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001-es BibID:	BIBFORM087248
Első szerző:	Molnár Ildikó (belgyógyász, endokrin, immun- és allergológiai szakorvos)
Cím:	Hyperthyroidism in Patients with Graves' Ophthalmopathy, and Thyroidal, Skeletal and Eye Muscle Specific Type 2 Deiodinase Enzyme Activities / Ildikó Molnár, József A. Szentmiklósi, Éva Somogyiné-Vári
Dátum:	2017
ISSN:	0947-7349 1439-3646
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Experimental And Clinical Endocrinology & Diabetes. - 125 : 8 (2017), p. 514-521. -
További szerzők:	Szentmiklósi József András (1948-) (farmakológus, klinikai laboratóriumi szakorvos) Somogyiné-Vári Éva
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001-es BibID:	BIBFORM076858
Első szerző:	Molnár Ildikó (belgyógyász, endokrin, immun- és allergológiai szakorvos)
Cím:	Effect of antithyroid drugs on the occurrence of antibodies against type 2 deiodinase (DIO2), which are involved in hyperthyroid Graves' disease influencing the therapeutic efficacy / Ildikó Molnár, József A. Szentmiklósi, Rudolf Gesztelyi, Éva Somogyiné-Vári
Dátum:	2019
ISSN:	1591-8890
Megjegyzések:	Graves' disease is an organ-specific autoimmune disease with hyperthyroidism, diffuse goiter and autoantibodies against TSH receptor, thyroid peroxidase (TPO) and/or thyroglobulin (Tg). Graves' hyperthyroidism is characterized by T3 dominance due to the conversion of T4 into T3 through type 1 and 2 deiodinase enzymes (DIO1, DIO2). Methimazole (MMI) and propylthiouracil (PTU) therapies inhibit thyroid hormone synthesis blocking the activity of deiodinase and TPO enzymes. The study investigated the occurrence of autoantibodies against DIO2 peptides (cys- and hom-peptides) with the effect of antithyroid drugs on their frequencies in 78 patients with Graves' disease and 30 controls. In hyperthyroidism, the presence of DIO2 peptide antibodies was as follows: 20 and 11 cases out of 51 for cys- and hom-peptide antibodies, respectively, of whom 8 cases possessed antibodies against both peptides. Antithyroid drugs differently influenced their frequencies, which were greater in PTU than in MMI (3/6 vs 13/45 cases, P?<?0.016 for cys- and 0/6 vs 2/45 cases for hom-peptide antibodies). Antibodies against both peptides demonstrated more reduced levels of anti-TPO (P?<?0.003) and anti-Tg antibodies (P?<?0.002) compared with those without peptide antibodies. PTU compared with MMI increased the levels of TSH receptor antibodies (32.5 UI/l vs 2.68 IU/l, P?<?0.009). MMI treatment led to more reduced FT3 levels and FT3/FT4 ratios in hyperthyroid Graves' ophthalmopathy (P?<?0.028 for FT3, P?<?0.007 for FT3/FT4 ratio). In conclusion, the presence of DIO2 peptide antibodies is connected to Graves' hyperthyroidism influencing the levels of antibodies against TPO, Tg and TSH receptor, as well as the therapeutic efficacy of antithyroid drugs.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Antithyroid drugs Hyperthyroidism Graves' disease Antithyroid antibodies Type 2 deiodinase
Megjelenés:	Clinical and Experimental Medicine. - 19 : 2 (2019), p. 245-254. -
További szerzők:	Szentmiklósi József András (1948-) (farmakológus, klinikai laboratóriumi szakorvos) Gesztelyi Rudolf (1969-) (kísérletes farmakológus) Somogyiné-Vári Éva
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001-es BibID:	BIBFORM002477
Első szerző:	Molnár Ildikó (belgyógyász, endokrin, immun- és allergológiai szakorvos)
Cím:	Immunohistochemical studies using immunized Guinea Pig sera with features of anti-human thyroid, eye and skeletal antibody and graves sera / Ildikó Molnár, Zita Szombathy, Ilona Kovács, József Szentmiklósi
Dátum:	2007
Megjegyzések:	Type 2 5' deiodinase enzyme was observed in both thyroid and eye muscle tissues, highlighting its possible role as a common antigen in thyroid-associated ophthalmopathy. Sera of 105 Graves' patients and 40 controls, and immunized guinea pig sera against TCSS peptide, showing homology to the amino acid sequence from 132 to 152 of type 2 5' deiodinase, were investigated to demonstrate the binding effects to human thyroid, eye and skeletal muscle tissues. Twenty-two Graves' patients were positive for anti-TCSS peptide antibodies, of whom 18 cases had ophthalmopathy. The levels of anti-TCSS peptide antibodies were higher not only in Graves' patients with (P<0.0001) and without (P<0.036) eye symptoms compared to controls but also the difference was significant between patients with and without ophthalmopathy (P<0.049). In Western blot, immunized sera showed binding reactions to the supernatant fractions of human thyroid, eye and skeletal muscle tissues at the range of 29 kDa. Patient sera with Graves' ophthalmopathy resulted in positive reactions directed to membrane areas in thyroid follicular cells, and to fibers in eye and skeletal muscles using immunohistochemical method, while no positive staining was present after adding control sera. The binding features of immunized guinea pig sera exhibited similar staining in all human tissues but could be blocked with Graves' sera. Our results suggest that type 2 5' deiodinase enzyme protein could play a role as an antigen in Graves' disease. Immunized guinea pig sera against TCSS
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Type 2 5' deiodinase Graves' ophthalmopathy antibodies
Megjelenés:	Journal of Clinical Immunology. - 27 : 2 (2007), p. 172-180. -
További szerzők:	Szombathy Zita Kovács Ilona (1965-) (patológus) Szentmiklósi József András (1948-) (farmakológus, klinikai laboratóriumi szakorvos)
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