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001-es BibID:BIBFORM118666
035-os BibID:(Scopus)85184251918 (WOS)001155051600001
Első szerző:Ababneh, Haneen Muntasir
Cím:High glucose promotes osteogenic differentiation of human lens epithelial cells through hypoxia-inducible factor (HIF) activation / Haneen Ababneh, Enikő Balogh, Dávid Máté Csiki, Gréta Lente, Ferenc Fenyvesi, Andrea Tóth, Viktória Jeney
Dátum:2024
ISSN:0021-9541 1097-4652
Megjegyzések:Cataract, a leading cause of blindness, is characterised by lens opacification. Type 2 diabetes is associated with a two- to fivefold higher prevalence of cataracts. The risk of cataract formation increases with the duration of diabetes and the severity of hyperglycaemia. Hydroxyapatite deposition is present in cataractous lenses that could be the consequence of osteogenic differentiation and calcification of lens epithelial cells (LECs). We hypothesised that hyperglycaemia might promote the osteogenic differentiation of human LECs (HuLECs). Osteogenic medium (OM) containing excess phosphate and calcium with normal (1 g/L) or high (4.5 g/L) glucose was used to induce HuLEC calcification. High glucose accelerated and intensified OM-induced calcification of HuLECs, which was accompanied by hyperglycaemia-induced upregulation of the osteogenic markers Runx2, Sox9, alkaline phosphatase and osteocalcin, as well as nuclear translocation of Runx2. High glucose-induced calcification was abolished in Runx2-deficient HuLECs. Additionally, high glucose stabilised the regulatory alpha subunits of hypoxia-inducible factor 1 (HIF-1), triggered nuclear translocation of HIF-1? and increased the expression of HIF-1 target genes. Gene silencing of HIF-1? or HIF-2? attenuated hyperglycaemia-induced calcification of HuLECs, while hypoxia mimetics (desferrioxamine, CoCl2) enhanced calcification of HuLECs under normal glucose conditions. Overall, this study suggests that high glucose promotes HuLEC calcification via Runx2 and the activation of the HIF-1 signalling pathway. These findings may provide new insights into the pathogenesis of diabetic cataracts, shedding light on potential factors for intervention to treat this sight-threatening condition.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
cataract
hyperglycaemia
hypoxia-inducible factor (HIF)
lens calcification
lens epithelial cell
osteogenic differentiation
Megjelenés:Journal Of Cellular Physiology. - [Epub ahead of print] (2024). -
További szerzők:Balogh Enikő (1987-) (molekuláris biológus) Csiki Dávid Máté (1993-) (biomérnök) Lente Gréta (1994-) (klinikai laboratóriumi kuatató) Fenyvesi Ferenc (1977-) (gyógyszerész, gyógyszertechnológus) Tóth Andrea (1992-) (molekuláris biológus) Jeney Viktória (1971-) (vegyész, kémia tanár)
Pályázati támogatás:NKFIH K146669
Egyéb
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2.

001-es BibID:BIBFORM120492
Első szerző:Abdisa, Kenbon Beyene
Cím:Metabolic Syndrome and Biotherapeutic Activity of Dairy (Cow and Buffalo) Milk Proteins and Peptides : fast Food-Induced Obesity Perspective - A Narrative Review / Kenbon Beyene Abdisa, Emőke Szerdahelyi, Máté András Molnár, László Friedrich, Zoltán Lakner, András Koris, Attila Toth, Arijit Nath
Dátum:2024
ISSN:2218-273X
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Biomolecules. - 14 : 4 (2024), p. 1-61. -
További szerzők:Szerdahelyi Emőke Molnár Máté András Friedrich László Lakner Zoltán (agrárökonómia) Koris András Tóth Attila (1971-) (biológus) Nath, Arijit
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3.

