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1.

001-es BibID:BIBFORM075918
035-os BibID:(WOS)000458515000002 (Scopus)85064672339
Első szerző:Béres Mónika (képalkotó diagnoszta, eü. mérnökinformatikus)
Cím:Comparing the reliability of biomedical texture analysis tools on different image types / Béresová M., Forgács A., Bujdosó B., Székely A., Varga J., Berényi E., Balkay L.
Dátum:2018
ISSN:1785-8860
Megjegyzések:The aim of this study was to analyze the reliability of texture index (TI) calculations using two different approaches. First, we calculated texture parameters on synthetically constructed images using four different biomedical software tools (CGITA, InterView Fusion, Matlab, MaZda). Second, we investigated the reliability of texture parameters, particularly how the texture indices diverge between two similar images with substantially different texture. We generated five different heterogeneous synthetic images, thereafter, histogram-based and co-occurrence matrix features were calculated. The co-occurrence based indices were computed after two (8 and 64) different gray scale normalizations. For the reliability test, we compared 22 texture indices using a histological slice of the brain and Michelangelo's painting, and the gray level dependence was also analyzed. The histogram-based parameters of all images and from all software were very similar. Differences were found in the co-occurrence based indices after both gray level image normalizations. The reliability tests showed that from 22 parameters only 5 texture indices changed more than 20%, and at least 64 normalization levels were necessary for acceptable results. Our results underline that in medical multicenter studies it is especially critical to use the same software package. Some parameters do not reliably reflect changes, so texture analysis (TA) should be used with caution.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban
folyóiratcikk
texture analysis
medical imaging
software
comparative study
co-occurrence matrix
Megjelenés:Acta Polytechnica Hungarica. - 15 : 7 (2018), p. 29-48. -
További szerzők:Forgács Attila (1985-) (fizikus) Bujdosó Blanka Székely András (1982-) (radiológus) Varga József (1955-) (fizikus) Berényi Ervin (1964-) (radiológus) Balkay László (1963-) (biofizikus)
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2.

001-es BibID:BIBFORM065882
035-os BibID:(cikkazonosító)e0164113 (WOS)000385505800040 (Scopus)84991336354
Első szerző:Forgács Attila (fizikus)
Cím:A Study on the Basic Criteria for Selecting Heterogeneity Parameters of F18-FDG PET Images / Attila Forgács, Hermann Pall Jonsson, Magnus Dahlbom, Freddie Daver, Matthew D. DiFranco, Gabor Opposits, Aron K. Krizsan, Ildiko Garai, Johannes Czernin, Jozsef Varga, Lajos Tron, Laszlo Balkay
Dátum:2016
ISSN:1932-6203
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Plos One. - 11 : 10 (2016), p. 1-14. -
További szerzők:Jonsson, Hermann Pall Dahlbom, Magnus Daver, Freddie DiFranco, Matthew D. Opposits Gábor (1974-) (fizikus, szoftver fejlesztő) Krizsán Áron Krisztián (1986-) (fizikus) Garai Ildikó (1966-) (radiológus) Czernin, Johannes Varga József (1955-) (fizikus) Trón Lajos (1941-) (biofizikus) Balkay László (1963-) (biofizikus)
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3.

