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1.

001-es BibID:BIBFORM013054
Első szerző:Harmati Gábor (élettanász)
Cím:Effects of β-adrenoceptor stimulation on delayed rectifier K(+) currents in canine ventricular cardiomyocytes / Harmati G., Bányász T., Bárándi L., Szentandrássy N., Horváth B., Szabó G., Szentmiklósi J., Szénási G., Nánási P., Magyar J.
Dátum:2011
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
isoproterenol
beta adrenerg
canine
cardiomyocyte
ionic current
Megjelenés:British Journal of Pharmacology. - 162 : 4 (2011), p. 890-896. -
További szerzők:Bányász Tamás (1960-) (élettanász) Bárándi László (1984-) (élettanász) Szentandrássy Norbert (1976-) (élettanász) Horváth Balázs (1981-) (élettanász) Szabó G. (orvos) Szentmiklósi József András (1948-) (farmakológus, klinikai laboratóriumi szakorvos) Szénási Gábor Nánási Péter Pál (1956-) (élettanász) Magyar János (1961-) (élettanász)
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2.

001-es BibID:BIBFORM017197
Első szerző:Szentandrássy Norbert (élettanász)
Cím:Powerful technique to test selectivity of agents acting on cardiac ion channels : the action potential voltage-clamp / Norbert Szentandrássy, Dénes Nagy, Ferenc Ruzsnavszky, Gábor Harmati, Tamás Bányász, János Magyar, A. József Szentmiklósi, Péter P. Nánási
Dátum:2011
ISSN:0929-8673
Megjegyzések:Action potential voltage-clamp (APVC) is a technique to visualize the profile of various currents during the cardiacaction potential. This review summarizes potential applications and limitations of APVC, the properties of the mostimportant ion currents in nodal, atrial, and ventricular cardiomyocytes. Accordingly, the profiles ("fingerprints") of themajor ion currents in canine ventricular myocytes, i.e. in cells of a species having action potential morphology and setof underlying ion currents very similar to those found in the human heart, are discussed in details. The degree ofselectivity of various compounds, which is known to be a critical property of drugs used in APVC experiments, isoverviewed. Thus the specificity of agents known to block sodium (tetrodotoxin, saxitoxin), potassium (chromanol293B, HMR 1556, E-4031, dofetilide, sotalol, 4-aminopyridine, BaCl2), calcium (nifedipine, nisolpidine, nicardipine,diltiazem, verapamil, gallopamil), and chloride (anthracene-9-carboxylic acid, DIDS) channels, the inhibitor of thesodium-calcium exchanger (SEA0400), and the activator of sodium current (veratridine) are accordingly discussed.Based on a theory explaining how calcium current inhibitors block calcium channels, the structural comparison of thestudied substances usually confirmed the results of the literature. Using these predictions, a hypothetical super-selectivecalcium channel inhibitor structure was designed. APVC is a valuable tool not only for studying the selectivity of theknown ion channel blockers, but is also suitable for safety studies to exclude cardiac ion channel actions of any agentunder development.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
action potential
action potential voltage-clamp
Molekuláris Medicina
calcium channel
chemical structure
ion current
ion channel blocker
Molekuláris Medicina
selective calcium channel blocker
Megjelenés:Current Medicinal Chemistry. - 18 : 24 (2011), p. 3737-3756. -
További szerzők:Nagy Dénes (1984-) (vegyész) Ruzsnavszky Ferenc (1984-) (élettanász) Harmati Gábor (1983-) (élettanász) Bányász Tamás (1960-) (élettanász) Magyar János (1961-) (élettanász) Szentmiklósi József András (1948-) (farmakológus, klinikai laboratóriumi szakorvos) Nánási Péter Pál (1956-) (élettanász)
Pályázati támogatás:K 73160
OTKA
CNK 77855
OTKA
K 68457
OTKA
TáMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
A feszültségfüggő K-csatornák szerepe excitábilis sejtekben
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
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3.

