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001-es BibID:BIBFORM103390
035-os BibID:(cikkazonosító)1132 (Wos)000846594700001 (Scopus)84897012855
Első szerző:Buzzaccarini, Giovanni
Cím:Pain Management during Office Hysteroscopy : an Evidence-Based Approach / Buzzaccarini Giovanni, Alonso Pacheco Luis, Vitagliano Amerigo, Haimovich Sergio, Chiantera Vito, Török Péter, Vitale Salvatore Giovanni, Lagana Antonio Simone, Carugno Jose
Dátum:2022
ISSN:1010-660X 1648-9144
Megjegyzések:Background and Objectives: Hysteroscopy is a reliable technique which is highly useful for the evaluation and management of intrauterine pathology. Recently, the widespread nature of in-office procedures without the need for anesthesia has been requesting validation of practical approach in order to reduce procedure-related pain. In this regard, we performed a comprehensive review of literature regarding pain management in office hysteroscopic procedures. Materials and Methods: MEDLINE, EMBASE, The Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Cochrane Methodology Register), Global Health, Health Technology Assessment Database and Web of Science, other research registers (for example Clinical Trials database) were searched. We searched for all original articles regarding pain relief strategy during office hysteroscopy, without date restriction. Results have been collected and recommendations have been summarized according to the Appraisal of Guidelines for Research and Evaluation (AGREE) tool. Moreover, the strength of each recommendation was scored following the Grading of Recommendations Assessment (GRADE) system, in order to present the best available evidence. Results: Both pharmacological and non-pharmacological strategies for pain management are feasible and can be applied in office setting for hysteroscopic procedures. The selection of strategy should be modulated according to the characteristics of the patient and difficulty of the procedure. Conclusions: Accumulating evidence support the use of pharmacological and other pharmacological-free strategies for reducing pain during office hysteroscopy. Nevertheless, future research priorities should aim to identify the recommended approach (or combined approaches) according to the characteristics of the patient and difficulty of the procedure.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
anxiety
office hysteroscopy
outpatient hysteroscopy
pain
practical guidelines
Megjelenés:Medicina. - 58 : 8 (2022), p. 1-14. -
További szerzők:Alonso Pacheco, Luis Vitagliano, Amerigo Haimovich, Sergio Chiantera, Vito Török Péter (1975-) (szülész-nőgyógyász) Vitale, Salvatore Giovanni Laganà, Antonio Simone Carugno, Jose
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2.

001-es BibID:BIBFORM106175
035-os BibID:(cikkazonosító)811 (WOS)000911130600001 (Scopus)85145909463
Első szerző:Gullo, Giuseppe
Cím:Fertility-Sparing Strategies for Early-Stage Endometrial Cancer : Stepping towards Precision Medicine Based on the Molecular Fingerprint / Gullo Giuseppe, Cucinella Gaspare, Chiantera Vito, Dellino Miriam, Cascardi Eliano, Török Péter, Herman Tünde, Garzon Simone, Uccella Stefano, Lagana Antonio Simone
Dátum:2023
ISSN:1422-0067
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:International Journal Of Molecular Sciences. - 24 : 1 (2023), p. 1-5. -
További szerzők:Cucinella, Gaspare Chiantera, Vito Dellino, Miriam Cascardi, Eliano Török Péter (1975-) (szülész-nőgyógyász) Herman Tünde (1979-) (orvos) Garzon, Simone Uccella, Stefano Laganà, Antonio Simone
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3.