001-es BibID:BIBFORM102721
035-os BibID:(Scopus)85137125116
Első szerző:Képes Zita (orvos)
Cím:Initial clinical experience with dedicated multi-pinhole (MPH) collimator for 99mTc-HMPAO brain perfusion SPECT / Zita Képes, Kornél Kukuts, Attila Oszlánszki, Iván Mihovk, Áron Krizsán, Sándor Barna, Andrew Robinson, Daniel Deidda, János Mester, József Varga, Ildikó Garai, Attila Forgács
Dátum:2022
ISSN:1790-5427
Megjegyzések:Abstract Objective: Dedicated multi-pinhole (MPH) collimators have been successfully tested in selected clinical investigations. The aim of our work was to report initial experiences with an MPH collimator set designed for brain perfusion single photon emission tomography (SPECT). Methods: Ten patients underwent sequential technetium-99m-hexamethylpropyleneamineoxime (99mTc-HMPAO) SPECT with a dual-head SPECT camera equipped with conventional low-energy parallel hole collimators (LEHR), and with a triple-head system equipped with MPH collimators. Low-energy parallel hole collimators data were reconstructed by filtered back projection (FBP), ordered subset expectation maximization (OSEM), software for tomographic image reconstruction (STIR). In addition, both the parallel hole data and MPH data were reconstructed by Tera-TomoTM 3D iterative reconstruction denoted LEHR_TT3D and MPH_TT3D, respectively. Five medical experts visually compared the reconstructed images of the five data sets and defined a ranking sequence from the lowest (1) to the highest (5) image quality. Results were compared using the Friedman test. P values below 0.05 were considered significant. Results: Low-energy parallel hole collimators acquisition resulted in 5 million, while MPH acquisition in 13 million total counts with 30 and 34 minutes of acquisition time, respectively. Mean rank coefficients of the reconstruction methods were 1.96?0.52, 2.66?0.46, 2.86?0.60, 3.62?0.55, 3.9?0.68 for FBP, STIR, LEHR_TT3D, LEHR_OSEM, MPH_TT3D respectively. The differences between MPH_TT3D-FBP (P<0.01); MPH_TT3D-STIR (P<0.05); LEHR_OSEM-FBP (P<0.01) were significant. Conclusion: Image quality provided by MPH collimator is comparable to that provided by conventional LEHR imaging. Higher sensitivity has the potential to shorten acquisition time or to reduce the amount of administered activity.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Brain perfusion
SPECT
Multi-pinhole collimator
Reconstruction
Image quality
Megjelenés:Hellenic Journal of Nuclear Medicine. - 25 : 2 (2022), p. 143-147. -
További szerzők:Kukuts Kornél Oszlánszki Attila Mihovk Iván Krizsán Áron Krisztián (1986-) (fizikus) Barna Sándor (1982-) (kutató orvos) Robinson, Andrew Deidda, Daniel Mester János Varga József (1955-) (fizikus) Garai Ildikó (1966-) (radiológus) Forgács Attila (1985-) (fizikus)
Pályázati támogatás:National Grant No. GINOP-2.1.1-15-2015-00609
GINOP
UK National Physical Laboratory through the National Measurement System
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4.

001-es BibID:BIBFORM099030
035-os BibID:(Scopus)85122905153 (WOS)000754954100007
Első szerző:Képes Zita (orvos)
Cím:Homocysteine-related alterations of [18F]FDG brain pattern in metabolic diseases / Zita Képes, Csaba Aranyi, Attila Forgács, Ferenc Nagy, Kornél Kukuts, Regina Esze, Sándor Somodi, Miklós Káplár, József Varga, Miklós Emri, Ildikó Garai
Dátum:2021
ISSN:1790-5427
Megjegyzések:Since hyperhomocysteinaemia (HHcys) is implicated as a risk factor for the development of neurodegeneration, and is associated with the development of metabolic diseases, we aimed at analysing the effect of homocysteine (Hcys) on regional fluorine-18-fluorodeoxyglucose (18F-FDG) brain metabolism in 51 controlled type 2 diabetic and in 48 non-DM obese participants. Plasma Hcys levels were measured by an immunoassay. Homocysteine-related 18F-FDG regional brain metabolism was evaluated applying 18F-FDG PET/CT using magnetic resonance imaging (MRI)-based brain template for Statistical Parametric Mapping (SPM) analysis. Homocysteine-related decreased 18F-FDG uptake was shown in the right middle temporal gyrus in the whole population. Diabetics with Hcys above the reference limit expressed decreased glucose metabolism in the left calcarine cortex compared to the obese with HHcys. Regional metabolic alterations evoked on the basis of HHcys draw attention to the potential risk of neurodegeneration caused by metabolic disturbances.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Diabetes
Obesity
(18)-F-FDG PET/CT
Homocysteine
Neurodegeneration
Megjelenés:Hellenic Journal of Nuclear Medicine. - 24 : 3 (2021), p. 222-227. -
További szerzők:Aranyi Sándor Csaba (1988-) (programtervező informatikus) Forgács Attila (1985-) (fizikus) Nagy Ferenc (1984-) (fizikus) Kukuts Kornél Esze Regina Somodi Sándor (1977-) (belgyógyász) Káplár Miklós (1965-) (belgyógyász, diabetológus) Varga József (1955-) (fizikus) Emri Miklós (1962-) (fizikus) Garai Ildikó (1966-) (radiológus)
Pályázati támogatás:National Grant No. GINOP-2.1.1-15-2015-00609
GINOP
National Brain Research Program No. 2017-1.2.1-NKP-2017-00002
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5.

