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001-es BibID:	BIBFORM027720
Első szerző:	Kárpáti István (belgyógyász, nephrológus)
Cím:	Disturbed LDL and scavenger receptor functions in monocytes from chronic haemodialysed patients / István Kárpáti, György Paragh, Éva Kovács, Zoltán Balogh, Márton Szabolcs, Jenő Szabó, György Kakuk, Gabriella Fóris
Dátum:	1999
Megjegyzések:	BACKGROUND: The most frequent complication in patients with end-stage renal failure on chronic haemodialysis (HD) treatment is atherosclerosis, i.e. the different forms of heart and vascular diseases. The complete disorder of serum lipid and lipoprotein patterns is well demonstrated, whereas our knowledge about the low-density lipoprotein (LDL) and scavenger receptor expression and function are poorly understood. METHODS: In our current work, LDL and scavenger receptor expression and functions were simultaneously studied in monocytes obtained from 15 healthy male control subjects and from 11 chronic HD male patients applied with (125)I-labelled LDL, isolated from healthy volunteers. To study the scavenger LDL receptors, labelled acetylated LDL (acLDL) was used. RESULTS: LDL binding to the monocytes of the HD-group was found to be decreased in comparison to that of the controls. As a result, the 50 microg LDL protein-induced inhibition of endogenous cholesterol synthesis was also diminished. In contrast, acLDL binding was greatly increased, though it could trigger only a low apoE synthesis. Consequently the number of cholesterol inclusions in monocytes was increased. CONCLUSIONS: The disturbed expression and function of LDL and scavenger receptors both may play significant roles in pathogenesis of cardiovascular complications in chronic HD patients. Based on our present results, it can be assumed that dysfunction of scavenger receptors is at the centre of cardiovascular complications of HD patients with renal failure.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Nephrology, Dialysis, Transplantation. - 14 : 11 (1999), p. 2664-2668. -
További szerzők:	Paragh György (1953-) (belgyógyász) Kovács Éva Balogh Zoltán (1965-) (belgyógyász, gasztroenterológus, diabetológus) Szabolcs Márton Szabó Jenő (belgyógyász, endocrinologus) Kakuk György (1938-2018) (belgyógyász) Fóris Gabriella (1937-) (belgyógyász)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM031123
Első szerző:	Mezősi Emese
Cím:	The role of technetium-99m methoxyisobutylisonitrile scintigraphy in the differential diagnosis of cold thyroid nodules / Emese Mezősi, Laszló Bajnok, Ferenc Gyory, Jozsef Varga, Ilona Sztojka, Jeno Szabo, Laszlo Galuska, Andras Leovey, György Kakuk, Endre Nagy
Dátum:	1999
ISSN:	1619-7070
Megjegyzések:	Various diagnostic techniques have been successfully used in the clinical management of cold nodules; however, the decision on whether to employ surgery or a conservative treatment is not always easy. This study was designed to appraise the diagnostic value of technetium-99m methoxyisobutylisonitrile (MIBI) scintigraphy in the assessment of cold nodules detected using (99m)Tc-pertechnetate. Fifty-two patients were included in the study. All had already been selected for surgery, based on their clinical and laboratory findings, including fine-needle aspiration biopsy. The total number of cold nodules on (99m)Tc-pertechnetate scans was 59. The thyroid scan was performed 20-40 min after i.v. injection of 400 MBq of (99m)Tc-MIBI. Uptake of MIBI in thyroid nodules was compared with that in the surrounding normal thyroid tissue, and a score of between 0 and 3 was assigned to each nodule as follows: 0, cold; 1, decreased; 2, equal; 3, hot. Definitive histology revealed nodular goitre in 24 cases, adenoma in 19, thyroiditis in 1, differentiated cancer in 12, medullary cancer in 2, and anaplastic cancer in 1. None of the degenerative nodules were hot on MIBI scan, while the adenomas showed a variety of MIBI imaging patterns, most frequently the score 3 pattern. In the diagnosis of differentiated thyroid cancer the sensitivities of score 3 and score 2+3 MIBI uptake patterns were 83% (10/12) and 100%, respectively. The score 3 MIBI uptake pattern had a specificity of 100% and a positive predictive value of 100% with respect to thyroid (benign and malignant) neoplastic diseases, whereas a specificity of 72% and a positive predictive value of 43% were observed in the detection of differentiated cancer. After a cold nodule had been detected using (99m)Tc-pertechnetate, a second scan with high MIBI uptake increased by 7.8 times the probability that this nodule would be a differentiated cancer. In conclusion, (99m)Tc-MIBI scintigraphy is a useful method in the differential diagnosis of cold thyroid nodules if the primary aim is to differentiate degenerative from neoplastic diseases rather than to differentiate benign from malignant nodules. High MIBI uptake considerably increases the probability of a differentiated thyroid cancer and facilitates immediate surgical removal, while decreased uptake actually excludes it. We suggest a combination of fine-needle aspiration biopsy and MIBI scan as a routine diagnostic approach to cold thyroid nodules.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	European Journal of Nuclear Medicine 26 : 8 (1999), p. 798-803. -
További szerzők:	Bajnok László (1961-) (belgyógyász) Győry Ferenc (1969-) (kardiológus) Varga József (1955-) (fizikus) Sztojka Ilona Szabó Jenő (belgyógyász, endocrinologus) Galuska László (1946-) (belgyógyász, izotópdiagnoszta) Leövey András (1926-) (belgyógyász) Kakuk György (1938-2018) (belgyógyász) Nagy Endre V. (1957-) (belgyógyász, endokrinológus)
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