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1.

001-es BibID:BIBFORM092039
035-os BibID:(cikkazonosító)401 (scopus)85077911940 (wos)000515380000031
Első szerző:Costea, Teodora
Cím:Alleviation of Multidrug Resistance by Flavonoid and Non-Flavonoid Compounds in Breast, Lung, Colorectal and Prostate Cancer / Teodora Costea , Oana Cezara Vlad, Luminita-Claudia Miclea, Constanta Ganea, János Szöllősi, Maria-Magdalena Mocanu
Dátum:2020
ISSN:1661-6596 1422-0067
Megjegyzések:The aim of the manuscript is to discuss the influence of plant polyphenols in overcoming multidrug resistance in four types of solid cancers (breast, colorectal, lung and prostate cancer). Effective treatment requires the use of multiple toxic chemotherapeutic drugs with different properties and targets. However, a major cause of cancer treatment failure and metastasis is the development of multidrug resistance. Potential mechanisms of multidrug resistance include increase of drug efflux, drug inactivation, detoxification mechanisms, modification of drug target, inhibition of cell death, involvement of cancer stem cells, dysregulation of miRNAs activity, epigenetic variations, imbalance of DNA damage/repair processes, tumor heterogeneity, tumor microenvironment, epithelial to mesenchymal transition and modulation of reactive oxygen species. Taking into consideration that synthetic multidrug resistance agents have failed to demonstrate significant survival benefits in patients with different types of cancer, recent research have focused on beneficial effects of natural compounds. Several phenolic compounds (flavones, phenolcarboxylic acids, ellagitannins, stilbens, lignans, curcumin, etc.) act as chemopreventive agents due to their antioxidant capacity, inhibition of proliferation, survival, angiogenesis, and metastasis, modulation of immune and inflammatory responses or inactivation of pro-carcinogens. Moreover, preclinical and clinical studies revealed that these compounds prevent multidrug resistance in cancer by modulating different pathways. Additional research is needed regarding the role of phenolic compounds in the prevention of multidrug resistance in different types of cancer
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
chemoresistance
malignancy
phenolic compounds
Megjelenés:International Journal Of Molecular Sciences. - 21 : 2 (2020), p. 1-52. -
További szerzők:Vlad, Oana Cezara Miclea, Luminita-Claudia Ganea, Constanta Szöllősi János (1953-) (biofizikus) Mocanu, Maria-Magdalena
Pályázati támogatás:GINOP-2.3.2-15-2016-00050
GINOP
GINOP-2.3.3-15-2016-00003
GINOP
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2.

001-es BibID:BIBFORM077632
035-os BibID:(cikkazonosító)1062 (scopus)85063627035 (wos)000462542300061
Első szerző:Costea, Teodora
Cím:Molecular Mechanisms and Bioavailability of Polyphenols in Prostate Cancer / Teodora Costea, Péter Nagy, Constanța Ganea, János Szöllősi, Maria-Magdalena Mocanu
Dátum:2019
ISSN:1661-6596 1422-0067
Megjegyzések:: Prostate cancer is the one of the most frequently diagnosed cancers among men over the age of 50. Several lines of evidence support the observation that polyphenols have preventive and therapeutic effects in prostate cancer. Moreover, prostate cancer is ideal for chemoprevention due to its long latency. We propose here an equilibrated lifestyle with a diet rich in polyphenols as prophylactic attempts to slow down the progression of localized prostate cancer or prevent the occurrence of the disease. In this review, we will first summarize the molecular mechanisms of polyphenols in prostate cancer with a focus on the antioxidant and pro-oxidant effects, androgen receptors (AR), key molecules involved in AR signaling and their transactivation pathways, cell cycle, apoptosis, angiogenesis, metastasis, genetic aspects, and epigenetic mechanisms. The relevance of the molecular mechanisms is discussed in light of current bioavailability data regarding the activity of polyphenols in prostate cancer. We also highlight strategies for improving the bioavailability of polyphenols. We hope that this review will lead to further research regarding the bioavailability and the role of polyphenols in prostate cancer prevention and treatment.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
dietary polyphenols
bioavailability
molecular mechanisms
prostate cancer
Megjelenés:International Journal of Molecular Sciences. - 20 : 5 (2019), p. 1-39. -
További szerzők:Nagy Péter (1971-) (biofizikus) Ganea, Constanta Szöllősi János (1953-) (biofizikus) Mocanu, Maria-Magdalena
Pályázati támogatás:GINOP-2.3.2-15-2016-00020
GINOP
GINOP-2.3.2-15-2016-00044
GINOP
GINOP-2.3.3-15-2016-00003
GINOP
K120302
Egyéb
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3.

