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1.

001-es BibID:BIBFORM068033
Első szerző:Chen, Ji-Qing
Cím:Simultaneously increased expression of microRNA-155 and suppressor of cytokine signaling 1 (SOCS1) gene in the peripheral blood mononuclear cells of patients with primary Sjogren's syndrome / Chen Ji-Qing, Zilahi Erika, Papp Gábor, Sipka Sándor, Zeher Margit
Dátum:2017
Megjegyzések:AIM:The microRNA-155 (miR-155) is regarded as a central modulator of T-cell responses and could be a potential therapeutic target for certain inflammatory diseases. In our present study we analyzed the expression rate of miR-155 and its functionally linked gene, the suppressor gene of cytokine signaling 1 (SOCS1) in primary Sjögren's syndrome (pSS).METHOD:We enrolled 23 pSS patients and 10 healthy individuals in the study. The expression of miR-155 and SOCS1 gene were measured by real-time polymerase chain reaction.RESULTS:We observed the over-expression of miR-155 in the peripheral mononuclear cells of patients with pSS. Surprisingly, SOCS1 gene was also over-expressed in pSS patients.CONCLUSION:This unanticipated phenomenon might be a laboratory characteristic of Sjögren's syndrome, and presumably a consequence of the noteworthy difference in the pSS immune system reacting with Epstein-Barr virus.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
microRNA-155
primary Sjögren's syndrome
suppressor of cytokine signaling 1
Megjelenés:International Journal of Rheumatic Diseases 20 : 5 (2017), p. 609-613. -
További szerzők:Zilahi Erika (1964-) (molekuláris biológus) Papp Gábor (1984-) (belgyógyász) Sipka Sándor (1945-) (laboratóriumi szakorvos) Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus)
Pályázati támogatás:K 101470
OTKA
TÁMOP-4.2.2.A-11/1/KONV-2012-0023
TÁMOP
Internet cím:Szerző által megadott URL
DOI
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2.

001-es BibID:BIBFORM007067
Első szerző:Kapitány Anikó (molekuláris biológus)
Cím:Association of rheumatoid arthritis with HLA-DR1 and HLA-DR4 in Hungary / Kapitany, A., Zilahi, E., Szanto, S., Szucs, G., Szabo, Z., Vegvari, A., Rass, P., Sipka, S., Szegedi, G., Szekanecz, Z.
Dátum:2005
ISSN:0077-8923 (Print)
Megjegyzések:Susceptibility to and outcome for rheumatoid arthritis (RA) have been associated with particular HLA-DR alleles, but these alleles vary among ethnic groups and geographic areas. The frequency of HLA-DR1 (HLA-DRB1*0101, DRB1*0102) and HLA-DR4 (DRB1*0401, DRB1*0404) alleles is elevated among Caucasian patients with RA. We studied a northeastern Hungarian population of RA patients to determine the frequency of HLA-DR1 and HLA-DR4 phenotypes in this population and to compare it with healthy control subjects, as well as to investigate whether the presence of these alleles could be a marker for RA. We performed HLA-DRB1 genotyping (DRB1*01-DRB1*16) in 83 RA patients and 55 healthy controls using polymerase chain reaction with sequence-specific primers (PCR-SSP). In the case of HLA-DR1- or HLA-DR4-positive patients, the DR1 and DR4 subtypes were also determined. The frequency of HLA-DR4 alleles was significantly higher in RA patients than in controls (31.3 vs. 10.9%; P <.05). HLA-DR1, in particular, tended to be more frequent in patients than in controls (32.5 vs. 18.1%). Among the HLA-DR4 subtypes, DRB1*0401 and DRB1*0404 were the most common alleles found in both groups. However, no significant differences were seen in the frequency of HLA-DRB1*0401 and HLA-DRB1*0404 between RA patients and controls. In contrast, HLA-DRB1*0405 and HLA-DRB1*0408 were significantly more common in RA patients than in control subjects. Among HLA-DR1 subtypes, the DRB1*0101 allele was most commonly detected, but HLA-DRB1*0101 as well as DRB1*0102 and DRB1*0105 were similarly frequent in RA patients and controls. HLA-DR12 was more common among controls than in RA patients (18.1 vs. 0%; P <.05). Our results generally agree with the findings in other Caucasian populations. Nonetheless, we found differences in the frequency of HLA-DR1 and HLA-DR4 subtypes among Hungarian patients compared with reports from other geographic regions (e.g., Finland and Asia). Our data suggest that in northeastern Hungary, HLA-DR4 as well as its subtypes DRB1*0405 and DRB1*0408 may be involved in susceptibility to RA, but HLA-DR1 may not. In addition, the presence of HLA-DR12, at least in Hungary, may protect from this disease.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Adolescent
Adult
Aged
Aged, 80 and over
Alleles
Arthritis, Rheumatoid
Female
HLA-DR Antigens
HLA-DR1 Antigen
Humans
Male
Middle Aged
Megjelenés:Annals of the New York Academy of Sciences. - 1051 (2005), p. 263-270. -
További szerzők:Zilahi Erika (1964-) (molekuláris biológus) Szántó Sándor (1968-) (belgyógyász, reumatológus) Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Szabó Zoltán (1970-) (belgyógyász, reumatológus) Végvári Anikó (belgyógyász, III. sz. Belgyógyászati Klinika) Rass Péter Sipka Sándor (1945-) (laboratóriumi szakorvos) Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Internet cím:elektronikus változat
elektronikus változat
DOI
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3.

