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001-es BibID:	BIBFORM111993
035-os BibID:	(cikkazonosító)1149 (WoS)001016877300001 (Scopus)85163968050
Első szerző:	Balázs Gergely (csecsemő- és gyermekgyógyász, neonatológus)
Cím:	Prevention of Chronic Morbidities in Extremely Premature Newborns with LISA-nCPAP Respiratory Therapy and Adjuvant Perinatal Strategies / Gergely Balázs, András Balajthy, István Seri, Thomas Hegyi, Tibor Ertl, Tamás Szabó, Tamás Röszer, Ágnes Papp, József Balla, Tamás Gáll, György Balla
Dátum:	2023
ISSN:	2076-3921
Megjegyzések:	Less invasive surfactant administration techniques, together with nasal continuous airway pressure (LISA-nCPAP) ventilation, an emerging noninvasive ventilation (NIV) technique in neonatology, are gaining more significance, even in extremely premature newborns (ELBW), under 27 weeks of gestational age. In this review, studies on LISA-nCPAP are compiled with an emphasis on short- and long-term morbidities associated with prematurity. Several perinatal preventative and therapeutic investigations are also discussed in order to start integrated therapies as numerous organ-saving techniques in addition to lung-protective ventilations. Two thirds of immature newborns can start their lives on NIV, and one third of them never need mechanical ventilation. With adjuvant intervention, these ratios are expected to be increased, resulting in better outcomes. Optimized cardiopulmonary transition, especially physiologic cord clamping, could have an additively beneficial effect on patient outcomes gained from NIV. Organ development and angiogenesis are strictly linked not only in the immature lung and retina, but also possibly in the kidney, and optimized interventions using angiogenic growth factors could lead to better morbidity-free survival. Corticosteroids, caffeine, insulin, thyroid hormones, antioxidants, N-acetylcysteine, and, moreover, the immunomodulatory components of mother's milk are also discussed as adjuvant treatments, since immature newborns deserve more complex neonatal interventions.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Antioxidants. - 12 : 6 (2023), p. 1-36. -
További szerzők:	Balajthy András (1988-) (általános orvos) Seri István Hegyi Thomas Ertl Tibor Szabó Tamás (1968-) (gyermekgyógyász) Röszer Tamás (1979-) (orvos, biológus) Papp Ágnes (1967-) (gyermekgyógyász, pulmonológus) Balla József (1959-) (belgyógyász, nephrológus) Gáll Tamás (1982-) (molekuláris biológus, mikrobiológus) Balla György (1953-) (csecsemő és gyermekgyógyász, neonatológus)
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001-es BibID:	BIBFORM015066
035-os BibID:	(WOS)000297855700007 (Scopus)82455174750
Első szerző:	Galajda Zoltán (szívsebész, érsebész)
Cím:	Histamine and H1-Histamine receptors faster venous circulation / Zoltan Galajda, Jozsef Balla, A. Jozsef Szentmiklosi, Tamas Biro, Gabriella Czifra, Nora Dobrosi, Agnes Cseppento, Lajos Patonay, Tamas Roszer, Gyorgy Balla, Laurenciu M. Popescu, Istvan Lekli, Arpad Tosaki
Dátum:	2011
Megjegyzések:	The study has analysed the action of histamine in the rabbit venous system and evaluated its potential role in contraction during increased venous pressure. We have found that a great variety exists in histamine sensitivity and H1-histamine receptor expression in various types of rabbit veins. Veins of the extremities (saphenous vein, femoral vein, axillary vein) and abdomen (common iliac vein, inferior vena cava) responded to histamine by a prominent, concentration-dependent force generation, whereas great thoracic veins (subclavian vein, superior vena cavas, intrathoracic part of inferior vena cava) and a pelvic vein (external iliac vein) exhibited slight sensitivity to exogenous histamine. The lack of reactivity to histamine was not due to increased activity of nitric oxide synthase (NOS) or heme oxygenase-1. H1-histamine receptor expression of veins correlated well with the histamine-induced contractions. Voltage-dependent calcium channels mediated mainly the histamine-induced force generation of saphenous vein, whereas it did not act in the inferior vena cava. In contrast, the receptor-operated channels were not involved in this response in either vein. Tyrosine phosphorylation occurred markedly in response to histamine in the saphenous vein, but not in the inferior vena cava. Histamine induced a prominent p kinase activation in both vessels. Protein kinase C and mitogen-activated protein kinase (MAPK) were not implicated in the histamine-induced intracellular calcium sensitization. Importantly, transient clamping of the femoral vein in animals caused a short-term constriction, which was inhibited by H1-histamine receptor antagonist in vivo. Furthermore, a significantly greater histamine immunopositivity was detected in veins after stretching compared to the resting state. We conclude that histamine receptor density adapts to the actual requirements of the circulation, and histamine liberated by the venous wall during increased venous pressure contributes to the contraction of vessels, providing a force for the venous return.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Molekuláris Medicina
Megjelenés:	Journal of Cellular and Molecular Medicine. - 15 : 12 (2011), p. 2614-2623. -
További szerzők:	Balla József (1959-) (belgyógyász, nephrológus) Szentmiklósi József András (1948-) (farmakológus, klinikai laboratóriumi szakorvos) Bíró Tamás (1968-) (élettanász) Czifra Gabriella (1975-) (élettanász) Dobrosi Nóra (1981-) (molekuláris biológus) Cseppentő Ágnes (1953-) (orvos) Patonay Lajos (anatómus) Röszer Tamás (1979-) (orvos, biológus) Balla György (1953-) (csecsemő és gyermekgyógyász, neonatológus) Popescu, Laurenciu M. Lekli István (1981-) (gyógyszerész) Tósaki Árpád (1958-) (kísérletes farmakológus, gyógyszerész)
Pályázati támogatás:	TÁMOP-4.2.1/B-09/1/KONV-2010-0007 TÁMOP Vaszkuláris biológia K-72315 OTKA TÁMOP 4.2.2-08/1-2008-0007 TÁMOP ETT 586/2006 EGYÉB ETT 147/2009 EGYÉB K 75883 OTKA K 83478 OTKA MTA-DE-11003 EGYÉB
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