001-es BibID:BIBFORM117961
035-os BibID:(cikkazonosító)27 (scopus)85182418710 (wos)001144630300003
Első szerző:Aggarwal, Rohit
Cím:Safety and tolerability of intravenous immunoglobulin in patients with active dermatomyositis : results from the randomised, placebo-controlled ProDERM study / Aggarwal Rohit, Schessl Joachim, Charles-Schoeman Christina, Bata-Csörgő Zsuzsanna, Dimachkie Mazen M., Griger Zoltan, Moiseev Sergey, Oddis Chester V., Schiopu Elena, Vencovsky Jiri, Beckmann Irene, Clodi Elisabeth, Levine Todd, ProDERM investigators
Dátum:2024
ISSN:1478-6354 1478-6362
Megjegyzések:Abstract Introduction: Dermatomyositis (DM) is an inflammatory myopathy characterized by distinct skin manifestations and muscle weakness. Intravenous immunoglobulin (IVIg) has been used off-label as adjuvant therapy in DM, but is not indicated for DM, due to lack of proven efficacy in a large randomized controlled trial. The objective of the ProDERM (Progress in DERMatomyositis) study was to evaluate the efficacy, safety and long-term tolerability of IVIg (Octagam 10%) in patients with DM in a randomized, placebo-controlled, double-blind, Phase III study. Methods: Adult patients with active DM who were continuing standard therapy at a stable dose were eligible for this study. Patients were randomized 1:1 to receive either 2 g/kg of IVIg or placebo, administered every 4 weeks until week 16 (First Period). Patients were switched to the alternate treatment if they showed clinical deterioration in the First Period. After response assessment at week 16, all patients on placebo and those without deterioration on IVIg entered the open-label Extension Period, receiving 2 g/kg IVIg every 4 weeks for 24 weeks. Results: The primary efficacy endpoint was the proportion of responders in the IVIg vs placebo arm at week 16, where response was defined per 2016 ACR/EULAR Myositis Response Criteria of at least minimal improvement [Total Improvement Score (TIS) ?20] and without deterioration at 2 consecutive visits up to week 16. TIS consists of composite response criteria, combining weighted improvement in 6 core set measures (CSMs), Global Disease Activity (Physician and Patient), manual muscle testing-8 (MMT-8), Health Assessment Questionnaire, extra-muscular disease activity, and muscle enzymes. Secondary endpoints included the mean change in individual CSMs, time to improvement in TIS, time to confirmed deterioration in the First Period, and the overall proportion of patients with deteriorations. Adverse events, including infusion reactions and thromboembolic events, were recorded. Conclusions: The ProDERM study was the first to assess the long-term efficacy and safety of IVIg (Octagam 10%) in a placebo-controlled, blinded, randomized trial in DM. The study aimed to inform on the use of IVIg in the treatment of DM, and results are expected in Q3 2020.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Dermatomyositis
Intravenous immunoglobulin
Myositis
Safety
Tolerability
Megjelenés:Arthritis Research & Therapy. - 26 : 1 (2024), p. 1-13. -
További szerzők:Schessl, Joachim Charles-Schoeman, Christina Bata-Csörgő Zsuzsanna Dimachkie, Mazen M. Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Moiseev, Sergey Oddis, Chester V. Schiopu, Elena Vencovsky, Jiri Beckmann, Irene Clodi, Elisabeth Levine, Todd ProDERM Trial Group
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4.

001-es BibID:BIBFORM117873
Első szerző:Al-Smadi, Mohammad Walid
Cím:Minor micro-rheological alterations in the presence of an artificial saphenous arteriovenous shunt, as an arteriovenous malformation model in the rat / Mohammad Walid Al-Smadi, Laszlo Adam Fazekas, Adam Varga, Adam Attila Matrai, Siran Aslan, Anas Beqain, Mustafa Qais Muhsin Al-Khafaji, Barbara Bedocs-Barath, Laszlo Novak, Norbert Nemeth
Dátum:2024
ISSN:1386-0291
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Clinical Hemorheology And Microcirculation. - [Epub ahead of print] (2024). -
További szerzők:Fazekas László Varga Ádám Mátrai Ádám Attila (1997-) (klinikai laboratóriumi kutató) Aslan, Siran Beqain, Anas Al-Khafaji, Mustafa Qais Muhsin Baráth Barbara (1993-) (tudományos segédmunkatárs) Novák László (1964-) (idegsebész) Németh Norbert (1975-) (kutatóorvos)
Pályázati támogatás:K-139184
OTKA
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5.