001-es BibID:BIBFORM007079
Első szerző:Rass Péter
Cím:Vitamin D receptor gene polymorphism in rheumatoid arthritis and associated osteoporosis / Rass, P., Pakozdi, A., Lakatos, P., Zilahi, E., Sipka, S., Szegedi, G., Szekanecz, Z.
Dátum:2006
ISSN:0172-8172
Megjegyzések:Rheumatoid arthritis (RA) is commonly associated with decreased bone mineral density (BMD) due to numerous factors. BsmI polymorphism of the vitamin D receptor (VDR) gene has been implicated in the pathogenesis of osteoporosis. Vitamin D has several immunomodulatory effects and thus may play a role in the course of arthritis. However, little data is available on the possible relationship between RA and VDR gene polymorphisms. In this study, the frequency of BsmI polymorphism genotypes were compared with that found in other countries. In this study, 64 RA patients and 40 healthy controls were tested for VDR gene BsmI polymorphism genotypes. Frequencies of B and b alleles were associated with markers of bone metabolism and RA. Among control subjects, the frequency of the BB genotype is relatively high (27.5%). In RA with secondary osteopenia/osteoporosis the BB genotype was more rare, the bb was more common than in control subjects. Markers of bone metabolism were associated with the B allele. RA patients carrying the B allele had lower BMD and increased bone loss over 1 year. The B allele was also correlated with increased osteoclast and osteoblast function, as determined by the assessment of biochemical markers of bone metabolism. Rheumatoid factor titer, which is an independent marker for disease progression in RA, was higher in bb patients. Our data suggest, that the imbalance in B and b allele expression may be involved in the pathogenesis of RA-associated osteoporosis. The possible involvement of vitamin D and VDR gene polymorphisms in the development and progression of RA needs further elucidation.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Adult
Aged
Alleles
Arthritis, Rheumatoid
Bone Density
Deoxyribonucleases, Type II Site-Specific
Female
Genetic Markers
Genetic Predisposition to Disease
Genotype
Humans
Hungary
Male
Middle Aged
Osteoporosis
Polymorphism, Genetic
Postmenopause
Receptors, Calcitriol
Megjelenés:Rheumatology International. - 26 : 11 (2006), p. 964-971. -
További szerzők:Pákozdi Angéla Lakatos Péter Zilahi Erika (1964-) (molekuláris biológus) Sipka Sándor (1945-) (laboratóriumi szakorvos) Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Internet cím:elektronikus változat
DOI
elektronikus változat
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4.

