CCL

Összesen 6 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM072240
Első szerző:Csorba Roland (szülész-nőgyógyász, gyermeknőgyógyász)
Cím:Correlation of rheological parameters in maternal and fetal blood at term / Csorba Roland, Soliman Amr A., Wieg Christian, Tsikouras Panagiotis, Rath Werner, von Tempelhoff Georg-Friedrich
Dátum:2014
ISSN:1476-7058 1476-4954
Megjegyzések:Objective: An association between maternal and fetal blood rheology has not yet been investigated nor is it known whether and to what extent fetal blood rheology may be affected by maternal conditions. Methods: At delivery, blood was drawn from the cubital vein of 4985 consecutive mothers and from the umbilical cord during birth for determination of blood rheological parameters (erythrocyte aggregation stasis [E0], low shear [E1], plasma viscosity [Pv]) in addition to hemoglobin (Hb) values and hematocrit (Hct). Results: Maternal and newborn Pv (r = 0.2; p < 0.0001) correlated statistically significant. There was a remarkable correlation between fetal Pv and gestational age (r = 0.197; p < 0.001). Iron supplementation during pregnancy led to increased fetal Hb, Hct as well as E0 and E1 (p < 0.0001), did not have a significant impact on neonatal Pv (p = 0.068). Smoking mothers gave birth to neonates with significantly higher Pv (p = 0.049), E0 (p = 0.016) and E1 (p = 0.013). Conclusions: The increase of fetal plasma viscosity at advanced delivery time-points refers to a more gaining protein synthesis by the fetal liver and thus maturity of the fetus. Iron supplementation as well as smoking during pregnancy is associated with a relative hyper-viscosity in the fetus at delivery.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Fetal maturity
Plasma viscosity
Pregnancy
Red blood cell aggregation
Rheology
Megjelenés:The Journal of Maternal-Fetal & Neonatal Medicine 28 : 8 (2014), p. 969-976. -
További szerzők:Soliman, Amr A. Wieg, Christian Tsikouras, Panagioti Rath, Werner Tempelhoff, Georg-Friedrich von
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

2.

001-es BibID:BIBFORM072237
Első szerző:Soliman, Amr A.
Cím:Antiphopholipid antibodies and functional activated protein C resistance in patients with breast cancer during anthracycline-based chemotherapy administered through an intravenous port-catheter device / Soliman A. A., Csorba R., Ullrich A., Tsikouras P., Rath W., von Tempelhoff, G.-F.
Dátum:2014
ISSN:1076-0296
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Clinical And Applied Thrombosis-Hemostasis 20 : 3 (2014), p. 338-340. -
További szerzők:Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász) Ullrich, A. Tsikouras, Panagioti Rath, Werner Tempelhoff, Georg-Friedrich von
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

3.

