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001-es BibID:BIBFORM103108
035-os BibID:(Wos)000394367300011 (Scopus)84992745671
Első szerző:Röszer Tamás (orvos, biológus)
Cím:Transcriptional control of apoptotic cell clearance by macrophage nuclear receptors / Tamás Röszer
Dátum:2016
ISSN:1360-8185 1573-675X
Megjegyzések:Apoptotic cell clearance by macrophages is key for normal tissue development and homeostasis. Nuclear receptors, such as peroxisome proliferator activated receptors (PPARs), liver X receptor (LXR), retinoic acid receptor (RAR), retinoid X receptor (RXR) and glucocorticoid receptor (GR) orchestrate this vital process. The underlying mechanism involves the transcriptional control of key genes of apoptotic cell recognition and internalization, such as Cd36, Mertk, Axl, C1qa, Tgm2, Abca1. In addition, apoptotic cell uptake leads to M2 activation of macrophages, and this process is also controlled at the gene transcription level by nuclear receptors. Apoptotic cells provide signals for nuclear receptors, which in turn accelerate the safe disposal of apoptotic debris, which eventually allows renewal of the tissues, and impedes the development of inflammation and autoimmunity against dying cells. Nuclear receptor signaling is vulnerable to endocrine disruptors, which may interfere with the ability of macrophages to phagocytose and acquire M2 activation. This review summarizes the mechanisms, which allow nuclear receptors to control apoptotic cell clearance by macrophages.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
M2-macrophage
PPAR
RXR
Obesogens
Phagocytosis
Megjelenés:Apoptosis. - 22 : 2 (2016), p. 284-294. -
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001-es BibID:BIBFORM001242
035-os BibID:(Wos)000235672300004 (Scopus)33344470488
Első szerző:Röszer Tamás (orvos, biológus)
Cím:The neuropeptide FMRFamide can protect cells against apoptosis in the snail digestive gland / T. Rőszer, J. Kappelmayer, G. G. Nagy, A. J. Szentmiklósi, A. G. Basnakian, G. Bánfalvi
Dátum:2006
Megjegyzések:FMRFamide-related peptides are widespread neurotransmitters or neurohormones regulating somatic or visceral motor activity. Some recent data indicate that these neuropeptides may be involved in the control of cell proliferation and apoptosis. In this work we investigated the possible effect of FMRFamide on cell viability in an invertebrate-type proliferating tissue. As a model, we used the midintestinal gland of the snail, Helix lucorum Linnaeus. Immunohistochemistry demonstrated the direct innervation of the gland cells by FMRFamide-containing nerve fibers. Midintestinal glands of snails were injected with 50 microM FMRFamide and the control with sterile deionised water or bovine serum albumin (BSA). Injections were administrated 4 times. Transmission electron microscopy, annexin V-labeling, thiazolyl blue (MTT) viability tests and ploidy analyses were carried out to define the viable/dead cell ratio in the tissue samples. FMRFamide increased the MTT-reduction of tissues, reduced the amount of apoptotic nuclei and annexin V-labeled cells. Deionised water or BSA injection induced cell death. Cell cycle analysis revealed that FMRFamide significantly elevated the amount of cells in G0/G1 phase, but did not induce mitosis. We conclude, that the FMRFamide can be a life-signal for cells, protect them from apoptosis without altering mitosis.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
antiapoptotikus neuropeptid
Megjelenés:Apoptosis. - 11 : 2 (2006), p. 173-182. -
További szerzők:Kappelmayer János (1960-) (laboratóriumi szakorvos) Szemán-Nagy Gábor (1975-) (biológia tanár-molekuláris biológus) Szentmiklósi József András (1948-) (farmakológus, klinikai laboratóriumi szakorvos) Basnakian, Alexei G. Bánfalvi Gáspár (1943-) (sejtbiológus, gyógyszerész)
Internet cím:elektronikus változat
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