001-es BibID:BIBFORM117861
Első szerző:Herman Tünde (orvos)
Cím:Hashimoto's thyroiditis negatively influences ICSI outcome in euthyroid women on T4 substitution therapy; a retrospective study / Tünde Herman, Péter Török, Antonio Simone Laganà, Vito Chiantera, Renato Venezia, Attila Jakab
Dátum:2024
ISSN:0378-7346
Megjegyzések:Abstract Objective: To analyze the impact of thyroid autoimmunity (TAI) on reproductive outcome parameters of ICSI cycles as compared to TAI negative ICSI cycles. Design: In this single IVF center retrospective study 86 infertile women with elevated TPOAb or TGAb levels, but euthyroid after thyroxine replacement (study group), were compared to 69 female patients with no thyroid abnormalities (controls). Following ICSI treatment fertilization rate (FR), clinical pregnancy rate (CPR), miscarriage rate (MR) and live birth rate (LBR) were analyzed. Materials, Setting, Methods: All subjects with various infertility factors were treated with ICSI in university based IVF center. Patients in the study group received thryroxine replacement and were euthyreoid at IVF treatment. Before the IVF cycles endocrinological parameters were uniformly assessed: thyroid function and antibodies, reproductive hormones (AMH, FSH, LH, E2, PRL, testosterone, DHEAS, 17-OHP, AD) and OGTT (0-60-120 min glucose and insulin). Following descriptive comparison of laboratory parameters, age adjusted analyses of FR, CPR, MR and LBR were performed. Results: TAI positive women were older (mean age 35.31?4.95 vs. 32.15?4.87 years; p=0.002), had higher FSH (8.4?3.4 vs. 7.4?2.32 U/L; p=0.024), higher E2 (53.94?47.61 vs. 42.93?18.92 pg/ml; p=0.025) levels, while AMH (2.88?2.62 vs. 3.61?1.69 ng/ml; p=0.0002) was lower. There were no differences in TSH levels (1.64?0.96 vs. 1.66?0.65 uIU/ml; p=0.652) between the two groups. FT3 (2.63?0.58 vs. 2.98?0.55 pg/ml; p=0.002) was lower and FT4 (1.3?0.29 vs. 1.13?0.21 ng/dl; p=0.0002) was higher in the TAI positive group, reflecting clinically irrevelant differences. Egg cell counts (6?3.8 vs. 7.5?3.95; p=0.015) were lower in TAI and remained so following age adjustment. Although the overall ICSI FR did not differ (62.9 % vs. 69.1 %, p=0.12), it was lower for patients under 35 with TAI showing decreasing differences in line with age. The CPR (36.04 % vs. 69.56 %; p<0.001), LBR (23.25 % vs. 60.86 %; p<0.001) were lower, the MR (35.48 % vs. 12.5 %; p=0.024) was higher in the TAI group and these differences remained after age adjustment. Limitations: Since the higher age of the study group may interfere with the effect of TAI, age adjustment calculations were necessary to perform to eliminate this confounding factor. Conclusion: Despite optimal thyroid supplementation in clinical or subclinical hypothyreoidism, the presence of TAI negatively influences clinical pregnancy rate and is connected to a higher miscarriage rate, thus resulting in a lower live birth rate after ICSI. Decreased fertilization rate with ICSI in TAI patients may also contribute to poorer outcomes, especially in younger women.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
IVF
ICSI
Hashimoto thyreoiditis
Megjelenés:Gynecologic And Obstetric Investigation. - [Epub ahead of print] (2024). -
További szerzők:Török Péter (1975-) (szülész-nőgyógyász) Laganà, Antonio Simone Chiantera, Vito Venezia, Renato Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus)
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4.

001-es BibID:BIBFORM105360
035-os BibID:(WoS)000894986300001 (Scopus)85143521697
Első szerző:Herman Tünde (orvos)
Cím:Impact of endocrine disorders on IVF outcomes : results from a large, single-centre, prospective study / T. Herman, Sz. Csehely, M. Orosz, H. P. Bhattoa, T. Deli, P. Török, A. S. Laganà, V. Chiantera, A. Jakab
Dátum:2023
ISSN:2045-2322
