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001-es BibID:	BIBFORM103092
035-os BibID:	(Wos)000487075100007 (Scopus)85064700512
Első szerző:	Ampem, Grace
Cím:	The environmental obesogen bisphenol A increases macrophage self-renewal / Grace Ampem, Alexandra Junginger, Haidong Yu, Lajos Balogh, Julianna Thuróczy, Marion E. Schneider, Tamás Röszer
Dátum:	2019
ISSN:	0302-766X
Megjegyzések:	Self-renewal of macrophages is important for the healthy development and replenishment of tissue-resident macrophage pools. How this mechanism is controlled by endocrine signals is still largely unexplored. Here, we show that the endocrine disruptor bisphenol A (BPA) increases macrophage self-renewal. This effect was associated with phosphorylation of extracellular signal-regulated kinase (ERK) and a slight increase in the expression of liver X receptor alpha (LXRalpha). We found that LXRaplha inhibition induced, while LXRalpha activation impeded, macrophage self-renewal. LXRalpha signaling hence may protect from excessive macrophage expansion. Self-renewing macrophages, however, had negligible LXR expression when compared with quiescent macrophages. Accordingly, tissue-resident macrophage pools, which are dominated by quiescent macrophages, were rich in LXRalpha-expressing macrophages. Overall, we show that BPA increases macrophage self-renewal and that this effect, at least in part, can be inhibited by increasing LXRalpha expression. Since BPA is accumulated in the adipose tissue, it has the potential to increase self-renewal of adipose tissue macrophages, leading to a condition that might negatively impact adipose tissue health.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Endocrine disruptors ERK LXR Obesity Obesogens
Megjelenés:	Cell And Tissue Research. - 378 : 1 (2019), p. 81-96. -
További szerzők:	Junginger, Alexandra Yu, Haidong Balogh Lajos Thuróczy Julianna Schneider, Marion E. Röszer Tamás (1979-) (orvos, biológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM103061
035-os BibID:	(cikkazonosító)2368 (WoS)000699490600001 (Scopus)85115891080
Első szerző:	Hoang, Anh Cuong
Cím:	Transcriptional Landscaping Identifies a Beige Adipocyte Depot in the Newborn Mouse / Anh Cuong Hoang, Haidong Yu, Tamás Röszer
Dátum:	2021
ISSN:	2073-4409
Megjegyzések:	The present study sought to identify gene networks that are hallmarks of the developing inguinal subcutaneous adipose tissue (iWAT) and the interscapular brown adipose tissue (BAT) in the mouse. RNA profiling revealed that the iWAT of postnatal (P) day 6 mice expressed thermogenic and lipid catabolism transcripts, along with the abundance of transcripts associated with the beige adipogenesis program. This was an unexpected finding, as thermogenic BAT was believed to be the only site of nonshivering thermogenesis in the young mouse. However, the transcriptional landscape of BAT in P6 mice suggests that it is still undergoing differentiation and maturation, and that the iWAT temporally adopts thermogenic and lipolytic potential. Moreover, P6 iWAT and adult (P56) BAT were similar in their expression of immune gene networks, but P6 iWAT was unique in the abundant expression of antimicrobial proteins and virus entry factors, including a possible receptor for SARS-CoV-2. In summary, postnatal iWAT development is associated with a metabolic shift from thermogenesis and lipolysis towards fat storage. However, transcripts of beige-inducing signal pathways including ?-adrenergic receptors and interleukin-4 signaling were underrepresented in young iWAT, suggesting that the signals for thermogenic fat differentiation may be different in early postnatal life and in adulthood.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk adipose tissue adipogenesis brown fat thermogenesis obesity
Megjelenés:	Cells. - 10 : 9 (2021), p. 1-22. -
További szerzők:	Yu, Haidong Röszer Tamás (1979-) (orvos, biológus)
Pályázati támogatás:	German Research Fund (DFG) RO 4856 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM114971
035-os BibID:	(cikkazonosító)2345 (scopus)85175587052 (wos)001085681900001
Első szerző:	Varga Kornél Z.