001-es BibID:BIBFORM116356
035-os BibID:(Scopus)85176405586 (WoS)001105456700001
Első szerző:Andrásdi Zita
Cím:Health related quality of life is associated with gastroesophageal reflux symptoms in overweight children / Andrásdi Zita, Müller Katalin E., Gaál Zsuzsanna, Nemes Éva, Felszeghy Enikő
Dátum:2024
ISSN:0334-018X
Megjegyzések:The association between obesity and gastroesophageal reflux disease (GERD) is well-established in adults; however, data in pediatric population is scarce. Our study aimed to assess the association between GERD and health-related quality of life (HRQoL) in overweight children. From April to August of 2020, we included children aged 7-18 years who attended the Endocrinological Outpatient Clinic at the Paediatric Institute, University of Debrecen, Hungary. The participants completed two questionnaires: the Pediatric Gastroesophageal Reflux Disease Symptom Questionnaire (PGSQ) and the HRQoL questionnaire (PedsQL). Based on the criteria of the World Health Organization (WHO), the patients were categorized into two groups: an overweight or obese group and a group with normal weight. A total of 107 children (51 % female, mean age 13.2 years, 46 % overweight or obese) completed the questionnaires. The median PGSQ score was similar in both groups (4.0 (IQR: 1.0-7.8) vs. 3.0 (IQR: 1.0-7.0), p=0.6). However, the total PedsQL score was significantly lower in the children with overweight or obesity compared to those with normal weight (80.1 (71.1-91.0) vs. 88.0 (76.1-94.6), p=0.031). The PedsQL score was lower among overweight patients with GERD symptoms than that of normal-weight patients without GERD symptoms. Our findings highlight the importance of raising awareness about GERD to enhance the HRQoL and prevent long-term complications in obese children.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
children
gastroesophageal reflux disease
obesity
quality of life
Megjelenés:Journal Of Pediatric Endocrinology & Metabolism. - 37 : 1 (2024), p. 27-32. -
További szerzők:Müller Katalin Eszter Gaál Zsuzsanna (1990-) (csecsemő-és gyermekgyógyász központi gyakornok) Nemes Éva (1957-) (csecsemő- és gyermekgyógyász, gasztroenterológus) Felszeghy Enikő Noémi (1970-) (gyermekgyógyász)
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6.

001-es BibID:BIBFORM118888
Első szerző:Arató Viktória Zsófia (gyógyszerész)
Cím:Acute Myelomonoblastic Leukemia (My1/De) : a Preclinical Rat Model / Viktória Arató, Zita Képes, Judit P. Szabó, Gergely Farkasinszky, Tamás Sass, Noémi Dénes, Adrienn Kis, Gábor Opposits, István Jószai, Ferenc Krisztián Kálmán, István Hajdu, György Trencsényi, István Kertész
Dátum:2024
ISSN:0258-851X
Megjegyzések:Background/Aim: Since acute myeloid leukemias still represent the most aggressive type of adult acute leukemias, the profound understanding of disease pathology is of paramount importance for diagnostic and therapeutic purposes. Hence, this study aimed to explore the real-time disease fate with the establishment of an experimental myelomonoblastic leukemia (My1/De) rat model using preclinical positron emission tomography (PET) and whole-body autoradiography. Materials and Methods: In vitro [18F]F-FDG uptake studies were performed to compare the tracer accumulation in the newly cultured My1/De tumor cell line (blasts) with that in healthy control and My1/De bone marrow suspensions. Post transplantation of My1/De cells under the left renal capsule of Long-Evans