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001-es BibID:BIBFORM048861
Első szerző:Koukoulomati, A.
Cím:Diagnostic approach and therapeutic management in early-stage endometrial cancer / A. Koukoulomati, P. Tsikouras, N. Tsagias, R. Csorba, A. Liberis, A. T. Teichmann, V. S. Liberis, G. Galazios
Dátum:2013
ISSN:0392-2936
Megjegyzések:OBJECTIVE:The effectiveness of pelvic and para-aortic lymphadenectomy in the morbidity of patients affected by early-stage endometrial carcinoma (EC) is the subject of this study.STUDY DESIGN:Ninety-two cases with endometrial cancer that underwent para-aortic and pelvic lymphadenectomy, from June 1995 to June 2006, were studied and compared with 30 cases of patients with endometrial cancer without lymphadenectomy.RESULTS:According to the results, systematic pelvic and para-aortic lymphadenectomies improved disease-free and overall survival rates among the patients with endometrial cancer. The mean number of removed para-aortic lymph nodes was 19.01 +/- 5.88, whereas the mean number of removed iliac lymph nodes was 32.94 +/- 6.69. Forty-two and 31 metastatic iliac and para-aortic nodes were found, respectively. No surgery-related deaths and major intraoperative injuries occurred. The frequency and the type of postoperative complications were not affected by the performance of lymphadenectomy. The morbidity rate was 6.2%, similar to the group without lymphadenectomy (5.79%). No recurrence occurred in the group with lymphadenectomy, while in the other group the recurrence rate was 23.3%.CONCLUSIONS:Lymph nodes metastases can be observed in early stages of EC. Pelvic and para-aortic lymphadenectomies seems to provide profound information about the Stage of the disease and the patient's survival, identifying which patients are suitable for supplementary treatment, without significant clinical increase of morbidity.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Endometrial cancer
Paraortal iliac lymphadenectomy
morbidity
early stages
Megjelenés:European Journal of Gynaecological Oncology. - 34 : 4 (2013), p. 319-321. -
További szerzők:Tsikouras, Panagioti Tsagias, Nikolaos Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász) Liberis, Anastasios Teichmann, Alexander Liberis, V. S. Galazios, Georgios
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2.

001-es BibID:BIBFORM072233
Első szerző:Liatsikos, Spyros A.
Cím:Inherited thrombophilia and reproductive disorders / Liatsikos Spyros A., Tsikouras Panagiotis, Manav Bachar, Csorba Roland, Tempelhoff Georg Friedrich von, Galazios Georgios
Dátum:2016
ISSN:1309-0399 1309-0380
Megjegyzések:Apart from its established role in the pathogenesis of venous thromboembolism (VTE), inherited thrombophilia has been proposed as a possible cause of pregnancy loss and vascular gestational complications. There is a lot of controversy in the literature on the relationship between inherited prothrombotic defects and these obstetric complications. This is a review of the literature on inherited thrombophilia and reproductive disorders. Factor V Leiden, prothrombin G20210A mutation, and protein S deficiency seem to be associated with late and recurrent early pregnancy loss, while their impact on other pregnancy complications is conflicting. No definite association has been established between protein C and antithrombin deficiency and adverse pregnancy outcome, primarily due to their low prevalence. Screening is suggested only for women with early recurrent loss or late pregnancy loss. Anticoagulant treatment during pregnancy should be considered for women with complications who were tested positive for thrombophilia.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Inherited thrombophilia
Recurrent pregnancy loss
Reproductive disorders
Megjelenés:Journal of the Turkish German Gynecology Association 17 : 1 (2016), p. 45-50. -
További szerzők:Tsikouras, Panagioti Manav, Bachar Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász) Tempelhoff, Georg-Friedrich von Galazios, Georgios
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3.

