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001-es BibID:	BIBFORM113832
Első szerző:	Astuti, Putri Kusuma (állattenyésztési genetikus)
Cím:	Heat Stress: Can Animals be Stressed but still be Healthy? / Putri Kusuma Astuti, Roland Fajardo, George Wanjala, Nelly Kichamu, Husein Ohran, Bouabid Badaoui, Zoltán Bagi, Szilvia Kusza
Dátum:	2023
ISSN:	1841-9364 2344-4576
Megjegyzések:	In this era of rapid climate change, heat stress has emerged as a major problem for sheep farming. The quantity and quality of sheep production, as well as the welfare, are all shown to be negatively impacted by heat stress. Reduced cellular immune function in sheep exposed to high temperatures increases susceptibility to various diseases,although the underlying mechanisms are unclear. The imbalance between oxidants and antioxidants, known as oxidative stress, negatively impacts animal health due to heat stress-induced impairments in immune responses, increased production of reactive oxygen species, and/or a lack of antioxidants. Heat stress in livestock has negative effects on both the cell-mediated and humoral immune responses. However, the negative effects of heat stress on immune response in sheep can vary by breed. This review discusses how heat stress affects sheep's immunity. An overview of some molecular markers related to immunity, such as interleukin (ILs), Toll-like receptors (TLRs), and also the heat stress protein (HSPs) in sheep, is also discussed. Finally, recent researchon the effects of antioxidant supplementation and other promising nutritional strategies for reducing heat stress and improving animal health is presented.
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok konferenciacikk folyóiratcikk animal health antioxidant heat stress immunity sheep
Megjelenés:	Scientific Papers: Animal Science and Biotechnologies. - 56 : 1 (2023), p. 194-202. -
További szerzők:	Fajardo, Roland Wanjala, George (1984-) (Animal scientist) Kichamu, Nelly (1978-) Ohran, Husein Badaoui, Bouabid (1979-) (animal genetics engineer) Bagi Zoltán (1987-) (természetvédelmi mérnök, állatgenetika) Kusza Szilvia (1979-) (agrármérnök)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM112083
Első szerző:	Astuti, Putri Kusuma (állattenyésztési genetikus)
Cím:	Heat stress: Can animals be stressed but still be healthy? / Putri Kusuma Astuti, Roland Fajardo, George Wanjala, Husein Ohran, Bouabid Badaoui, Zoltán Bagi, Szilvia Kusza
Dátum:	2023
ISSN:	2821-4293
Megjegyzések:	In this era of rapid climate change, heat stress has emerged as a major problem for sheep farming. The quantity and quality of sheep production, as well as the welfare, are all shown to be negatively impacted by heat stress. Reduced cellular immune function in sheep exposed to high temperatures increases susceptibility to various diseases, although the underlying mechanisms are unclear. The imbalance between oxidants and antioxidants, known as oxidative stress, negatively impacts animal health due to heat stress-induced impairments in immune responses, increased production of reactive oxygen species, and/or a lack of antioxidants. Heat stress in livestock has negative effects on both the cell-mediated and humoral immune responses. However, the negative effects of heat stress on immune response in sheep can vary by breed. This review discusses how heat stress affects sheep's immunity. An overview of some molecular markers related to immunity, such as interleukin (ILs), Toll-like receptors (TLRs), and also the heat stress protein (HSPs) in sheep, is also discussed. Finally, recent research on the effects of antioxidant supplementation and other promising nutritional strategies for reducing heat stress and improving animal health is presented.