rats, primary My1/De tumorigenesis, and metastatic propagation were investigated using [18F]F-FDG PET imaging, whole-body autoradiography and phosphorimage analyses. To assess the organ uptake profile of the tumor-carrying animals we accomplished ex vivo biodistribution studies. Results: The tracer accumulation in the My1/De culture cells exceeded that of both the tumorous and the healthy bone marrow suspensions (p<0.01). Based on in vivo imaging, the subrenally transplanted My1/De cells resulted in the development of leukemia in the abdominal organs, and metastasized to the mesenterial and thoracic parathymic lymph nodes (PTLNs). The lymphatic spread of metastasis was further confirmed by the significantly higher %ID/g values of the metastatic PTLNs (4.25?0.28) compared to the control (0.94?0.34). Cytochemical staining of the peripheral blood, autopsy findings, and wright-Giemsa-stained post-mortem histological sections proved the leukemic involvement of the assessed tissues/organs. Conclusion: The currently established My1/De model appears to be well-suited for further leukemia-related therapeutic and diagnostic investigations.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
2-deoxy-2-[18F]fluoro-D-glucose ([18F]F-FDG)
metastasis
myelomonoblastic leukemia (My1/De)
parathymic lymph node
(PTLN)
preclinical
positron emission tomography (PET)
whole-body autoradiography
Megjelenés:In Vivo. - "Accepted by Publisher" (2024). -
További szerzők:Képes Zita (1991-) (orvos) Péli-Szabó Judit (1977-) (vegyész) Farkasinszky Gergely (1990-) (gyógyszerész) Sass Tamás (1989-) (sebész szakorvos) Dénes Noémi (1992-) (vegyész) Kis Adrienn (1991-) (molekuláris biológus) Opposits Gábor (1974-) (fizikus, szoftver fejlesztő) Jószai István (1978-) (vegyész) Kálmán Ferenc K. (1978-) (vegyész) Hajdu István (1981-) (vegyész) Trencsényi György (1978-) (biológus, biokémikus, molekuláris biológus) Kertész István (1966-) (vegyész)
Pályázati támogatás:FK-134551
Egyéb
ÚNKP-23-4-II
Egyéb
ÚNKP-23-5
Egyéb
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7.

001-es BibID:BIBFORM118990
Első szerző:Attanasio, Roberto
Cím:Patients' persistent symptoms, clinician demographics and geo-economic factors are associated with choice of therapy for hypothyroidism by European thyroid specialists : The "THESIS"* collaboration (*Treatment of Hypothyroidism in Europe by Specialists, an International Survey) / Roberto Attanasio, Miloš Žarković, Enrico Papini, Endre Vezekenyi Nagy, Roberto Negro, Petros Perros, Ersin Akarsu, Maria Alevizaki, Göksun Ayvaz, Tomasz Bednarczuk, Biljana Beleslin, Eszter Berta, Miklos Bodor, Anna Maria Borissova, Mihail Boyanov, Camille Buffet, Maria-Cristina Burlacu, Jasmina Ciric, Juan J. Díez, Harald Dobnig, Valentin V. Fadeyev, Benjamin C. T. Field, Eric Fliers, Dagmar Führer, Juan Carlos Galofré, Tommi Hakala, Jan Jiskra, Peter A. Kopp, Michael Krebs, Michal Kršek, Martin Kuzma, Mikael Lantz, Ivica Lazúrová, Laurence Leenhardt, Vitaliy Luchytskiy, Francisca Marques Puga, Anne McGowan, Saara Metso, Carla Moran, Tatyana Morgunova, Dan Alexandru Niculescu, Božidar Perić, Tereza Planck, Catalina Poiana, Eyal Robenshtok, Patrick Olivier Rosselet, Marek Ruchala, Kamilla Ryom Riis, Alla Shepelkevich, Mykola D. Tronko, David Unuane, Irfan Vardarli, W. Edward Visser, Andromachi Vryonidou, Younes Ramazan Younes, Laszlo Hegedus
Dátum:2024
ISSN:1050-7256
