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001-es BibID:BIBFORM004690
035-os BibID:(scopus)0035191769 (wos)000172278000004
Első szerző:Pfeiffer, Alexandra
Cím:Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts / Pfeiffer, A., Bottcher, A., Orso, E., Kapinsky, M., Nagy, P., Bodnar, A., Spreitzer, I., Liebisch, G., Drobnik, W., Gempel, K., Horn, M., Holmer, S., Hartung, T., Multhoff, G., Schutz, G., Schindler, H., Ulmer, A. J., Heine, H., Stelter, F., Schutt, C., Rothe, G., Szollosi, J., Damjanovich, S., Schmitz, G.
Dátum:2001
Megjegyzések:The glycosylphosphatidylinositol-anchored receptor CD14 plays a major role in the inflammatory response of monocytes to lipopolysaccharide. Here, we describe that ceramide, a constituent of atherogenic lipoproteins, binds to CD14 and induces clustering of CD14 to co-receptors in rafts. In resting cells, CD14 was associated with CD55, the Fcgamma-receptors CD32 and CD64 and the pentaspan CD47. Ceramide further recruited the complement receptor 3 (CD11b/CD18) and CD36 into proximity of CD14. Lipopolysaccharide, in addition, induced co-clustering with Toll-like receptor 4, Fcgamma-RIIIa (CD16a) and the tetraspanin CD81 while CD47 was dissociated. The different receptor complexes may be linked to ligand-specific cellular responses initiated by CD14.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Antigens,CD
Antigens,CD14
Carrier Proteins
Ceramides
chemistry
Glycoproteins
Human
Inflammation
Ligands
Lipopolysaccharides
Macrophage-1 Antigen
Membrane Glycoproteins
Membrane Microdomains
metabolism
Monocytes
pharmacology
Receptors,Cell Surface
Support,Non-U.S.Gov't
Megjelenés:European Journal of Immunology. - 31 : 11 (2001), p. 3153-3164. -
További szerzők:Böttcher, Alfred Orsó Evelyn Kapinsky, Michael Nagy Péter (1971-) (biofizikus) Dóczy-Bodnár Andrea (1970-) (biofizikus) Spreitzer, Ingo Liebisch, Gerhard Drobnik, Wolfgang Gempel, Klaus Horn, Markus Holmer, Stefan Hartung, Thomas Multhoff, Gabriele Schütz, Gerhard Schindler, Hansgeorg Ulmer, Artur J. Heine, Holger Stelter, Felix Schütt, Christine Rothe, Gregor Szöllősi János (1953-) (biofizikus) Damjanovich Sándor (1936-2017) (biofizikus) Schmitz, Gerd
Internet cím:DOI
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2.

001-es BibID:BIBFORM004691
035-os BibID:(scopus)17944377750 (wos)000174074500011
Első szerző:Pfeiffer, Alexandra
Cím:The cholesterol content of the plasma membrane as a regulator of CD14 dependent signal transduction / Pfeiffer, A., Kapinsky, M., Orso, E., Schutz, G., Schindler, H., Nagy, P., Rothe, G., Szollosi, J., Damjanovich, S., Schmitz, G.
Dátum:2001
Megjegyzések:Lipopolysaccharide (LPS) is known to bind to several surface molecules on various cells. The best characterized LPS-binding protein is CD14, strongly expressed in the majority of monocytes. Since CD14 is a glycosylphosphatidyl-inositol (GPI)-anchor protein without a cytoplasmic tail, it has been suggested that additional signalling receptors co-associate with CD14 in order to initiate signal transduction cascades. Here we show that after ligand binding in human blood monocytes, the b2-integrin CD11b/CD18 forms clusters with CD14, after ligand binding. Thus, in response to LPS stimulation a receptor complex is formed in the plane of the plasma membrane which may be of central importance for cellular responses to LPS. We also show that another physiologically relevant ligand of CD14, ceramide, which is structurally similar to LPS, induces a complex of CD14 and CD11b/CD18 after binding to CD14.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Cholesterol
Signal Transduction
Megjelenés:Single Molecules. - 2 : 2 (2001), p. 113-115. -
További szerzők:Kapinsky, Michael Orsó Evelyn Schutz, G. Schindler, Hansgeorg Nagy Péter (1971-) (biofizikus) Rothe, Gregor Szöllősi János (1953-) (biofizikus) Damjanovich Sándor (1936-2017) (biofizikus) Schmitz, Gerd
Internet cím:elektronikus változat
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