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok előadáskivonat könyvrészlet animal health antioxidant heat stress immunity sheep
Megjelenés:	Book of abstract : Multidisciplinary Conference on Sustainable Development : 25-26 May 2023 : Section : Animal Resources Bioengineering. - p. 17. -
További szerzők:	Fajardo, Roland Wanjala, George (1984-) (Animal scientist) Ohran, Husein Badaoui, Bouabid (1979-) (animal genetics engineer) Bagi Zoltán (1987-) (természetvédelmi mérnök, állatgenetika) Kusza Szilvia (1979-) (agrármérnök)
Pályázati támogatás:	2021-1.2.4-TÉT-2021-00047 Egyéb 2021-1.2.4-TÉT-2021-00014 Egyéb
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM106134
035-os BibID:	(cikkazonosító)22348 (WOS)000904416000001 (Scopus)85144635665
Első szerző:	Astuti, Putri Kusuma (állattenyésztési genetikus)
Cím:	Validation of SNP markers for thermotolerance adaptation in Ovis aries adapted to different climatic regions using KASP-PCR technique / Putri Kusuma Astuti, Daniela Elena Ilie, Dinu Gavojdian, George Wanjala, Bouabid Badaoui, Husein Ohran, Eva Pasic-Juhas, Zoltán Bagi, András Jávor, Szilvia Kusza
Dátum:	2022
ISSN:	2045-2322
Megjegyzések:	A study on 51 SNPs belonging to 29 genes related to heat stress was carried out in 720 sheep from 17 different breeds adapted to different climates from Hungary, Bosnia and Herzegovina, Morocco and Romania, using Kompetitive Allele?Specific Polymerase Chain Reaction. Genotype frequency and the Hardy?Weinberg equilibrium were calculated, followed by a clustering using the Principal Component Analysis. We analyzed the polymorphisms in the following genes analyzed: HSPA12A, HSP90AA1, IL33, DIO2, BTNL2, CSN2, ABCG1, CSN1S1, GHR, HSPA8, STAT3, and HCRT. We emphasized on HSPA12A and HSPA8 genes as they were successfully genotyped in all studied flocks in which genotype frequency patterns were identified. Contrary to previous findings, the A allele for HSPA8 SNP was not observed in the heat tolerant breeds, being found exclusively in cold-tolerant breeds. The principal component analysis could not clearly differentiate the breeds, while plot concentration was slightly varied among the three groups, with HSP90AA1 and IL33 SNPs' loading values significantly contributing to PC1 and PC2. We confirmed previous works that the HSPA12A, HSPA8, HSP90AA1 and IL33 SNPs are potential candidate markers for thermotolerance adaptation in sheep. This research contributes to the genetic variability of SNPs for thermotolerance adaptability in sheep.
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Scientific Reports. - 12 (2022), p. 1-9. -
További szerzők:	Ilie, Daniela Elena Gavojdian, Dinu Wanjala, George (1984-) (Animal scientist) Badaoui, Bouabid (1979-) (animal genetics engineer) Ohran, Husein Pasic-Juhas, Eva Bagi Zoltán (1987-) (természetvédelmi mérnök, állatgenetika) Jávor András (1952-) (agrármérnök) Kusza Szilvia (1979-) (agrármérnök)
Pályázati támogatás:	EFOP-3.6.2-16-2017-00001 EFOP 2021-1.2.4-TÉT-2021-00014 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM117398
035-os BibID:	(cikkazonosító)05001 (Scopus)85181554728
Első szerző:	Fajardo, Roland
Cím:	Continental vs. tropical breed: Immunity comparison under heat stress conditions utilizing qRT-PCR technique / Roland Fajardo, Putri Kusuma Astuti, Zoltán Bagi, Lilla Bodrogi, Tímea Pintér, Gabriella Skoda, Husein Ohran, George Wanjala, Szilvia Kusza
Dátum:	2023
ISSN:	2273-1709 2117-4458
Megjegyzések:	Understanding the responses of animals to seasonal heat stress on the genomic level has led to the identification of genes implicated in thermal stress reaction mechanisms. In this study, the relative gene expression of Interleukin-10 (IL-10), an anti-inflammatory cytokine and biomarker for heat stress-mediated immune modulation, was observed during the summer and winter seasons in continental and tropical sheep breeds, namely, Hungarian Indigenous Tsigai and White Dorper, employing quantitative real-time polymerase chain reaction (qRT-PCR). Temperature-humidity indices (THI) were calculated to assess heat stress levels. The results indicate that IL-10 CT-values were significantly higher during the summer, when heat stress prevails, in both sheep breeds compared to winter. While the White Dorper exhibited a higher numerical value for the summer relative gene expression ratio (16.2) compared to the Hungarian Indigenous Tsigai (12.3), no significant differences in CT values were observed between breeds or among sexes. These findings suggest the immune-adaptive characteristics of the two sheep breeds during seasonal heat stress. The variation of IL-10 gene expression levels between the two breeds can be attributed to their geographical origins; the White Dorper emerging from arid subtropical South Africa and the Hungarian Indigenous Tsigai Sheep thriving in the seasonally harsh Carpathian climate for centuries.
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok konferenciacikk folyóiratcikk gene expression heat stress Hungarian Tsigai IL-10 White Dorper
Megjelenés:	BIO Web of Conferences. - 8 (2023), p. 1-8. -
További szerzők:	Astuti, Putri Kusuma (1994-) (állattenyésztési genetikus) Bagi Zoltán (1987-) (természetvédelmi mérnök, állatgenetika) Bodrogi Lilla Pintér Tímea Skoda Gabriella Ohran, Husein Wanjala, George (1984-) (Animal scientist) Kusza Szilvia (1979-) (agrármérnök)
Pályázati támogatás:	2021-1.2.4-TÉT-2021-00047 Egyéb EFOP-3.6.2-16-2017-00001 EFOP
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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