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001-es BibID:BIBFORM092039
035-os BibID:(cikkazonosító)401 (scopus)85077911940 (wos)000515380000031
Első szerző:Costea, Teodora
Cím:Alleviation of Multidrug Resistance by Flavonoid and Non-Flavonoid Compounds in Breast, Lung, Colorectal and Prostate Cancer / Teodora Costea , Oana Cezara Vlad, Luminita-Claudia Miclea, Constanta Ganea, János Szöllősi, Maria-Magdalena Mocanu
Dátum:2020
ISSN:1661-6596 1422-0067
Megjegyzések:The aim of the manuscript is to discuss the influence of plant polyphenols in overcoming multidrug resistance in four types of solid cancers (breast, colorectal, lung and prostate cancer). Effective treatment requires the use of multiple toxic chemotherapeutic drugs with different properties and targets. However, a major cause of cancer treatment failure and metastasis is the development of multidrug resistance. Potential mechanisms of multidrug resistance include increase of drug efflux, drug inactivation, detoxification mechanisms, modification of drug target, inhibition of cell death, involvement of cancer stem cells, dysregulation of miRNAs activity, epigenetic variations, imbalance of DNA damage/repair processes, tumor heterogeneity, tumor microenvironment, epithelial to mesenchymal transition and modulation of reactive oxygen species. Taking into consideration that synthetic multidrug resistance agents have failed to demonstrate significant survival benefits in patients with different types of cancer, recent research have focused on beneficial effects of natural compounds. Several phenolic compounds (flavones, phenolcarboxylic acids, ellagitannins, stilbens, lignans, curcumin, etc.) act as chemopreventive agents due to their antioxidant capacity, inhibition of proliferation, survival, angiogenesis, and metastasis, modulation of immune and inflammatory responses or inactivation of pro-carcinogens. Moreover, preclinical and clinical studies revealed that these compounds prevent multidrug resistance in cancer by modulating different pathways. Additional research is needed regarding the role of phenolic compounds in the prevention of multidrug resistance in different types of cancer
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
chemoresistance
malignancy
phenolic compounds
Megjelenés:International Journal Of Molecular Sciences. - 21 : 2 (2020), p. 1-52. -
További szerzők:Vlad, Oana Cezara Miclea, Luminita-Claudia Ganea, Constanta Szöllősi János (1953-) (biofizikus) Mocanu, Maria-Magdalena
Pályázati támogatás:GINOP-2.3.2-15-2016-00050
GINOP
GINOP-2.3.3-15-2016-00003
GINOP
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2.

001-es BibID:BIBFORM077632
035-os BibID:(cikkazonosító)1062 (scopus)85063627035 (wos)000462542300061
Első szerző:Costea, Teodora
Cím:Molecular Mechanisms and Bioavailability of Polyphenols in Prostate Cancer / Teodora Costea, Péter Nagy, Constanța Ganea, János Szöllősi, Maria-Magdalena Mocanu
Dátum:2019
ISSN:1661-6596 1422-0067
Megjegyzések:: Prostate cancer is the one of the most frequently diagnosed cancers among men over the age of 50. Several lines of evidence support the observation that polyphenols have preventive and therapeutic effects in prostate cancer. Moreover, prostate cancer is ideal for chemoprevention due to its long latency. We propose here an equilibrated lifestyle with a diet rich in polyphenols as prophylactic attempts to slow down the progression of localized prostate cancer or prevent the occurrence of the disease. In this review, we will first summarize the molecular mechanisms of polyphenols in prostate cancer with a focus on the antioxidant and pro-oxidant effects, androgen receptors (AR), key molecules involved in AR signaling and their transactivation pathways, cell cycle, apoptosis, angiogenesis, metastasis, genetic aspects, and epigenetic mechanisms. The relevance of the molecular mechanisms is discussed in light of current bioavailability data regarding the activity of polyphenols in prostate cancer. We also highlight strategies for improving the bioavailability of polyphenols. We hope that this review will lead to further research regarding the bioavailability and the role of polyphenols in prostate cancer prevention and treatment.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
dietary polyphenols
bioavailability
molecular mechanisms
prostate cancer
Megjelenés:International Journal of Molecular Sciences. - 20 : 5 (2019), p. 1-39. -
További szerzők:Nagy Péter (1971-) (biofizikus) Ganea, Constanta Szöllősi János (1953-) (biofizikus) Mocanu, Maria-Magdalena
Pályázati támogatás:GINOP-2.3.2-15-2016-00020
GINOP
GINOP-2.3.2-15-2016-00044
GINOP
GINOP-2.3.3-15-2016-00003
GINOP
K120302
Egyéb
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3.