Megjegyzések:Background. Hypothyroidism is common, however, aspects of its treatment remain controversial. Our survey aimed at documenting treatment choices of European thyroid specialists and exploring how patients' persistent symptoms, clinician demographics, and geo-economic factors relate to treatment choices. Methods. 17,247 thyroid specialists from 28 countries were invited to participate in an online questionnaire survey. The survey included respondent demographic data and treatment choices for hypothyroid patients with persistent symptoms. Geo-economic data for each country were included in the analyses. Results. The response rate was 32.9% (6,058 respondents out of 17,247 invitees). Levothyroxine (LT4) was the initial treatment preferred by the majority (98.3%). Persistent symptoms despite normal serum thyrotropin (TSH) while receiving LT4 treatment were reported to affect up to 10.0% of patients by 75.4% of respondents, while 28.4% reported an increasing such trend in the past five years. The principal explanations offered for patients' persistent symptoms were psychosocial factors (77.1%), comorbidities (69.2%), and unrealistic patient expectations (61.0%). Combination treatment with LT4 + liothyronine (LT3) was chosen by 40.0% of respondents for patients who complained of persistent symptoms despite a normal TSH. This option was selected more frequently by female thyroid specialists, with high-volume practice, working in countries with high gross national income per capita. Conclusions. The perception of patients' dissatisfaction reported by physicians seems lower than that described by hypothyroid patients in previous surveys. LT4+LT3 treatment is used frequently by thyroid specialists in Europe for persistent hypothyroid-like symptoms even if they generally attribute such symptoms to non-endocrine causes and despite the evidence of non-superiority of the combined over the LT4 therapy. Pressure by dissatisfied patients on their physicians for LT3-containing treatments is a likely explanation. The association of the therapeutic choices with the clinician demographic characteristics and geo-economic factors in Europe is a novel information and requires further investigation.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
quality of life
geoeconomics
survey
hypothyroidism
levothyroxine
triiodothyronine
Megjelenés:Thyroid. - [Epub ahead of print] (2024). -
További szerzők:Zarkovic, Milos Papini, Enrico Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Negro, Roberto Perros, Petros Akarsu, Ersin Alevizaki, Maria Ayvaz, Goksun Bednarczuk, Tomasz Beleslin, Biljana Nedeljkovic Berta Eszter (1980-) (belgyógyász) Bodor Miklós (1969-) (belgyógyász, endokrinológus) Borissova, Anna-Maria I. Boyanov, Mihail A. Buffet, Camille Burlacu, Maria-Cristina Ciric, Jasmina Díez, Juan J. Dobnig, Harald Fadeyev, Valentin Field, Benjamin C. T. Fliers, Eric Führer, Dagmar Galofré, Juan C. Hakala, Tommi Jiskra, Jan Kopp, Peter Krebs, Michael Krsek, Michal Kuzma, Martin Lantz, Mikael Lazúrová, Ivica Leenhardt, Laurence Luchytskiy, Vitaliy Marques Puga, Francisca McGowan, Anne Metso, Saara Moran, Carla Morgunova, Tatyana Niculescu, Dan Alexandru Peric, Bozidar Planck, Tereza Poiana, Catalina Robenshtok, Eyal Rosselet, Patrick Ruchaa, Marek Ryom Riis, Kamilla Shepelkevich, Alla P. Tronko, Mykola D. Unuane, David Vardarli, Irfan Visser, W. Edward Vryonidou, Andromachi Younes, Younes Ramazan Hegedüs László
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8.