Megjegyzések:Endocrine disorders negatively influence the ovarian function and increasing incidence of endocrine diseases with age may have further negative effects on pregnancy rate. Prospective cohort study of 231 consecutively enrolled patients underwent IVF treatment. In patients with known endocrine disorders the laboratory parameters were corrected before IVF treatment. 161 patients (69.7%) had at least one known and treated endocrine disorder (study group), and 70 patients were endocrine negative (control group). Endocrine disorders diagnosed were thyroid disorders (32,5%), diminished ovarian reserve (23,8%), insulin resistance (22,5%), PCOS (15,2%), hyperprolactinemia (13,4%), obesity (12,1%), hypogonadotropic hypogonadism (0,8%), congenital adrenal hyperplasia (0.2%). Before the IVF treatment systematic endocrine laboratory examinations were performed in all patients. Higher age, BMI, and FSH was found in the study group, while AMH level was lower. There were no differences in LH, E2, prolactin, TSH, FT3, FT4, TT, DHEAS, androstendione, 17-OHP, SHBG level between the study and control groups. The study group had higher baseline glucose, baseline insulin, 120 minute glucose and 120 minute insulin level after oral glucose tolerance test. With no difference in the IVF cycles performed, pregnancy rate was lower in the study group (61.43 % vs. 34.16 %; p=0.003), and this difference (p=0.0151) remained in age-corrected rates, as well. The analysis were also performed in individual endocrinology groups. The prevalence of endocrine disorders is high in females participating in IVF programs and they often accompanying to each other. Even after proper correction, the presence of the endocrine disorder negatively influences the pregnancy rate in IVF treatment.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
assisted reproduction
in vitro fertilization
endocrine diseases
thyroid diseases
Megjelenés:Reproductive Sciences. - 30 : 6 (2023), p. 1878-1890. -
További szerzők:Csehely Szilvia (1990-) (szülész-nőgyógyász szakorvos) Orosz Mónika (1991-) (Szülész-nőgyógyász) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Deli Tamás Török Péter (1975-) (szülész-nőgyógyász) Laganà, Antonio Simone Chiantera, Vito Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus)
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Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM113217
035-os BibID:(cikkazonosító)1922 (WoS)001028126600001 (Scopus)85165067689
Első szerző:Pecorino, Basilio
Cím:Evaluation of Borderline Ovarian Tumor Recurrence Rate after Surgery with or without Fertility-Sparing Approach : Results of a Retrospective Analysis / Pecorino Basilio, Lagana Antonio Simone, Mereu Liliana, Ferrara Martina, Carrara Grazia, Etrusco Andrea, Di Donna Mariano Catello, Chiantera Vito, Cucinella Giuseppe, Barra Fabio, Török Péter, Scollo Paolo
Dátum:2023
ISSN:2227-9032
Megjegyzések:Borderline ovarian tumors (BOTs) comprise 15?20% of primary ovarian neoplasms and represent an independent disease entity among epithelial ovarian cancers. The present study (ClinicalTrial ID: NCT05791838) aimed to report a retrospective analysis of the management and outcomes of 86 consecutive BOTs patients, 54 of which were at a reproductive age. All patients with BOTs undergoing surgical treatment from January 2010 to December 2017 were included. Data were retrospectively reviewed. High levels of Ca-125 were observed in 25.6% of the FIGO stage I patients and 58.3% of the advanced disease patients. Fertility-sparing surgery and comprehensive surgical staging were performed in 36.7% and 49.3% of the patients, respectively. Laparotomy was the most frequent surgical approach (65.1%). The most common diagnosis at frozen sections was serous BOT(50.6%). Serous BOTs have significantly smaller tumor diameters than mucinous BOTs (p < 0.0001).The mean postoperative follow-up was 29.8 months (range 6?87 months). Three patients experienced are currence, with an overall recurrence rate of 3.5% (10% considering only the patients who underwent fertility-sparing treatment). BOTs have low recurrence rates, with excellent prognosis. Surgery with proper staging is the main treatment. Conservative surgery is a valid option for women with reproductive potential
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
borderline ovarian tumors
conservative surgery
micropapillary patterns
surgicalstaging
fertility-sparing surgery
Megjelenés:Healthcare (Switzerland). - 11 : 13 (2023), p. 1-12. -
További szerzők:Laganà, Antonio Simone Mereu, Liliana Ferrara, Martina Carrara, Grazia Etrusco, Andrea Di Donna, Mariano Catello Chiantera, Vito Cucinella, Giuseppe Barra, Fabio Török Péter (1975-) (szülész-nőgyógyász) Scollo, Paolo
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Intézményi repozitóriumban (DEA) tárolt változat
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6.

