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001-es BibID:BIBFORM060588
Első szerző:Jenei Ágnes (fogszakorvos)
Cím:Oral health-related quality of life after prosthetic rehabilitation: a longitudinal study with the OHIP questionnaire / Ágnes Jenei, János Sándor, Csaba Hegedűs, Kinga Bágyi, László Nagy, Csongor Kiss, Gyula Szabó, Ildikó J. Márton
Dátum:2015
ISSN:1477-7525
Megjegyzések:Background: Aspects of oral health related quality of life (OHRQoL) attracted an increased attention recently.Objective: The aim of the study was to assess self-reported oral health related quality of life (OHRQoL) amongpatients requiring prosthetic rehabilitation and to determine the rate of improvement 1 month and 6?12 monthsafter therapy. In addition, effect of age, gender, oral health indicators and denture types before treatment wereassessed on OHRQoL as evaluated and reported by the patients.Methods: Hungarian version of OHIP-49 (OHIP-49-H) questionnaire was completed before oral rehabilitation (T0-phase)by 389 patients undergoing prosthetic replacement. After 1 month (T1-phase) and 6?12 months (T2-phase) recallperiods 235 and 92 patients completed the questionnaire. The median interquartile range (IQR) values of the totalOHIP-49-H score were calculated for T0-, T1- and T2-phases. Reliability of the questionnaire was checked by Cronbach'sstatistics. Age, gender, oral health indicators and denture types of patients before and after treatment were recordedand treatment-associated changes in OHRQoL were evaluated.Results: The study demonstrated the excellent reliability and internal consistency of OHIP-49-H by a high andnarrow range of Cronbach's alpha value (0.81-0.93). A median OHIP-49-H score of 52; IQR = 25-83 demonstrated apoor OHRQoL on first admission. Decreasing median total OHIP-49-H scores 1 month (24; IQR = 9-51; p < 0.001)and 6?12 months (20; IQR = 7-37; p = 0,055) after therapy indicated an improvement of OHRQoL. Patients' ageand CPI value assessed before treatment proved to be significant factors of OHRQoL.Conclusions: Here we presented representative data about self-assessed OHRQoL of patients requiring prosthetictreatment from Hungary using OHIP-49-H questionnaire. The results demonstrated that the restoration of oralhealth was associated with an improvement in patients' OHRQoL. According to the demographical and T0 phaseclinical status, the treatment was more effective in the respect of OHIP-49-H score improvement among females(than among males), among younger (than among more aged), and among patients with more serious CPIassessed at T0. The type of prosthetic interventions did not exert a significant effect on total OHIP-49-H score,suggesting that the improvement in OHRQoL is independent from the type of denture applied.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Quality of life
Prosthodontics
Oral health
Oral Health Impact Profile (OHIP) questionnaire
Megjelenés:Health and Quality of Life Outcomes. - 13 : 99 (2015), p. 1-7. -
További szerzők:Sándor János (1966-) (orvos-epidemiológus) Hegedűs Csaba (1953-) (fogszakorvos) Bágyi Kinga (1971-) (fogszakorvos) Nagy László (1966-) (molekuláris sejtbiológus, biokémikus) Kiss Csongor (1956-) (hematológus, onkológus) Szabó Gyula (orvos) Márton Ildikó (1954-) (fogszakorvos)
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001-es BibID:BIBFORM034578
Első szerző:Kappelmayer János (laboratóriumi szakorvos)
Cím:Coagulation factor XIII-A. A flow cytometric intracellular marker in the classification of acute myeloid leukemias / Kappelmayer, J., Simon, A., Katona, E., Szanto, A., Nagy, L., Kiss, A., Kiss, C., Muszbek, L.
Dátum:2005
ISSN:0340-6245
Megjegyzések:The association of coagulation factors with leukocytes have been demonstrated in several previous studies. This study was designed to study the sensitivity and specificity of factor XIII subunit A (FXIII-A) labelling in cultured myeloblastic and monoblastic cell lines and to investigate the intracytoplasmic expression of FXIII-A in de novo acute myeloid leukemia (AML) samples. Myeloblastic and a monoblastic cell lines were cultured and investigated for lineage specific maturation markers and FXIII-A expression. Furthermore, FXIII-A expression was investigated in 12 normal samples (7 bone marrow and 5 peripheral blood), 86 de novo AML samples and 6 chronic myelomonocytic leukemia (CMML) samples. In the monoblastic MonoMac6 cell line the appearance of FXIII-A preceded that of CD14 while it remained negative in the myeloblastic PLB-985 cell line throughout its maturation period. Among the AML samples the average frequency of FXIII-A positive cells in myeloblastic leukemia samples was below 10%, while in M4 and M5AML samples it was above 50% and was significantly higher than the generally used CD14 marker (p < 0.0001). In the AML M4 and M5 cases, FXIII-A proved sensitive for the identification of monoblasts. FXIII-A can be considered as a reliable intracytoplasmic marker for the monocytic and megakaryocytic series and its presence is highly predictive for mono- and megakaryocytic AML and for CMML.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Thrombosis And Haemostasis. - 94 : 2 (2005), p. 454-459. -
További szerzők:Simon Ágnes (1969-) (laboratóriumi szakorvos) Katona Éva (1961-) (klinikai biokémikus) Szántó Attila (1976-) (orvos, biokémikus) Nagy László (1966-) (molekuláris sejtbiológus, biokémikus) Kiss Attila (1942-) (belgyógyász, haematológus) Kiss Csongor (1956-) (hematológus, onkológus) Muszbek László (1942-) (haematológus, kutató orvos)
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DOI
Intézményi repozitóriumban (DEA) tárolt változat
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