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001-es BibID:BIBFORM072240
Első szerző:Csorba Roland (szülész-nőgyógyász, gyermeknőgyógyász)
Cím:Correlation of rheological parameters in maternal and fetal blood at term / Csorba Roland, Soliman Amr A., Wieg Christian, Tsikouras Panagiotis, Rath Werner, von Tempelhoff Georg-Friedrich
Dátum:2014
ISSN:1476-7058 1476-4954
Megjegyzések:Objective: An association between maternal and fetal blood rheology has not yet been investigated nor is it known whether and to what extent fetal blood rheology may be affected by maternal conditions. Methods: At delivery, blood was drawn from the cubital vein of 4985 consecutive mothers and from the umbilical cord during birth for determination of blood rheological parameters (erythrocyte aggregation stasis [E0], low shear [E1], plasma viscosity [Pv]) in addition to hemoglobin (Hb) values and hematocrit (Hct). Results: Maternal and newborn Pv (r = 0.2; p < 0.0001) correlated statistically significant. There was a remarkable correlation between fetal Pv and gestational age (r = 0.197; p < 0.001). Iron supplementation during pregnancy led to increased fetal Hb, Hct as well as E0 and E1 (p < 0.0001), did not have a significant impact on neonatal Pv (p = 0.068). Smoking mothers gave birth to neonates with significantly higher Pv (p = 0.049), E0 (p = 0.016) and E1 (p = 0.013). Conclusions: The increase of fetal plasma viscosity at advanced delivery time-points refers to a more gaining protein synthesis by the fetal liver and thus maturity of the fetus. Iron supplementation as well as smoking during pregnancy is associated with a relative hyper-viscosity in the fetus at delivery.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Fetal maturity
Plasma viscosity
Pregnancy
Red blood cell aggregation
Rheology
Megjelenés:The Journal of Maternal-Fetal & Neonatal Medicine 28 : 8 (2014), p. 969-976. -
További szerzők:Soliman, Amr A. Wieg, Christian Tsikouras, Panagioti Rath, Werner Tempelhoff, Georg-Friedrich von
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2.

001-es BibID:BIBFORM072237
Első szerző:Soliman, Amr A.
Cím:Antiphopholipid antibodies and functional activated protein C resistance in patients with breast cancer during anthracycline-based chemotherapy administered through an intravenous port-catheter device / Soliman A. A., Csorba R., Ullrich A., Tsikouras P., Rath W., von Tempelhoff, G.-F.
Dátum:2014
ISSN:1076-0296
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Clinical And Applied Thrombosis-Hemostasis 20 : 3 (2014), p. 338-340. -
További szerzők:Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász) Ullrich, A. Tsikouras, Panagioti Rath, Werner Tempelhoff, Georg-Friedrich von
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3.

001-es BibID:BIBFORM048838
035-os BibID:(WoS)000429590100003 (Scopus)85047832575
Első szerző:Soliman, Amr A.
Cím:Neonatal blood rheological parameters at delivery in healthy neonates and in those with morbidities / Amr A. Soliman, Roland Csorba, Pagnaioti Tsikouras, Christian Wieg, Harald Harnack, Georg-Friedrich von Tempelhoff
Dátum:2018
ISSN:1386-0291 1875-8622
Megjegyzések:Rheological blood parameters of neonates are different form those of adults. Many authors have studied changes in blood rheology in neonates in different clinical disorders. To-date, no one set the normal values for blood rheological parameters in healthy neonates. The aim of this study is to set the norm for rheological blood parameters in healthy newborns and to describe the changes in those parameters in common clinical disorders that affect the newborns. We recruited all the neonates born to mothers experiencing un eventful pregnancies, blood was taken from the umbilical cord right after the delivery. In this time period we recruited 4985 neonate. From this huge database we were able to set the standards for blood rheology in neonates, namely plasma viscosity of 1.06 ? 0.072 mPa, erythrocyte aggregation at stasis of 2.41 ? 2.74 s-1 and erythrocyte aggregation under low shear forces of 8.51 ? 6.38 s-1. These values changed significantly in some diseased neonates. This is the largest study investigating normal rheological parameters and deviations from the norm in common clinical disorders occurring in this early stage of life.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Neonate
blood rheology
SGA
LBW
red blood cell aggregation
Megjelenés:Clinical Hemorheology and Microcirculation. - 68 : 4 (2018), p. 335-345. -
További szerzők:Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász) Tsikouras, Panagioti Wieg, Christian Harnack, Harald Tempelhoff, Georg-Friedrich von
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4.