001-es BibID:BIBFORM072235
Első szerző:Tempelhoff, Georg-Friedrich von
Cím:Thrombelastometric results and platelet function during pregnancy in women receiving low molecular weight heparin with a history of recurrent/late abortion : a retrospective analysis / von Tempelhoff Georg-Friedrich, Schelkunov Olga, Demirhan Attila, Tsikouras Panagiotis, Rath Werner, Velten Eva, Csorba Roland
Dátum:2015
ISSN:1386-0291
Megjegyzések:In women with a history of recurrent/late abortion and confirmed genetic/acquired thrombophilia, LMWH was given during subsequent pregnancy and serial coagulation testing was performed. In 82 consecutive pregnant women with recurrent (?2) and/or late abortion (>12 GW) in the presence of single (n = 62; 75.6) or combined (n = 20; 24.4) genetic and/or acquired thrombophilia, Thromboelastometry (n = 50; ROTEM, TEM) and closure-time (n = 82; PFA-100; Siemens) underwent serial testing before and during pregnancy while receiving LMWH and puerperal. Throughout pregnancy, clotting-time (CT) after intrinsic and extrinsic induced coagulation activation in Thromboelastometry remained unchanged. TF-induced coagulation activation resulted in statistically significantly decreased mean clot-formation-times (CFT) (Trim I: 108.9 ? 5.2 S to Trim III; 81.7 ? 5.4 S; p = 0.001), whereas after contact activation (Intem-S: Trim I: 70.1 ? 4.0 S to Trim III: 65.4 ? 6.8; n.s.) CFT remained unchanged. Mean maximal-clot-firmness (MCF) continuously increased in the Intem-S and Extem-S during each trimester and decreased until 4th puerperal week (Extem-S: Trim I: 61.9 ? 1.0 S; Trim II: 65.4 ? 0.58 S; Trim III: 68.3 ? 1.1 S; p < 0.001; Intem-S: Trim I: 64.1 ? 0.6 S; Trim II: 66.8 ? 0.5 S; Trim III: 69.5 ? 1.2 S; p < 0.001). Mean Closure-times after Epinephrine/ADP/Collagen stimulation remained unchanged during pregnancy. In women with different thrombophilia receiving LMWH at prophylactic dose a significant increase in MCF was accompanied by barely unchanged CT after intrinsic and extrinsic coagulation activation and platelet mediated closure-times in the course of the pregnancy. Decrease in CFT was only seen after extrinsic coagulation activation, whereas unchanged CFT after intrinsic coagulation activation may be the result of LMWH given at low dose.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
low-molecular-weight-heparin
platelet-function-analyser
Pregnancy
recurrent abortion
Thromboelastometry
Megjelenés:Clinical Hemorheology And Microcirculation 61 : 1 (2015), p. 99-110. -
További szerzők:Schelkunov, Olga Demirhan Attila Tsikouras, Panagioti Rath, Werner Velten, Eva Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

4.

001-es BibID:BIBFORM072234
035-os BibID:(Wos)000371008900006 (Scopus)84959020058
Első szerző:Tempelhoff, Georg-Friedrich von
Cím:Correlation between blood rheological properties and red blood cell indices(MCH, MCV, MCHC) in healthy women / von Tempelhoff Georg-Friedrich, Schelkunov Olga, Demirhan Attila, Tsikouras Panagiotis, Rath Werner, Velten Eva, Csorba Roland
Dátum:2016
ISSN:1386-0291
Megjegyzések:OBJECTIVE: Structure and mechanical properties of red blood cells are markedly influenced by pathophysiology of many diseases which in turn potentially impair microcirculatory blood flow. The physiological association between blood rheological parameters and red blood cell indices was investigated in otherwise healthy unselected mid-age women prior to elective gynaecological surgery. METHODS: Red Blood Cell-deformability (RBC 1.2, 3.0; 6.0, 12.0; 30.0, 60.0) during exposure to low (RBC 1.2, 3.0), moderate (RBC 16.0, 12.0) and high shear forces (RBC 30.0, 60.0; Rheodyn; Myrenne), -aggregation (MA1; Myrenne) during low shear (E1; 4-1 S) and in stasis (E0) and plasma viscosity (Pv; KSV 1; Fresenius) were correlated with red blood cell indices (RBC-I: MCV, MCH and MCHC) and subjects' characteristics in 286 healthy women the day before undergoing gynaecologic standard surgery. Women with known pregnancy, malign-, infective-, chronic-disease or extreme BMI (<16; >40 Kg/m2) were excluded from this trial. RESULTS: From June 2014 to December 2014 a total of 286 healthy women (age: 46.5?17.6 y; BMI: 25.5?5.2 kg/m2) were eligible for inclusion into this prospective evaluation. Pv (mean?SD: 1.17?0.12 mPa s) and RBC aggregation (E0:12.6?6.3; E1:17.9?7.3) were not significantly correlated with RBC-I but with age and BMI. In contrast, RBC-deformability correlated significantly with MCV and MCH but significantly inversely correlated with MCHC. Deformability significantly increased with age but was unaffected by BMI of women. The correlation between RBC-I and RBC deformability was most remarkable during moderate shear force exposure. Neither haemoglobin nor haematocrit were correlated with RBC deformability or RBC-I. CONCLUSIONS: Cell volume and haemoglobin content had a strong impact on deformability in apparently healthy mid age women, whereas low MCHC and large MCV were associated with an increase in deformability while high MCHC and small MCV correlated with increased rigidity of RBC. BMI had no impact on deformability while age was associated with an increase in all determinants of blood viscosity. RBC aggregability was not affected by MCV, MCHC or MCH in mid-age women.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
MCHC
MCV
Plasma viscosity
red blood cell aggregation
red blood cell deformability MCH
Megjelenés:Clinical Hemorheology And Microcirculation. - 62 : 1 (2016), p. 45-54. -
További szerzők:Schelkunov, Olga Demirhan Attila Tsikouras, Panagioti Rath, Werner Velten, Eva Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