001-es BibID:BIBFORM020347
035-os BibID:WOS:000294414700008
Első szerző:Szentmiklósi József András (farmakológus, klinikai laboratóriumi szakorvos)
Cím:Xanthine derivatives in the heart : blessed or cursed? / Szentmiklosi A. J., Cseppento A., Gesztelyi R., Zsuga J., Kortvely A., Harmati G., Nanasi P. P.
Dátum:2011
ISSN:0929-8673
Megjegyzések:Methylxanthines, such as theophylline, have been used to treat cardiorespiratory disorders, whereas caffeine is the most widely consumed psychoactive agent in various soft drinks. Because of the worldwide use of these drugs and the recently synthesized xanthine derivatives, an intensive research on the cardiac actions of these substances is under progress. This review focuses on the molecular mechanisms involved in the actions of xanthine derivatives with special reference to their adenosine receptor antagonistic properties. The main basic and human studies on the action of xanthines on impulse initiation and conduction, as well as the electrophysiological and mechanical activity of the working myocardium will be overviewed. The potential beneficial and harmful actions of the methylxanthines will be discussed in light of the recent experimental and clinical findings. The pharmacological features and clinical observations with adenosine receptor subtype-specific xanthine antagonists are also the subject of this paper. Based on the adenosine receptor-antagonistic activity of these compounds, it can be raised that xanthine derivatives might inhibit the cardioprotective action of endogenous adenosine on various subtypes (A(1), A(2A), A(2B) and A(3)) of adenosine receptors. Adenosine is an important endogenous substance with crucial role in the regulation of cardiac function under physiological and pathological conditions (preconditioning, postconditioning, ischemia/reperfusion injury). Recent clinical studies show that acute administration of caffeine or theophylline can inhibit various types of preconditioning in human subjects. There are no human studies, however, for the cardiovascular actions of long-term administration of these drugs. Upregulation of adenosine receptors and increased effectiveness of adenosine receptor-related cardiovascular functions have been observed after long-lasting treatment with methylxanthines. In addition, there are data indicating that blood adenosine level increases after long-term caffeine administration. Since the salutary actions (and also the adverse reactions) of a number of xanthine derivatives are repeatedly shown, the main goal is the development of novel structures that mimic the actions of the conventional methylxanthines as lead compounds, but their adenosine receptor subtype-specificity is higher, their water solubility is optimal, and the unwanted reactions are minimized.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Current Medicinal Chemistry. - 18 : 24 (2011), p. 3695-3706. -
További szerzők:Cseppentő Ágnes (1953-) (orvos) Gesztelyi Rudolf (1969-) (kísérletes farmakológus) Zsuga Judit (1973-) (neurológus, pszichoterapeuta, egészségügyi szakmanager) Körtvély Ágnes Harmati Gábor (1983-) (élettanász) Nánási Péter Pál (1956-) (élettanász)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
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4.

001-es BibID:BIBFORM016601
Első szerző:Szentmiklósi József András (farmakológus, klinikai laboratóriumi szakorvos)
Cím:Novel trends in the treatment of cardiovascular disorders : site- and event- selective adenosinergic drugs. / Szentmiklósi A. J., Cseppento A., Harmati G., Nánási P. P.
Dátum:2011
ISSN:0929-8673
Megjegyzések:This review focuses on the potential role of site- and event-selective adenosinergic drugs in the treatment of cardiovascular diseases. Adenosine is released from the myocardium and vessels in response to various forms of stress and acts on four receptor subtypes (A1, A2A, A2B and A3). Adenosine is an important endogenous substance with important homeostatic activity in the regulation of cardiac function and circulation. Adenosine receptors are also involved in the modulation of various cellular events playing crucial role in physiological and pathological processes of the cardiovascular system. These actions are associated to activation of distinct adenosine receptor subtypes, therefore drugs targeting specific adenosine receptors might be promising therapeutic tools in treatment of several disorders including various forms of cardiac arrhythmia, myocardial ischemia-reperfusion injury, angina pectoris, chronic heart failure, etc. Recently, in addition to subtype-specific adenosine receptor agonists and antagonists, a number of substances that enhance adenosine receptor activation locally at the site where the release of endogenous adenosine is the most intensive have been developed. Thus global actions of adenosine receptor agonists and antagonists, as well as desensitization or down-regulation following chronic administration of these orthosteric compounds can possibly be avoided. We discuss the chemical, pharmacological and clinical features of these compounds: (1) inhibitors of membrane adenosine transporters (NBTI, dipyridamole), (2) inhibitors of adenosine deaminase (coformycin, EHNA), (3) inhibitors of adenosine kinase (tubercidin, aristeromycin), (4) inhibitors of AMP deaminase (GP3269), (5) activators of 5'- nucleotidase (methotrexate), (6) adenosine regulators (acadesine) and (7) allosteric adenosine receptor modulators (PD81723, LUF6000). The development of this type of substances might offer a novel therapeutic approach for treating cardiovascular diseases in the near future.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Site and event specific action
adenosinergic drugs
membrane adenosine transport
adenosine deaminase
adenosine kinase
AMP deaminase
5'-nucleotidase
adenosine regulators
allosteric receptor modulators
Megjelenés:Current Medicinal Chemistry. - 18 : 8 (2011), p. 1164-1187. -
További szerzők:Cseppentő Ágnes (1953-) (orvos) Harmati Gábor (1983-) (élettanász) Nánási Péter Pál (1956-) (élettanász)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
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