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001-es BibID:BIBFORM040285
Első szerző:Conlon, J. Michael
Cím:A melittin-related peptide from the skin of the Japanese frog, Rana tagoi, with antimicrobial and cytolytic properties / Conlon J. M., Sonnevend A., Patel M., Camasamudram V., Nowotny N., Zilahi E., Iwamuro S., Nielsen P. F., Pál T.
Dátum:2003
Megjegyzések:Two peptides with antimicrobial and cytolytic properties were purified from an extract of the skin of Tago's brown frog Rana tagoi. The primary structure of one peptide (FLPILGKLLS(10)GIL.NH(2)) identifies it as a member of the temporin family, whereas the second peptide (AIGSILGALA(10)KGLPTLISWI(20)KNR.NH(2)) displays 78% sequence identity to melittin from the venom of the honeybee Apis florea. Compared with melittin, the melittin-related peptide (MRP) was equipotent in inhibiting the growth of the Gram-positive bacterium Staphylococcus aureus, 5-fold less potent against the Gram-negative bacterium Escherichia coli and against the fungal pathogen, Candida albicans. MRP was 13-fold less hemolytic than melittin against human erythrocytes and 4- and 5-fold less cytolytic against mouse EL4 T-lymphoma-derived cells and L929 fibroblasts, respectively. However, at non-cytotoxic concentrations (<or=8 microM), MRP did not protect HeLa cells from cell death produced by human rhinovirus type 2 infection.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Frog skin
Melittin
Temporin
Hemolytic
Cytolytic
Antimicrobial
Antiviral
Megjelenés:Biochemical and Biophysical Research Communications. - 306 : 2 (2003), p. 496-500. -
További szerzők:Sonnevend Ágnes Patel, Mahendra Camasamudram, Vijayayasarathy Nowotny, Norbert Zilahi Erika (1964-) (molekuláris biológus) Iwamuro, Shawichi Nielsen, Per F. Pál Tibor
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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