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001-es BibID:BIBFORM048836
Első szerző:Csorba Roland (szülész-nőgyógyász, gyermeknőgyógyász)
Cím:Rheological parameters in the umbilical cord blood in moderate and severe forms of preeclampsia / Roland Csorba, Asli Yilmaz, Panagiotis Tsikouras, Christian Wieg, Alexander Teichmann, Georg-Friedrich von Tempelhoff
Dátum:2013
ISSN:1386-0291
Megjegyzések:Previous studies have dealt with maternal blood rheology in preeclampsia (PE), but only a few focused on the fetal rheological parameters in this maternal state. PE is one of the most common severe complications of pregnancy world-wide associated with high maternal morbidity and mortality and intrauterine fetal growth restriction. Our objective was to explore the rheological parameters in the umbilical cord blood at term in the presence of moderate and severe forms of PE.METHODS:A subgroup analysis was performed in a community based retrospective study of 4,951 consecutively recorded singleton pregnant women of whom 423 had PE. In the latter, umbilical cord blood was collected during delivery for testing of hematological and blood rheological parameters of their fetus. Fetal results from uneventful pregnancy were compared with those associated with preeclampsia. Furthermore, results were also evaluated in the presence of moderate and severe forms of PE. Plasma viscosity (pv) was examined using KSPV 1 Fresenius and Red Blood Cell (RBC) aggregation (stasis: E0 and low shear: E1) using MA1-Aggregometer; Myrenne.RESULTS:According to the definition of the German Society of Gynecology and Obstetrics (DGGG) 314 women had moderate (74.2%), while 109 had severe forms of PE due to the presence of a blood pressure > 170/110 mmHg (n = 41; 9.7%), and/or IUGR < 5th percentile (n = 28; 6.6%), and/or HELLP-Syndrome (n = 10; 2.4%), and/or proteinuria ? 5 g/24 h (n = 30; 7.1%). When comparing the fetal results from pregnancies with and without preeclampsia mean hemoglobin values (p < 0.001) and hematocrit (p < 0.001) were markedly higher, while plasma viscosity (p = 0.006) and erythrocyte aggreagtion (stase: p = 0.35; low shear: p = 0.08) were lower in association with preeclampsia. Gestational age, fetal birth-weight and umbilical arterial cord blood pH in women with severe PE was statistically significant lower as compared to those with moderate disease (p < 0.001). Mean hemoglobin level and hematocrit were higher in fetus from women with severe compared to moderate PE, while plasma viscosity (1.03 ? 0.07 mPas vs. 1.05 ? 0.07; p = 0.05) and erythrocyte aggregation in stase (2.3 ? 2.47 vs. 2.41 ? 2.46; p = 0.11) as well as under low shear (7.86 ? 4.63 vs. 8.06 ? 4.60; p = 0.15) were lower. HELLP-Syndrome was associated with the lowest plasma viscosity (1.00 ? 0.07 mPas; p = 0.019) and erythrocyte aggregation (low shear: 5.1 ? 5.0; p = 0.04) in fetus.CONCLUSION:The results of this study including a notable number of patients with PE and their newborns revealed an in part statistically significant association between variables of blood rheology and the presence, severity and type of preeclampsia with a trend towards hyper viscosity in severe forms of preeclampsia. The behaviour of blood rheological components in the neonate is remarkable since the number of red blood cells is raised while RBC aggregability and plasma viscosity is low.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Pregnancy
fetal hemorheology
plasma viscosity
preeclampsia
red blood cell aggregation
Megjelenés:Clinical Hemorheology and Microcirculation 55 : 4 (2013), p. 391-401. -
További szerzők:Yilmaz, Asli Tsikouras, Panagioti Wieg, Christian Teichmann, Alexander Tempelhoff, Georg-Friedrich von
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2.

001-es BibID:BIBFORM048861
Első szerző:Koukoulomati, A.