001-es BibID:BIBFORM109152
035-os BibID:(WoS)000937906300001 (Scopus)85148576802
Első szerző:Török Péter (szülész-nőgyógyász)
Cím:Reproductive outcomes after expectant and surgical management for tubal pregnancy : a retrospective study / Török Péter, Naem Antoine, Csehely Szilvia, Chiantera Vito, Sleiman Zaki, Lagana Antonio Simone
Dátum:2023
ISSN:1364-5706 1365-2931
Megjegyzések:Background: The management of ectopic pregnancy is widely debated. Salpingectomy, salpin- gostomy, and expectant management are widely performed, but the best approach in terms of keeping good future spontaneous fertility chances is yet to be determined. Material and methods: We performed a retrospective analysis (Clinical Trial ID: NCT05479786) of the medical records of patients with an ultrasonographic or surgical diagnosis of tubal ectopic pregnancy that were admitted to the University of Debrecen Clinical Centre between 2012 and 2020. Results: A total of 312 patients were included in the analysis. Patients managed expectantly and patients treated with salpingostomy had significantly higher rates of clinical pregnancy than patients treated with salpingectomy. Pregnancy outcomes and recurrence rates were compar- able between the study groups. Salpingectomy was found to decrease the likelihood of conceiv- ing spontaneously by 65%. A stratified analysis based on serum b-HCG levels demonstrated that all treatment modalities carry the same reproductive opportunities for patients presenting with b-HCG levels 1745 IU/L. Conclusion: Salpingectomy was found to decrease the patient's chance of achieving a natural conception. Conservative approaches should be considered with caution only when the patient's clinical condition permits, and the patient is appropriately counseled.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Ectopic pregnancy
expectant management
pregnancy outcomes
salpingectomy
salpingostomy
Megjelenés:Minimally Invasive Therapy & Allied Technologies. - 32 : 3 (2023), p. 127-135. -
További szerzők:Naem, Antoine Csehely Szilvia (1990-) (szülész-nőgyógyász szakorvos) Chiantera, Vito Sleiman, Zaki Laganà, Antonio Simone
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7.

001-es BibID:BIBFORM110695
035-os BibID:(cikkazonosító)102588 (Scopus)85153232429 (WoS)000990464300001
Első szerző:Vitale, Salvatore Giovanni
Cím:Endometrial Biopsy : Indications, Techniques and Recommendations. An Evidence-Based Guideline for Clinical Practice / Vitale Salvatore Giovanni, Buzzaccarini Giovanni, Riemma Gaetano, Pacheco Luis Alonso, Sardo Attilio Di Spiezio, Carugno Jose, Chiantera Vito, Török Peter, Noventa Marco, Haimovich Sergio, De Franciscis Pasquale, Perez-Medina Tirso, Angioni Stefano, Lagana Antonio Simone
Dátum:2023
ISSN:2468-7847
Megjegyzések:This practice guideline provides updated evidence for the gynecologist who performs endometrial biopsy (EB) in gynecologic clinical practice. An international committee of gynecology experts developed the recommendations according to AGREE Reporting Guideline. An adequate tissue sampling is mandatory when performing an EB. Blind methods should not be first choice in patients with suspected endometrial malignancy. Hysteroscopy is the targeted-biopsy method with highest diagnostic accuracy and cost-effectiveness. Blind suction techniques are not reliable for the diagnosis of endometrial polyps. In low resources settings, and in absence of the capacity to perform office hysteroscopy, blind techniques could be used for EB. Hysteroscopic punch biopsy allows to collect only limited amount of endometrial tissue. grasp biopsy technique should be considered first choice in reproductive aged women, bipolar electrode chip biopsy should be preferred with hypotrophic or atrophic endometrium. EB is required for the final diagnosis of chronic endometritis. There is no consensus regarding which endometrial thickness cut-off should be used for recommending EB in asymptomatic postmenopausal women. EB should be offered to young women with abnormal uterine bleeding and risk factors for endometrial carcinoma. Endometrial pathology should be excluded with EB in nonobese women with unopposed hyperestrogenism. Hysteroscopy with EB is useful in patients with abnormal bleeding even without sonographic evidence of pathology. EB has high sensitivity for detecting intrauterine pathologies. In postmenopausal women with uterine bleeding, EB is recommended. Women with sonographic endometrial thickness > 4mm using tamoxifen should undergo hysteroscopic EB.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Hysteroscopy
Practical guidelines
Endometrium
Endometrial biopsy
Megjelenés:Journal of Gynecology Obstetrics and Human Reproduction. - 52 : 6 (2023), p. 1-7. -
További szerzők:Buzzaccarini, Giovanni Riemma, Gaetano Pacheco, Luis Alonso Sardo, Attilio Di Spiezio Carugno, Jose Chiantera, Vito Török Péter (1975-) (szülész-nőgyógyász) Noventa, Marco Haimovich, Sergio De Franciscis, Pasquale Perez-Medina, Tirso Angioni, Stefano Laganà, Antonio Simone
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