001-es BibID:BIBFORM117737
035-os BibID:(WoS)001134150900001 (Scopus)85181231963
Első szerző:Azzam, Ahmed
Cím:HBV Reactivation in Patients Receiving Bruton Tyrosine Kinase Inhibitors (BTKIs) : a Systematic Review and Meta-Analysis / Ahmed Azzam, Heba Khaled, Basem Osama Ashry, Sarah Mohamed Hussein, Manar Osama, Ameer Ahmed, Omar Yousef, Anees Hjazeen, Ahmed A. Allam, Gellan Alaa Mohamed Kamel
Dátum:2024
ISSN:1523-3847 1534-3146
Megjegyzések:Purpose of Review: Bruton tyrosine kinase inhibitors (BTKIs) are immunosuppressive cancer therapies approved for the treatment of various mature B-cell malignancies. Hepatitis B virus reactivation (HBVr) is a known complication in patients with chronic or past HBV infection undergoing immunosuppressive chemotherapy. The present work aims to establish the correlation between HBVr and patients receiving BTKIs. Recent Findings: This review included 18 studies. The overall incidence of HBVr was found to be 6.6% in patients with past HBV infections who received ibrutinib. Fourteen cases of HBVr were associated with ibrutinib (two occult hepatitis B infections and twelve past HBV infections). One case of HBV past infection was associated with zanubrutinib, and three cases were recorded for acalabrutinib (one chronic HBV and two past HBV). Most incidents occurred in males older than 60 years within the first year after initiating BTKIs. Three reported cases documented HBVr after discontinuing ibrutinib and zanubrutinib. Two deaths caused by HBVr in patients with past HBV infections were recorded (one for each of acalabrutinib and ibrutinib). Remarkably, HBV antiviral treatment normalized liver functions and eliminated serum HBV in most cases. It was reported that false negativity of HBsAg following reactivation occurred in two cases: one case was attributed to HBsAg escape mutations, and the other to the hook effect. Summary: Our findings show that HBVr risk is intermediate in patients with past HBV infections who receive ibrutinib. Universal anti-HBV prophylaxis before initiating ibrutinib may be an option.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Bruton tyrosine kinase inhibitors
BTKIs
Ibrutinib
Zanubrutinib
Acalabrutinib
Hepatitis B virus reactivation
HBVr
Systematic review
Meta-analysis
Megjelenés:Current Infectious Disease Reports. - [Epub ahead of print] (2024). -
További szerzők:Khaled, Heba Ashry, Basem Osama Hussein, Sarah Mohamed Osama, Manar Ahmed, Ameer Yousef, Omar Ahmed Elsayed Hjazeen, Anees Allam, Ahmed A. Kamel, Gellan Alaa Mohamed
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9.

001-es BibID:BIBFORM118924
035-os BibID:(cikkazonosító)1581 (Scopus)85184721995 (WoS)001161185700001
Első szerző:Bácsi Attila (immunológus)
Cím:Radiation-Detoxified Form of Endotoxin Effectively Activates Th1 Responses and Attenuates Ragweed-Induced Th2-Type Airway Inflammation in Mice / Attila Bácsi, Beatrix Ágics, Kitti Pázmándi, Béla Kocsis, Viktor Sándor, Lóránd Bertók, Géza Bruckner, Sándor Sipka
Dátum:2024
ISSN:1422-0067
Megjegyzések:Urbanization with reduced microbial exposure is associated with an increased burden of asthma and atopic symptoms. Conversely, environmental exposure to endotoxins in childhood can protect against the development of allergies. Our study aimed to investigate whether the renaturation of the indoor environment with aerosolized radiation-detoxified lipopolysaccharide (RD-LPS) has a preventative effect against the development of ragweed-induced Th2-type airway inflammation. To explore this, cages of six-week-old BALB/c mice were treated daily with aerosolized native LPS (N-LPS) or RD-LPS. After a 10-week treatment period, mice were sensitized and challenged with ragweed pollen extract, and inflammatory cell infiltration into the airways was observed. As dendritic cells (DCs) play a crucial role in the polarization of T-cell responses, in our in vitro experiments, the effects of N-LPS and RD-LPS were compared on human monocyte-derived DCs (moDCs). Mice in RD-LPS-rich milieu developed significantly less allergic airway inflammation than mice in N-LPS-rich or common environments. The results of our in vitro experiments demonstrate that RD-LPS-exposed moDCs have a higher Th1-polarizing capacity than moDCs exposed to N-LPS. Consequently, we suppose that the aerosolized, non-toxic RD-LPS applied in early life for the renaturation of urban indoors may be suitable for the prevention of Th2-mediated allergies in childhood.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
endotoxin
lipopolysaccharide
radiation-detoxified
Th2-type airway inflammation
allergy
dendritic cells
ragweed
mice
Megjelenés:International Journal Of Molecular Sciences. - 25 : 3 (2024), p. 1-22. -
További szerzők:Ágics Beatrix (1995-) Pázmándi Kitti Linda (1984-) (molekuláris biológus, immunológus) Kocsis Béla Sándor Viktor Bertók Lóránd (1934-) (sugárbiológus, immunológus) Bruckner Géza Sipka Sándor (1945-) (laboratóriumi szakorvos)
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10.