001-es BibID:BIBFORM074167
Első szerző:Filippi, Alexandru
Cím:Epigallocatechin-3-gallate alleviates the malignant phenotype in A-431 epidermoid and SK-BR-3 breast cancer cell lines / Filippi Alexandru, Picot Tiphanie, Aanei Carmen Mariana, Nagy Péter, Szöllősi János, Campos Lydia, Ganea Constanţa, Mocanu Maria-Magdalena
Dátum:2018
ISSN:0963-7486
Megjegyzések:In this study, we evaluated the effects of epigallocatechin-3-O-gallate (EGCG) in two cancer cell lines, A-431 overexpressing ErbB1 and SK-BR-3, overexpressing ErbB2. EGCG treatment showed dose-dependent collapse of mitochondrial membrane potential (??m), increase in reactive oxygen species (ROS) production, changes in nuclear morphology and reduced viability. Flow cytometry data indicated that EGCG partially decreases the phosphorylation of several proteins involved in cell proliferation and survival: pErbB1(Y1173, Y1068), pAkt(S473) and pERK(Y204). EGCG affected the clonogenic growth in both cell lines with an EC50 of 2.5 and 5.4??M for A-431 and SK-BR-3, respectively. Wound scratch assay demonstrated that EGCG inhibited the healing in dose-dependent manner and the effect was correlated with partial reduction in phosphorylation of pFAK(S910). Our data suggest that EGCG administration might reduce the unfavourable traits, particularly associated with ErbB1/EGFR overexpression.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:International Journal Of Food Sciences And Nutrition. - 69 : 5 (2018), p. 584-597. -
További szerzők:Picot, Tiphanie Aanei, Carmen Mariana Nagy Péter (1971-) (biofizikus) Szöllősi János (1953-) (biofizikus) Campos, Lydia Ganea, Constanta Mocanu, Maria-Magdalena
Pályázati támogatás:K120302
OTKA
K103906
OTKA
GINOP-2.3.2-15-2016-00020
GINOP
GINOP-2.3.2-15-2016-00050
GINOP
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM070072
035-os BibID:(WoS)000405907100005 (Scopus)85023170074
Első szerző:Mocanu, Maria-Magdalena
Cím:Detection of protein interactions by Subcellular Localization Assay / Mocanu Maria-Magdalena, Nagy Péter, Szöllősi János
Dátum:2017
ISSN:1552-4922 1552-4930
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Cytometry Part A. - 91 : 7 (2017), p. 657-658. -
További szerzők:Nagy Péter (1971-) (biofizikus) Szöllősi János (1953-) (biofizikus)
Pályázati támogatás:GINOP-2.3.2-15-2016-00050
GINOP
GINOP-2.3.2-15-2016-00020
GINOP
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5.