Cím:Diagnostic approach and therapeutic management in early-stage endometrial cancer / A. Koukoulomati, P. Tsikouras, N. Tsagias, R. Csorba, A. Liberis, A. T. Teichmann, V. S. Liberis, G. Galazios
Dátum:2013
ISSN:0392-2936
Megjegyzések:OBJECTIVE:The effectiveness of pelvic and para-aortic lymphadenectomy in the morbidity of patients affected by early-stage endometrial carcinoma (EC) is the subject of this study.STUDY DESIGN:Ninety-two cases with endometrial cancer that underwent para-aortic and pelvic lymphadenectomy, from June 1995 to June 2006, were studied and compared with 30 cases of patients with endometrial cancer without lymphadenectomy.RESULTS:According to the results, systematic pelvic and para-aortic lymphadenectomies improved disease-free and overall survival rates among the patients with endometrial cancer. The mean number of removed para-aortic lymph nodes was 19.01 +/- 5.88, whereas the mean number of removed iliac lymph nodes was 32.94 +/- 6.69. Forty-two and 31 metastatic iliac and para-aortic nodes were found, respectively. No surgery-related deaths and major intraoperative injuries occurred. The frequency and the type of postoperative complications were not affected by the performance of lymphadenectomy. The morbidity rate was 6.2%, similar to the group without lymphadenectomy (5.79%). No recurrence occurred in the group with lymphadenectomy, while in the other group the recurrence rate was 23.3%.CONCLUSIONS:Lymph nodes metastases can be observed in early stages of EC. Pelvic and para-aortic lymphadenectomies seems to provide profound information about the Stage of the disease and the patient's survival, identifying which patients are suitable for supplementary treatment, without significant clinical increase of morbidity.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Endometrial cancer
Paraortal iliac lymphadenectomy
morbidity
early stages
Megjelenés:European Journal of Gynaecological Oncology. - 34 : 4 (2013), p. 319-321. -
További szerzők:Tsikouras, Panagioti Tsagias, Nikolaos Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász) Liberis, Anastasios Teichmann, Alexander Liberis, V. S. Galazios, Georgios
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3.

001-es BibID:BIBFORM073324
035-os BibID:(Scopus)85045740530 (WOS)000434868800230 (cikkazonosító)791
Első szerző:Tsikouras, Panagioti
Cím:Comparative Evaluation of Arabin Pessary and Cervical Cerclage for the Prevention of Preterm Labor in Asymptomatic Women with High Risk Factors / Panagiotis Tsikouras, George Anastasopoulos, Vasileios Maroulis, Anastasia Bothou, Anna Chalkidou, Dorelia Deuteraiou, Xanthoula Anthoulaki, Georgios Tsatsaris, Arzou Halil Bourazan, George Iatrakis, Stefanos Zervoudis, Georgios Galazios, Lola-Katerina Inagamova, Roland Csorba, Alexander-Tobias Teichmann
Dátum:2018
ISSN:1661-7827 1660-4601
Megjegyzések:Abstract: Objective: Preterm labor is one of the most significant obstetric problems associated withhigh rate of actual and long-term perinatal complications. Despite the creation of scoring systems,uterine activity monitoring, cervical ultrasound and several biochemical markers, the prediction andprevention of preterm labor is still a matter of concern. The aim of this study was to examine cervicalfindings for the prediction and the comparative use of Arabin pessary or cerclage for the preventionof preterm birth in asymptomatic women with high risk factors for preterm labor. Material andmethods: The study group was composed of singleton pregnancies (spontaneously conceived) withhigh risk factors for preterm labor. Cervical length, dilatation of the internal cervical os and funneling,were estimated with transvaginal ultrasound during the first and the second trimesters of pregnancy.Results: Cervical funneling, during the second trimester of pregnancy, was the most significant factorfor the prediction of preterm labor. The use of Arabin cervical pessary was found to be more effectivethan cerclage in the prolongation of pregnancy. Conclusion: In women at risk for preterm labor,the detection of cervical funneling in the second trimester of pregnancy may help to predict pretermlabor and to apply the appropriate treatment for its prevention. Although the use of cervical pessarywas found to be more effective than cerclage, more studies are needed to classify the effectiveness ofdifferent methods for such prevention.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
cervical Arabin pessary
cerclage
second trimester of pregnancy
Megjelenés:International Journal of Environmental Research and Public Health. - 15 : 4 (2018), p. 1-10. -
További szerzők:Anastasopoulos, George Maroulis, Vasileios Bothou, Anastasia Chalkidou, Anna Deuteraiou, Dorelia Anthoulaki, Xanthoula Tsatsaris, Georgios Bourazan, Arzou Iatrakis, George Zervoudis, Stefanos Galazios, Georgios Inagamova, Lola-Katerina Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász) Teichmann, Alexander
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4.