001-es BibID:BIBFORM091785
035-os BibID:(cikkazonosító)3 (WOS)000672838300001 (Scopus)85100999105
Első szerző:Képes Zita (orvos)
Cím:Glucose-level dependent brain hypometabolism in type 2 diabetes mellitus and obesity / Z. Képes, Cs. Aranyi, A. Forgács, F. Nagy, K. Kukuts, Zs. Hascsi, R. Esze, S. Somodi, M. Káplár, J. Varga, M. Emri, I. Garai
Dátum:2021
Megjegyzések:Glucose-level dependent brain hypometabolism in type 2 diabetes mellitus and obesity Background: Metabolic syndrome and its individual components lead to wide-ranging consequences, many of which affect the central nervous system. In this study, we compared the [18F]FDG regional brain metabolic pattern of participants with type 2 diabetes mellitus (T2DM) and non-DM obese individuals. Methods: In our prospective study 51 patients with controlled T2DM (ages 50.6 ? 8.0 years) and 45 non-DM obese participants (ages 52.0 ? 9.6 years) were enrolled. Glucose levels measured before PET/CT examination (pre-PET glucose) as well as laboratory parameters assessing glucose and lipid status were determined. NeuroQ application (NeuroQTM 3.6, Syntermed, Philips) was used to evaluate regional brain metabolic differences. [18F]FDG PET/CT (AnyScan PC, Mediso) scans, estimating brain metabolism were transformed to MNI152 brain map after T1 registration and used for SPM-based group comparison of brain metabolism corrected for pre-PET glucose, and correlation analysis with laboratory parameters. Results: NeuroQ analysis did not reveal significant regional metabolic defects in either group. Voxel-based group comparison revealed significantly (pFWE<0.05) decreased metabolism in the region of the precuneus and in the right superior frontal gyrus (rSFG) in the diabetic group as compared to the obese patients. Data analysis corrected for pre-PET glucose level showed a hypometabolic difference only in the rSFG in T2DM. Voxel-based correlation analysis showed significant negative correlation of the metabolism in the following brain regions with pre-PET glucose in diabetes: precuneus, left posterior orbital gyrus, right calcarine cortex and right orbital part of inferior frontal gyrus; while in the obese group only the right rolandic (pericentral) operculum proved to be sensitive to pre-PET glucose level. Conclusions: To our knowledge this is the first study to perform pre-PET glucose level corrected comparative analysis of brain metabolism in T2DM and obesity. We also examined the pre-PET glucose level dependency of regional cerebral metabolism in the two groups separately. Large-scale future studies are warranted to perform further correlation analysis with the aim of determining the effects of metabolic disturbances on brain metabolism. Keywords: [18F]FDG, metabolism, brain, type 2 diabetes mellitus, obesity
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
[18F]FDG
metabolism
brain
type 2 diabetes mellitus
obesity
Megjelenés:European Journal of Hybrid Imaging. - 5 : 1 (2021), p. 1-15. -
További szerzők:Aranyi Sándor Csaba (1988-) (programtervező informatikus) Forgács Attila (1985-) (fizikus) Nagy Ferenc (1984-) (fizikus) Kukuts Kornél Hascsi Zsolt Esze Regina Somodi Sándor (1977-) (belgyógyász) Káplár Miklós (1965-) (belgyógyász, diabetológus) Varga József (1955-) (fizikus) Emri Miklós (1962-) (fizikus) Garai Ildikó (1966-) (radiológus)
Pályázati támogatás:GINOP-2.1.1-15-2015-00609
GINOP
National Brain Research Program No. 2017-1.2.1-NKP-2017-00002.
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6.

001-es BibID:BIBFORM073947
Első szerző:Kracskó Bertalan (orvos)
Cím:Effect of patient positioning on the evaluation of myocardial perfusion SPECT / Kracskó Bertalan, Barna Sándor, Sántha Orsolya, Kiss Anett, Varga József, Forgács Attila, Garai Ildikó
Dátum:2018
ISSN:1071-3581
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Nuclear Cardiology. - 25 : 5 (2018), p. 1645-1654. -
További szerzők:Barna Sándor (1982-) (kutató orvos) Sántha Orsolya Kiss Anett Varga József (1955-) (fizikus) Forgács Attila (1985-) (fizikus) Garai Ildikó (1966-) (radiológus)
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7.

