Találati lista | Tudóstér

001-es BibID:	BIBFORM048821
Első szerző:	Tsikouras, Panagioti
Cím:	The contribution of catumaxomab in the treatment of malignant ascites in patients with ovarian cancer : a review of the literature / Panagiotis Tsikouras, Nikolaos Tsagias, Petros Pinidis, Roland Csorba, Nikolaos Vrachnis, Alexandros Dafopoulos, Sophia Bouchlariotou, Anastasios Liberis, Alexander Tobias Teichmann, Georg Friedrich von Tempelhoff
Dátum:	2013
ISSN:	0932-0067 1432-0711
Megjegyzések:	The approval of the first specific drug catumaxomab for the treatment of malignant ascites is the subject of this review. This trifunctional antibody is known to kill EpCAM-positive tumor cells and therefore attacks the primary cause of malignant ascites formation in the peritoneal cavity. Until today catumaxomab is the only EpCam-targeted antibody approved by the European Medicines Agency. Ovarian cancer is caused by epithelial tumors cells which overexpress epithelial cell adhesion molecule (EpCAM). The existing literature concerning the use of catumaxomab for the treatment of malignant ascites associated with ovarian cancer until today is reported in this article. It is very encouraging that different prospective studies from diverse scientific teams recently presented positive results concerning the efficacy and the safety of catumaxomab in the treatment of malignant ascites in patients with ovarian cancer. A case of a patient with ovarian cancer FIGO IIIc is also referred in this article. A complete remission and stable disease was found after 4 i.p. infusions of catumaxomab.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Catumaxomab Malignant ascites Ovarian cancer
Megjelenés:	Archives of Gynecology and Obstetrics. - 288 : 3 (2013), p. 581-585. -
További szerzők:	Tsagias, Nikolaos Pinidis, Petros Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász) Vrachnis, Nikolaos Dafopoulos, Alexandros Bouchlariotou, Sofia Liberis, Anastasios Teichmann, Alexander Tempelhoff, Georg-Friedrich von
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM048822
Első szerző:	Tsikouras, Panagioti
Cím:	Endometrial cancer : molecular and therapeutic aspects / Panagiotis Tsikouras, Sofia Bouchlariotou, Nikolaos Vrachnis, Alexandros Dafopoulos, Georgios Galazios, Roland Csorba, Georg Friedrich von Tempelhoff
Dátum:	2013
ISSN:	0301-2115
Megjegyzések:	Endometrial cancer (EC) is the most commonly diagnosed gynecologic malignancy. Although early-stage EC is effectively treated surgically, commonly without adjuvant therapy, the treatment of high-risk and advanced disease is more complex. Chemotherapy has evolved into an important modality in high-risk early-stage and advanced-stage disease, and in recurrent EC. Multi-institutional trials are in progress to better define optimal adjuvant treatment for subsets of patients, as well as the role of surgical staging in reducing both overuse and underuse of radiation therapy. Understanding and identifying the molecular biology and genetics of EC are central to the development of novel therapies. A number of molecular and genetic events have been observed in ECs, which have enabled us to have a better understanding of the biology and development of the disease. For example, the PTEN/AKT pathway and its downstream targets and the mTOR pathway have been shown to play an important role in EC pathogenesis. This review summarizes the background of the known molecular alterations, and the management of patients with EC.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Endometrial cancer Management Molecular biology
Megjelenés:	European Journal of Obstetrics Gynecology and Reproductive Biology. - 169 : 1 (2013), p. 1-9. -
További szerzők:	Bouchlariotou, Sofia Vrachnis, Nikolaos Dafopoulos, Alexandros Galazios, Georgios Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász) Tempelhoff, Georg-Friedrich von
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: