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001-es BibID:	BIBFORM103061
035-os BibID:	(cikkazonosító)2368 (WoS)000699490600001 (Scopus)85115891080
Első szerző:	Hoang, Anh Cuong
Cím:	Transcriptional Landscaping Identifies a Beige Adipocyte Depot in the Newborn Mouse / Anh Cuong Hoang, Haidong Yu, Tamás Röszer
Dátum:	2021
ISSN:	2073-4409
Megjegyzések:	The present study sought to identify gene networks that are hallmarks of the developing inguinal subcutaneous adipose tissue (iWAT) and the interscapular brown adipose tissue (BAT) in the mouse. RNA profiling revealed that the iWAT of postnatal (P) day 6 mice expressed thermogenic and lipid catabolism transcripts, along with the abundance of transcripts associated with the beige adipogenesis program. This was an unexpected finding, as thermogenic BAT was believed to be the only site of nonshivering thermogenesis in the young mouse. However, the transcriptional landscape of BAT in P6 mice suggests that it is still undergoing differentiation and maturation, and that the iWAT temporally adopts thermogenic and lipolytic potential. Moreover, P6 iWAT and adult (P56) BAT were similar in their expression of immune gene networks, but P6 iWAT was unique in the abundant expression of antimicrobial proteins and virus entry factors, including a possible receptor for SARS-CoV-2. In summary, postnatal iWAT development is associated with a metabolic shift from thermogenesis and lipolysis towards fat storage. However, transcripts of beige-inducing signal pathways including ?-adrenergic receptors and interleukin-4 signaling were underrepresented in young iWAT, suggesting that the signals for thermogenic fat differentiation may be different in early postnatal life and in adulthood.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk adipose tissue adipogenesis brown fat thermogenesis obesity
Megjelenés:	Cells. - 10 : 9 (2021), p. 1-22. -
További szerzők:	Yu, Haidong Röszer Tamás (1979-) (orvos, biológus)
Pályázati támogatás:	German Research Fund (DFG) RO 4856 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM103104
035-os BibID:	(Wos)000443248600019 (Scopus)85063293908 (cikkazonosító)103
Első szerző:	Röszer Tamás (orvos, biológus)
Cím:	Understanding the Biology of Self-Renewing Macrophages / Tamás Röszer
Dátum:	2018
ISSN:	2073-4409
Megjegyzések:	Macrophages reside in specific territories in organs, where they contribute to the development, homeostasis, and repair of tissues. Recent work has shown that the size of tissue macrophage populations has an impact on tissue functions and is determined by the balance between replenishment and elimination. Macrophage replenishment is mainly due to self-renewal of macrophages, with a secondary contribution from blood monocytes. Self-renewal is a recently discovered trait of macrophages, which can have a major impact on their physiological functions and hence on the wellbeing of the organism. In this review, I discuss our current understanding of the developmental origin of self-renewing macrophages and the mechanisms used to maintain a physiologically stable macrophage pool.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk macrophage leukocyte biology stem cell proliferation
Megjelenés:	Cells. - 7 : 8 (2018), p. 1-21. -
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM103062
035-os BibID:	(cikkazonosító)2288 (WoS)000699281300001 (Scopus)85115886588
Első szerző:	Röszer Tamás (orvos, biológus)
Cím:	Adipose Tissue Immunometabolism and Apoptotic Cell Clearance / Tamás Röszer
Dátum:	2021
ISSN:	2073-4409
Megjegyzések:	The safe removal of apoptotic debris by macrophages-often referred to as efferocytosis-is crucial for maintaining tissue integrity and preventing self-immunity or tissue damaging inflammation. Macrophages clear tissues of hazardous materials from dying cells and ultimately adopt a pro-resolving activation state. However, adipocyte apoptosis is an inflammation-generating process, and the removal of apoptotic adipocytes by so-called adipose tissue macrophages triggers a sequence of events that lead to meta-inflammation and obesity-associated metabolic diseases. Signals that allow apoptotic cells to control macrophage immune functions are complex and involve metabolites released by the apoptotic cells and also metabolites produced by the macrophages during the digestion of apoptotic cell contents. This review provides a concise summary of the adipocyte-derived metabolites that potentially control adipose tissue macrophage immune functions and, hence, may induce or alleviate adipose tissue inflammation.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk apoptosis obesity meta-inflammation immunometabolism macrophage M2 macrophage efferocytosis phagocytosis
Megjelenés:	Cells. - 10 : 9 (2021), p. 1-16. -
Pályázati támogatás:	German Research Fund (DFG) RO-4856 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM114971
035-os BibID:	(cikkazonosító)2345 (scopus)85175587052 (wos)001085681900001
Első szerző:	Varga Kornél Z.
Cím:	Stimulator of Interferon Genes (STING) Triggers Adipocyte Autophagy / Varga Kornél Z., Gyurina Katalin, Radványi Ádám, Pál Tibor, Sasi-Szabó László, Yu Haidong, Felszeghy Enikő, Szabó Tamás, Röszer Tamás
Dátum:	2023
ISSN:	2073-4409
Megjegyzések:	Innate immune signaling in adipocytes affects systemic metabolism. Cytosolic nucleic acid sensing has been recently shown to stimulate thermogenic adipocyte differentiation and protect from obesity; however, DNA efflux from adipocyte mitochondria is a potential proinflammatory signal that causes adipose tissue dysfunction and insulin resistance. Cytosolic DNA activates the stimulator of interferon response genes (STING), a key signal transducer which triggers type I interferon (IFN-I) expression; hence, STING activation is expected to induce IFN-I response and adipocyte dysfunction. However, we show herein that mouse adipocytes had a diminished IFN-I response to STING stimulation by 2·3·-cyclic-GMP-AMP (cGAMP). We also show that cGAMP triggered autophagy in murine and human adipocytes. In turn, STING inhibition reduced autophagosome number, compromised the mitochondrial network and caused inflammation and fat accumulation in adipocytes. STING hence stimulates a process that removes damaged mitochondria, thereby protecting adipocytes from an excessive IFN-I response to mitochondrial DNA efflux. In summary, STING appears to limit inflammation in adipocytes by promoting mitophagy under non-obesogenic conditions.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk obesity
Megjelenés:	Cells. - 12 : 19 (2023), p. 1-17. -
További szerzők:	Gyurina Katalin (1986-) (tudományos segédmunkatárs) Radványi Ádám Pál Tibor Sasi Szabó László András (1974-) (sebész) Yu, Haidong Felszeghy Enikő Noémi (1970-) (gyermekgyógyász) Szabó Tamás (1968-) (gyermekgyógyász) Röszer Tamás (1979-) (orvos, biológus)
Pályázati támogatás:	142939 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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