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001-es BibID:BIBFORM062465
Első szerző:Mocanu, Maria-Magdalena
Cím:Chemoprevention of Breast Cancer by Dietary Polyphenols / Maria-Magdalena Mocanu, Péter Nagy, János Szöllősi
Dátum:2015
ISSN:1420-3049
Megjegyzések:The review will discuss in detail the effects of polyphenols on breast cancer, including both the advantages and disadvantages of the applications of these natural compounds. First, we focus on the characterization of the main classes of polyphenols and then on in vitro and in vivo experiments carried out in breast cancer models. Since the therapeutic effects of the administration of a single type of polyphenol might be limited because of the reduced bioavailability of these drugs, investigations on combination of several polyphenols or polyphenols with conventional therapy will also be discussed. In addition, we present recent data focusing on clinical trials with polyphenols and new approaches with nanoparticles in breast cancer. Besides the clinical and translational findings this review systematically summarizes our current knowledge about the molecular mechanisms of anti-cancer effects of polyphenols, which are related to apoptosis, cell cycle regulation, plasma membrane receptors, signaling pathways and epigenetic mechanisms. At the same time the effects of polyphenols on primary tumor, metastasis and angiogenesis in breast cancer are discussed. The increasing enthusiasm regarding the combination of polyphenols and conventional therapy in breast cancer might lead to additional efforts to motivate further research in this field.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
polyphenols
breast cancer
prevention
apoptosis
cell cycle
signaling pathways
Megjelenés:Molecules. - 20 (2015), p. 22578-22620. -
További szerzők:Nagy Péter (1971-) (biofizikus) Szöllősi János (1953-) (biofizikus)
Pályázati támogatás:K103906
OTKA
NK101337
OTKA
TÁMOP-4.2.2-08/1-2008-0019
TÁMOP
TÁMOP-4.2.1.B-09/1/KONV-2010-0007
TÁMOP
TÁMOP-4.2.2.A-11/1/KONV-2012-0025
TÁMOP
TÁMOP-4.2.2.D-15/1/ KONV-2015-0016
TÁMOP
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DOI
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2.

001-es BibID:BIBFORM004691
035-os BibID:(scopus)17944377750 (wos)000174074500011
Első szerző:Pfeiffer, Alexandra
Cím:The cholesterol content of the plasma membrane as a regulator of CD14 dependent signal transduction / Pfeiffer, A., Kapinsky, M., Orso, E., Schutz, G., Schindler, H., Nagy, P., Rothe, G., Szollosi, J., Damjanovich, S., Schmitz, G.
Dátum:2001
Megjegyzések:Lipopolysaccharide (LPS) is known to bind to several surface molecules on various cells. The best characterized LPS-binding protein is CD14, strongly expressed in the majority of monocytes. Since CD14 is a glycosylphosphatidyl-inositol (GPI)-anchor protein without a cytoplasmic tail, it has been suggested that additional signalling receptors co-associate with CD14 in order to initiate signal transduction cascades. Here we show that after ligand binding in human blood monocytes, the b2-integrin CD11b/CD18 forms clusters with CD14, after ligand binding. Thus, in response to LPS stimulation a receptor complex is formed in the plane of the plasma membrane which may be of central importance for cellular responses to LPS. We also show that another physiologically relevant ligand of CD14, ceramide, which is structurally similar to LPS, induces a complex of CD14 and CD11b/CD18 after binding to CD14.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Cholesterol
Signal Transduction
Megjelenés:Single Molecules. - 2 : 2 (2001), p. 113-115. -
További szerzők:Kapinsky, Michael Orsó Evelyn Schutz, G. Schindler, Hansgeorg Nagy Péter (1971-) (biofizikus) Rothe, Gregor Szöllősi János (1953-) (biofizikus) Damjanovich Sándor (1936-2017) (biofizikus) Schmitz, Gerd
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