001-es BibID:BIBFORM048839
035-os BibID:PMID:23089882
Első szerző:Soliman, Amr A.
Cím:Rheologic results and their correlation to hemostatic changes in patients with moderate and severe preeclampsia : an observational cross-sectional study / Amr A. Soliman, Roland Csorba, Asli Yilmaz, Georg-Friedrich von Tempelhoff
Dátum:2015
ISSN:1386-0291
Megjegyzések:Previous study have shown an association between failure of physiological hemodilution during 2nd trimester and an increased risk for the development of subsequent pregnancy complications such as early birth, birth of a growth retarded newborn (IUGR), low fetal birth weight and preeclampsia. The latter complication in particular goes along with dramatic changes in the placental perfusion as well as systemic maternal blood flow. Severity of preeclampsia may be preceded by distinct impaired hemodilution and reflected by the results of rheological parameters. A subgroup analysis was performed in a community based retrospective study of 4,985 consecutively recorded singleton pregnant women of whom 423 had preeclampsia. Mean 2nd trimester hemoglobin levels and blood rheological results at the time of delivery were assessed and compared in women with moderate and severe preeclampsia. Mean 2nd trimester hemoglobin levels were calculated from the maternal records. Rheological variables included plasma viscosity (KSPV 1 Fresenius) and Red blood cell aggregation in stasis and under low shear conditions (MA1-Aggregometer; Myrenne). According to the definition of the German Society of Gynecology and Obstetrics (DGGG) 314 women had moderate preeclampsia (74.2%), while 109 had severe preeclampsia due to the presence of a blood pressure >170/110 mmHg (n = 41; 9.7%), and/or IUGR <5th percentile (n = 28; 6.6%), and/or HELLP-Syndrome (n = 10; 2.4%), and/or proteinuria ?5 g/24 h (n = 30; 7.1%). Age, BMI, smoking, and maternal weight were comparable in the groups, while gestational age at delivery as well as fetal outcome parameter were statistically significant unfavourable in patients with severe preeclampsia. Mean 2nd trimester hemoglobin level were statistically significantly higher in women who developed severe vs. moderate preeclampsia (m = 12.75 ? 0.99 g/dL vs. m = 12.50 ? 1.05 g/dL; p = 0.033). However, in the ROC calculations a hemoglobin value of 12.05 g/dL revealed best sensitivity (78%) and specificity (33.8%) in women with subsequent diagnosis of severe preeclampsia, whereas sensitivity was 100% for a value >10.95 g/dL. There were no statistically significant differences for none of the rheological parameters at the time of delivery between groups of patient with moderate v.s severe preeclampsia. Severe preeclampsia and IUGR, however, was associated with statistically significantly higher RBC aggregation as compared to patients with moderate preeclampsia. Plasma viscosity was statistically significantly (p < 0.05) correlated with Fibrinogen values (r = 1.69), leukocyte-(r = 0.11) and platelets-count (r = 0.127), and hemoglobin/hematocrit values in particular (r = 0.23/0.26). Although mean 2nd trimester hemoglobin concentration are higher in patients with subsequent development of severe preeclampsia, due to the low sensitivity and specificity of this parameter clinical use for identifying women at risk is of limited value. On the other hand, a hemoglobin value below 11.0 g/dL excluded the risk for severe preeclampsia to 100%. Blood rheological parameters at the time of delivery in the absence of IUGR are not markedly influenced by severity of preeclampsia.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Blood fluidity
haemostasis
pregnancy
preeclampsia
red blood cell aggregation
Megjelenés:Clinical Hemorheology and Microcirculation. - 59 : 1 (2015), p. 1-15. -
További szerzők:Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász) Yilmaz, Asli Tempelhoff, Georg-Friedrich von
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