5.

001-es BibID:BIBFORM072236
Első szerző:Tempelhoff, Georg-Friedrich von
Cím:Rheological, hemostaseological changes during immunetherapy for prevention of HELLP-syndrome in a patient with elevated phospholipid antibodies / von Tempelhoff Georg-Friedrich, Tsikouras Panagiotis, Rath Werner, Velten Eva, Csorba Roland
Dátum:2015
ISSN:1386-0291
Megjegyzések:OBJECTIVE: Patients with a history of severe obstetric complications in the presence of elevated phospholipid antibodies are at high risk for recurrent obstetric debacle. We report a successful immunologic treatment for prevention of HELLP-Syndrome in subsequent pregnancy in a patient with elevated Phospholipid antibodies, while under rheological and hemostaseological monitoring. METHODS: The patient with prior severe HELLP-Syndrome at term in the presence of reconfirmed elevated phospholipid antibodies in her first pregnancy received pooled immunoglobulins (Sandoglobulin 3 g - Novartis) intravenously for immunological treatment every three weeks in addition to low molecular weight heparin (Clexane 40 mg/d s.c.) and Aspirin (100 mg/d from 2nd trimester) during her subsequent pregnancy. Before each of 10 treatment cycles blood rheological parameters (Red Blood cell {RBC} aggregation stasis E0, low shear E1, RBC - deformability low-, moderate-, and high shear force, plasma viscosity {Pv}), as well as thrombelastometry (ROTEM) and in vitro platelet function (PFA-100) for hemostaseological evaluation was performed. At the same times non-invasive, physical thrombosis screening took place using impedance plethysmography (Filtrass) RESULTS: During pregnancy a constant increase in PV and E1 (>45 S-1) was accompanied by a delayed but continuous increase in RBC deformability beginning at the end of the 2nd trimester. Thrombelastometry revealed a continuous reduction of clot formation time (CFT; extem: 84 to 38 sec) and an increase in maximal clot firmness (MCF; extem: 64 to 78 sec) after TF-induced coagulation activation while MCF and CFT after contact activation (intem) was barely unchanged. Platelet bleedingtime after EPI/Coll stimulation was temporary prolonged by the onset of Aspirin intake (>300 sec) but normalized soon after 20th gestational week, while ADP/Coll stimulation revealed a trend towards prolonged bleeding times at the same time. There was a strong and statistically significant inverse correlation between E1 and TF induced CFT (r =-0.82; p = 0.002) and a positive correlation between E1 and TF induced MCF (r = 0.89; p < 0.001), while the correlation between E1 and contact activated CFT and MCF was weak or absent, respectively. Until GW 38th routine laboratory- (Platelet-count, Haptoglobin, liver enzymes) and clinical findings remained normal, without evidence of HELLP-Syndrome reoccurrence or development of thrombosis. CONCLUSIONS: During immunotherapy in this high risk patient HELLP-Syndrome did not reoccur. The aggregability of RBC was closely related with the formation speed and firmness of clot after TF activated coagulation but not after contact activated coagulation. At the beginning of 3rd trimester RBC aggregation remained dramatically higher as compared to the normal value range of pregnant women found in a large recent trial which may have been an early indicator of imminent HELLP-Syndrome.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
antiphospholipid syndrome
HELLP syndrome
immunological treatment
plasma viscosity
platelet function
Pregnancy
red blood cell aggregation
thrombelastometry
Megjelenés:Clinical Hemorheology And Microcirculation 60 : 1 (2015), p. 123-131. -
További szerzők:Tsikouras, Panagioti Rath, Werner Velten, Eva Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

6.