001-es BibID:BIBFORM073324
035-os BibID:(Scopus)85045740530 (WOS)000434868800230 (cikkazonosító)791
Első szerző:Tsikouras, Panagioti
Cím:Comparative Evaluation of Arabin Pessary and Cervical Cerclage for the Prevention of Preterm Labor in Asymptomatic Women with High Risk Factors / Panagiotis Tsikouras, George Anastasopoulos, Vasileios Maroulis, Anastasia Bothou, Anna Chalkidou, Dorelia Deuteraiou, Xanthoula Anthoulaki, Georgios Tsatsaris, Arzou Halil Bourazan, George Iatrakis, Stefanos Zervoudis, Georgios Galazios, Lola-Katerina Inagamova, Roland Csorba, Alexander-Tobias Teichmann
Dátum:2018
ISSN:1661-7827 1660-4601
Megjegyzések:Abstract: Objective: Preterm labor is one of the most significant obstetric problems associated withhigh rate of actual and long-term perinatal complications. Despite the creation of scoring systems,uterine activity monitoring, cervical ultrasound and several biochemical markers, the prediction andprevention of preterm labor is still a matter of concern. The aim of this study was to examine cervicalfindings for the prediction and the comparative use of Arabin pessary or cerclage for the preventionof preterm birth in asymptomatic women with high risk factors for preterm labor. Material andmethods: The study group was composed of singleton pregnancies (spontaneously conceived) withhigh risk factors for preterm labor. Cervical length, dilatation of the internal cervical os and funneling,were estimated with transvaginal ultrasound during the first and the second trimesters of pregnancy.Results: Cervical funneling, during the second trimester of pregnancy, was the most significant factorfor the prediction of preterm labor. The use of Arabin cervical pessary was found to be more effectivethan cerclage in the prolongation of pregnancy. Conclusion: In women at risk for preterm labor,the detection of cervical funneling in the second trimester of pregnancy may help to predict pretermlabor and to apply the appropriate treatment for its prevention. Although the use of cervical pessarywas found to be more effective than cerclage, more studies are needed to classify the effectiveness ofdifferent methods for such prevention.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
cervical Arabin pessary
cerclage
second trimester of pregnancy
Megjelenés:International Journal of Environmental Research and Public Health. - 15 : 4 (2018), p. 1-10. -
További szerzők:Anastasopoulos, George Maroulis, Vasileios Bothou, Anastasia Chalkidou, Anna Deuteraiou, Dorelia Anthoulaki, Xanthoula Tsatsaris, Georgios Bourazan, Arzou Iatrakis, George Zervoudis, Stefanos Galazios, Georgios Inagamova, Lola-Katerina Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász) Teichmann, Alexander
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4.

001-es BibID:BIBFORM072232
Első szerző:Tsikouras, Panagioti
Cím:Induction of Labor in Post-Term Nulliparous and Parous Women : potential Advantages of Misoprostol over Dinoprostone = Geburtseinleitung bei übertragenen Schwangerschaften in Nulliparae und Parae - mögliche Vorteile von Misoprostol gegenüber Dinoproston / Tsikouras P., Koukouli Z., Manav B., Soilemetzidis M., Liberis A., Csorba R., Trypsianis G., Galazios G.
Dátum:2016
ISSN:0016-5751
Megjegyzések:Introduction: We undertook a prospective cohort study to compare the effectiveness and safety of 50 ?g misoprostol versus 3 mg dinoprostone in two vaginal doses 6 hours apart, followed if necessary by oxytocin for labor induction in low-risk post-term (> 40 weeks) pregnancies with unfavorable cervix (Bishop score ? 6). Methods: Labor induction and subsequent management were conducted using a standardized protocol. The primary outcome of the study was labor induction rate. Secondary outcomes included mode of delivery, time interval from induction to delivery, maternal complications and neonatal outcome. Results: 107 patients received misoprostol (Group A) and 99 patients received dinoprostone (Group B). Compared with group A, more women in Group B needed a second vaginal dose of prostaglandin or oxytocin infusion in order to proceed to labor (21.5 vs. 43.4 %; p = 0.01). Misoprostol alone as a single or double vaginal dose was more effective than dinoprostone alone in inducing labor without oxytocin administration (85.0 vs. 50.4 %; p = 0.04). Overall, the rate of successful induction of labor did not differ between groups (91.6 vs. 85.8 %; p = 0.75). Vaginal delivery, operative vaginal delivery and Caesarean section rates were not significantly different. Time interval from induction to delivery however, was shorter for Group A (median 11 hours vs. 14.1 hours; p < 0.001). Though emergency Caesarean section due to fetal distress was more frequent in Group A (16.8 vs. 4.0 %; p = 0.007), low Apgar scores < 7 and NICU admissions did not differ significantly. Maternal complications, mostly not serious, were higher in Group A (31.8 vs. 2.0, p < 0.001). Conclusion: Misoprostol is a more effective agent than dinoprost in post-term pregnancy for labor induction with few maternal adverse effects.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
dinoprostone
labor induction
misoprostol
post-term pregnancy
Megjelenés:Geburtshilfe Und Frauenheilkunde 76 : 7 (2016), p. 785-792. -
További szerzők:Koukouli, Zacharoula Manav, Bachar Soilemetzidis, M. Liberis, Anastasios Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász) Trypsianis, G. Galazios, Georgios
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5.

