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001-es BibID:BIBFORM105853
035-os BibID:(Scopus)85143117906 (Wos)000889427400002
Első szerző:Hoang, Anh Cuong
Cím:Mitochondrial RNA stimulates beige adipocyte development in young mice / Anh Cuong Hoang, László Sasi-Szabó, Tibor Pál, Tamás Szabó, Victoria Diedrich, Annika Herwig, Kathrin Landgraf, Antje Körner, Tamás Röszer
Dátum:2022
ISSN:2522-5812
Megjegyzések:Childhood obesity is a serious public health crisis and a critical factor that determines future obesity prevalence. Signals affecting adipocyte development in early postnatal life have a strong potential to trigger childhood obesity; however, these signals are still poorly understood. We show here that mitochondrial (mt)RNA efflux stimulates transcription of nuclear-encoded genes for mitobiogenesis and thermogenesis in adipocytes of young mice and human infants. While cytosolic mtRNA is a potential trigger of the interferon (IFN) response, young adipocytes lack such a response to cytosolic mtRNA due to the suppression of IFN regulatory factor (IRF)7 expression by vitamin D receptor signalling. Adult and obese adipocytes, however, strongly express IRF7 and mount an IFN response to cytosolic mtRNA. In turn, suppressing IRF7 expression in adult adipocytes restores mtRNA-induced mitobiogenesis and thermogenesis and eventually mitigates obesity. Retrograde mitochondrion-to-nucleus signalling by mtRNA is thus a mechanism to evoke thermogenic potential during early adipocyte development and to protect against obesity.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Antimicrobial responses
Fat metabolism
Mitochondria
Megjelenés:Nature Metabolism. - 4 : 12 (2022) p. 1684-1696. -
További szerzők:Sasi Szabó László András (1974-) (sebész) Pál Tibor Szabó Tamás (1968-) (gyermekgyógyász) Diedrich, Victoria Herwig, Annika Landgraf, Kathrin Körner, Antje Röszer Tamás (1979-) (orvos, biológus)
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2.

001-es BibID:BIBFORM103061
035-os BibID:(cikkazonosító)2368 (WoS)000699490600001 (Scopus)85115891080
Első szerző:Hoang, Anh Cuong
Cím:Transcriptional Landscaping Identifies a Beige Adipocyte Depot in the Newborn Mouse / Anh Cuong Hoang, Haidong Yu, Tamás Röszer
Dátum:2021
ISSN:2073-4409
Megjegyzések:The present study sought to identify gene networks that are hallmarks of the developing inguinal subcutaneous adipose tissue (iWAT) and the interscapular brown adipose tissue (BAT) in the mouse. RNA profiling revealed that the iWAT of postnatal (P) day 6 mice expressed thermogenic and lipid catabolism transcripts, along with the abundance of transcripts associated with the beige adipogenesis program. This was an unexpected finding, as thermogenic BAT was believed to be the only site of nonshivering thermogenesis in the young mouse. However, the transcriptional landscape of BAT in P6 mice suggests that it is still undergoing differentiation and maturation, and that the iWAT temporally adopts thermogenic and lipolytic potential. Moreover, P6 iWAT and adult (P56) BAT were similar in their expression of immune gene networks, but P6 iWAT was unique in the abundant expression of antimicrobial proteins and virus entry factors, including a possible receptor for SARS-CoV-2. In summary, postnatal iWAT development is associated with a metabolic shift from thermogenesis and lipolysis towards fat storage. However, transcripts of beige-inducing signal pathways including ?-adrenergic receptors and interleukin-4 signaling were underrepresented in young iWAT, suggesting that the signals for thermogenic fat differentiation may be different in early postnatal life and in adulthood.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
adipose tissue
adipogenesis
brown fat
thermogenesis
obesity
Megjelenés:Cells. - 10 : 9 (2021), p. 1-22. -
További szerzők:Yu, Haidong Röszer Tamás (1979-) (orvos, biológus)
Pályázati támogatás:German Research Fund (DFG) RO 4856
Egyéb
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3.

