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001-es BibID:BIBFORM006055
035-os BibID:PM:2272119
Első szerző:Timár József
Cím:Modulation of membrane phenotype, matrix adhesion and microinvasiveness of metastatic tumour cells by HUdR / Timar, J., Pogany, G., Balazs, M., Szollosi, J., Ladanyi, A., Olah, J., Timar, F., Lapis, K., Jeney, A.
Dátum:1990
Megjegyzések:The effect of HUdR, proved to be anti-metastatic in vivo, was studied in vitro on cell proliferation, nucleoside uptake, membrane fluidity, expression of galactosylated glycans and proteoglycans in metastatic HM tumour cells. The observed increase in membrane fluidity and the suppression of nucleoside transport were early events of the HUdR action followed by decrease of galactosylated glycan and HSPG expression. However, these changes did not influence the proliferation capacity of the cells at the concentrations studied. As a consequence of the membrane alterations a reduced adhesiveness and spreading on extracellular matrix components was detected. In addition, the HUdR treated HM cells showed reduced capacity to invade fibroblast monolayers in vitro. Based on these observations, HUdR could be the prototype of new anti-metastatic agents acting at the level of tumour-host interaction.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
analysis
Animal
Antimetabolites,Antineoplastic
Cell Adhesion
Cell Division
Cell Membrane
chemistry
Deoxyuridine
diagnostic use
drug effects
Extracellular Matrix
Glycoconjugates
Human
Hungary
immunology
In Vitro
Membrane Fluidity
metabolism
Neoplasm Invasiveness
Nucleosides
pathology
pharmacology
Phenotype
physiology
Proteoglycans
Research
Tritium
Megjelenés:Cell Biochemistry and Function. - 8 : 4 (1990), p. 211-220. -
További szerzők:Pogány G. Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus) Szöllősi János (1953-) (biofizikus) Ladányi A. Oláh J. Timár F. Lapis Károly Jeney A.
Internet cím:DOI
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