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001-es BibID:	BIBFORM079827
035-os BibID:	(cikkazonosító)AS24-060
Első szerző:	Árokszállási Tamás (neurológus)
Cím:	Hemostasis biomarkers in the prognosis of non-traumatic intracerebral hemorrhage / T. Arokszallasi, Z. Bagoly, K. Fekete, I. Fekete, I. Szegedi, M. Andrejkovics, J. Toth, L. Csiba
Dátum:	2019
Megjegyzések:	Background and Aims: Non-traumatic intracerebral hemorrhage (ICH) accounts for 10?15% of all strokes and results in higher rate of mortality as compared to ischemic strokes. In the IRONHEART study we aimed to find potential hemostasis biomarkers with prognostic value in patients with ICH. Methods: In this prospective, observational study, 183 acute stroke patients and 140 healthy controls were included. Patients were grouped: 51 primary ICH patients (PICH), 118 acute ischemic stroke patients who underwent thrombolysis without hemorrhagic events (AIS), 13 patients with AIS who suffered hemorrhagic complications after intravenous thrombolysis (AIS-ICH). On admission, CT angiography, detailed clinical and laboratory investigations were performed. The following hemostasis measurements were carried out from blood samples: hemostasis screening tests, von Willebrand factor (VWF) antigen, factor XIII (FXIII), plasminogen and a2 antiplasmin activity, D-dimer. Patients were followed for 90 days, long term outcomes were defined using the modified Rankin Scale. Results: VWF level was significantly higher in all patient groups as compared to controls. VWF levels were significantly higher in patients with worse long-term outcomes (mRS>3) in all patient cohorts. FXIII activity was significantly elevated in the PICH group as compared to controls and to both AIS groups. FXIII activity in the lowest quartile was associated with a significant risk of mortality in the PICH group (OR: 9.9; 95%CI:1.6- 61.6, p ? 0.015). Among fibrinolytic markers, only D-dimer showed association with worse long-term outcomes (mRS>3). Conclusions: VWF antigen, FXIII activity and D-dimer could serve as biomarkers of long-term outcomes in PICH patients.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt haemorrhage
Megjelenés:	European Stroke Journal. - 4 : Suppl. 1 (2019), p. 449. -
További szerzők:	Bagoly Zsuzsa (1978-) (orvos) Fekete Klára (1978-) (neurológus) Fekete István (1951-) (neurológus, pszichiáter) Szegedi István (1992-) (orvos) Andrejkovics Mónika (1967-) (klinikai szakpszichológus, neuropszichológus, pszichoterapeuta) Tóth J. Csiba László (1952-) (neurológus, pszichiáter)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00043 GINOP NKFI-K120042 NKFI
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM083072
Első szerző:	Csikai Enikő
Cím:	Influence of angiotensin-converting enzyme inhibition on reversibility of alterations in arterial wall and cognitive performance associated with early hypertension : a follow-up study / Csikai Enikő, Andrejkovics Mónika, Balajthy-Hidegh Bernadett, Hofgárt Gergely, Kardos László, Diószegi Ágnes, Rostás Róbert, Czuriga-Kovács Katalin Réka, Csongrádi Éva, Csiba László
Dátum:	2019
ISSN:	0025-7974
Megjegyzések:	The importance of optimal blood pressure control for preventing or reducing the impairment of vascular and cognitive functions is well known. However, the reversibility of early alterations in vascular and cognitive functions through antihypertensive agents is under-investigated. In this study, we evaluated the influence of 3 months of angiotensin-converting enzyme (ACE) inhibition treatment on the morphological and functional arterial wall and cognitive performance changes in 30 newly diagnosed primary hypertensive patients. Common carotid intima-media thickness (IMT) and brachial artery flow-mediated dilatation (FMD) were detected by ultrasonography. Arterial stiffness indicated by augmentation index (AIx) and pulse wave velocity (PWV) was assessed by arteriography. Cognitive functions were assessed by neuropsychological examination. The executive function overall score was significantly higher at 3-month follow-up than at baseline (median, 0.233 (IQR, 0.447) vs ?0.038 (0.936); P?=?.001). Three-month ACE inhibition did not produce significant improvement in IMT, FMD, AIx and PWV values. Significant negative associations were revealed between IMT and complex attention (r?=??0.598, P?=?.0008), executive function (r?=??0.617, P?=?.0005), and immediate memory (r?=??0.420, P?=?.026) overall scores at follow-up. AIx had significant negative correlations with complex attention (r?=??0.568, P?=?.001), executive function (r?=??0.374, P?=?.046), and immediate memory (r?=??0.507, P?=?.005). PWV correlated significantly and negatively with complex attention (r?=??0.490, P?=?.007). Timely and effective antihypertensive therapy with ACE inhibitors has significant beneficial effects on cognitive performance in as few as 3 months. Early ACE inhibition may have an important role in the reversal of initial impairments of cognitive function associated with hypertension-induced vascular alterations.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk arterial stiffness carotid intima-media thickness cognition flow-mediated vasodilatation hypertension
Megjelenés:	Medicine. - 98 : 34 (2019), p. 1-9. -
További szerzők:	Andrejkovics Mónika (1967-) (klinikai szakpszichológus, neuropszichológus, pszichoterapeuta) Balajthy-Hidegh Bernadett Hofgárt Gergely (1984-) (neurológus) Kardos László (1970-) (megelőző orvostan és népegészségtan szakorvos) Diószegi Ágnes (1987-) (belgyógyász) Rostás Róbert (1991-) (Orvos) Czuriga-Kovács Katalin Réka (1981-) (neurológus) Csongrádi Éva (1969-) (szakorvos) Csiba László (1952-) (neurológus, pszichiáter)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00048 GINOP Gedeon Richter research grant 4700168520-KK/186/2016 Egyéb NKFI K120042 Egyéb
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001-es BibID:	BIBFORM029317
Első szerző:	Kemény Vendel
Cím:	Acute and chronic effects of vinpocetine on cerebral hemodynamics and neuropsychological performance in multi-infarct patients / Kemeny, V., Molnar, S., Andrejkovics, M., Makai, A., Csiba, L.
Dátum:	2005
ISSN:	0091-2700
Megjegyzések:	A double-blind, prospective, randomized, placebo-controlled clinical trial was carried out to test the acute and long-term hemodynamical and beneficial cognitive effects of the vasoactive agent vinpocetine on patients suffering from multiple cerebral infarcts by means of functional transcranial Doppler examinations and by neuropsychological tests. Twenty-six patients (17 men, 9 women) with multiple cerebral infarctions, aged between 50 and 83 years (mean age+/-SD=63.4+/-9.39 years) were examined, 14 of whom received vinpocetine and 12 placebo. The functional transcranial Doppler included breath-holding tests, finger movement, word fluency, and picture-discrimination tasks. Twenty-five patients were assessed by neuropsychological battery. No serious side effect was found in the vinpocetine group. The flow velocities were significantly lower in the acute phase after breath holding in the vinpocetine group than in the placebo group. Three months later, the vinpocetine patients did not show any significant worsening in digit span backward test, while the placebo group did. No other significant differences in the neuropsychological test could be detected between the treatment and the placebo groups. Longer lasting and higher dosage of vinpocetine therapy is suggested to prove its potential effect.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Clinical Pharmacology. - 45 : 9 (2005), p. 1048-1054. -
További szerzők:	Molnár Sándor (1973-) (neurológus) Andrejkovics Mónika (1967-) (klinikai szakpszichológus, neuropszichológus, pszichoterapeuta) Makai Attila Csiba László (1952-) (neurológus, pszichiáter)
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