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001-es BibID:	BIBFORM103063
035-os BibID:	(Wos)000831161900001 (Scopus)85135075118
Első szerző:	Röszer Tamás (orvos, biológus)
Cím:	Metabolic impact of adipose tissue macrophages in the early postnatal life / Tamás Röszer
Dátum:	2022
ISSN:	0741-5400
Megjegyzések:	Adipose tissue macrophages (ATMs) play key roles in metabolic inflammation, insulin resistance, adipose tissue fibrosis, and immune disorders associated with obesity. Research on ATM biology has mostly been conducted in the setting of adult obesity, since adipocyte hypertrophy is associated with a significant increase in ATM number. Signals that control ATM activation toward a proinflammatory or a proresolving phenotype also determine the developmental program and lipid metabolism of adipocytes after birth. ATMs are present at birth and actively participate in the synthesis of mediators, which induce lipolysis, mitobiogenesis, and mitochondrial uncoupling in adipocytes. ATMs in the newborn and the infant promote a lipolytic and fatty acid oxidizing adipocyte phenotype, which is essential to support the lipid-fueled metabolism, to maintain nonshivering thermogenesis and counteract an excessive adipose tissue expansion. Since adipose tissue metabolism in the early postnatal life determines obesity status in adulthood, early-life ATM functions may have a life-long impact.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk inflammation macrophage obesity pediatric adiposity
Megjelenés:	Journal Of Leukocyte Biology. - 112 : 6 (2022), p.1515-1524. -
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM103107
035-os BibID:	(Wos)000413395700029 (Scopus)85028650246
Első szerző:	Waqas, Syed F. Hassnain
Cím:	Adipose tissue macrophages develop from bone marrow-independent progenitors in Xenopus laevis and mouse / Syed F. Hassnain Waqas, Anna Noble, Anh C. Hoang, Grace Ampem, Manuela Popp, Sarah Strauss, Matthew Guille, Tamás Röszer
Dátum:	2017
ISSN:	0741-5400
Megjegyzések:	ATMs have a metabolic impact in mammals as they contribute to metabolically harmful AT inflammation. The control of the ATM number may have therapeutic potential; however, information on ATM ontogeny is scarce. Whereas it is thought that ATMs develop from circulating monocytes, various tissue-resident M?s are capable of self-renewal and develop from BM-independent progenitors without a monocyte intermediate. Here, we show that amphibian AT contains self-renewing ATMs that populate the AT before the establishment of BM hematopoiesis. Xenopus ATMs develop from progenitors of aVBI. In the mouse, a significant amount of ATM develops from the yolk sac, the mammalian equivalent of aVBI. In summary, this study provides evidence for a prenatal origin of ATMs and shows that the study of amphibian ATMs can enhance the understanding of the role of the prenatal environment in ATM development.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk fat body yolk sac M phi s CX(3)CR1 neuropeptide FF
Megjelenés:	Journal Of Leukocyte Biology. - 102 : 3 (2017), p. 845-855. -
További szerzők:	Noble, Anna Hoang, Anh Cuong Ampem, Grace Popp, Manuela Strauss, Sarah Guille, Matthew Röszer Tamás (1979-) (orvos, biológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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