Cím:	Stimulator of Interferon Genes (STING) Triggers Adipocyte Autophagy / Varga Kornél Z., Gyurina Katalin, Radványi Ádám, Pál Tibor, Sasi-Szabó László, Yu Haidong, Felszeghy Enikő, Szabó Tamás, Röszer Tamás
Dátum:	2023
ISSN:	2073-4409
Megjegyzések:	Innate immune signaling in adipocytes affects systemic metabolism. Cytosolic nucleic acid sensing has been recently shown to stimulate thermogenic adipocyte differentiation and protect from obesity; however, DNA efflux from adipocyte mitochondria is a potential proinflammatory signal that causes adipose tissue dysfunction and insulin resistance. Cytosolic DNA activates the stimulator of interferon response genes (STING), a key signal transducer which triggers type I interferon (IFN-I) expression; hence, STING activation is expected to induce IFN-I response and adipocyte dysfunction. However, we show herein that mouse adipocytes had a diminished IFN-I response to STING stimulation by 2·3·-cyclic-GMP-AMP (cGAMP). We also show that cGAMP triggered autophagy in murine and human adipocytes. In turn, STING inhibition reduced autophagosome number, compromised the mitochondrial network and caused inflammation and fat accumulation in adipocytes. STING hence stimulates a process that removes damaged mitochondria, thereby protecting adipocytes from an excessive IFN-I response to mitochondrial DNA efflux. In summary, STING appears to limit inflammation in adipocytes by promoting mitophagy under non-obesogenic conditions.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk obesity
Megjelenés:	Cells. - 12 : 19 (2023), p. 1-17. -
További szerzők:	Gyurina Katalin (1986-) (tudományos segédmunkatárs) Radványi Ádám Pál Tibor Sasi Szabó László András (1974-) (sebész) Yu, Haidong Felszeghy Enikő Noémi (1970-) (gyermekgyógyász) Szabó Tamás (1968-) (gyermekgyógyász) Röszer Tamás (1979-) (orvos, biológus)
Pályázati támogatás:	142939 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM103080
035-os BibID:	(Wos)000470082800036 (Scopus)85066061092
Első szerző:	Yu, Haidong
Cím:	Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages / Haidong Yu, Sedat Dilbaz, Jonas Comann, Anh Cuong Hoang, Victoria Diedrich, Annika Herwig, Akiko Harauma, Yukino Hoshi, Toru Moriguchi, Kathrin Landgraf, Antje Körner, Christina Lucas, Susanne Brodesser, Lajos Balogh, Julianna Thuróczy, Gopal Karemore, Michael Scott Kuefner, Edwards A. Park, Christine Rapp, Jeffrey Bryant Travers, Tamás Röszer
Dátum:	2019
ISSN:	0021-9738
Megjegyzések:	Prevalence of obesity among infants and children below 5 years of age is rising dramatically, and early childhood obesity is a forerunner of obesity and obesity-associated diseases in adulthood. Childhood obesity is hence one of the most serious public health challenges today. Here, we have identified a mother-to-child lipid signaling that protects from obesity. We have found that breast milk-specific lipid species, so-called alkylglycerol-type (AKG-type) ether lipids, which are absent from infant formula and adult-type diets, maintain beige adipose tissue (BeAT) in the infant and impede the transformation of BeAT into lipid-storing white adipose tissue (WAT). Breast milk AKGs are metabolized by adipose tissue macrophages (ATMs) to platelet-activating factor (PAF), which ultimately activates IL-6/STAT3 signaling in adipocytes and triggers BeAT development in the infant. Accordingly, lack of AKG intake in infancy leads to a premature loss of BeAT and increases fat accumulation. AKG signaling is specific for infants and is inactivated in adulthood. However, in obese adipose tissue, ATMs regain their ability to metabolize AKGs, which reduces obesity. In summary, AKGs are specific lipid signals of breast milk that are essential for healthy adipose tissue development.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Adipose tissue Immunology Macrophages Metabolism Obesity
Megjelenés:	Journal Of Clinical Investigation. - 129 : 6 (2019), p. 2485-2499. -
További szerzők:	Dilbaz, Sedat Comann, Jonas Hoang, Anh Cuong Diedrich, Victoria Herwig, Annika Harauma, Akiko Hoshi, Yukino Moriguchi, Toru Landgraf, Kathrin Körner, Antje Lucas, Christina Brodesser, Susanne Balogh Lajos Thuróczy Julianna Karemore, Gopal Kuefner, Michael Scott Park, Edwards A. Rapp, Christine Travers, Jeffrey Bryant Röszer Tamás (1979-) (orvos, biológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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