001-es BibID:BIBFORM117889
Első szerző:Balatoni Ildikó (orvos)
Cím:Assessment of the physical activity of children with asthma bronchiale / Ildikó Balatoni, Tímea Kiss, György Balla, Ágnes Papp, László Csernoch
Dátum:2024
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Sports. - 12 : 4 (2024), p. 114. -
További szerzők:Kiss Tímea (1986-) (molekuláris biológus) Balla György (1953-) (csecsemő és gyermekgyógyász, neonatológus) Papp Ágnes (1967-) (gyermekgyógyász, pulmonológus) Csernoch László (1961-) (élettanász)
Pályázati támogatás:EFOP-3.6.2-16-2017-00003
EFOP
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11.

001-es BibID:BIBFORM119032
035-os BibID:(Scopus)85189437153 (WoS)001194169500001
Első szerző:Baráth Benjámin Regő
Cím:A serine metabolic enzyme is flexing its muscle to help repair skeletal muscle / Benjámin R. Baráth, László Nagy
Dátum:2024
ISSN:0890-9369 1549-5477
Megjegyzések:Psat1-generated a-ketoglutarate and glutamine promote muscle stem cell activation and regeneration / In: Genes & Development. - Megjelenés alatt (2024). -
Tárgyszavak:Orvostudományok Elméleti orvostudományok recenzió, folyóiratcikk-ismertetés
folyóiratcikk
skeletal muscle repair
Megjelenés:Genes & Development. - 38 : 3-4 (2024), p. 95-97. -
További szerzők:Nagy László
Pályázati támogatás:ÚNKP
Egyéb
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

12.

001-es BibID:BIBFORM118662
035-os BibID:(WoS)001161390600001 (Scopus)85185143533
Első szerző:Baráth Sándor (biológus)
Cím:Enhancing HLA-B27 antigen detection : Leveraging machine learning algorithms for flow cytometric analysis / Baráth Sándor, Singh Parvind, Hevessy Zsuzsanna, Ujfalusi Anikó, Mezei Zoltán, Balogh Mária, Száraz Széles Marianna, Kappelmayer János
Dátum:2024
ISSN:1552-4949
Megjegyzések:As the association of human leukocyte antigen B27 (HLA-B27) with spondylarthropathies is widely known, HLA-B27 antigen expression is frequently identified using flow cytometric or other techniques. Because of the possibility of cross-reaction with off target antigens, such as HLA-B7, each flow cytometric technique applies a "gray zone" reserved for equivocal findings. Our aim was to use machine learning (ML) methods to classify such equivocal data as positive or negative. Equivocal samples (n = 99) were selected from samples submitted to our institution for clinical evaluation by HLA-B27 antigen testing. Samples were analyzed by flow cytometry and polymerase chain reaction. Features of histograms generated by flow cytometry were used to train and validate ML methods for classification as logistic regression (LR), decision tree (DT), random forest (RF) and light gradient boost method (GBM). All evaluated ML algorithms performed well, with high accuracy, sensitivity, specificity, as well as negative and positive predictive values. Although, gradient boost approaches are proposed as high performance methods; nevertheless, their effectiveness may be lower for smaller sample sizes. On our relatively smaller sample set, the random forest algorithm performed best (AUC: 0.92), but there was no statistically significant difference between the ML algorithms used. AUC values for light GBM, DT, and LR were 0.88, 0.89, 0.89, respectively. Implementing these algorithms into the process of HLA-B27 testing can reduce the number of uncertain, false negative or false positive cases, especially in laboratories where no genetic testing is available.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Cytometry Part B-Clinical Cytometry. - [Epub ahead of print] (2024). -
További szerzők:Singh, Parvind (1995-) (PhD hallgató) Hevessy Zsuzsanna (1966-) (laboratóriumi szakorvos) Ujfalusi Anikó (1968-) (gyermekorvos, laboratóriumi szakorvos) Mezei Zoltán András (1980-) (orvos) Balogh Mária Széles Mariann Kappelmayer János (1960-) (laboratóriumi szakorvos)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
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