosylation is the most complex and prevalent posttranslation modification in terms of the number of proteins modified and the diversity generated. To understand the functional roles of glycoproteins it is important to gain an insight into the repertoire of oligosaccharides present. The comparison and relative quantitation of glycoforms combined with site-specific identification and occupancy are necessary steps in this direction. Computational platforms have continued to mature assisting researchers with the interpretation of such glycomics and glycoproteomics data sets, but frequently support dedicated workflows and users rely on the manual interpretation of data to gain insights into the glycoproteome. The growth of site-specific knowledge has also led to the implementation of machine-learning algorithms to predict glycosylation which is now being integrated into glycoproteomics pipelines. This short review describes commercial and open-access databases and software with an emphasis on those that are actively maintained and designed to support current analytical workflows.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Current Opinion In Structural Biology. - 62 (2020), p. 56-69. -
További szerzők:Taherzadeh, Ghazaleh Járvás Gábor (1982-) (vegyészmérnök) Guttman András (1954-) (vegyészmérnök) Zhou, Yaoqi Campbell, Matthew P.
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2.

001-es BibID:BIBFORM091875
035-os BibID:(WOS)000581183900014 (Scopus)85094685088
Első szerző:Acar-Denizli, Nihan
Cím:Systemic phenotype related to primary Sjögren's syndrome in 279 patients carrying isolated anti-La/SSB antibodies / N. Acar-Denizli, I. F. Horváth, T. Mandl, R. Priori, A. Vissink, G. Hernandez-Molina, B. Armagan, S. Praprotnik, A. Sebastian, E. Bartoloni, M. Rischmueller, S. G. Pasoto, G. Nordmark, H. Nakamura, V. Fernandes Moça Trevisani, S. Retamozo, S. E. Carsons, B. Maure-Noia, I. Sánchez-Berná, M. López-Dupla, E. Fonseca-Aizpuru, S. Melchor Díaz, M. Vázquez, P. E. Díaz Cuiza, B. de Miguel Campo, W. F. Ng, A. Rasmussen, X. Dong, X. Li, C. Baldini, R. Seror, Jacques-Eric Gottenberg, A. A. Kruize, P. Sandhya, S. Gandolfo, Seung-Ki Kwok, M. Kvarnstrom, R. Solans, D. Sene, Y. Suzuki, D. A. Isenberg, V. Valim, B. Hofauer, R. Giacomelli, V. Devauchelle-Pensec, F. Atzeni, T. A. Gheita, J. Morel, R. Izzo, U. Kalyoncu, A. Szántó, P. Olsson, H. Bootsma, M. Ramos-Casals, B. Kostov, P. Brito-Zerón, Sjögren Big Data Consortium
Dátum:2020
ISSN:0392-856X
Megjegyzések:Objectives: To evaluate the systemic phenotype associated with the presence of isolated anti-La/SSB antibodies in a large international registry of patients with primary Sjögren's syndrome (pSS) fulfilling the 2002 classification criteria. Methods: The Big Data Sjögren Project Consortium is an international, multicentre registry created in 2014. Baseline clinical information from leading centres on clinical research in SS of the 5 continents was collected. Combination patterns of anti-Ro/SSA-La/SSB antibodies at the time of diagnosis defined the following four immunological phenotypes: double positive (combined Ro/SSA and La/SSB,) isolated anti-Ro/SSA, isolated anti-La/SSB, and immunonegative. Results: The cohort included 12,084 patients (11,293 females, mean 52.4 years) with recorded ESSDAI scores available. Among them, 279 (2.3%) had isolated anti-La/SSB antibodies. The mean total ESSDAI score at diagnosis of patients with pSS carrying isolated anti-La/SSB was 6.0, and 80.4% of patients had systemic activity (global ESSDAI score ?1) at diagnosis. The domains with the highest frequency of active patients were the biological (42.8%), glandular (36.8%) and articular (31.2%) domains. Patients with isolated anti-La/SSB showed a higher frequency of active patients in all ESSDAI domains but two (articular and peripheral nerve) in comparison with immune-negative patients, and even a higher absolute frequency in six clinical ESSDAI domains in comparison with patients with isolated anti-Ro/SSA. In addition, patients with isolated anti-La/SSB showed a higher frequency of active patients in two ESSDAI domains (pulmonary and glandular) with respect to the most active immunological subset (double-positive antibodies). Meanwhile, systemic activity detected in patients with isolated anti-La/SSB was overwhelmingly low. Even in ESSDAI domains where patients with isolated anti-La/SSB had the highest frequencies of systemic activity (lymphadenopathy and muscular), the percentage of patients with moderate or high activity was lower in comparison with the combined Ro/SSA and La/SSB group. Conclusions: Patients carrying isolated La/SSB antibodies represent a very small subset of patients with a systemic SS phenotype characterised by a significant frequency of active patients in most clinical ESSDAI domains but with a relative low frequency of the highest severe organ-specific involvements. Primary SS still remains the best clinical diagnosis for this subset of patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
primary Sjögren's syndrome
isolated La/SSB autoantibodies
anti-Ro/SSA antibodies
systemic disease
ESSDAI
big data
Megjelenés:Clinical and Experimental Rheumatology. - 38 : 4 (2020), p. 85-94. -
További szerzők:Horváth Ildikó Fanny (1980-) (belgyógyász, allergológus, klinikai immunológus) Mandl, Thomas Priori, Roberta Vissink, Arjan Hernandez-Molina, Gabriela Armagan, Berkan Praprotnik, Sonja Sebastian, Agata Bartoloni, Elena Rischmueller, Maureen Pasoto, Sandra Nordmark, Gunnel Nakamura, Hideki Fernandes Moça Trevisani, Virginia Retamozo, Soledad Carsons, Steven E. Maure-Noia, B. Sánchez-Berná, I. López-Dupla, Miguel Fonseca-Aizpuru, Eva Melchor Díaz, S. Vázquez, Marta Díaz Cuiza, P. E. Miguel Campo, B. de Ng, Wan Fai Rasmussen, Astrid Dong, X. Li, X. Baldini, Chiara Seror, Raphaele Gottenberg, Jacques-Eric Kruize, Aike A. Sandhya, Pulukool Gandolfo, Saviana Kwok, Seung-Ki Kvarnstrom, Marika Solans, Roser Sene, Damien Suzuki, Yasunori Isenberg, David A. Valim, Valeria Hofauer, Benedikt Giacomelli, Roberto Devauchelle-Pensec, Valerie Atzeni, F. Gheita, Tamer A. Morel, Jacques Izzo, R. Kalyoncu, U. Szántó Antónia (1977-) (belgyógyász, allergológus és klinikai immunológus) Olsson, Peter Bootsma, Hendrika Ramos-Casals, Manuel Kostov, Belchin Brito-Zerón, Pilar Sjögren Big Data Consortium
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3.

