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001-es BibID:	BIBFORM113715
035-os BibID:	(cikkazonosító)2268 (scopus)85164741999 (wos)001028272300001
Első szerző:	Kovács Anna Rebeka (általános orvos)
Cím:	Prognostic Significance of Preoperative NLR, MLR, and PLR Values in Predicting the Outcome of Primary Cytoreductive Surgery in Serous Epithelial Ovarian Cancer / Kovács Anna Rebeka, Sulina Anita, Kovács Kincső Sára, Lukács Luca, Török Péter, Lampé Rudolf
Dátum:	2023
ISSN:	2075-4418
Megjegyzések:	(1) The degree of cytoreduction achieved during primary debulking surgery (PDS) is an important prognostic factor for the survival of patients with epithelial ovarian cancer (EOC). Our aim was to investigate the prognostic value of preoperative laboratory parameters for the outcome of PDS. (2) We analyzed the preoperative laboratory parameters of 150 serous EOC patients who underwent PDS between 2006 and 2013. Receiver operating characteristic (ROC) curve analysis was used to determine the optimal cut-off values of the variables for predicting the PDS outcome. We used binary logistic regression to examine the independent predictive value of the factors for incomplete cytoreduction. (3) Among the parameters, we established optimal cut-off values for cancer antigen (Ca)-125, neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet- to-lymphocyte ratio (PLR) to predict the outcome of PDS. The results of binary logistic regression showed that stage (FIGO III-IV), MLR (>0.305), and Ca-125 (>169.15 kU/L) were independent significant predictors of the degree of tumor reduction achieved during PDS. (4) In the future, MLR, especially in combination with other parameters, may be useful in determining prognosis and selecting the best treatment option (PDS or neoadjuvant chemotherapy + interval debulking surgery) for ovarian cancer patients.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk epithelial ovarian cancer cytoreductive surgery prognostic factors
Megjelenés:	Diagnostics. - 13 : 13 (2023), p. 1-13. -
További szerzők:	Sulina Anita Kovács Kincső Sára Lukács Luca (1995-) (hallgató) Török Péter (1975-) (szülész-nőgyógyász) Lampé Rudolf (1983-) (szülész-nőgyógyász)
Pályázati támogatás:	EFOP-3.6.2-16-2017-00009 EFOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM101455
035-os BibID:	(cikkazonosító)970 (WoS)000786981800001 (Scopus)85128843077
Első szerző:	Szegeczki Vince
Cím:	Endometrium as Control of Endometriosis in Experimental Research : assessment of Sample Suitability / Szegeczki Vince, Fazekas László, Kulcsár Máté, Reglodi Dora, Török Péter, Orlik Brigitta, Lagana Antonio Simone, Jakab Attila, Juhasz Tamas
Dátum:	2022
ISSN:	2075-4418
Megjegyzések:	Endometriosis is a chronic gynecological disease that causes numerous severe symptoms in affected women. Revealing alterations of the molecular processes in ectopic endometrial tissue is the current policy for understanding the pathomechanisms and discovering potential novel thera- peutic targets. Examining molecular processes of eutopic endometrium is likely to be a convenient method to compare it with the molecular alterations observed in ectopic tissues. The aim of the present study was to determine what proportion of the surgically resected eutopic endometrial samples is suitable for further experiments so that these can be comparable with endometriosis. Final hospital reports and histopathology reports of a 3-year-long period (1162 cases) were ana- lysed. The application of a retrospective screening method promoted the categorization of these cases, and quantification of the categorized cases was accomplished. In addition, results obtained from cultured endometrium samples were also detailed. Only a small number of the harvested en- dometrial samples was suitable for further molecular analysis, while preoperative screening proto- col could enlarge this fraction. Applying clinical and histopathological selection and exclusion cri- teria for tissue screening and histopathological examination of samples could ensure the compara- bility of healthy endometrium with endometriosis. The present study could be useful for research- ers who intend to perform molecular experiments to compare endometriosis with the physiological processes of the endometrium.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk endometrium curettage hysteroscopy endometrial sampling in vitro endometrial culturing
Megjelenés:	Diagnostics. - 12 : 4 (2022), p. 1-17. -
További szerzők:	Fazekas László Kulcsár Máté Reglődi Dóra (Idegtudományok) Török Péter (1975-) (szülész-nőgyógyász) Orlik Brigitta Laganà, Antonio Simone Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus) Juhász Tamás (1976-) (biológus, orvosbiológus)
Pályázati támogatás:	ÚNKP-17-2 Egyéb ÚNKP-19-3 Egyéb ÚNKP-20-3-II Egyéb EFOP-3.6.3-VEKOP-16-2017-00009 EFOP NKFIHK139396 Egyéb MTA-TKI 14016 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM108374
035-os BibID:	(cikkazonosító)339 (WoS)000929385200001 (Scopus)85147813463
Első szerző:	Vitale, Salvatore Giovanni
Cím:	Hysteroscopic Endometrial Ablation : from Indications to Instrumentation and Techniques - A Call to Action / Salvatore Giovanni Vitale, Luigi Della Corte, Michał Ciebiera, Josè Carugno, Gaetano Riemma, Ricardo Bassil Lasmar, Bernardo Portugal Lasmar, Ilker Kahramanoglu, Bulent Urman, Mislav Mikuš, Carlo De Angelis, Péter Török, Stefano Angioni
Dátum:	2023
ISSN:	2075-4418
Megjegyzések:	The development of minimally invasive techniques has led to the creation of innovative alternatives in cases where traditional methods are not applicable. In modern gynecology, hysteroscopy has become the gold standard for the evaluation and treatment of intrauterine pathology. Endometrial ablation (EA) is a procedure that uses different types of energy to destroy the endometrium and is currently used as an alternative technique in cases of heavy menstrual bleeding when medical treatment has failed and uterine preservation is desired. The aim of this review was to evaluate the feasibility, safety, and clinical outcomes of hysteroscopic EA as an alternative in patients with abnormal uterine bleeding. A detailed computerized search of the literature was performed in the main electronic databases (MEDLINE, EMBASE, Web of Science, PubMed, and Cochrane Library), from 1994 to June 2022, to evaluate the outcomes in patients with abnormal uterine bleeding (AUB) undergoing EA using hysteroscopic and non-hysteroscopic techniques. Only scientific publications in English were included. Twelve articles on the current use of endometrial ablation were included. Data on patient symptoms, tools used for EA, primary outcomes, and adverse events were recorded. EA should be considered an effective and safe approach in the management of patients with abnormal uterine bleeding caused by benign pathology, in whom medical treatment has failed or is contraindicated. Due to the lack of evidence, it would be interesting to determine whether EA would also have a role in the treatment of women with premalignant lesions, avoiding invasive surgical procedures or medical treatment in those patients for whom hysterectomy or the use of hormonal treatment is contraindicated.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk hysteroscopy endometrium ablation endometrial ablation hysterectomy abnormal uterine bleeding heavy menstrual bleeding myoma polyp resectoscope
Megjelenés:	Diagnostics. - 13 : 3 (2023), p. 339-. -
További szerzők:	Della Corte, Luigi Ciebiera, Michał Carugno, Jose Riemma, Gaetano Lasmar, Ricardo Bassil Lasmar, Bernardo Portugal Kahramanoglu, Ilker Urman, Bulent Mikuš, Mislav De Angelis, Carlo Török Péter (1975-) (szülész-nőgyógyász) Angioni, Stefano
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