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001-es BibID:	BIBFORM119171
035-os BibID:	(WoS)000378016800015 (Scopus)84969988171
Első szerző:	Lakatos Gábor
Cím:	Pancreatic Cancer : multicenter Prospective Data Collection and Analysis by the Hungarian Pancreatic Study Group / Gábor Lakatos, Anita Balázs, Balázs Kui, Szilárd Gódi, Ákos Szücs, Andrea Szentesi, Zsolt Szentkereszty, Richárd Szmola, Dezső Kelemen, Róbert Papp, Áron Vincze, József Czimmer, Gabriella Pár, Judit Bajor, Imre Szabó, Ferenc Izbéki, Adrienn Halász, László Leindler, Gyula Farkas Jr., Tamás Takács, László Czakó, Zoltán Szepes, Péter Hegyi, Zsuzsanna Kahán
Dátum:	2016
ISSN:	1841-8724 1842-1121
Megjegyzések:	Background & Aims: Pancreatic cancer is a devastating disease with poor prognosis. There is very limited information available regarding the epidemiology and treatment strategies of pancreatic cancer in Central Europe. The purpose of the study was to prospectively collect and analyze data of pancreatic cancer in the Hungarian population. Methods: The Hungarian Pancreatic Study Group (HPSG) organized prospective, uniform data collection. Altogether 354 patients were enrolled from 14 Hungarian centers. Results: Chronic pancreatitis was present in 3.7% of the cases, while 33.7% of the patients had diabetes. Family history for pancreatic cancer was positive in 4.8%. The most frequent presenting symptoms included pain (63.8%), weight loss (63%) and jaundice (52.5%). The reported frequency of smoking and alcohol consumption was lower than expected (28.5% and 27.4%, respectively). The majority of patients (75.6%) were diagnosed with advanced disease. Most patients (83.6%) had a primary tumor located in the pancreatic head. The histological diagnosis was ductal adenocarcinoma in 90.7% of the cases, while neuroendocrine tumor was present in 5.3%. Biliary stent implantation was performed in 166 patients, 59.2% of them received metal stents. Primary tumor resection was performed in 60 (16.9%) patients. Enteral or biliary bypass was done in 35 and 49 patients, respectively. In a multivariate Cox-regression model, smoking status and presence of gemcitabine-based chemotherapy were identified as independent predictors for overall survival. Conclusion: We report the first data from a large cohort of Hungarian pancreatic cancer patients. We identified smoking status and chemotherapy as independent predictors in this cohort.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk pancreatic cancer Hungarian cohort acute pancreatitis chronic pancreatitis diabetes mellitus
Megjelenés:	Journal Of Gastrointestinal And Liver Diseases. - 25 : 2 (2016), p. 219-225. -
További szerzők:	Balázs Anita (1984-) (molekuláris biológus) Kui Balázs Gódi Szilárd Szűcs Ákos (sebész) Szentesi Andrea Szentkereszty Zsolt (1961-) (sebész) Szmola Richárd (gasztroenterológus) Kelemen Dezső Papp Róbert Vincze Áron Czimmer József Pár Gabriella Bajor Judit Szabó Imre Izbéki Ferenc Halász Adrienn Leindler László Farkas Gyula Jr. Takács Tamás Czakó László Szepes Zoltán Hegyi Péter Kahán Zsuzsa
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