001-es BibID:BIBFORM091399
035-os BibID:(Scopus)85098571249 (cikkazonosító)9417 (WOS)000603017600001
Első szerző:Ádám Balázs (megelőző orvostan és népegészségtan szakorvos)
Cím:Use of Genomic Information in Health Impact Assessment is Yet to Come : a Systematic Review / Ádám Balázs, Lovas Szabolcs, Ádány Róza
Dátum:2020
ISSN:1661-7827 1660-4601
Megjegyzések:Information generated by genetic epidemiology and genomics studies has been accumulating at fast pace, and this knowledge opens new vistas in public health, allowing for the understanding of gene?environment interactions. However, the translation of genome-based knowledge and technologies to the practice of healthcare, and especially of public health, is challenging. Because health impact assessment (HIA) proved to be an effective tool to assist consideration of health issues is sectoral policymaking, this study aimed at exploring its role in the translational process by a systematic literature review on the use of genetic information provided by genetic epidemiology and genomics studies in HIA. PubMed, Scopus, and Web of Science electronic databases were searched and the findings systematically reviewed and reported by the PRISMA guidelines. The review found eight studies that met the inclusion criteria, most of them theoretically discussing the use of HIA for introducing genome-based technologies in healthcare practice, and only two articles considered, in short, the possibility for a generic application of genomic information in HIA. The findings indicate that HIA should be more extensively utilized in the translation of genome-based knowledge to public health practice, and the use of genomic information should be facilitated in the HIA process
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
genetic epidemiology
genomics
translation
health impact assessment
public health
public health genomics
Megjelenés:International Journal of Environmental Research and Public Health. - 17 : 24 (2020), p. 1-13. -
További szerzők:Lovas Szabolcs (1989-) (tudományos segédmunkatárs) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
GINOP
TK2016-78
OTKA
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4.

