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001-es BibID:	BIBFORM016299
Első szerző:	Nemes Éva (csecsemő- és gyermekgyógyász, gasztroenterológus)
Cím:	Activation of human granulocytes by intravenous immunoglobulin preparations is mediated by FcgammaRII and FcgammaRIII receptors / Nemes Éva, Teichmann Farkas, Roos Dirk, Maródi László
Dátum:	2000
ISSN:	0031-3998
Megjegyzések:	Previous studies from our laboratory have shown that i.v. Ig (IVIG) exposure triggers superoxide anion (O2) generation by and increases bactericidal capacity of human blood granulocytes. However, the molecular interactions between IVIG and granulocytes have not been evaluated before. The objective of this study was to investigate the role of FcgammaRII and FcgammaRIII receptors in the immunomodulatory effects of IVIG concentrates on granulocytes. We found that four different IVIG preparations (concentration range, 1-10 mg/mL) shared the ability to stimulate O2- release in vitro by granulocytes in a dose-dependent manner. Dimers fractionated from IVIG were significantly more potent in inducing activity of the respiratory burst than were monomers. MAb (concentration range, 0.1-10 microg/mL) specific for FcgammaRII and FcgammaRIII receptors inhibited the IVIG-induced O2- release, with a more profound inhibitory effect observed with anti-FcgammaRIII. These findings suggest the involvement of Fcgamma receptors in triggering O2- release by granulocytes exposed to IVIG. We also report that IVIG added to granulocyte suspensions elicited a rapid and vigorous increase in the concentration of cytosolic free calcium, a finding suggesting direct activation and not priming of granulocytes by IVIG through FcgammaRII and FcgammaRIII receptors. The in vitro effects described here might occur in patients treated with IVIG and may, in part, be responsible for inflammatory reactions evoked by infused Ig concentrates as well as the immunomodulatory effect of Ig in patients with autoimmune and inflammatory diseases.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Pediatric Research. - 47 : 3 (2000), p. 357-361. -
További szerzők:	Teichmann Farkas Roos, Dirk Maródi László (1949-) (gyermekgyógyász infektológus, immunológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat elektronikus változat
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001-es BibID:	BIBFORM013549
Első szerző:	Roos, Dirk
Cím:	Hematologically important mutations : X-linked chronic granulomatous disease (third update) / Dirk Roos, Douglas B. Kuhns, Anne Maddalena, Joachim Roesler, Juan Alvaro Lopez, Tadashi Ariga, Tadej Avcin, Martin de Boer, Jacinta Bustamante, Antonio Condino-Neto, Gigliola Di Matteo, Jianxin He, Harry R. Hill, Steven M. Holland, Caroline Kannengiesser, M. Yavuz Köker, Irina Kondratenko, Karin van Leeuwen, Harry L. Malech, László Marodi, Hiroyuki Nunoi, Marie-José Stasia, Anna Maria Ventura, Carl T. Witwer, Baruch Wolach, John I. Gallin
Dátum:	2010
ISSN:	1079-9796
Megjegyzések:	Chronic granulomatous disease (CGD) is an immunodeficiency disorder affecting about 1 in 250,000 individuals. The disease is caused by a lack of superoxide production by the leukocyte enzyme NADPH oxidase. Superoxide is used to kill phagocytosed micro-organisms in neutrophils, eosinophils, monocytes and macrophages. The leukocyte NADPH oxidase is composed of five subunits, of which the enzymatic component is gp91-phox, also called Nox2. This protein is encoded by the CYBB gene on the X chromosome. Mutations in this gene are found in about 70% of all CGD patients. This article lists all mutations identified in CYBB in the X-linked form of CGD. Moreover, apparently benign polymorphisms in CYBB are also given, which should facilitate the recognition of future disease-causing mutations.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Blood Cells Molecules And Diseases. - 45 : 3 (2010), p. 246-265. -
További szerzők:	Kuhns, Douglas B. Maddalena, Anne Roesler, Joachim Lopez, Juan Alvaro Ariga, Tadashi Avcin, Tadej Bustamante, Jacinta Condino-Neto, Antonio Matteo, Gigliola He, Jianxin Hill, Harry R. Holland, Steven M. Kannengiesser, Caroline Köker, M. Yavuz Kondratenko, Irina van Leeuwen, Karin Malech, Harry L. Maródi László (1949-) (gyermekgyógyász infektológus, immunológus) Nunoi, Hiroyuki Stasia, Marie-José Ventura, Anna Maria Witwer, Carl T. Wolach, Baruch Gallin, John
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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