001-es BibID:BIBFORM062465
Első szerző:Mocanu, Maria-Magdalena
Cím:Chemoprevention of Breast Cancer by Dietary Polyphenols / Maria-Magdalena Mocanu, Péter Nagy, János Szöllősi
Dátum:2015
ISSN:1420-3049
Megjegyzések:The review will discuss in detail the effects of polyphenols on breast cancer, including both the advantages and disadvantages of the applications of these natural compounds. First, we focus on the characterization of the main classes of polyphenols and then on in vitro and in vivo experiments carried out in breast cancer models. Since the therapeutic effects of the administration of a single type of polyphenol might be limited because of the reduced bioavailability of these drugs, investigations on combination of several polyphenols or polyphenols with conventional therapy will also be discussed. In addition, we present recent data focusing on clinical trials with polyphenols and new approaches with nanoparticles in breast cancer. Besides the clinical and translational findings this review systematically summarizes our current knowledge about the molecular mechanisms of anti-cancer effects of polyphenols, which are related to apoptosis, cell cycle regulation, plasma membrane receptors, signaling pathways and epigenetic mechanisms. At the same time the effects of polyphenols on primary tumor, metastasis and angiogenesis in breast cancer are discussed. The increasing enthusiasm regarding the combination of polyphenols and conventional therapy in breast cancer might lead to additional efforts to motivate further research in this field.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
polyphenols
breast cancer
prevention
apoptosis
cell cycle
signaling pathways
Megjelenés:Molecules. - 20 (2015), p. 22578-22620. -
További szerzők:Nagy Péter (1971-) (biofizikus) Szöllősi János (1953-) (biofizikus)
Pályázati támogatás:K103906
OTKA
NK101337
OTKA
TÁMOP-4.2.2-08/1-2008-0019
TÁMOP
TÁMOP-4.2.1.B-09/1/KONV-2010-0007
TÁMOP
TÁMOP-4.2.2.A-11/1/KONV-2012-0025
TÁMOP
TÁMOP-4.2.2.D-15/1/ KONV-2015-0016
TÁMOP
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6.

001-es BibID:BIBFORM057539
035-os BibID:(scopus)84896847673 (wos)000332354700009
Első szerző:Mocanu, Maria-Magdalena
Cím:Epigallocatechin 3-O-gallate induces 67 kDa laminin receptor-mediated cell death accompanied by downregulation of ErbB proteins and altered lipid raft clustering in mammary and epidermoid carcinoma cells / Maria-Magdalena Mocanu, Constanta Ganea, Laura Georgescu, Tímea Váradi, Dilip Shrestha, Irina Baran, Eva Katona, Peter Nagy, János Szöllősi
Dátum:2014
ISSN:0163-3864
Megjegyzések:Since the administration of synthetic medicines is associated with drug resistance and undesired side effects, utilization of natural compounds could be an alternative and complementary modality to inhibit or prevent the development of tumors. Epigallocatechin 3-O-gallate (EGCG, 1), the major flavan component of green tea, and genistein (2), a soy isoflavonoid, are known to have chemopreventive and chemotherapeutic effects against cancer. This study demonstrated that both flavonoids inhibit cell proliferation, an effect enhanced under serum-free conditions. Compound 1, but not 2, induced downregulation of ErbB1 and ErbB2 in mammary and epidermoid carcinoma cells, and its inhibitory effect on cell viability was mediated by the 67 kDa laminin receptor (67LR). While 1 was superior in inducing cell death, 2 was more efficient in arresting the tumor cells in the G2/M phase. Furthermore, number and brightness analysis revealed that 1 decreased the homoclustering of a lipid raft marker, glycosylphosphatidylinositol-anchored GFP, and it also reduced the co-localization between lipid rafts and 67LR. The main conclusion made is that the primary target of 1 may be the lipid raft component of the plasma membrane followed by secondary changes in the expression of ErbB proteins. Compound 2, on the other hand, must have other unidentified targets.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Epigallocatechin
Molekuláris Medicina
Megjelenés:Journal Of Natural Products. - 77 : 2 (2014), p. 250-257. -
További szerzők:Ganea, Constanta Georgescu, Laura Váradi Tímea (1982-) (okleveles vegyész) Shrestha, Dilip (1980-) (biológus) Baran, Irina Katona Éva (1961-) (klinikai biokémikus) Nagy Péter (1971-) (biofizikus) Szöllősi János (1953-) (biofizikus)
Pályázati támogatás:TÁMOP-4.2.2-08/1-2008-0019
TÁMOP
TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
Receptor tirozin kinázok mint terápiás célpontok: működésük szabályozásának, és a közöttük fellépő molekuláris kölcsönhatások vizsgálata
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7.