001-es BibID:BIBFORM086813
035-os BibID:(Scopus)85087398268 (cikkazonosító)4833 (WOS)000550348400001
Első szerző:Ádány Róza (megelőző orvostan és népegészségtan szakorvos)
Cím:Prevalence of Insulin Resistance in the Hungarian General and Roma Populations as Defined by Using Data Generated in a Complex Health (Interview and Examination) Survey / Róza Ádány, Péter Pikó, Szilvia Fiatal, Zsigmond Kósa, János Sándor, Éva Bíró, Karolina Kósa, György Paragh, Éva Bácsné Bába, Ilona Veres-Balajti, Klára Bíró, Orsolya Varga, Margit Balázs
Dátum:2020
ISSN:1661-7827 1660-4601
Megjegyzések:Data mainly from one-off surveys clearly show that the health of Roma, the largest ethnic minority of Europe, is much worse than that of the general population. However, results from comprehensive exploratory studies are missing. The aim of our study was to create a complex database for comparative and association studies to better understand the background of the very unfavourable health of Roma, especially the high burden of cardiometabolic diseases. A three-pillar (questionnaire-based, physical and laboratory examinations) health survey was carried out on randomly selected samples of the Hungarian general (HG, n = 417) and Roma (HR, n = 415) populations, and a database consisting of more than half a million datapoints was created. Using selected data, the prevalence rates of metabolic syndrome (MetS) and of its components were determined, and to estimate the risk of insulin resistance (IR), surrogate measures (the homeostasis model assessment of insulin resistance index, quantitative insulin sensitivity check index, McAuley and TyG indices and the TG/HDL-C ratio) were calculated. Receiver operating characteristic curve analysis and Youden's method were used to define the optimal cut-off values of each IR index. The prevalence of MetS was very high in both study populations (HG: 39.8%, HR: 44.0%) with no statistically significant difference between the two groups in females or males. The prevalence of MetS showed a very marked increase in the HR 35?49 years age group. Among surrogate measures, the TyG index showed the greatest power for predicting IR/MetS at a cut-off value of 4.69 (77% sensitivity, 84% specificity) and indicated a 42.3% (HG) and 40.5% (HR) prevalence of IR. The prevalence of MetS and IR is almost equally very unfavourable in both groups; thus, the factors underlying the high premature mortality burden of Roma should be further clarified by investigating the full spectrum of risk factors available in the database, with a special focus on the access of Roma people to preventive and curative health services.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Roma population
health survey
metabolic syndrome
insulin resistance
cut-off values for surrogate indices
HOMA-IR
QUICKI
McAuley index
TG/HDL-C ratio
TyG index
Megjelenés:International Journal of Environmental Research and Public Health. - 17 : 4833 (2020), p. 1-22. -
További szerzők:Pikó Péter (1987-) (biológus) Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Bíró Éva (1980-) (megelőző orvostan és népegészségtan szakorvos, egészségfejlesztő) Kósa Karolina (1962-) (népegészségügyi szakember) Paragh György (1953-) (belgyógyász) Bácsné Bába Éva (1968-) (bölcsésztanár, szakközgazda) Veres-Balajti Ilona (1965-) (gyógytornász, egészségfejlesztő) Bíró Klára (1970-) (egészségügyi menedzsment) Varga Orsolya (1977-) (orvos, jogász) Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
GINOP
MTA11010
Egyéb
TK2016-78
Egyéb
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5.

001-es BibID:BIBFORM089348
035-os BibID:(cikkazonosító)1581 (WoS)000592983700001 (Scopus)85096519824
Első szerző:Aladdin, Azzam (molekuláris biológus)
Cím:The Proteasome Activators Blm10/PA200 Enhance the Proteasomal Degradation of N-Terminal Huntingtin / Aladdin Azzam, Yao Yanhua, Yang Ciyu, Kahlert Günther, Ghani Marvi, Király Nikolett, Boratkó Anita, Uray Karen, Dittmar Gunnar, Tar Krisztina
Dátum:2020
ISSN:2218-273X
Megjegyzések:The Blm10/PA200 family of proteasome activators modulates the peptidase activity of the core particle (20S CP). They participate in opening the 20S CP gate, thus facilitating the degradation of unstructured proteins such as tau and Dnm1 in a ubiquitin- and ATP-independent manner. Furthermore, PA200 also participates in the degradation of acetylated histones. In our study, we use a combination of yeast and human cell systems to investigate the role of Blm10/PA200 in the degradation of N-terminal Huntingtin fragments (N-Htt). We demonstrate that the human PA200 binds to N-Htt. The loss of Blm10 in yeast or PA200 in human cells results in increased mutant N-Htt aggregate formation and elevated cellular toxicity. Furthermore, Blm10 in vitro accelerates the proteasomal degradation of soluble N-Htt. Collectively, our data suggest N-Htt as a new substrate for Blm10/PA200-proteasomes and point to new approaches in Huntington's disease (HD) research.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Biomolecules. - 10 : 11 (2020), p. 1-33. -
További szerzők:Yao, Yanhua Yang, Ciyu Kahlert, Günther Ghani, Marvi (1990-) (PhD hallgató) Király Nikolett (1992-) (molekuláris biológus, biokémikus) Boratkó Anita (1985-) (biokémikus, molekuláris biológus) Uray Karen (1964-) (biokémikus) Dittmar, Gunnar Tar Krisztina (1975-) (biokémikus, molekuláris biológus)
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6.

