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001-es BibID:	BIBFORM103106
035-os BibID:	(WOS)000228340800003 (Scopus)19544370693
Első szerző:	Röszer Tamás (orvos, biológus)
Cím:	Seasonal periodicity of enteric nitric oxide synthesis and its regulation in the snail, Helix lucorum / Tamás Röszer, Éva Kiss-Tóth, A. József Szentmiklósi, Gáspár Bánfalvi
Dátum:	2005
ISSN:	1077-8306
Megjegyzések:	The snail Helix lucorum has been used as a model to study the adaptation of a nitric oxide (NO)-forming enteric neural network to the long-term resting period of summer estivation or winter hibernation. Quantification of the NO-derived nitrite established that NO formation is confined to the nitric oxide synthase (NOS)-containing myenteric network of the mid-intestine. In active snails but not in resting snails, NO production could be enhanced by the NOS substrate l-arginine (l-ARG, 1?mM). We followed the enteric NO synthesis in a snail population kept at natural conditions for 1 year. Our findings indicate that NO synthesis was depressed in July during entry to the estivation, had a peak in autumn before hibernation, and finally was reduced during hibernation. Monoamines (histamine, serotonin, and adrenalin) could inhibit the NO liberation in active snails. Cofactors of NOS (?-NADPH, ?-NAD, FAD, FMN, Ca2+, TH4) did not alter the low nitrite production in hibernating snails. We conclude that enteric NO synthesis in H. lucorum has a regular seasonal periodicity following the annual physiological cycles of terrestrial snails. During estivation or hibernation, NOS activity is blocked. Monoamines, the levels of which are elevated during hibernation, can trigger decreased NOS activity. The reduced activity of NOS cannot be restored by the administration of NOS cofactors; therefore, their absence cannot be the cause of the temporarily blocked L-ARG/NO conversion ability of NOS.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk NADPH diaphorase nitric oxide synthase enteric nervous system Helix lucorum
Megjelenés:	Invertebrate Biology. - 124 : 1 (2005), p. 18-24. -
További szerzők:	Kiss-Tóth Éva (1983-) (biológus) Szentmiklósi József András (1948-) (farmakológus, klinikai laboratóriumi szakorvos) Bánfalvi Gáspár (1943-) (sejtbiológus, gyógyszerész)
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001-es BibID:	BIBFORM001297
035-os BibID:	(Wos)000222590300004 (Scopus)2442668507
Első szerző:	Röszer Tamás (orvos, biológus)
Cím:	Structural diversity of NADPH diaphorase-reactive enteral networks in Stylommatophora (Gastropoda, Pulmonata) / Tamás Röszer, Zsolt Jenei, Zoltán Serfözö, Zsolt Czimmerer, Gáspár Bánfalvi
Dátum:	2004
Megjegyzések:	In this work we investigated the involvement of putative nitric oxide (NO)-forming neurons in enteric plexuses of stylommatophoran gastropods. The nitric oxide synthase (NOS)-containing cells were detected by NADPH diaphorase (NADPHd) histochemistry in the entreral nervous systems of several stylommatophoran species (Achatinacea: Achatina fulica, Helicacea: Cepaea hortensis, Cepaea nemoralis, Discus rotundatus, Helicella obvia, Helix lucorum, Helix lutescens, Monachoides umbrosa, Trichia hispida, Zebrina detrita, Succineacea: Succinea putris, Vertiliginacea: Clausilia dubia, Zonitacea: Arion ater, Arion subfuscus, Limax maximus). We detected the NO synthesis of isolated midintestinal segments by Griess's quantification of nitrite, one end product of NO. Effects of the NOS substrate L-arginine and the NOS inhibitor N?-nitro-L-arginine (NOARG) were also tested on nitrite production. We found NADPHd-reactive neurons and extrinsic nerves with NADPHd-stained fibers within the myenteric and submucosal networks of the midintestine of investigated members of Helicacea, Succineacea, and Vertiliginacea families. These networks innervated the midintestinal musculature and several nerve cells of the myenteric and submucosal plexi. In investigated members of Achatinacea and Zonitacea, NADPHd-stained networks were not detectable within the digestive tract. Administration of 1 mM L-arginine elevated, whereas 2 mM of NOARG diminished, the nitrite levels of the NADPHd-stained networks containing midintestine in C. nemoralis and H. lucorum. Enteral NADPHd staining was not detected in A. ater and L. maximus, and the nitrite production was not affected by L-arginine. Our results indicate a possible, but evolutionarily not conserved, NO-mediated enteral transmission in stylommatophoran gastropods.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban NADPH diaforáz nitrogénmonoxid szintáz enterális idegrendszer lábasfejűek
Megjelenés:	Invertebrate Biology. - 123 : 2 (2004), p. 128-135. -
További szerzők:	Jenei Zsolt Serfőző Zoltán Czimmerer Zsolt (1981-) (molekuláris biológus) Bánfalvi Gáspár (1943-) (sejtbiológus, gyógyszerész)
Internet cím:	elektronikus változat
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