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001-es BibID:	BIBFORM053494
Első szerző:	Égerházi Anikó (neurológus, pszichiáter, pszichoterapeuta)
Cím:	P300 enyhe kognitív zavarban és demenciában = P300 in mild cognitive impairment and in dementia / Égerházi Anikó, Glaub Theodóra, Balla Petra, Berecz Roland, Degrell István
Dátum:	2008
Megjegyzések:	OBJECTIVES:The late component of the event-related potential (ERP), P300 is a marker for cognitive brain functions. The objective of this study was to examine P300 parameters in dementia and in mild cognitive impairment (MCI), to examine whether there is a correlation between the changes in P300 parameters and the type and severity of dementia, and to determine P300 abnormalities in MCI in relation to the presence/absence of CT/MRI abnormalities.METHOD:Auditory event-related potentials, P300 were recorded in 28 MCI patients (14 of them with normal CT/MRI findings and 10 subjects with mild ventricular enlargement). In another group of patients, 31 demented patients were examined, of whom 17 patients were diagnosed with Alzheimer's dementia (AD), and 14 patients with vascular dementia (VD). Forty healthy volunteers served as the control group.RESULTS:Mean P300 latency was significantly increased for both demented patient-groups. We found that prolongation of P300 latency was correlated with the severity of dementia. Mean P300 amplitude was significantly decreased in both groups of demented patients. In MCI, the mean latency of P300 was significantly longer among patients with mild cerebral atrophy compared to control volunteers and no significant changes were found for MCI patients with normal CT/MRI findings. Mean P300 amplitude was decreased only in demented patients.CONCLUSIONS:The prolongation of P300 latency was significant among patients with both vascular and Alzheimer's dementia, and also among MCI patients with mild cerebral atrophy. The severity of dementia is positively correlated with P300 latency; however, this prolongation is independent of the type of dementia. The structural brain changes in MCI are related to P300 latency prolongation and thus may indicate an increased risk for developing dementia in MCI patients.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok magyar nyelvű folyóiratközlemény hazai lapban Alzheimer demencia auditoros eseményfüggő potenciál kognitív funkciók enhye kognitív zavar vaszkuláris demencia Clinical Global Impression Költség
Megjelenés:	Psychiatria Hungarica. - 23 : 5 (2008), p. 349-357. -
További szerzők:	Glaub Teodóra (1951-) (pszichiáter) Balla Petra (1971-) (pszichiáter) Berecz Roland (1970-) (pszichiáter szakorvos) Degrell István (1947-) (pszichiáter)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM053099
Első szerző:	Égerházi Anikó (neurológus, pszichiáter, pszichoterapeuta)
Cím:	Automated Neuropsychological Test Battery in depression - preliminary data / Aniko Egerházi, Petra Balla, Andrea Ritzl, Zsofia Varga, Ede Frecska, Roland Berecz
Dátum:	2013
Megjegyzések:	AIMS:Studies have demonstrated neuropsychological deficits across a variety of cognitive domains in patients with major depressive disorder (MDD) during acute episode. However, limited data are available concerning whether these abnormalities persist in the remission phase.METHODS:In the present study CANTAB (Cambridge Automated Neuropsychological Test Battery) was used to evaluate the cognitive impairment associated with depression during acute episode and in remission. 25 patients with MDD during an acute episode and 11 patients also during remission were tested with CANTAB.RESULTS:During the acute episode, Delayed matching to sample, Paired associate learning, Spatial recognition memory, Rapid visual processing and Visuospatial planning were impaired. In remission the improvement of visual learning ability, spatial recognition memory, psychomotor speed, and executive function was observed.CONCLUSIONS:The results suggest that MDD is associated with neurocognitive dysfunctions in different domains, the most prominent deficit was found in the Paired associate learning test, which requires both the elaboration of "frontal strategies" and the "mnemonic processes". Cognitive impairment was found to improve partly in remission, suggesting that an individual's current mood interacts with the ability to perform a cognitive task. Besides these state markers, trait deficits are important because cognitive impairments which do not improve in remission might serve as endophenotypes of depression.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban cognitive function unipolar depression remission endophenotypes
Megjelenés:	Neuropsychopharmacologia Hungarica. - 15 : 1 (2013), p. 5-11. -
További szerzők:	Balla Petra (1971-) (pszichiáter) Ritzl Andrea Varga Zsófia (1970-) (pszichiáter) Frecska Ede (1953-) (pszichiáter) Berecz Roland (1970-) (pszichiáter szakorvos)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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