001-es BibID:BIBFORM086920
035-os BibID:(cikkazonosító)1591 (WoS)000554261900001 (Scopus)85087733361
Első szerző:Alatshan, Ahmad (immunológus)
Cím:All-Trans Retinoic Acid Enhances both the Signaling for Priming and the Glycolysis for Activation of NLRP3 Inflammasome in Human Macrophage / Ahmad Alatshan, Gergő E. Kovács, Azzam Aladdin, Zsolt Czimmerer, Krisztina Tar, Szilvia Benkő
Dátum:2020
ISSN:2073-4409
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Cells. - 9 : 7 (2020), p. 1591. -
További szerzők:Kovács Gergő E. Aladdin, Azzam (1980-) (molekuláris biológus) Czimmerer Zsolt (1981-) (molekuláris biológus) Tar Krisztina (1975-) (biokémikus, molekuláris biológus) Benkő Szilvia (1973-) (molekuláris biológus)
Pályázati támogatás:NKFIH-OTKA 131844
OTKA
OTKA FK132185
OTKA
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7.

001-es BibID:BIBFORM089876
Első szerző:Allanore, Yannick
Cím:Health Assessment Questionnaire-Disability Index (HAQ-DI) use in modelling disease progression in diffuse cutaneous systemic sclerosis : an analysis from the EUSTAR database / Yannick Allanore, Sylvie Bozzi, Augustin Terlinden, Doerte Huscher, Caroline Amand, Christina Soubrane, Elise Siegert, László Czirják, Patricia E. Carreira, Eric Hachulla, Elisabetta Zanatta, Mengtao Li, Paolo Airò, Fabian A. Mendoza, Edoardo Rosato, Oliver Distler, EUSTAR Collaborators
Dátum:2020
ISSN:1478-6354 1478-6362
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Arthritis Research & Therapy. - 22 (2020), p. 257-267. -
További szerzők:Bozzi, Sylvie Terlinden, Augustin Huscher, Dörte Amand, Caroline Soubrane, Christina Siegert, Elise Czirják László Carreira, Patricia E. Hachulla, Eric Zanatta, Elisabetta Li, Mengtao Airò, Paolo Mendoza, Fabian A. Rosato, Edoardo Distler, Oliver Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) EUSTAR
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8.

001-es BibID:BIBFORM116507
035-os BibID:(WoS)000563781500002 (Scopus)85089543989 (cikkazonosító)2001410
Első szerző:Alm, Erik
Cím:Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020 / Erik Alm, Eeva K. Broberg, Thomas Connor, Emma B. Hodcroft, Andrey B. Komissarov, Sebastian Maurer-Stroh, Angeliki Melidou, Richard A. Neher, Áine O'Toole, Dmitriy Pereyaslov, WHO European Region sequencing laboratories and GISAID EpiCoV group
Dátum:2020
ISSN:1560-7917
Megjegyzések:We show the distribution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three genomic nomenclature systems to all sequence data from the World Health Organization European Region available until 10 July 2020. We highlight the importance of real-time sequencing and data dissemination in a pandemic situation, compare the nomenclatures and lay a foundation for future European genomic surveillance of SARS-CoV-2.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
SARS-CoV-2
Megjelenés:Eurosurveillance. - 25 : 32 (2020), p. 1-8. -
További szerzők:Broberg, Eeva K. Connor, Thomas Hodcroft, Emma B. Komissarov, Andrey B. Maurer-Stroh, Sebastian Melidou, Angeliki Neher, Richard A. O'Toole, Áine Pereyaslov, Dmitriy Csoma Eszter (1978-) (molekuláris biológus, mikrobiológus) WHO European Region sequencing laboratories and GISAID EpiCoV group
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9.