001-es BibID:BIBFORM061306
Első szerző:Krizsán Áron Krisztián (fizikus)
Cím:Orvosi képalkotás : diagnosztika a képelemek mögött / Krizsán Áron Krisztián, Varga József, Forgács Attila, Balkay László
Dátum:2015
ISSN:0015-3257 1588-0540
Tárgyszavak:Orvostudományok Klinikai orvostudományok magyar nyelvű folyóiratközlemény hazai lapban
Megjelenés:Fizikai Szemle. - 65 : 3 (2015), p. 88-91. -
További szerzők:Varga József (1955-) (fizikus) Forgács Attila (1985-) (fizikus) Balkay László (1963-) (biofizikus)
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8.

001-es BibID:BIBFORM087279
035-os BibID:(WoS)000492444401187
Első szerző:Mikó Márton
Cím:Alterations of peripherial micorcirculation in Diabetes mellitus and Obesity / M. Mikó, J. Varga, F. Nagy, M. Emri, M. Káplár, A. Forgács, I. Garai
Dátum:2019
ISSN:1619-7070 1619-7089
Megjegyzések:Aim/Introduction: The number of people with obesity and diabetes is continously growing. These are important metabolic drivers of cerebrovascular and cardiovascular diseases as well as peripheral neuropathy. Damage to the microcirculation is the basis for these conditions.In our study we investigated peripheral perfusion in these two metabolic diseases and its correlation with laboratory parameters and neuropathy. Materials and Methods: In this prospective study, 57 patients with controlled type 2 diabetes mellitus (T2DM) (mean age:52?9.6) and 46 patients with obesity (50.6?7.9) were recruited. BMI was 34.1?5.9 in T2DM and 38.1?6.1 in the obese group. Quantitative Tc99m HMPAO (Mediradiopharma, Hungary) SPECT/CT (AnyscanFlexSC, Mediso, Hungary) studies were performed to assess peripheral microcirculation in the legs. Patients with known symptomatic peripheral circulation abnormalities were excluded from the study. For the SUVmean calculation, fixed sized spheric VOIs (volume of interest) were drawn in the calf musculature bilaterally. Neurometer testing (NM-01/CPT) was used for evaluating sub-clinical peripheral nerve dysfunction. For statistical analysis, Shapiro normality test, Wilcoxon test and paired Spearman correlation was done. Results: There were no significant differences of calculated SUVmean values in right and left legs in both groups, neither were there any in neurometer testing. However, leg perfusion was significantly lower in the diabetic group predominantly on the left side (p=0.015 right leg, p=0,00065 left leg). Neurometer data showed correlation with HBA1C in the diabetic group, but none with leg perfusion. There was no correlation between neurometer test results and leg perfusion in the obese group. We also investigated the correlation of BMI, age and leg perfusion. BMI showed positive correlation with mean leg perfusion (rho=0,36, p=0,001) and no correlation with age was found. Conclusion: Quantitative leg perfusion SPECT/CT with Tc99m HMPAO is a sensitive method for evaluating subclinical perfusion abnormalities, providing complementary information for early assessment of peripheral neuropathy in diabetes. Further investigation is needed to understand the background of correlation of leg perfusion and BMI. References: None
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:European Journal of Nuclear Medicine and Molecular Imaging. - 46 : S1 (2019), p. S204-S205. -
További szerzők:Varga József (1955-) (fizikus) Nagy Ferenc (1984-) (fizikus) Emri Miklós (1962-) (fizikus) Káplár Miklós (1965-) (belgyógyász, diabetológus) Forgács Attila (1985-) (fizikus) Garai Ildikó (1966-) (radiológus)
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9.

001-es BibID:BIBFORM075955
Első szerző:Varga József (fizikus)
Cím:A New Statistical Model For Quantifying Tumor Heterogeneity in Emission Tomography / Varga J., Forgács A.
Dátum:2015
ISSN:1619-7070 1619-7089
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:European Journal Of Nuclear Medicine And Molecular Imaging. - 42 : Suppl. 1 (2015), p. S51. -
További szerzők:Forgács Attila (1985-) (fizikus)
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