001-es BibID:BIBFORM103512
035-os BibID:(Wos)000408842300035 (Scopus)85055814380 (Pubmed)28758905
Első szerző:Waqas, Syed F. Hassnain
Cím:Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages(vol 127, pg 2842, 2017) / Syed F. Hassnain Waqas, Anh Cuong Hoang, Ya-Tin Lin, Grace Ampem, Hind Azegrouz, Lajos Balogh, Julianna Thuróczy, Jin-Chung Chen, Ivan C. Gerling, Sorim Nam, Jong-Seok Lim, Juncal Martinez-Ibañez, José T. Real, Stephan Paschke, Raphaëlle Quillet, Safia Ayachi, Frédéric Simonin, E. Marion Schneider, Jacqueline A. Brinkman, Dudley W. Lamming, Christine M. Seroogy, Tamás Röszer
Dátum:2017
ISSN:0021-9738
Tárgyszavak:Orvostudományok Elméleti orvostudományok hozzászólás
folyóiratcikk
Megjelenés:Journal of Clinical Investigation. - 127 : 9 (2017), p. 3559. -
További szerzők:Hoang, Anh Cuong Lin, Ya-Tin Ampem, Grace Azegrouz, Hind Balogh Lajos Thuróczy Julianna Chen, Jin-Chung Gerling, Ivan C. Nam, Sorim Lim, Jong-Seok Martinez-Ibanez, Juncal Real, José T. Paschke, Stephan Quillet, Raphaëlle Ayachi, Safia Simonin, Frédéric Schneider, Marion E. Brinkman, Jacqueline A. Lamming, Dudley W. Seroogy, Christine M. Röszer Tamás (1979-) (orvos, biológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM103107
035-os BibID:(Wos)000413395700029 (Scopus)85028650246
Első szerző:Waqas, Syed F. Hassnain
Cím:Adipose tissue macrophages develop from bone marrow-independent progenitors in Xenopus laevis and mouse / Syed F. Hassnain Waqas, Anna Noble, Anh C. Hoang, Grace Ampem, Manuela Popp, Sarah Strauss, Matthew Guille, Tamás Röszer
Dátum:2017
ISSN:0741-5400
Megjegyzések:ATMs have a metabolic impact in mammals as they contribute to metabolically harmful AT inflammation. The control of the ATM number may have therapeutic potential; however, information on ATM ontogeny is scarce. Whereas it is thought that ATMs develop from circulating monocytes, various tissue-resident M?s are capable of self-renewal and develop from BM-independent progenitors without a monocyte intermediate. Here, we show that amphibian AT contains self-renewing ATMs that populate the AT before the establishment of BM hematopoiesis. Xenopus ATMs develop from progenitors of aVBI. In the mouse, a significant amount of ATM develops from the yolk sac, the mammalian equivalent of aVBI. In summary, this study provides evidence for a prenatal origin of ATMs and shows that the study of amphibian ATMs can enhance the understanding of the role of the prenatal environment in ATM development.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
fat body
yolk sac M phi s
CX(3)CR1
neuropeptide FF
Megjelenés:Journal Of Leukocyte Biology. - 102 : 3 (2017), p. 845-855. -
További szerzők:Noble, Anna Hoang, Anh Cuong Ampem, Grace Popp, Manuela Strauss, Sarah Guille, Matthew Röszer Tamás (1979-) (orvos, biológus)
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5.

