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001-es BibID:	BIBFORM091566
035-os BibID:	(cikkazonosító)155
Első szerző:	Franco, Nuno Henrique
Cím:	Assessing Scientific Soundness and Translational Value of Animal Studies on DPP4 Inhibitors for Treating Type 2 Diabetes Mellitus / Nuno Henrique Franco, Sonia Miranda Batista, Nóra Kovács, Attila Csaba Nagy, Thiên, Bùi Quôc, Flávio Reis, Orsolya Varga
Dátum:	2021
ISSN:	2079-7737
Megjegyzések:	Although there is a wide range of animal models of type 2 diabetes mellitus (T2DM) used in re-search; we have limited evidence on their translation value. This paper provides a) a comparison of preclinical animal and clinical results on the effect of five dipeptidyl peptidase-4 (DPP4) in-hibitors by comparing the pharmaceutical caused glucose changes, and b) an evaluation of methodological and reporting standards in T2DM preclinical animal studies. DPP4 inhibitors play an important role in the clinical management of T2DM: if metformin alone is not sufficient enough to control the blood sugar levels, DPP4 inhibitors are often used as second-line therapy; additionally, DPP-4 inhibitors are also used in triple therapies with metformin and sodi-um-glucose co-transporter-2 (SGLT-2) inhibitors or with metformin and insulin. In our analysis of 124 preclinical studies and 47 clinical trials, (1) we found no evidence of species differences in glucose change response to DPP4 inhibitors, which may suggest that, for this drug class, studies in mice and rats may be equally predictive of how well a drug will work in humans; and (2) there is good reporting of group size, sex, age, euthanasia method and self-reported compliance with animal welfare regulations in animal studies but poor reporting of justification of group size, along with a strong bias towards the use of male animals and young animals. Instead of the common non-transparent model selection, we call for a reflective and evidenced-based assess-ment of predictive validity of the animal models currently available.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Biology. - 10 : 2 (2021), p. 1-18. -
További szerzők:	Batista, Sonia Miranda Kovács Nóra (1989-) (népegészségügyi szakember) Nagy Attila Csaba (1981-) (megelőző orvostan és népegészségtan szakorvos, epidemiológus) Thiên, Bùi Quôc Reis, Flávio Varga Orsolya (1977-) (orvos, jogász)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM058659
Első szerző:	Kiss Tímea (molekuláris biológus)
Cím:	The role of osteopontin expression in melanoma progression / Timea Kiss, Szilvia Ecsedi, Laura Vizkeleti, Viktoria Koroknai, Gabriella Emri, Nora Kovács, Roza Adany, Margit Balazs
Dátum:	2015
ISSN:	1010-4283
Megjegyzések:	It was shown that osteopontin (OPN), a glycophosphoprotein, plays divergent roles in cancer progression. In addition to multiple intra- and extracellular functions, it facilitates migration of tumour cells, has crucial role in cell adhesion and is associated with increased metastasis formation. In previous studies, we performed global gene expression profiling on a series of primary melanoma samples and found that OPN was significantly overexpressed in ulcerated melanomas. The major purpose of this study was to define OPN expression in primary melanomas with differing biological behaviours. OPN mRNA expression was analysed by quantitative reverse transcription polymerase chain reaction (qRT-PCR) in primary melanoma tissues. Immunohistochemistry was performed using a tissue microarray. Cox regression tests were used for survival analysis. Greater than 50 % of the tissues exhibited high protein expression that was significantly associated with tumour thickness and metastasis. OPN mRNA expression was significantly increased in thicker melanomas and lesions with an ulcerated surface. Increased expression was primarily detected in advanced-stage tumours. A multivariate Cox regression analysis revealed that high OPN expression, tumour thickness and metastasis were significantly associated with reduced relapse-free survival. In summary, high OPN mRNA and protein expression were associated with a less favourable clinical outcome of primary melanoma patients. We determined that OPN is a significant predictive factor for the survival of primary melanoma patients. Based on our and others data, the high expression of OPN may have a crucial stimulatory role in tumour progression and metastasis formation, which, thus, have been proposed as potential targets for cancer diagnosis and therapy
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Melanoma progression Osteopontin Protein expression Tissue microarray
Megjelenés:	Tumor Biology. - 36 : 10 (2015), p. 7841-7847. -
További szerzők:	Ecsedi Szilvia (1982-) (molekuláris biológus, genetikus) Vízkeleti Laura (1984-) (molekuláris biológus, genetikus) Koroknai Viktória (1986-) (molekuláris biológus) Emri Gabriella (1972-) (bőrgyógyász, allergológus, onkológus) Kovács Nóra (1989-) (népegészségügyi szakember) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus)
Pályázati támogatás:	K112327 OTKA TÁMOP-4.2.2/B-10/1-2010-0024 TÁMOP Egészségtudományok Doktori Iskola 4.2.4.A/2-11/1-2012-0001 TÁMOP TÁMOP-4.2.2.A-11/1/KONV-2012-0031 TÁMOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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