001-es BibID:BIBFORM072241
Első szerző:Tsikouras, Panagioti
Cím:Predictive value of fetal scalp pH and base excess for fetal acidosis and poor neonatal outcome / Tsikouras Panagiotis, Koukouli Zacharoula, Niesigk Barbara, Manav Bachar, Farmakides George, Csorba Roland, Galazios Georgios, Teichmann Alexander Tobias
Dátum:2018
ISSN:1476-7058 1476-4954
Megjegyzések:Objective: The objective of this study is to assess retrospectively the predictive value of fetal scalp pH and base excess (BE) for fetal acidosis and poor neonatal outcome in term, low-risk, spontaneous deliveries with suspicious or pathological intrapartum cardiotocography (CTG) tracings. Methods: Umbilical artery pH and BE values obtained immediately after delivery and Apgar score were the outcomes under consideration. Statistics included receiver-operating characteristic curve (ROC) and multiple logistic regression analysis. Results: Four hundred and six deliveries were included in the study. Scalp pH?<?7.20 predicted umbilical pH ?7.1 with 64.3% sensitivity and 92.9% specificity (p?<?.001). The corresponding positive-predictive value (PPV) was 24.3% and the negative-predictive value (NPV) was 98.6%. Scalp BE????7?mmol/l (a cut-off value provided by ROC curve analysis) predicted Apgar score???7 at 5?min with 61.9% sensitivity and 91.7% specificity (p?<?.001). The corresponding PPV and NPV were 29.5 and 97.7%, respectively. Neither scalp pH nor BE was significantly associated with umbilical BE values. Infants with intrapartum BE????7?mmol/l were 30 times on an average more likely to get a low Apgar score, independently of intrapartum pH values. Conclusion: Our study supports the consideration of both scalp pH and BE values, when fetal blood sampling (FBS) is used.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The Journal of Maternal-Fetal & Neonatal Medicine. - 31 : 23 (2018), p. 3166-3171. -
További szerzők:Koukouli, Zacharoula Niesigk, Barbara Manav, Bachar Farmakides, George Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász) Galazios, Georgios Teichmann, Alexander
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5.

001-es BibID:BIBFORM048821
Első szerző:Tsikouras, Panagioti
Cím:The contribution of catumaxomab in the treatment of malignant ascites in patients with ovarian cancer : a review of the literature / Panagiotis Tsikouras, Nikolaos Tsagias, Petros Pinidis, Roland Csorba, Nikolaos Vrachnis, Alexandros Dafopoulos, Sophia Bouchlariotou, Anastasios Liberis, Alexander Tobias Teichmann, Georg Friedrich von Tempelhoff
Dátum:2013
ISSN:0932-0067 1432-0711
Megjegyzések:The approval of the first specific drug catumaxomab for the treatment of malignant ascites is the subject of this review. This trifunctional antibody is known to kill EpCAM-positive tumor cells and therefore attacks the primary cause of malignant ascites formation in the peritoneal cavity. Until today catumaxomab is the only EpCam-targeted antibody approved by the European Medicines Agency. Ovarian cancer is caused by epithelial tumors cells which overexpress epithelial cell adhesion molecule (EpCAM). The existing literature concerning the use of catumaxomab for the treatment of malignant ascites associated with ovarian cancer until today is reported in this article. It is very encouraging that different prospective studies from diverse scientific teams recently presented positive results concerning the efficacy and the safety of catumaxomab in the treatment of malignant ascites in patients with ovarian cancer. A case of a patient with ovarian cancer FIGO IIIc is also referred in this article. A complete remission and stable disease was found after 4 i.p. infusions of catumaxomab.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Catumaxomab
Malignant ascites
Ovarian cancer
Megjelenés:Archives of Gynecology and Obstetrics. - 288 : 3 (2013), p. 581-585. -
További szerzők:Tsagias, Nikolaos Pinidis, Petros Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász) Vrachnis, Nikolaos Dafopoulos, Alexandros Bouchlariotou, Sofia Liberis, Anastasios Teichmann, Alexander Tempelhoff, Georg-Friedrich von
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