001-es BibID:BIBFORM071723
Első szerző:Sipka Sándor (laboratóriumi szakorvos)
Cím:Down-regulation of increased TRAF6 expression in the peripheral mononuclear cells of patients with primary Sjögren's syndrome by an EBV-EBER1-specific synthetic single-stranded complementary DNA molecule / Sipka Sándor, Zilahi Erika, Papp Gábor, Chen Ji-Qing, Nagy Andrea, Hegyi Katalin, Kónya József, Zeher Margit
Dátum:2017
ISSN:1756-1841
Megjegyzések:AIM:We described earlier a simultaneously increased that the increased expression of miRNA-146a/b was accompanied by an increase in the expression of and TRAF6 and a decrease in the expression of IRAK1 genes in the peripheral mononuclear cells (PBMCs) of patients with primary Sjogren's syndrome (pSS) patients. Recently, the expression of EBV encoded. RNA (EBER) was published in the B cells of salivary glands of in pSS. In the present study, we applied an EBV-EBER1 specific synthetic single stranded complementary DNA molecule (EBV-EBER1-cDNA) to test whether any EBER1 related effect exists also in PBMCs of pSS patients.METHODS:In the PBMCs of pSS patients and healthy controls, we investigated in vitro the effects of a synthetic single stranded EBV-EBER1-cDNA molecule, synthetic double-stranded (ds)RNA polyinosinic-polycytidylic acid [poly (I:C)] and polyadenylic acid potassium salt poly-adenylic acid [poly-(A)] on the expression of TRAF6 gene tested by qRTPCR. The release of interferon -? was detected by ELISA.RESULTS:EBV-EBER1-cDNA resulted in a significant reduction in the expression of TRAF6 in the cells of patients, but in the healthy controls not, whereas the treatments with poly (I:C) and poly-(A) could not reduce the TRAF6 over-expression. No release of EBER1 could be observed in the culture supernatants of patients with pSS. Only the treatment with poly (I:C) resulted in a significant increase of interferon -? release, and only in the heathy controls. No release of EBER1 molecules took place during the culturing of cells. EBV-EBER- cDNA acted functionally on the cells of patients only.CONCLUSION:These findings give a further evidence of the linkage between EBV and pSS, furthermore, they show the possible role of EBV-EBER1 in the induction of increased TRAF6 expression in the peripheral B cells of Sjögren's patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:International Journal of Rheumatic Diseases 20 : 5 (2017), p. 614-621. -
További szerzők:Zilahi Erika (1964-) (molekuláris biológus) Papp Gábor (1984-) (belgyógyász) Chen, Ji-Qing Nagy Andrea (1958-) (csecsemő és gyermekgyógyász, neonatológus) Dull Katalin (1983-) (molekuláris biológus, genetikus) Kónya József (1964-) (szakorvos, klinikai mikrobiológus) Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus)
Pályázati támogatás:K 71833
OTKA
K 101470
OTKA
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM028786
Első szerző:Váróczy László (belgyógyász, haematológus)
Cím:Fc-gamma-receptor IIIa polymorphism and gene expression profile do not predict the prognosis in diffuse large B-cell lymphoma treated with R-CHOP protocol / László Váróczy, Erika Zilahi, Ágnes Gyetvai, Béla Kajtár, Lajos Gergely, Sándor Sipka, Árpád Illés
Dátum:2012
ISSN:1219-4956
Megjegyzések:The addition of rituximab to conventional chemotherapy has significantly improved the treatment outcome in diffuse large B-cell lymphoma. However, differences in treatment response and survival data can be observed independently from the International Prognostic Index scores. The current study evaluated the impact of Fc-gamma-receptor IIIa polymorphism and gene expression profile on the response of DLBCL patients to R-CHOP therapy as well as on their survival results. Fifty-one patients were involved, thirty-two females, nineteen males, their median age was 53.1 years. The FCGR3A polymorphism at the 158. amino acid position determined with PCR method showed the following results: VV: 12 cases (23.5%), VF: 29 cases (56.8%) and FF: 10 cases (19.6%), respectively. There was no significant difference between the treatment responses of the three groups. The event-free survival data were less favorable in the F-allele carriers than in V/V homozygous patients, but without any significancy, and the overall survival curves were almost the same. As for the gene expression profile, 20 patients' biopsy specimens showed germinal center and 31 showed non-germinal center characteristics. Treatment results did not differ from each other in the two groups. Both the event-free and the overall survival data were more favorable in the GC group, however the differences were not significant. Our results contest the predictive value of Fc-gamma-receptor IIIa polymorphism and gene expression profile in diffuse large B-cell lymphoma.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Diffuse large B-cell lymphoma
Rituximab
Fc-gamma-receptor IIIa polymorphism
Gene expression profile
Treatment response
Survival
egyetemen (Magyarországon) készült közlemény
Megjelenés:Pathology and Oncology Research 18 : 1 (2012), p. 43-48. -
További szerzők:Zilahi Erika (1964-) (molekuláris biológus) Gyetvai Ágnes Kajtár Béla (1977-) (patológus) Gergely Lajos (1965-) (belgyógyász, haematológus) Sipka Sándor (1945-) (laboratóriumi szakorvos) Illés Árpád (1959-) (belgyógyász, haematológus, onkológus)
Pályázati támogatás:MECANTURA
Egyéb
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Intézményi repozitóriumban (DEA) tárolt változat
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6.