001-es BibID:BIBFORM062699
035-os BibID:(scopus)84925853989 (wos)000354040400007
Első szerző:Shrestha, Dilip (biológus)
Cím:Understanding FRET as a Research Tool for Cellular Studies / Dilip Shrestha, Attila Jenei, Péter Nagy, György Vereb, János Szöllősi
Dátum:2015
ISSN:1661-6596 1422-0067
Megjegyzések:Communication of molecular species through dynamic association and/or dissociation at various cellular sites governs biological functions. Understanding these physiological processes require delineation of molecular events occurring at the level of individual complexes in a living cell. Among the few non-invasive approaches with nanometer resolution are methods based on Förster Resonance Energy Transfer (FRET). FRET is effective at a distance of 1?10 nm which is equivalent to the size of macromolecules, thus providing an unprecedented level of detail on molecular interactions. The emergence of fluorescent proteins and SNAP- and CLIP- tag proteins provided FRET with the capability to monitor changes in a molecular complex in real-time making it possible to establish the functional significance of the studied molecules in a native environment. Now, FRET is widely used in biological sciences, including the field of proteomics, signal transduction, diagnostics and drug development to address questions almost unimaginable with biochemical methods and conventional microscopies. However, the underlying physics of FRET often scares biologists. Therefore, in this review, our goal is to introduce FRET to non-physicists in a lucid manner. We will also discuss our contributions to various FRET methodologies based on microscopy and flow cytometry, while describing its application for determining the molecular heterogeneity of the plasma membrane in various cell types.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
FRET
Megjelenés:International Journal Of Molecular Sciences. - 16 : 4 (2015), p. 6718-6756. -
További szerzők:Jenei Attila (1966-) (biofizikus) Nagy Péter (1971-) (biofizikus) Vereb György (1965-) (biofizikus, orvos) Szöllősi János (1953-) (biofizikus)
Pályázati támogatás:MTA-DE
MTA
Sejtbiológiai és Jelátvitel Kutatócsoport
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM083356
035-os BibID:(cikkazonosító)1039 (scopus)85079082860 (wos)000522551606025
Első szerző:Tóth Gábor (általános orvos)
Cím:A Small Number of HER2 Redirected CAR T Cells Significantly Improves Immune Response of Adoptively Transferred Mouse Lymphocytes against Human Breast Cancer Xenografts / Tóth Gábor, Szöllősi János, Abken Hinrich, Vereb György, Szöőr Árpád
Dátum:2020
ISSN:1661-6596 1422-0067
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:International Journal Of Molecular Sciences. - 21 : 3 (2020), p. 1-11. -
További szerzők:Szöllősi János (1953-) (biofizikus) Abken, Hinrich Vereb György (1965-) (biofizikus, orvos) Szöőr Árpád (1984-) (orvos)
Pályázati támogatás:K119690
OTKA
FK132773
OTKA
GINOP-2.3.2-15-2016-00050
GINOP
Deutsche Krebshilfe, Bonn, FRG
Egyéb
János Bolyai Research Scholarship of the Hungarian Academy of Sciences
MTA
UNKP-19-4-DE-167 New National Excellence Program of the Ministry for Innovation and Technology
Egyéb
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM079931
035-os BibID:(cikkazonosító)3370 (scopus)85071327332 (wos)000477041100254
Első szerző:Vámosi György (biofizikus)
Cím:EGF Receptor Stalls upon Activation as Evidenced by Complementary Fluorescence Correlation Spectroscopy and Fluorescence Recovery after Photobleaching Measurements / Vámosi György, Friedländer-Brock Elza, Ibrahim Shehu M., Brock Roland, Szöllősi János, Vereb György
Dátum:2019
ISSN:1661-6596 1422-0067
Megjegyzések:To elucidate the molecular details of the activation-associated clustering of epidermal growth factor receptors (EGFRs), the time course of the mobility and aggregation states of eGFP tagged EGFR in the membranes of Chinese hamster ovary (CHO) cells was assessed by in situ mobility assays. Fluorescence correlation spectroscopy (FCS) was used to probe molecular movements of small ensembles of molecules over short distances and time scales, and to report on the state of aggregation. The diffusion of larger ensembles of molecules over longer distances (and time scales) was investigated by fluorescence recovery after photobleaching (FRAP). Autocorrelation functions could be best fitted by a two-component diffusion model corrected for triplet formation and blinking. The slow, 100?1000 ms component was attributed to membrane localized receptors moving with free Brownian diffusion, whereas the fast, ms component was assigned to cytosolic receptors or their fragments. Upon stimulation with 50 nM EGF, a significant decrease from 0.11 to 0.07 ?m2/s in the diffusion coefficient of membrane-localized receptors was observed, followed by recovery to the original value in ~20 min. In contrast, the apparent brightness of diffusing species remained the same. Stripe FRAP experiments yielded a decrease in long-range molecular mobility directly after stimulation, evidenced by an increase in the recovery time of the slow component from 13 to 21.9 s. Our observations are best explained by the transient attachment of ligand-bound EGFRs to immobile or slowly moving structures such as the cytoskeleton or large, previously photobleached receptor aggregates.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Fluorescence correlation spectroscopy
FCS
fluorescence recovery after photobleaching
FRAP
epidermal growth factor receptor
translational diffusion
EGFR?eGFP fusion protein
Megjelenés:International Journal Of Molecular Sciences. - 20 : 13 (2019), p. 1-22. -
További szerzők:Friedländer Elza (1980-) (biofizikus) Ibrahim, Shehu M. Brock Roland Szöllősi János (1953-) (biofizikus) Vereb György (1965-) (biofizikus, orvos)
Pályázati támogatás:K119690
OTKA
NN129371
OTKA
GINOP-2.3.2-15-2016-00050
GINOP
GINOP-2.3.3-15-2016-00003
GINOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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