001-es BibID:BIBFORM042484
035-os BibID:(scopus)23844475901 (wos)000231845600013
Első szerző:Mocanu, Maria-Magdalena
Cím:Associations of ErbB2, beta1-integrin and lipid rafts on Herceptin (Trastuzumab) resistant and sensitive tumor cell lines / Maria-Magdalena Mocanu, Zsolt Fazekas, Miklós Petrás, Péter Nagy, Zsolt Sebestyén, Jorma Isola, József Tímár, John W. Park, György Vereb, János Szöllősi
Dátum:2005
ISSN:0304-3835
Megjegyzések:ErbB2-mediated transmembrane signaling is a key target of novel anticancer agents such as Herceptin. Our comparison of Herceptin resistant (JIMT-1, MKN-7) and sensitive (SKBR-3, N-87) cell lines demonstrates the importance of ErbB2 association patterns involving integrins and lipid rafts. Flow cytometric FRET and confocal microscopic measurements revealed colocalization and molecular proximity between b1-integrins and ErbB2, as well as their association with lipid rafts. A weak functional interaction between ErbB2 and b1-integrin and the fact that ErbB2 did not co-patch with b1-integrins uponcrosslinking imply that ErbB2 and b1-integrin define two distinct molecular association clusters from a functional point of view. Although Herceptin-sensitive cell lines expressed more ErbB2 and fewer b1-integrin molecules on their surface than their resistant counterparts, this finding probably does not explain the Herceptin resistant phenotype due to the weak interaction between b1-integrins and ErbB2. Our results imply that the true significance of the expression profile of proteins involved inoncogenesis can only be understood after characterizing their molecular interactions.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Antibodies
Antibodies,Monoclonal
Antigens,CD29
Biophysics
Breast Neoplasms
Cell Line
Cell Membrane
Drug Resistance,Neoplasm
Humans
Hungary
Membrane Microdomains
metabolism
pathology
pharmacology
Phenotype
physiology
Proteins
Receptor,erbB-2
Research
Support
Tumor Cells,Cultured
egyetemen (Magyarországon) készült közlemény
Megjelenés:Cancer Letters. - 227 : 2 (2005), p. 201-212. -
További szerzők:Fazekas Zsolt (1971-) (biofizikus) Petrás Miklós (1977-) (orvos) Nagy Péter (1971-) (biofizikus) Sebestyén Zsolt Isola, Jorma Timár József Park, John W. Vereb György (1965-) (biofizikus, orvos) Szöllősi János (1953-) (biofizikus)
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8.

001-es BibID:BIBFORM022767
Első szerző:Mocanu, Maria-Magdalena
Cím:Comparative analysis of fluorescence resonance energy transfer (FRET) and proximity ligation assay (PLA) / Mocanu M. M., Váradi T., Szöllosi J., Nagy P.
Dátum:2011
ISSN:1615-9853
Megjegyzések:Both fluorescence resonance energy transfer (FRET) and proximity ligation assay (PLA) are techniques used in the investigation of protein interactions but the latter has not been evaluated in a systematic way, prompting us to compare their performance quantitatively. Proteins were labeled with oligonucleotide- or fluorophore-conjugated antibodies and their proximity was analyzed by flow cytometry in order to obtain statistically robust data. Both intermolecular and intramolecular PLA signals reached saturation at high expression levels. At the same time, the FRET efficiency was independent of, while the FRET signal exhibited a strict linear correlation with the expression levels of proteins. When the density of oligonucleotide- and fluorophore-conjugated antibodies was systematically changed by competition with unlabeled antibodies the FRET signal was linearly proportional to the amount of bound fluorophore-tagged antibodies, whereas the PLA signal was again saturated. The saturation phenomenon in PLA could not be eliminated by decreasing the duration of the rolling circle amplification reaction. Our data imply that PLA is a semiquantitative measure of protein colocalizations due to non-linear effects in the reaction and that caution should be exercised when interpreting PLA data in a quantitative way.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Cell biology
Fluorescence resonance energy transfer
Flow cytometry
Protein associations
Proximity ligation assay
Megjelenés:Proteomics. - 11 : 10 (2011), p. 2063-2070. -
További szerzők:Váradi Tímea (1982-) (okleveles vegyész) Szöllősi János (1953-) (biofizikus) Nagy Péter (1971-) (biofizikus)
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Intézményi repozitóriumban (DEA) tárolt változat
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