001-es BibID:BIBFORM028791
Első szerző:Zilahi Erika (molekuláris biológus)
Cím:Increased microRNA-146a/b, TRAF6 gene and decreased IRAK1 gene expressions in the peripheral mononuclear cells of patients with Sjögren's syndrome / Erika Zilahi, Tünde Tarr, Gábor Papp, Zoltán Griger, Sándor Sipka, Margit Zeher
Dátum:2012
ISSN:0165-2478
Megjegyzések:MicroRNA-146a (miR-146a) is a microRNA supposed to regulate innate immune, inflammatory response and antiviral pathway negatively. Recently, its potential use as a biomarker for disease diagnosis, prevention and treatment has become widely investigated. In the current study, we measured the expression of miR-146a/b, and their target genes, IRAK1, IRAK4, TRAF6 in the peripheral mononuclear cells of patients with Sjögren's syndrome (n = 21) and healthy controls (n = 10) by quantitative reverse transcription polymerase chain reaction. We found that both miR-146a and miR-146b, furthermore, the gene of TRAF6 were significantly overexpressed in the Sjögren's patients, whereas the expression of IRAK1 gene was significantly decreased. The expression of IRAK4 did not differ significantly. These results suggest that in the peripheral mononuclear cells of Sjögren's patients, the transcriptional repression of IRAK1 is taking place, whereas the other NF-?B pathway regulating gene, TRAF6 is overexpressed. As IRAK1 has been regarded a crucial gene in the pathogenesis of systemic lupus erythematosus, TRAF6 can be a Sjögren's syndrome specific biomarker, confirming and partly explaining the existance of different pathogenic pathways in the two diseases. These observations, however, need still wider confirmations.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Egészség- és Környezettudomány
egyetemen (Magyarországon) készült közlemény
MicroRNA-146a
IRAK1
TRAF6
Sjögren's syndrome
egyetemen (Magyarországon) készült közlemény
Megjelenés:Immunology Letters 141 : 2 (2012), p. 165-168. -
További szerzők:Tarr Tünde (1976-) (belgyógyász, allergológus és klinikai immunológus) Papp Gábor (1984-) (belgyógyász) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Sipka Sándor (1945-) (laboratóriumi szakorvos) Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus)
Pályázati támogatás:TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
Szisztémás szklerózis
Internet cím:Szerző által megadott URL
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Intézményi repozitóriumban (DEA) tárolt változat
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7.

001-es BibID:BIBFORM040672
035-os BibID:PMID:16331753
Első szerző:Zsilák Szilvia
Cím:HLA-DR genotypes in familial rheumatoid arthritis : increased frequency of protective and neutral alleles in a multicase family / Szilvia Zsilák, János Gál, László Hodinka, Katalin Rajczy, Attila Balog, Sándor Sipka, Sándor Baráth, Anikó Kapitány, Erika Zilahi, Zoltán Szekanecz
Dátum:2005
Megjegyzések:We describe a unique family where each of the 5 siblings in the second generation has rheumatoid arthritis (RA). Two other members of the family have RA and systemic lupus erythematosus (SLE), respectively. No members of previous generations in the family had documented inflammatory arthritis. Due to the suspected genetic predisposition, HLA-DR genotypes were determined in the affected siblings and their parents, children, and grandchildren. We investigated the possible role of various HLA-DR alleles in the evolution of RA in this multicase family. METHODS: HLA-DRB1* alleles were determined by polymerase chain reaction using the sequence-specific primer-Olerup method. RESULTS: The most common alleles in the 6 persons with RA were HLA-DRB1*07 and DRB1*15, which are known to be protective and neutral in RA. No patient or family member carried any HLA-DR4 alleles. CONCLUSION: HLA-DRB1*07 and DRB1*15 alleles are thought to be protective or neutral in RA. However, the majority of RA patients in the family and nearly half of all family members carried these alleles, suggesting a role of these genotypes in susceptibility to RA. No RA patient in this family carried HLA-DR4 alleles. Thus, in our rare family with 6 RA cases, an unexpected genetic background may be involved in the increased susceptibility to inflammatory arthritis.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Adult
Arthritis, Rheumatoid
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
HLA-DR Antigens
Humans
Lupus Erythematosus, Systemic
Male
egyetemen (Magyarországon) készült közlemény
Megjelenés:The Journal of Rheumatology. - 32 : 12 (2005), p. 2299-2302. -
További szerzők:Gál János Hodinka László Rajczy Katalin Balog Attila Sipka Sándor (1945-) (laboratóriumi szakorvos) Baráth Sándor (1977-) (biológus) Kapitány Anikó (1979-) (molekuláris biológus) Zilahi Erika (1964-) (molekuláris biológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Internet cím:Szerző által megadott URL
Intézményi repozitóriumban (DEA) tárolt változat
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