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001-es BibID:	BIBFORM104099
035-os BibID:	(Scopus)85065441701 (WOS)000487261300018
Első szerző:	Waqas, Syed F. Hassnain
Cím:	Analysis of IL-4/STAT6 Signaling in Macrophages / Waqas S. F. H., Ampem G., Röszer T.
Dátum:	2019
Megjegyzések:	Activation of signal transducer and activator of transcription 6 (STAT6) is a key signaling pathway in macrophage function, and is required for the so-called alternative (M2) activation of macrophages. Interleukin (IL)-4 and IL-13 are important M2 polarizing cytokines that act through STAT6 by inducing its phosphorylation and promoting transcription of STAT6-responsive genes. Inactivation of STAT6 signaling in macrophages has not been fully explored; however, a recent model suggests that inactivation of STAT6 signaling can occur via ubiquitination and proteasomal degradation. In this chapter, we describe a combination of techniques that can be used to study the activation/inactivation of STAT6 signaling in macrophages.
ISBN:	978-1-4939-9194-5
Tárgyszavak:	Orvostudományok Elméleti orvostudományok könyvfejezet könyvrészlet Macrophage M2 activation IL-4 IL-13 Immunology
Megjelenés:	Nuclear receptors : methods and experimental protocols / ed. by Mostafa Z. Badr. - p. 211-224. -
További szerzők:	Ampem, Grace Röszer Tamás (1979-) (orvos, biológus)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM103512
035-os BibID:	(Wos)000408842300035 (Scopus)85055814380 (Pubmed)28758905
Első szerző:	Waqas, Syed F. Hassnain
Cím:	Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages(vol 127, pg 2842, 2017) / Syed F. Hassnain Waqas, Anh Cuong Hoang, Ya-Tin Lin, Grace Ampem, Hind Azegrouz, Lajos Balogh, Julianna Thuróczy, Jin-Chung Chen, Ivan C. Gerling, Sorim Nam, Jong-Seok Lim, Juncal Martinez-Ibañez, José T. Real, Stephan Paschke, Raphaëlle Quillet, Safia Ayachi, Frédéric Simonin, E. Marion Schneider, Jacqueline A. Brinkman, Dudley W. Lamming, Christine M. Seroogy, Tamás Röszer
Dátum:	2017
ISSN:	0021-9738
Tárgyszavak:	Orvostudományok Elméleti orvostudományok hozzászólás folyóiratcikk
Megjelenés:	Journal of Clinical Investigation. - 127 : 9 (2017), p. 3559. -
További szerzők:	Hoang, Anh Cuong Lin, Ya-Tin Ampem, Grace Azegrouz, Hind Balogh Lajos Thuróczy Julianna Chen, Jin-Chung Gerling, Ivan C. Nam, Sorim Lim, Jong-Seok Martinez-Ibanez, Juncal Real, José T. Paschke, Stephan Quillet, Raphaëlle Ayachi, Safia Simonin, Frédéric Schneider, Marion E. Brinkman, Jacqueline A. Lamming, Dudley W. Seroogy, Christine M. Röszer Tamás (1979-) (orvos, biológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM103107
035-os BibID:	(Wos)000413395700029 (Scopus)85028650246
Első szerző:	Waqas, Syed F. Hassnain
Cím:	Adipose tissue macrophages develop from bone marrow-independent progenitors in Xenopus laevis and mouse / Syed F. Hassnain Waqas, Anna Noble, Anh C. Hoang, Grace Ampem, Manuela Popp, Sarah Strauss, Matthew Guille, Tamás Röszer
Dátum:	2017
ISSN:	0741-5400