001-es BibID:BIBFORM103105
035-os BibID:(Wos)000404557400039 (Scopus)85021739476
Első szerző:Waqas, Syed F. Hassnain
Cím:Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages / Syed F. Hassnain Waqas, Anh Cuong Hoang, Ya-Tin Lin, Grace Ampem, Hind Azegrouz, Lajos Balogh, Julianna Thuróczy, Jin-Chung Chen, Ivan C. Gerling, Sorim Nam, Jong-Seok Lim, Juncal Martinez-Ibanez, José T. Real, Stephan Paschke, Raphaëlle Quillet, Safia Ayachi, Frédéric Simonin, E. Marion Schneider, Jacqueline A. Brinkman, Dudley W. Lamming, Christine M. Seroogy, Tamás Röszer
Dátum:2017
ISSN:0021-9738
Megjegyzések:The quantity and activation state of adipose tissue macrophages (ATMs) impact the development of obesity-induced metabolic diseases. Appetite-controlling hormones play key roles in obesity; however, our understanding of their effects on ATMs is limited. Here, we have shown that human and mouse ATMs express NPFFR2, a receptor for the appetite-reducing neuropeptide FF (NPFF), and that NPFFR2 expression is upregulated by IL-4, an M2-polarizing cytokine. Plasma levels of NPFF decreased in obese patients and high-fat diet-fed mice and increased following caloric restriction. NPFF promoted M2 activation and increased the proliferation of murine and human ATMs. Both M2 activation and increased ATM proliferation were abolished in NPFFR2-deficient ATMs. Mechanistically, the effects of NPFF involved the suppression of E3 ubiquitin ligase RNF128 expression, resulting in enhanced stability of phosphorylated STAT6 and increased transcription of the M2 macrophage-associated genes IL-4 receptor alpha (Il4ra), arginase 1 (Arg1), IL-10 (Il10), and alkylglycerol monooxygenase (Agmo). NPFF induced ATM proliferation concomitantly with the increase in N-Myc downstream-regulated gene 2 (Ndrg2) expression and suppressed the transcription of Ifi200 cell-cycle inhibitor family members and MAF bZIP transcription factor B (Mafb), a negative regulator of macrophage proliferation. NPFF thus plays an important role in supporting healthy adipose tissue via the maintenance of metabolically beneficial ATMs.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal Of Clinical Investigation. - 127 : 7 (2017), p. 2842-2854. -
További szerzők:Hoang, Anh Cuong Lin, Ya-Tin Ampem, Grace Azegrouz, Hind Balogh Lajos Thuróczy Julianna Chen, Jin-Chung Gerling, Ivan C. Nam, Sorim Lim, Jong-Seok Martinez-Ibanez, Juncal Real, José T. Paschke, Stephan Quillet, Raphaëlle Ayachi, Safia Simonin, Frédéric Schneider, Marion E. Brinkman, Jacqueline A. Lamming, Dudley W. Seroogy, Christine M. Röszer Tamás (1979-) (orvos, biológus)
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6.

001-es BibID:BIBFORM103080
035-os BibID:(Wos)000470082800036 (Scopus)85066061092
Első szerző:Yu, Haidong
Cím:Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages / Haidong Yu, Sedat Dilbaz, Jonas Comann, Anh Cuong Hoang, Victoria Diedrich, Annika Herwig, Akiko Harauma, Yukino Hoshi, Toru Moriguchi, Kathrin Landgraf, Antje Körner, Christina Lucas, Susanne Brodesser, Lajos Balogh, Julianna Thuróczy, Gopal Karemore, Michael Scott Kuefner, Edwards A. Park, Christine Rapp, Jeffrey Bryant Travers, Tamás Röszer
Dátum:2019
ISSN:0021-9738
Megjegyzések:Prevalence of obesity among infants and children below 5 years of age is rising dramatically, and early childhood obesity is a forerunner of obesity and obesity-associated diseases in adulthood. Childhood obesity is hence one of the most serious public health challenges today. Here, we have identified a mother-to-child lipid signaling that protects from obesity. We have found that breast milk-specific lipid species, so-called alkylglycerol-type (AKG-type) ether lipids, which are absent from infant formula and adult-type diets, maintain beige adipose tissue (BeAT) in the infant and impede the transformation of BeAT into lipid-storing white adipose tissue (WAT). Breast milk AKGs are metabolized by adipose tissue macrophages (ATMs) to platelet-activating factor (PAF), which ultimately activates IL-6/STAT3 signaling in adipocytes and triggers BeAT development in the infant. Accordingly, lack of AKG intake in infancy leads to a premature loss of BeAT and increases fat accumulation. AKG signaling is specific for infants and is inactivated in adulthood. However, in obese adipose tissue, ATMs regain their ability to metabolize AKGs, which reduces obesity. In summary, AKGs are specific lipid signals of breast milk that are essential for healthy adipose tissue development.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Adipose tissue
Immunology
Macrophages
Metabolism
Obesity
Megjelenés:Journal Of Clinical Investigation. - 129 : 6 (2019), p. 2485-2499. -
További szerzők:Dilbaz, Sedat Comann, Jonas Hoang, Anh Cuong Diedrich, Victoria Herwig, Annika Harauma, Akiko Hoshi, Yukino Moriguchi, Toru Landgraf, Kathrin Körner, Antje Lucas, Christina Brodesser, Susanne Balogh Lajos Thuróczy Julianna Karemore, Gopal Kuefner, Michael Scott Park, Edwards A. Rapp, Christine Travers, Jeffrey Bryant Röszer Tamás (1979-) (orvos, biológus)
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