001-es BibID:BIBFORM082799
035-os BibID:(PMID)31907366
Első szerző:Altieri, Barbara
Cím:Vitamin D testing : advantages and limits of the current assays / Barbara Altieri, Etienne Cavalier, Harjit Pal Bhattoa, Faustino R. Pérez-López, María T. López-Baena, Gonzalo R. Pérez-Roncero, Peter Chedraui, Cedric Annweiler, Silvia Della Casa, Sieglinde Zelzer, Markus Herrmann, Antongiulio Faggiano, Annamaria Colao, Michael F. Holick
Dátum:2020
ISSN:0954-3007
Megjegyzések:Vitamin D deficiency and insufficiency has become a pandemic health problem with a consequent increase of requests for determining circulating levels of 25-hydroxyvitamin D [25(OH)D]. However, the analytical performance of these immunoassays, including radioimmunoassay and ELISA, is highly variable, and even mass spectrometric methods, which nowadays serves as the gold standard for the quantitatively determination of 25(OH)D, do not necessarily produce comparable results, creating limitations for the definition of normal vitamin D status ranges. To solve this problem, great efforts have been made to promote standardization of laboratory assays, which is important to achieve comparable results across different methods and manufacturers. In this review, we performed a systematic analysis evaluating critically the advantages and limits of the current assays available for the measure of vitamin D status, i.e., circulating 25(OH)D and its metabolites, making suggestions that could be used in the clinical practice. Moreover, we also suggest the use of alternatives to blood test, including standardized surveys that may be of value in alerting health-care professionals about the vitamin D status of their patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:European Journal Of Clinical Nutrition. - 74 : 2 (2020), p. 231-247. -
További szerzők:Cavalier, Etienne Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Pérez-López, Faustino R. López-Baena, María T. Pérez-Roncero, Gonzalo R. Chedraui, Peter Annweiler, Cedric Della Casa, Silvia Zelzer, Sieglinde Herrmann, Markus Faggiano, Antongiulio Colao, Annamaria Holick, Michael F.
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10.

001-es BibID:BIBFORM089749
035-os BibID:(cikkazonosító)8172 (scopus)85094855183 (wos)000588924400001
Első szerző:Alvarado, Gerardo
Cím:Heme-Induced Oxidation of Cysteine Groups of Myofilament Proteins Leads to Contractile Dysfunction of Permeabilized Human Skeletal Muscle Fibres / Alvarado Gerardo, Tóth Attila, Csősz Éva, Kalló Gergő, Dankó Katalin, Csernátony Zoltán, Smith Ann, Gram Magnus, Akerström Bo, Édes István, Balla György, Papp Zoltán, Balla József
Dátum:2020
ISSN:1661-6596 1422-0067
Megjegyzések:Heme released from red blood cells targets a number of cell components including the cytoskeleton. The purpose of the present study was to determine the impact of free heme (20?300 ?M) on human skeletal muscle fibres made available during orthopedic surgery. Isometric force production and oxidative protein modifications were monitored in permeabilized skeletal muscle fibre segments. A single heme exposure (20 ?M) to muscle fibres decreased Ca2+-activated maximal (active) force (Fo) by about 50% and evoked an approximately 3-fold increase in Ca2+-independent (passive) force (Fpassive). Oxidation of sulfhydryl (SH) groups was detected in structural proteins (e.g., nebulin, ?-actinin, meromyosin 2) and in contractile proteins (e.g., myosin heavy chain and myosin-binding protein C) as well as in titin in the presence of 300 ?M heme. This SH oxidation was not reversed by dithiothreitol (50 mM). Sulfenic acid (SOH) formation was also detected in the structural proteins (nebulin, ?-actinin, meromyosin). Heme effects on SH oxidation and SOH formation were prevented by hemopexin (Hpx) and ?1-microglobulin (A1M). These data suggest that free heme has a significant impact on human skeletal muscle fibres, whereby oxidative alterations in structural and contractile proteins limit contractile function. This may explain and or contribute to the weakness and increase of skeletal muscle stiffness in chronic heart failure, rhabdomyolysis, and other hemolytic diseases. Therefore, therapeutic use of Hpx and A1M supplementation might be effective in preventing heme-induced skeletal muscle alterations.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
skeletal muscle fibre
contractile dysfunction
heme
sulfhydryl groups
sulfenic acid formation
chronic heart failure
oxidation; hemopexin
[alfa]1-microglobulin
skeletal muscle myopathy
Megjelenés:International Journal Of Molecular Sciences. - 21 : 21 (2020), p. 1-17. -
További szerzők:Tóth Attila (1971-) (biológus) Csősz Éva (1977-) (biokémikus, molekuláris biológus) Kalló Gergő (1989-) (molekuláris biológus) Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus) Csernátony Zoltán (1959-2023) (ortopéd sebész, traumatológus) Smith, Ann Gram, Magnus Akerström, Bo Édes István (1952-) (kardiológus) Balla György (1953-) (csecsemő és gyermekgyógyász, neonatológus) Papp Zoltán (1965-) (kardiológus, élettanász) Balla József (1959-) (belgyógyász, nephrológus)
Pályázati támogatás:EFOP-3.6.2-16-2017-00006
EFOP
OTKA-K-132828
OTKA
K-84300
OTKA
K-109083
OTKA
GINOP-2.3.2-15-2016-00043
GINOP
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Intézményi repozitóriumban (DEA) tárolt változat
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11.