001-es BibID:BIBFORM072241
Első szerző:Tsikouras, Panagioti
Cím:Predictive value of fetal scalp pH and base excess for fetal acidosis and poor neonatal outcome / Tsikouras Panagiotis, Koukouli Zacharoula, Niesigk Barbara, Manav Bachar, Farmakides George, Csorba Roland, Galazios Georgios, Teichmann Alexander Tobias
Dátum:2018
ISSN:1476-7058 1476-4954
Megjegyzések:Objective: The objective of this study is to assess retrospectively the predictive value of fetal scalp pH and base excess (BE) for fetal acidosis and poor neonatal outcome in term, low-risk, spontaneous deliveries with suspicious or pathological intrapartum cardiotocography (CTG) tracings. Methods: Umbilical artery pH and BE values obtained immediately after delivery and Apgar score were the outcomes under consideration. Statistics included receiver-operating characteristic curve (ROC) and multiple logistic regression analysis. Results: Four hundred and six deliveries were included in the study. Scalp pH?<?7.20 predicted umbilical pH ?7.1 with 64.3% sensitivity and 92.9% specificity (p?<?.001). The corresponding positive-predictive value (PPV) was 24.3% and the negative-predictive value (NPV) was 98.6%. Scalp BE????7?mmol/l (a cut-off value provided by ROC curve analysis) predicted Apgar score???7 at 5?min with 61.9% sensitivity and 91.7% specificity (p?<?.001). The corresponding PPV and NPV were 29.5 and 97.7%, respectively. Neither scalp pH nor BE was significantly associated with umbilical BE values. Infants with intrapartum BE????7?mmol/l were 30 times on an average more likely to get a low Apgar score, independently of intrapartum pH values. Conclusion: Our study supports the consideration of both scalp pH and BE values, when fetal blood sampling (FBS) is used.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The Journal of Maternal-Fetal & Neonatal Medicine. - 31 : 23 (2018), p. 3166-3171. -
További szerzők:Koukouli, Zacharoula Niesigk, Barbara Manav, Bachar Farmakides, George Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász) Galazios, Georgios Teichmann, Alexander
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6.

001-es BibID:BIBFORM048822
Első szerző:Tsikouras, Panagioti
Cím:Endometrial cancer : molecular and therapeutic aspects / Panagiotis Tsikouras, Sofia Bouchlariotou, Nikolaos Vrachnis, Alexandros Dafopoulos, Georgios Galazios, Roland Csorba, Georg Friedrich von Tempelhoff
Dátum:2013
ISSN:0301-2115
Megjegyzések:Endometrial cancer (EC) is the most commonly diagnosed gynecologic malignancy. Although early-stage EC is effectively treated surgically, commonly without adjuvant therapy, the treatment of high-risk and advanced disease is more complex. Chemotherapy has evolved into an important modality in high-risk early-stage and advanced-stage disease, and in recurrent EC. Multi-institutional trials are in progress to better define optimal adjuvant treatment for subsets of patients, as well as the role of surgical staging in reducing both overuse and underuse of radiation therapy. Understanding and identifying the molecular biology and genetics of EC are central to the development of novel therapies. A number of molecular and genetic events have been observed in ECs, which have enabled us to have a better understanding of the biology and development of the disease. For example, the PTEN/AKT pathway and its downstream targets and the mTOR pathway have been shown to play an important role in EC pathogenesis. This review summarizes the background of the known molecular alterations, and the management of patients with EC.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Endometrial cancer
Management
Molecular biology
Megjelenés:European Journal of Obstetrics Gynecology and Reproductive Biology. - 169 : 1 (2013), p. 1-9. -
További szerzők:Bouchlariotou, Sofia Vrachnis, Nikolaos Dafopoulos, Alexandros Galazios, Georgios Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász) Tempelhoff, Georg-Friedrich von
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