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001-es BibID:	BIBFORM105853
035-os BibID:	(Scopus)85143117906 (Wos)000889427400002
Első szerző:	Hoang, Anh Cuong
Cím:	Mitochondrial RNA stimulates beige adipocyte development in young mice / Anh Cuong Hoang, László Sasi-Szabó, Tibor Pál, Tamás Szabó, Victoria Diedrich, Annika Herwig, Kathrin Landgraf, Antje Körner, Tamás Röszer
Dátum:	2022
ISSN:	2522-5812
Megjegyzések:	Childhood obesity is a serious public health crisis and a critical factor that determines future obesity prevalence. Signals affecting adipocyte development in early postnatal life have a strong potential to trigger childhood obesity; however, these signals are still poorly understood. We show here that mitochondrial (mt)RNA efflux stimulates transcription of nuclear-encoded genes for mitobiogenesis and thermogenesis in adipocytes of young mice and human infants. While cytosolic mtRNA is a potential trigger of the interferon (IFN) response, young adipocytes lack such a response to cytosolic mtRNA due to the suppression of IFN regulatory factor (IRF)7 expression by vitamin D receptor signalling. Adult and obese adipocytes, however, strongly express IRF7 and mount an IFN response to cytosolic mtRNA. In turn, suppressing IRF7 expression in adult adipocytes restores mtRNA-induced mitobiogenesis and thermogenesis and eventually mitigates obesity. Retrograde mitochondrion-to-nucleus signalling by mtRNA is thus a mechanism to evoke thermogenic potential during early adipocyte development and to protect against obesity.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Antimicrobial responses Fat metabolism Mitochondria
Megjelenés:	Nature Metabolism. - 4 : 12 (2022) p. 1684-1696. -
További szerzők:	Sasi Szabó László András (1974-) (sebész) Pál Tibor Szabó Tamás (1968-) (gyermekgyógyász) Diedrich, Victoria Herwig, Annika Landgraf, Kathrin Körner, Antje Röszer Tamás (1979-) (orvos, biológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM103080
035-os BibID:	(Wos)000470082800036 (Scopus)85066061092
Első szerző:	Yu, Haidong
Cím:	Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages / Haidong Yu, Sedat Dilbaz, Jonas Comann, Anh Cuong Hoang, Victoria Diedrich, Annika Herwig, Akiko Harauma, Yukino Hoshi, Toru Moriguchi, Kathrin Landgraf, Antje Körner, Christina Lucas, Susanne Brodesser, Lajos Balogh, Julianna Thuróczy, Gopal Karemore, Michael Scott Kuefner, Edwards A. Park, Christine Rapp, Jeffrey Bryant Travers, Tamás Röszer
Dátum:	2019
ISSN:	0021-9738
Megjegyzések:	Prevalence of obesity among infants and children below 5 years of age is rising dramatically, and early childhood obesity is a forerunner of obesity and obesity-associated diseases in adulthood. Childhood obesity is hence one of the most serious public health challenges today. Here, we have identified a mother-to-child lipid signaling that protects from obesity. We have found that breast milk-specific lipid species, so-called alkylglycerol-type (AKG-type) ether lipids, which are absent from infant formula and adult-type diets, maintain beige adipose tissue (BeAT) in the infant and impede the transformation of BeAT into lipid-storing white adipose tissue (WAT). Breast milk AKGs are metabolized by adipose tissue macrophages (ATMs) to platelet-activating factor (PAF), which ultimately activates IL-6/STAT3 signaling in adipocytes and triggers BeAT development in the infant. Accordingly, lack of AKG intake in infancy leads to a premature loss of BeAT and increases fat accumulation. AKG signaling is specific for infants and is inactivated in adulthood. However, in obese adipose tissue, ATMs regain their ability to metabolize AKGs, which reduces obesity. In summary, AKGs are specific lipid signals of breast milk that are essential for healthy adipose tissue development.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Adipose tissue Immunology Macrophages Metabolism Obesity
Megjelenés:	Journal Of Clinical Investigation. - 129 : 6 (2019), p. 2485-2499. -
További szerzők:	Dilbaz, Sedat Comann, Jonas Hoang, Anh Cuong Diedrich, Victoria Herwig, Annika Harauma, Akiko Hoshi, Yukino Moriguchi, Toru Landgraf, Kathrin Körner, Antje Lucas, Christina Brodesser, Susanne Balogh Lajos Thuróczy Julianna Karemore, Gopal Kuefner, Michael Scott Park, Edwards A. Rapp, Christine Travers, Jeffrey Bryant Röszer Tamás (1979-) (orvos, biológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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