Megjegyzések:	ATMs have a metabolic impact in mammals as they contribute to metabolically harmful AT inflammation. The control of the ATM number may have therapeutic potential; however, information on ATM ontogeny is scarce. Whereas it is thought that ATMs develop from circulating monocytes, various tissue-resident M?s are capable of self-renewal and develop from BM-independent progenitors without a monocyte intermediate. Here, we show that amphibian AT contains self-renewing ATMs that populate the AT before the establishment of BM hematopoiesis. Xenopus ATMs develop from progenitors of aVBI. In the mouse, a significant amount of ATM develops from the yolk sac, the mammalian equivalent of aVBI. In summary, this study provides evidence for a prenatal origin of ATMs and shows that the study of amphibian ATMs can enhance the understanding of the role of the prenatal environment in ATM development.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk fat body yolk sac M phi s CX(3)CR1 neuropeptide FF
Megjelenés:	Journal Of Leukocyte Biology. - 102 : 3 (2017), p. 845-855. -
További szerzők:	Noble, Anna Hoang, Anh Cuong Ampem, Grace Popp, Manuela Strauss, Sarah Guille, Matthew Röszer Tamás (1979-) (orvos, biológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM103105
035-os BibID:	(Wos)000404557400039 (Scopus)85021739476
Első szerző:	Waqas, Syed F. Hassnain
Cím:	Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages / Syed F. Hassnain Waqas, Anh Cuong Hoang, Ya-Tin Lin, Grace Ampem, Hind Azegrouz, Lajos Balogh, Julianna Thuróczy, Jin-Chung Chen, Ivan C. Gerling, Sorim Nam, Jong-Seok Lim, Juncal Martinez-Ibanez, José T. Real, Stephan Paschke, Raphaëlle Quillet, Safia Ayachi, Frédéric Simonin, E. Marion Schneider, Jacqueline A. Brinkman, Dudley W. Lamming, Christine M. Seroogy, Tamás Röszer
Dátum:	2017
ISSN:	0021-9738
Megjegyzések:	The quantity and activation state of adipose tissue macrophages (ATMs) impact the development of obesity-induced metabolic diseases. Appetite-controlling hormones play key roles in obesity; however, our understanding of their effects on ATMs is limited. Here, we have shown that human and mouse ATMs express NPFFR2, a receptor for the appetite-reducing neuropeptide FF (NPFF), and that NPFFR2 expression is upregulated by IL-4, an M2-polarizing cytokine. Plasma levels of NPFF decreased in obese patients and high-fat diet-fed mice and increased following caloric restriction. NPFF promoted M2 activation and increased the proliferation of murine and human ATMs. Both M2 activation and increased ATM proliferation were abolished in NPFFR2-deficient ATMs. Mechanistically, the effects of NPFF involved the suppression of E3 ubiquitin ligase RNF128 expression, resulting in enhanced stability of phosphorylated STAT6 and increased transcription of the M2 macrophage-associated genes IL-4 receptor alpha (Il4ra), arginase 1 (Arg1), IL-10 (Il10), and alkylglycerol monooxygenase (Agmo). NPFF induced ATM proliferation concomitantly with the increase in N-Myc downstream-regulated gene 2 (Ndrg2) expression and suppressed the transcription of Ifi200 cell-cycle inhibitor family members and MAF bZIP transcription factor B (Mafb), a negative regulator of macrophage proliferation. NPFF thus plays an important role in supporting healthy adipose tissue via the maintenance of metabolically beneficial ATMs.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal Of Clinical Investigation. - 127 : 7 (2017), p. 2842-2854. -
További szerzők:	Hoang, Anh Cuong Lin, Ya-Tin Ampem, Grace Azegrouz, Hind Balogh Lajos Thuróczy Julianna Chen, Jin-Chung Gerling, Ivan C. Nam, Sorim Lim, Jong-Seok Martinez-Ibanez, Juncal Real, José T. Paschke, Stephan Quillet, Raphaëlle Ayachi, Safia Simonin, Frédéric Schneider, Marion E. Brinkman, Jacqueline A. Lamming, Dudley W. Seroogy, Christine M. Röszer Tamás (1979-) (orvos, biológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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