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001-es BibID:	BIBFORM116667
035-os BibID:	(Scopus)85170843236 (WOS)001015187100005 (cikkazonosító)e220134
Első szerző:	Solymosi Tamás
Cím:	Considerable interobserver variation calls for unambiguous definitions of thyroid nodule ultrasound characteristics / Solymosi Tamas, Hegedűs Laszlo, Bonnema Steen J., Frasoldati Andrea, Jambor Laszlo, Karanyi Zsolt, Kovacs Gabor L., Papini Enrico, Rucz Karoly, Russ Gilles, Nagy Endre V.
Dátum:	2023
ISSN:	2235-0640 2235-0802
Megjegyzések:	Thyroid nodule ultrasound characteristics are used as an indication for fine-needle aspiration cytology, usually as the basis for Thyroid Imaging Reporting and Data System (TIRADS) score calculation. Few studies on interobserver variation are available, all of which are based on analysis of preselected still ultrasound images and often lack surgical confirmation.Methods: After the blinded online evaluation of video recordings of the ultrasound examinations of 47 consecutive malignant and 76 consecutive benign thyroid lesions, 7 experts from 7 thyroid centers answered 17 TIRADS-related questions. Surgical histology was the reference standard. Interobserver variations of each ultrasound characteristic were compared using Gwet's AC1 inter-rater coefficients; higher values mean better concordance, the maximum being 1.0.Results: On a scale from 0.0 to 1.0, the Gwet's AC1 values were 0.34, 0.53, 0.72, and 0.79 for the four most important features in decision-making, i.e. irregular margins, microcalcifications, echogenicity, and extrathyroidal extension, respectively. The concordance in the discrimination between mildly/moderately and very hypoechogenic nodules was 0.17. The smaller the nodule size the better the agreement in echogenicity, and the larger the nodule size the better the agreement on the presence of microcalcifications. Extrathyroidal extension was correctly identified in just 45.8% of the cases.Conclusions: Examination of video recordings, closely simulating the real-world situation, revealed substantial interobserver variation in the interpretation of each of the four most important ultrasound characteristics. In view of the importance for the management of thyroid nodules, unambiguous and widely accepted definitions of each nodule characteristic are warranted, although it remains to be investigated whether this diminishes observer variation.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk cytology thyroid cancer thyroid nodule TIRADS ultrasound
Megjelenés:	European Thyroid Journal. - 12 : 2 (2023), p. 1-11. -
További szerzők:	Hegedűs László Dávid (1992-) (PhD hallgató) Bonnema, Steen Joop Frasoldati, Andrea Jámbor László (1960-) (radiológus) Karányi Zsolt (1961-) (biostatisztikus, bioinformatikus) Kovács Gábor L. (Szeged) Papini, Enrico Rucz Károly Russ, Gilles Nagy Endre V. (1957-) (belgyógyász, endokrinológus)
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001-es BibID:	BIBFORM092856
Első szerző:	Solymosi Tamás
Cím:	Ultrasound-Based Indications for Thyroid Fine-Needle Aspiration: Outcome of a TIRADS-Based Approach versus Operators' Expertise / Tamas Solymosi, Laszlo Hegedüs, Steen Joop Bonnema, Andrea Frasoldati, Laszlo Jambor, Gabor Laszlo Kovacs, Enrico Papini, Karoly Rucz, Gilles Russ, Zsolt Karanyi, Endre V. Nagy
Dátum:	2021
ISSN:	2235-0640 2235-0802
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	European Thyroid Journal. - 10 : 5 (2021), p. 416-424. -
További szerzők:	Hegedűs László Bonnema, Steen Joop Frasoldati, Andrea Jámbor László (1960-) (radiológus) Kovács Gábor László Papini, Enrico Rucz Károly Russ, Gilles Karányi Zsolt (1961-) (biostatisztikus, bioinformatikus) Nagy Endre V. (1957-) (belgyógyász, endokrinológus)
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001-es BibID:	BIBFORM029177
Első szerző:	Ujhelyi Bernadett (szemész)
Cím:	Retrobulbar 99mTc-diethylenetriamine-pentaacetic-acid uptake may predict the effectiveness of immunosuppressive therapy in Graves' ophthalmopathy / Bernadett Ujhelyi, Annamaria Erdei, Laszlo Galuska, Jozsef Varga, Lajos Szabados, Erzsebet Balazs, Miklos Bodor, Bela Cseke, Zsolt Karanyi, Andras Leovey, Emese Mezosi, Kenneth D. Burman, Andras Berta, Endre V. Nagy
Dátum:	2009
ISSN:	1050-7256
Megjegyzések:	Background: In Graves' ophthalmopathy (GO), only patients with immunologically active disease respond toimmunosuppressive therapy. Previous studies and theoretical considerations suggest that elevated orbital 99mTcdiethylenetriamine-pentaacetic-acid (DTPA) single photon emission computed tomography (SPECT) reflectsinflammatory disease activity. We studied whether corticosteroid treatment causes a substantial decrease inDTPA uptake in GO, a result consistent with successful immunosuppressive treatment of GO and referred to asa favorable treatment outcome.Methods: One hundred fourteen orbits in 57 patients with active GO (CAS?4) were entered into the study. Allpatients received corticosteroid treatment. Orbital DTPA uptakes were numerically quantified for the entire orbitas well as the anterior and posterior segments separately. DTPA SPECT was performed before, and 2 to 9months after the initiation of immunosuppressive treatment. The normal range for DTPA uptake was establishedin 34 orbits of 17 patients who were being worked up for Raynaud's phenomenon and had no thyroiddisease.Results: The mean DTPA uptake of the 114 orbits of GO patients was higher prior to corticosteroid therapy thanafter this treatment (11.03?4.26MBq/cm3 and 9.84?3.51MBq/cm3, respectively, p<0.001) but a substantialdecline in DTPA uptake was seen in only 39.5% of GO patients. The positive predictive value of an initialDTPA >12.28MBq/cm3 for a substantial decline in DTPA uptake (favorable treatment outcome) was 76%, whilea negative predictive value of a pretreatment DTPA?12.28MBq/cm3 was 78%.Conclusions: Corticosteriod treatment is associated with a decline in DTPA uptake in a fraction of GO patients.GO patients with a DTPA uptake above 12.28MBq/cm3 are more likely to have a favorable response to corticosteroidtherapy while patients with lower values are less likely to have this potentially favorable response.An elevated DTPA uptake may identify patients who are most likely to benefit from immunosuppressivetreatment.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Graves' orbitopathy immunological activity DTPA SPECT egyetemen (Magyarországon) készült közlemény
Megjelenés:	Thyroid. - 19 : 4 (2009), p. 375-380. -
További szerzők:	Erdei Annamária (1976-) (belgyógyász) Galuska László (1946-) (belgyógyász, izotópdiagnoszta) Varga József (1955-) (fizikus) Szabados Lajos (1977-) (orvos) Balázs Erzsébet (1952-) (szemész) Bodor Miklós (1969-) (belgyógyász, endokrinológus) Cseke Béla (1974-) (belgyógyász, endokrinológus) Karányi Zsolt (1961-) (biostatisztikus, bioinformatikus) Leövey András (1926-) (belgyógyász) Mezősi Emese Burman, Kenneth D. Berta András (1955-) (szemész, gyermekszemész) Nagy Endre V. (1957-) (belgyógyász, endokrinológus)
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