001-es BibID:BIBFORM073441
035-os BibID:(WoS)000436922100013 (Scopus)85047246921
Első szerző:Tsikouras, Panagioti
Cím:Blood rheology during normal pregnancy / Panagiotis Tsikouras, Barbara Niesigk, Georg-Friedrich von Tempelhoff, Werner Rath, Olga Schelkunov, Peter Daragó, Roland Csorba
Dátum:2018
ISSN:1386-0291
Megjegyzések:INTRODUCTION: Recent studies have shown increased RBC aggregation and no difference in plasma viscosity in thepresence ofmarkedly lower hematocrit inwomen at termcompared to non-pregnantwomen. Little is known about the outcomeof blood rheological parameters and red blood cell (RBC) deformability particularly in the course of normal pregnancy.METHODS: During a 36 months interval 1.913 blood samples were randomly collected from a total of 945 pregnantwomen in the course of their pregnancy (n = 1.259) and during puerperium (upto 1 week; n = 654). Next to the bloodcount, hemorheological parameters including red blood cell (RBC) -aggregation (stasis E0; low shear E1), -deformability(low, moderate and high shear conditions) and plasma viscosity (pv) were assessed. Plasma viscosity (pv) was examinedusing KSPV 1 Fresenius, RBC aggregation (stasis: E0 and low shear: E1) using MA1-Aggregometer; Myrenne and RBCdeformability (def) was determined by Rheodyn SSD Diffractometer, Myrenne, Roetgen, Germany were tested. In someof these women laboratory results prior to pregnancy (n = 145) were available which were compared with those duringpregnancy.RESULTS: Mean maternal pv remained unchanged within each trimester and compared to the values before pregnancyand during early puerperium (Range of means: 1.18?1.20mPa S). In contrast, RBC agg (E0 and E1) was markedly higherin the 2nd (21.8?7.0 and 28.9?9.4; p < 0.001) and 3rd trimester (18.74?8.4 and 28.2?9.4; p < 0.01) compared to thevalues before pregnancy (16.4?6.4 and 20?7.5) and during 1st trimester (17.49?6.5 and 22.4?7.4). There was a stat.significant temporary reduction in RBC def. under all shear rate conditions during 2nd trimester compared to the valuesbefore pregnancy which remained significantly lower during 3rd trimester only under high shear rates.An increase RBC agg was stat. significantly inversely correlated with reduced RBC def being most pronounced under lowshear rate conditions. While RBC rigidity was stat. significantly correlated with higher hematocrit values there was only aweak correlation between RBC agg and haematocrit (E0: r = ?0.084; p = 0.03; E1: r = ?0.06; p = 0.1). Pv was not correlatedwith haematocrit or RBC def but stat. significantly correlated with RBC agg.CONCLUSION: Blood rheological changesmanifest during 1st trimester, and fairly remain unchanged during 2nd trimesteruntil term. Physiologic hemodilution and increasing hypercoagulability is accompanied by high RBC -aggregation and?rigidity during 2nd trimester while plasma viscosity remains nearly unaffected throughout normal pregnancy.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Clinical Hemorheology and Microcirculation. - 69:1-2 (2018), p. 101-114. -
További szerzők:Niesigk, Barbara Tempelhoff, Georg-Friedrich von Rath, Werner Schelkunov, Olga Daragó Péter Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász)
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1 
Corvina könyvtári katalógus v8.2.27 © 2023 Monguz kft. Minden jog fenntartva.