001-es BibID:BIBFORM092044
035-os BibID:(Cikkazonosító)18866 (WOS)000589618700038 (Scopus)85094893637
Első szerző:Ambrus Viktor Attila (biotechnológus)
Cím:Asymmetric dynamic coupling promotes alternative evolutionary pathways in an enzyme dimer / V. Ambrus, Gy. Hoffka, M. Fuxreiter
Dátum:2020
ISSN:2045-2322
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Matematikai és természettudományok - Kémiai tudományok
Megjelenés:Scientific Reports. - 10 : 1 (2020), p. 1-9. -
További szerzők:Hoffka Gyula (1992-) (vegyész) Fuxreiter Mónika (1969-) (kutató vegyész)
Pályázati támogatás:GINOP-2.3.2-15-2016-00044
GINOP
EFOP-3.6.3-VEKOP-16-2017-00009
EFOP
MTA-DE Lendület
MTA
Fehérjedinamikai Kutatócsoport
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Intézményi repozitóriumban (DEA) tárolt változat
Borító:

12.

001-es BibID:BIBFORM081820
035-os BibID:(WOS)000492009300002 (Scopus)85074658973
Első szerző:András Csilla (onkológus szakorvos)
Cím:Retrospective Analysis of Cancer-Associated Myositis Patients over the Past 3 Decades in a Hungarian Myositis Cohort / András Csilla, Bodoki Levente, Nagy-Vincze Melinda, Griger Zoltán, Csiki Emese, Dankó Katalin
Dátum:2020
ISSN:1219-4956 1532-2807
Megjegyzések:Association between cancer and myositis has been extensively reported and malignancy is a potentially life-threating complication in myositis. In this retrospective study authors give an overview of Hungarian cancer-associated myositis (CAM) patients treated at a single centre managing 450 myositis patients. All patients were diagnosed according to Bohan and Peter. Statistical analysis of disease onset, age, sex,muscle, skin and extramuscular symptoms,muscle enzymes, presence of antibodies, treatment and prognosis was performed. 43 patients could be considered as having CAM. 83.72% had cancer within one year of diagnosis of myositis. Most common localizations were ductal carcinoma of breast and adenocarcinoma of lung. Significant differences were observed between CAM and the non-CAM control patients: DM:PM ratio was 2.31:1 vs. 0.87:1, respectively (p = 0.029), age at diagnosis was 56.60 ? 12.79 vs. 38.88 ? 10.88 years, respectively (p < 0.001). Tumour-treatment was the following: surgical removal in 55.81%, chemotherapy in 51.1%, radiotherapy in 39.53%, hormone treatment in 18.6%, combination therapy in 51.16% of patients. Muscle enzyme levels of patients undergoing surgery were significantly reduced after intervention. 36 patients died (83.72%); 25 DM(83.33%) and 11 PM patients (84.62%); 5 years survival was 15.4% for PM and 27.5% for DM. This study demonstrates that DM, distal muscle weakness, asymmetric Raynaud's phenomenon, older age, ANA-negativity are risk factors for developing malignancy and polymyositis patients have less chance of long-lasting survival. It is very important to think about cancer and follow every single myositis patient in the clinical routine because survival rate of CAM is very poor.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Cancer-associatedmyositis (CAM)
Dermatomyositis (DM)
Polymyositis (PM)
Cancer
Muscle weakness
Megjelenés:Pathology & Oncology Research. - 26 : 3 (2020), p. 1749-1755. -
További szerzők:Bodoki Levente (1986-) (PhD hallgató) Nagy-Vincze Melinda (1985-) (orvos) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Csiki Emese (1986-) (onkoradiológus) Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus)
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Intézményi repozitóriumban (DEA) tárolt változat
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