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001-es BibID:	BIBFORM042484
035-os BibID:	(scopus)23844475901 (wos)000231845600013
Első szerző:	Mocanu, Maria-Magdalena
Cím:	Associations of ErbB2, beta1-integrin and lipid rafts on Herceptin (Trastuzumab) resistant and sensitive tumor cell lines / Maria-Magdalena Mocanu, Zsolt Fazekas, Miklós Petrás, Péter Nagy, Zsolt Sebestyén, Jorma Isola, József Tímár, John W. Park, György Vereb, János Szöllősi
Dátum:	2005
ISSN:	0304-3835
Megjegyzések:	ErbB2-mediated transmembrane signaling is a key target of novel anticancer agents such as Herceptin. Our comparison of Herceptin resistant (JIMT-1, MKN-7) and sensitive (SKBR-3, N-87) cell lines demonstrates the importance of ErbB2 association patterns involving integrins and lipid rafts. Flow cytometric FRET and confocal microscopic measurements revealed colocalization and molecular proximity between b1-integrins and ErbB2, as well as their association with lipid rafts. A weak functional interaction between ErbB2 and b1-integrin and the fact that ErbB2 did not co-patch with b1-integrins uponcrosslinking imply that ErbB2 and b1-integrin define two distinct molecular association clusters from a functional point of view. Although Herceptin-sensitive cell lines expressed more ErbB2 and fewer b1-integrin molecules on their surface than their resistant counterparts, this finding probably does not explain the Herceptin resistant phenotype due to the weak interaction between b1-integrins and ErbB2. Our results imply that the true significance of the expression profile of proteins involved inoncogenesis can only be understood after characterizing their molecular interactions.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Antibodies Antibodies,Monoclonal Antigens,CD29 Biophysics Breast Neoplasms Cell Line Cell Membrane Drug Resistance,Neoplasm Humans Hungary Membrane Microdomains metabolism pathology pharmacology Phenotype physiology Proteins Receptor,erbB-2 Research Support Tumor Cells,Cultured egyetemen (Magyarországon) készült közlemény
Megjelenés:	Cancer Letters. - 227 : 2 (2005), p. 201-212. -
További szerzők:	Fazekas Zsolt (1971-) (biofizikus) Petrás Miklós (1977-) (orvos) Nagy Péter (1971-) (biofizikus) Sebestyén Zsolt Isola, Jorma Timár József Park, John W. Vereb György (1965-) (biofizikus, orvos) Szöllősi János (1953-) (biofizikus)
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001-es BibID:	BIBFORM006055
035-os BibID:	PM:2272119
Első szerző:	Timár József
Cím:	Modulation of membrane phenotype, matrix adhesion and microinvasiveness of metastatic tumour cells by HUdR / Timar, J., Pogany, G., Balazs, M., Szollosi, J., Ladanyi, A., Olah, J., Timar, F., Lapis, K., Jeney, A.
Dátum:	1990
Megjegyzések:	The effect of HUdR, proved to be anti-metastatic in vivo, was studied in vitro on cell proliferation, nucleoside uptake, membrane fluidity, expression of galactosylated glycans and proteoglycans in metastatic HM tumour cells. The observed increase in membrane fluidity and the suppression of nucleoside transport were early events of the HUdR action followed by decrease of galactosylated glycan and HSPG expression. However, these changes did not influence the proliferation capacity of the cells at the concentrations studied. As a consequence of the membrane alterations a reduced adhesiveness and spreading on extracellular matrix components was detected. In addition, the HUdR treated HM cells showed reduced capacity to invade fibroblast monolayers in vitro. Based on these observations, HUdR could be the prototype of new anti-metastatic agents acting at the level of tumour-host interaction.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban analysis Animal Antimetabolites,Antineoplastic Cell Adhesion Cell Division Cell Membrane chemistry Deoxyuridine diagnostic use drug effects Extracellular Matrix Glycoconjugates Human Hungary immunology In Vitro Membrane Fluidity metabolism Neoplasm Invasiveness Nucleosides pathology pharmacology Phenotype physiology Proteoglycans Research Tritium
Megjelenés:	Cell Biochemistry and Function. - 8 : 4 (1990), p. 211-220. -
További szerzők:	Pogány G. Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus) Szöllősi János (1953-) (biofizikus) Ladányi A. Oláh J. Timár F. Lapis Károly Jeney A.
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