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001-es BibID:	BIBFORM010188
Első szerző:	Káplár Miklós (belgyógyász, diabetológus)
Cím:	Changes in cerebral blood flow detected by SPECT in type 1 and type 2 diabetic patients / Káplár Miklós, Paragh György, Erdei Annamária, Csongrádi Éva, Varga Éva, Garai Ildikó, Szabados Lajos, Galuska László, Varga József
Dátum:	2009
ISSN:	0161-5505 (Print)
Megjegyzések:	Although macrovascular complications are typical for type 2 diabetes mellitus (T2DM), cerebral microvascular damage develops both in type 1 diabetes mellitus (T1DM) and T2DM. Color Doppler ultrasound is widely used for the examination of large- and medium-sized arteries, whereas SPECT and MRI are capable of identifying disturbances in the circulation of microvessels. Former studies using semiquantitative methods showed reduced reactivity and reserve capacity of cerebral vessels in both T1DM and T2DM patients. Our aim was to investigate whether there was any difference in the effects of the 2 types of diabetes mellitus on the global or regional cerebral blood flow, influenced by microvascular damage. METHODS: In our study, the circulation and reserve capacity of cerebral arteries was examined using (99m)Tc-hexamethylpropylene amine oxime SPECT. A total of 17 individuals with T1DM and 43 individuals with T2DM were involved in the study. RESULTS: Both basal and acetazolamide-challenged brain circulation were significantly lower in T2DM patients than in T1DM patients. We did not find a significant difference in the reserve capacity. However, the circulation of the frontal and occipital lobes changed differently in the 2 groups. The ratio of the circulation of the frontal and occipital lobes was significantly reduced both in basal and in acetazolamide-stimulated states in T2DM patients, independently of age (P < 0.0005 and P < 0.017), showing a greater relative decrease in the circulation of the frontal lobe in T2DM patients. CONCLUSION: There was a significant association between basal brain circulation and age, body mass index, and high-density lipoprotein (HDL), whereas acetazolamide-stimulated circulation showed a significant association with serum triglyceride and HDL.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Journal of Nuclear Medicine. - 50 : 12 (2009), p. 1993-1998. -
További szerzők:	Paragh György (1953-) (belgyógyász) Erdei Annamária (1976-) (belgyógyász) Csongrádi Éva (1969-) (szakorvos) Varga Éva (1982-) (belgyógyász) Garai Ildikó (1966-) (radiológus) Szabados Lajos (1977-) (orvos) Galuska László (1946-) (belgyógyász, izotópdiagnoszta) Varga József (1955-) (fizikus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM021723
Első szerző:	Oláh Anna (klinikai biokémikus, vegyész)
Cím:	Monitoring of mycophenolic acid and kidney function during combined immunosuppressive therapy / Oláh A. V., Asztalos L., Ivády G., Varga E., Kovács A. M., Kappelmayer J., Varga J.
Dátum:	2011
ISSN:	1434-6621
Megjegyzések:	Mycophenolic acid (MPA), a selective inhibitor of lymphocyte proliferation, has lately been used to improve renal function and prolong graft survival in renal transplanted patients. Still, there is no consensus considering the recommended dosing and the therapeutic range of MPA. Methods: To estimate the safe therapeutic range of MPA, its plasma level and indicators of kidney function were measured in 216 patients (138 male, 78 female, age 46±12 years) 67±46 months after transplantation. Besides MPA, patients received cyclosporine (Group A, n=122) or tacrolimus (Group B, n=77). Seventeen patients (Group C) were treated with MPA in combination with everolimus or sirolimus. Plasma MPA was measured by enzyme inhibition assay. Results: In the whole study group MPA level increased with the dose of MPA (p=0.013). MPA level was below the therapeutic range in 40% (Group A) and 45% (Group B) of patients, respectively. MPA was 1.9±1.56 mg/L in Group A, 2.4±1.69 mg/L in Group B. In Group A MPA level increased and cyclosporine decreased with the progress of renal disease. Conclusions: Increasing MPA/cyclosporine ratio at more severe stages of chronic kidney disease was tolerable for the patients and rejection could be avoided. Tubular damage detected by urinary N-acetyl-β-D-glucosaminidase did not correlate with the MPA level.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Clinical Chemistry And Laboratory Medicine. - 49 : 11 (2011), p. 1849-1853. -
További szerzők:	Asztalos László (1951-) (sebész) Ivády Gergely (1979-) (laboratóriumi szakorvos) Varga Éva (1982-) (belgyógyász) Kovács M. Ágota Kappelmayer János (1960-) (laboratóriumi szakorvos) Varga József (1955-) (fizikus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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